Details for: CLK3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 143.7845
Cell Significance Index: -22.3700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 96.7106
Cell Significance Index: -24.5300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 66.9260
Cell Significance Index: -27.5700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 61.0011
Cell Significance Index: -28.8000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 59.8513
Cell Significance Index: -24.3200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 53.5980
Cell Significance Index: -27.5700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.7399
Cell Significance Index: -24.5800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.9845
Cell Significance Index: -24.6400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 7.8018
Cell Significance Index: -20.9000 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.0932
Cell Significance Index: -27.9900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 6.4627
Cell Significance Index: -19.8500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.9523
Cell Significance Index: -8.6500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.9792
Cell Significance Index: 13.3600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9622
Cell Significance Index: 26.1900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9164
Cell Significance Index: 149.0500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.8372
Cell Significance Index: 43.4900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8209
Cell Significance Index: 37.2100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5965
Cell Significance Index: 38.4900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5965
Cell Significance Index: 17.1900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5669
Cell Significance Index: 26.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.5666
Cell Significance Index: 26.6300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.5145
Cell Significance Index: 7.7100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4670
Cell Significance Index: 24.3300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4378
Cell Significance Index: 78.9300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4168
Cell Significance Index: 82.7200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4083
Cell Significance Index: 50.2100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3799
Cell Significance Index: 8.2300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.3683
Cell Significance Index: 4.3900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3579
Cell Significance Index: 10.2600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3363
Cell Significance Index: 8.9800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3325
Cell Significance Index: 181.6000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3104
Cell Significance Index: 42.6200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2977
Cell Significance Index: 29.4500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2882
Cell Significance Index: 260.2600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2813
Cell Significance Index: 56.4200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2779
Cell Significance Index: 19.2200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2708
Cell Significance Index: 31.9300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2647
Cell Significance Index: 13.9000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2504
Cell Significance Index: 18.6600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2381
Cell Significance Index: 6.2600 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2349
Cell Significance Index: 30.3500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2153
Cell Significance Index: 27.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2028
Cell Significance Index: 15.5700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1970
Cell Significance Index: 87.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1924
Cell Significance Index: 6.7600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.1777
Cell Significance Index: 3.7200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1702
Cell Significance Index: 9.5500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1591
Cell Significance Index: 57.0600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1496
Cell Significance Index: 4.1800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1411
Cell Significance Index: 26.8600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1383
Cell Significance Index: 95.6800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0879
Cell Significance Index: 5.5400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0277
Cell Significance Index: 1.9600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0276
Cell Significance Index: 37.5700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0202
Cell Significance Index: 37.9700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0193
Cell Significance Index: 0.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0074
Cell Significance Index: 13.7000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0037
Cell Significance Index: 5.6700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0016
Cell Significance Index: -0.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0165
Cell Significance Index: -12.0800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0206
Cell Significance Index: -13.0700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0213
Cell Significance Index: -16.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0277
Cell Significance Index: -2.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0285
Cell Significance Index: -12.9500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0334
Cell Significance Index: -24.7300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0396
Cell Significance Index: -6.7600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0457
Cell Significance Index: -25.7800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0503
Cell Significance Index: -31.4000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0528
Cell Significance Index: -1.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0601
Cell Significance Index: -6.8800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0671
Cell Significance Index: -1.2400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0814
Cell Significance Index: -23.4200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0925
Cell Significance Index: -1.6400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1154
Cell Significance Index: -16.7700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1162
Cell Significance Index: -7.1400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1263
Cell Significance Index: -2.6900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1295
Cell Significance Index: -2.1700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1350
Cell Significance Index: -15.7300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1497
Cell Significance Index: -31.5300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1814
Cell Significance Index: -5.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2357
Cell Significance Index: -6.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2467
Cell Significance Index: -25.6900 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2499
Cell Significance Index: -1.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2674
Cell Significance Index: -17.9800 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2748
Cell Significance Index: -7.0200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2993
Cell Significance Index: -3.4000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3037
Cell Significance Index: -24.0600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.3084
Cell Significance Index: -8.2500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3518
Cell Significance Index: -3.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3568
Cell Significance Index: -15.7800 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.3661
Cell Significance Index: -5.5600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.3763
Cell Significance Index: -3.9000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3946
Cell Significance Index: -4.2900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4487
Cell Significance Index: -7.6900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4516
Cell Significance Index: -27.6900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4582
Cell Significance Index: -17.3500 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.5241
Cell Significance Index: -4.0400 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.5308
Cell Significance Index: -7.4400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.5412
Cell Significance Index: -7.7500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5612
Cell Significance Index: -14.4300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 632523565
Symbol: CLK3_HUMAN
Name: Dual specificity protein kinase CLK3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7990150
Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
PubMed ID: 7990150
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9637771
Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.
PubMed ID: 9637771
PubMed ID: 14759258
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19168442
Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
PubMed ID: 19168442
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 21615147
Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
PubMed ID: 21615147
DOI: 10.1021/jm200274d
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 490
- Mass: 58588
- Checksum: 86A342ABB8AB24CA
- Sequence:
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER SFHTSRNPSR
Genular Protein ID: 3637432907
Symbol: B3KRI8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 638
- Mass: 73534
- Checksum: 833402BD33883073
- Sequence:
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRR MAYQLCHALR FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.