Details for: CLK3

Gene ID: 1198

Symbol: CLK3

Ensembl ID: ENSG00000179335

Description: CDC like kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.75
    Marker Score: 3055
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1818
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.17
    Marker Score: 1073
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.16
    Marker Score: 2739
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.16
    Marker Score: 366
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17853
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 343
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.05
    Marker Score: 1865
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 614
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34774
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.02
    Marker Score: 318
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.01
    Marker Score: 3758
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.01
    Marker Score: 2141
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71641
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47861
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.98
    Marker Score: 341
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.98
    Marker Score: 1404
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.97
    Marker Score: 2396
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.97
    Marker Score: 1687
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.96
    Marker Score: 1161
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.95
    Marker Score: 960
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2385
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.93
    Marker Score: 2564
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.92
    Marker Score: 2289.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.91
    Marker Score: 471
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.91
    Marker Score: 2480.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.91
    Marker Score: 619.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 428
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9
    Marker Score: 2054
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.9
    Marker Score: 709
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2678
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.89
    Marker Score: 1257
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.88
    Marker Score: 3797
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.88
    Marker Score: 8898
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5008.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.87
    Marker Score: 2719
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.84
    Marker Score: 200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.84
    Marker Score: 558
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.83
    Marker Score: 338
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.83
    Marker Score: 992
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 494
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.82
    Marker Score: 511
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.81
    Marker Score: 447
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.81
    Marker Score: 721
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.81
    Marker Score: 45125
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.8
    Marker Score: 9313.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8
    Marker Score: 1620
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.8
    Marker Score: 580
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.79
    Marker Score: 174
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 318
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.78
    Marker Score: 834
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.78
    Marker Score: 781
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.78
    Marker Score: 755
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.78
    Marker Score: 1590
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.78
    Marker Score: 416
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.78
    Marker Score: 444
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.77
    Marker Score: 547.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.77
    Marker Score: 725.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.77
    Marker Score: 199
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.77
    Marker Score: 924
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.76
    Marker Score: 1490
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.76
    Marker Score: 1590
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.76
    Marker Score: 201
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.76
    Marker Score: 506
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.76
    Marker Score: 7494
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.76
    Marker Score: 502
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.75
    Marker Score: 428
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.75
    Marker Score: 160
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.75
    Marker Score: 345
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.74
    Marker Score: 7485
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.74
    Marker Score: 39323.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.74
    Marker Score: 166
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.74
    Marker Score: 256
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.74
    Marker Score: 806
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.74
    Marker Score: 210
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.74
    Marker Score: 182
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.74
    Marker Score: 209
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.74
    Marker Score: 173
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.74
    Marker Score: 360
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.73
    Marker Score: 2883
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.73
    Marker Score: 364
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.73
    Marker Score: 259
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.72
    Marker Score: 387
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.72
    Marker Score: 209
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.72
    Marker Score: 754
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.71
    Marker Score: 325
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 471
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.71
    Marker Score: 187.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 184
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.71
    Marker Score: 1205
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.71
    Marker Score: 710

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Other Information

**Key characteristics:** * Protein structure: CLK3 is a serine/threonine kinase with a molecular weight of approximately 130 kDa. * Subcellular localization: CLK3 is found in the nucleus, cytoplasm, and cell membranes. * Regulation: CLK3 is a key regulator of gene expression through phosphorylation of various target proteins. * Phosphorylation sites: CLK3 can be phosphorylated by various kinases, including MAPK, PI3K, and AMPK. * Functions: Phosphorylation of target proteins by CLK3 can regulate their activity, localization, and stability. **Pathways and functions:** * **Acrosomal vesicle pathway:** CLK3 is involved in the regulation of gene expression through the acrosomal vesicle pathway. * **Atp binding:** CLK3 is a substrate for ATP, and its phosphorylation by ATP can regulate its activity. * **Identical protein binding:** CLK3 can bind to an identical protein called B3KRI8. * **Intermediate filament cytoskeleton:** CLK3 can interact with components of the intermediate filament cytoskeleton, which is involved in cell signaling and migration. * **Membrane:** CLK3 can interact with components of the plasma membrane, such as integrins and cadherins. * **Nuclear speck:** CLK3 is a component of the nuclear speck, a signaling complex that regulates gene expression. * **Nucleoplasm:** CLK3 can interact with components of the nucleoplasm, such as RNA and protein molecules. * **Nucleus:** CLK3 is a component of the nucleus, where it regulates gene expression and other cellular processes. * **Protein binding:** CLK3 can bind to various proteins, including those involved in cell cycle regulation, transcription, and translation. * **Protein phosphorylation:** CLK3 can be phosphorylated by various kinases, which can regulate its activity. **Clinical significance:** * Mutations in the CLK3 gene have been linked to several human diseases, including cancer, developmental disorders, and neurodegenerative diseases. * Targeting CLK3 has been investigated as a therapeutic strategy for these diseases. * CLK3 is a promising target for cancer immunotherapy due to its role in regulating cell cycle progression and survival.

Genular Protein ID: 910035259

Symbol: CLK3_HUMAN

Name: Dual specificity protein kinase CLK3

UniProtKB Accession Codes:

P49761 D3DW59 Q53Y48 Q9BRS3 Q9BUJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 4 EMBL 9 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 19 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 4 Rhea 9 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9637771

Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.

PubMed ID: 9637771

DOI: 10.1006/excr.1998.4083

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19168442

Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.

PubMed ID: 19168442

DOI: 10.1161/circresaha.108.183905

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21615147

Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

PubMed ID: 21615147

DOI: 10.1021/jm200274d

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 638
  • Mass: 73515
  • Checksum: D3B60A9DB4ECEC94
  • Sequence:
    • MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRH MAYQLCHALR 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR

Genular Protein ID: 3637432907

Symbol: B3KRI8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KRI8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 638
  • Mass: 73534
  • Checksum: 833402BD33883073
  • Sequence:
    • MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG 
GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL 
PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG 
RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR 
RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL 
QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD 
KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRR MAYQLCHALR 
FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT 
TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP 
IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM 
LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.