Details for: CLK3

Gene ID: 1198

Symbol: CLK3

Ensembl ID: ENSG00000179335

Description: CDC like kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.7845
    Cell Significance Index: -22.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.7106
    Cell Significance Index: -24.5300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.9260
    Cell Significance Index: -27.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.0011
    Cell Significance Index: -28.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.8513
    Cell Significance Index: -24.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.5980
    Cell Significance Index: -27.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.7399
    Cell Significance Index: -24.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9845
    Cell Significance Index: -24.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8018
    Cell Significance Index: -20.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0932
    Cell Significance Index: -27.9900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4627
    Cell Significance Index: -19.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9523
    Cell Significance Index: -8.6500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9792
    Cell Significance Index: 13.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9622
    Cell Significance Index: 26.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9164
    Cell Significance Index: 149.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8372
    Cell Significance Index: 43.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8209
    Cell Significance Index: 37.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5965
    Cell Significance Index: 38.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5965
    Cell Significance Index: 17.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5669
    Cell Significance Index: 26.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5666
    Cell Significance Index: 26.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5145
    Cell Significance Index: 7.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4670
    Cell Significance Index: 24.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4378
    Cell Significance Index: 78.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4168
    Cell Significance Index: 82.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4083
    Cell Significance Index: 50.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3799
    Cell Significance Index: 8.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3683
    Cell Significance Index: 4.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3579
    Cell Significance Index: 10.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3363
    Cell Significance Index: 8.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3325
    Cell Significance Index: 181.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3104
    Cell Significance Index: 42.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2977
    Cell Significance Index: 29.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2882
    Cell Significance Index: 260.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2813
    Cell Significance Index: 56.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2779
    Cell Significance Index: 19.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2708
    Cell Significance Index: 31.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2647
    Cell Significance Index: 13.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2504
    Cell Significance Index: 18.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2381
    Cell Significance Index: 6.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2349
    Cell Significance Index: 30.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2153
    Cell Significance Index: 27.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2028
    Cell Significance Index: 15.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1970
    Cell Significance Index: 87.1000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1924
    Cell Significance Index: 6.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1777
    Cell Significance Index: 3.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1702
    Cell Significance Index: 9.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1591
    Cell Significance Index: 57.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1496
    Cell Significance Index: 4.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1411
    Cell Significance Index: 26.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1383
    Cell Significance Index: 95.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0879
    Cell Significance Index: 5.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0277
    Cell Significance Index: 1.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0276
    Cell Significance Index: 37.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0202
    Cell Significance Index: 37.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0193
    Cell Significance Index: 0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0074
    Cell Significance Index: 13.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0037
    Cell Significance Index: 5.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0165
    Cell Significance Index: -12.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0206
    Cell Significance Index: -13.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0277
    Cell Significance Index: -2.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0285
    Cell Significance Index: -12.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0334
    Cell Significance Index: -24.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0396
    Cell Significance Index: -6.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0457
    Cell Significance Index: -25.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0503
    Cell Significance Index: -31.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0528
    Cell Significance Index: -1.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0601
    Cell Significance Index: -6.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0671
    Cell Significance Index: -1.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0814
    Cell Significance Index: -23.4200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0925
    Cell Significance Index: -1.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1154
    Cell Significance Index: -16.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1162
    Cell Significance Index: -7.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1263
    Cell Significance Index: -2.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1295
    Cell Significance Index: -2.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1350
    Cell Significance Index: -15.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1497
    Cell Significance Index: -31.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1814
    Cell Significance Index: -5.8100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2357
    Cell Significance Index: -6.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2467
    Cell Significance Index: -25.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2499
    Cell Significance Index: -1.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2674
    Cell Significance Index: -17.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2748
    Cell Significance Index: -7.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2993
    Cell Significance Index: -3.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3037
    Cell Significance Index: -24.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3084
    Cell Significance Index: -8.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3518
    Cell Significance Index: -3.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3568
    Cell Significance Index: -15.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3661
    Cell Significance Index: -5.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3763
    Cell Significance Index: -3.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3946
    Cell Significance Index: -4.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4487
    Cell Significance Index: -7.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4516
    Cell Significance Index: -27.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4582
    Cell Significance Index: -17.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5241
    Cell Significance Index: -4.0400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5308
    Cell Significance Index: -7.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5412
    Cell Significance Index: -7.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5612
    Cell Significance Index: -14.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Dual Specificity Kinase:** CLK3 is a unique kinase that exhibits dual specificity, meaning it can phosphorylate both serine/threonine and tyrosine residues on target proteins. 2. **Widespread Expression:** CLK3 is expressed in numerous cell types, including germ cells, epithelial cells, and immune cells, highlighting its importance in various cellular processes. 3. **Regulatory Functions:** CLK3 is involved in regulating protein phosphorylation, RNA splicing, and cell cycle progression, making it a key player in maintaining cellular homeostasis. 4. **Protein Interactions:** CLK3 interacts with various proteins, including RNA-binding proteins, to regulate cellular processes. **Pathways and Functions:** 1. **Protein Phosphorylation:** CLK3 phosphorylates specific residues on target proteins, influencing their activity, localization, and stability. 2. **RNA Splicing:** CLK3 regulates RNA splicing by phosphorylating RNA-binding proteins, which in turn affect the processing of RNA transcripts. 3. **Cell Cycle Progression:** CLK3 is involved in regulating cell cycle progression by phosphorylating proteins that control the cell cycle machinery. 4. **Acrosomal Vesicle Formation:** CLK3 is also involved in regulating acrosomal vesicle formation, which is essential for sperm function. **Clinical Significance:** CLK3 has been implicated in various diseases, including: 1. **Cancer:** CLK3 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential as a therapeutic target. 2. **Neurological Disorders:** CLK3 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, highlighting its role in regulating protein phosphorylation and neuronal function. 3. **Immunological Disorders:** CLK3 has been implicated in immunological disorders, such as autoimmune diseases, suggesting its potential as a therapeutic target. In conclusion, CLK3 is a multifaceted gene that plays a critical role in regulating various cellular processes, including protein phosphorylation, RNA splicing, and cell cycle progression. Its widespread expression and involvement in various diseases make it an attractive target for therapeutic intervention. Further research is needed to fully elucidate the functions of CLK3 and its role in human disease.

Genular Protein ID: 632523565

Symbol: CLK3_HUMAN

Name: Dual specificity protein kinase CLK3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637771

Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

PubMed ID: 9637771

DOI: 10.1006/excr.1998.4083

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21615147

Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

PubMed ID: 21615147

DOI: 10.1021/jm200274d

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 490
  • Mass: 58588
  • Checksum: 86A342ABB8AB24CA
  • Sequence:
  • MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR 
    YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS 
    ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK 
    SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG 
    KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY 
    NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI 
    GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD 
    GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER 
    SFHTSRNPSR

Genular Protein ID: 3637432907

Symbol: B3KRI8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 638
  • Mass: 73534
  • Checksum: 833402BD33883073
  • Sequence:
  • MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
    GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
    PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
    RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
    RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
    QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
    KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRR MAYQLCHALR 
    FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
    TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
    IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
    LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.