Details for: CLK3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 13.35rCSI 9.96%PRS 71.73
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CSI 12.87rCSI 12.84%PRS 47.69
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CSI 8.78rCSI 14.01%PRS 57.78
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CSI 6.2rCSI 5.6%PRS 50.84
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CSI 5.6rCSI 4.64%PRS 52.95
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CSI 5.42rCSI 8.29%PRS 58.62
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CSI 5.04rCSI 3.91%PRS 55.17
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CSI 4.76rCSI 17.24%PRS 73.81
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CSI 4.6rCSI 28.73%PRS 45.87
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CSI 4.44rCSI 3.56%PRS 75.24
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CSI 3.91rCSI 16.96%PRS 68.47
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CSI 3.62rCSI 2.75%PRS 66.58
-
CSI 3.45rCSI 3.99%PRS 43.98
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CSI 3.44rCSI 2.89%PRS 71.76
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CSI 3.37rCSI 16.93%PRS 66.29
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CSI 3.19rCSI 2.12%PRS 57.6
-
CSI 3.14rCSI 2.19%PRS 64.23
-
CSI 3.11rCSI 2.09%PRS 66.31
-
CSI 3.04rCSI 8.71%PRS 73.3
-
CSI 2.9rCSI 3.48%PRS 52.23
-
CSI 2.9rCSI 3.1%PRS 52.67
-
CSI 2.85rCSI 2.24%PRS 60.69
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CSI 2.83rCSI 2.78%PRS 56.55
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CSI 2.73rCSI 2.4%PRS 64.13
-
CSI 2.71rCSI 2.24%PRS 55.67
-
CSI 2.67rCSI 2.12%PRS 76.13
-
CSI 2.58rCSI 4.47%PRS 44.18
-
CSI 2.57rCSI 1.79%PRS 68.17
-
CSI 2.55rCSI 1.99%PRS 71.83
-
CSI 2.52rCSI 1.49%PRS 70.78
-
CSI 2.48rCSI 1.78%PRS 67.98
-
CSI 2.41rCSI 4.59%PRS 69.83
-
CSI 2.37rCSI 1.8%PRS 67.62
-
CSI 2.34rCSI 4.7%PRS 43.31
-
CSI 2.33rCSI 4.19%PRS 47.19
-
CSI 2.29rCSI 3.31%PRS 63.79
-
CSI 2.28rCSI 2.11%PRS 55.14
-
CSI 2.28rCSI 2.12%PRS 53.82
-
CSI 2.27rCSI 2.56%PRS 70.43
-
CSI 2.26rCSI 2.65%PRS 70.16
-
CSI 2.23rCSI 1.72%PRS 53.61
-
CSI 2.22rCSI 3.03%PRS 59.6
-
CSI 2.2rCSI 6.51%PRS 57.71
-
CSI 2.2rCSI 2.04%PRS 74.13
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CSI 2.2rCSI 1.64%PRS 67.95
-
CSI 2.17rCSI 1.63%PRS 58.68
-
CSI 2.15rCSI 4.88%PRS 59.14
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CSI 2.15rCSI 1.59%PRS 46.73
-
CSI 2.11rCSI 1.77%PRS 58.86
-
CSI 2.08rCSI 3.1%PRS 56.22
-
CSI 2.06rCSI 3.13%PRS 50.44
-
CSI 2.04rCSI 2.14%PRS 50.73
-
CSI 2.04rCSI 1.66%PRS 54.46
-
CSI 2.01rCSI 1.78%PRS 52.42
-
CSI 1.98rCSI 2.55%PRS 59.02
-
CSI 1.95rCSI 4.95%PRS 43.71
-
CSI 1.94rCSI 1.35%PRS 56.61
-
CSI 1.93rCSI 2.39%PRS 49.93
-
CSI 1.93rCSI 2.85%PRS 59.37
-
CSI 1.9rCSI 1.5%PRS 41.11
-
CSI 1.88rCSI 2.34%PRS 34.96
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CSI 1.87rCSI 1.84%PRS 69.84
-
CSI 1.81rCSI 3.19%PRS 35.75
-
CSI 1.8rCSI 3.83%PRS 67.08
-
CSI 1.79rCSI 2.62%PRS 57.79
-
CSI 1.76rCSI 2.4%PRS 56.31
-
CSI 1.76rCSI 4.17%PRS 58.86
-
CSI 1.74rCSI 2.39%PRS 74.31
-
CSI 1.74rCSI 2.32%PRS 62.87
-
CSI 1.71rCSI 1.5%PRS 42.44
-
CSI 1.69rCSI 1.36%PRS 55.21
-
CSI 1.66rCSI 1.69%PRS 67.59
-
CSI 1.65rCSI 2.49%PRS 57.14
-
CSI 1.62rCSI 1.56%PRS 44.58
-
CSI 1.61rCSI 4.09%PRS 62.42
-
CSI 1.55rCSI 2.39%PRS 62.31
-
CSI 1.55rCSI 4.47%PRS 55.85
-
CSI 1.53rCSI 1.76%PRS 47.79
-
CSI 1.53rCSI 9.81%PRS 73.84
-
CSI 1.52rCSI 2.32%PRS 63.42
-
CSI 1.48rCSI 2.03%PRS 62.37
-
CSI 1.44rCSI 1.85%PRS 51.73
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CSI 1.42rCSI 3.51%PRS 52.03
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CSI 1.4rCSI 2.01%PRS 44.22
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CSI 1.39rCSI 2.12%PRS 54.65
-
CSI 1.39rCSI 2.22%PRS 47.16
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CSI 1.34rCSI 2.97%PRS 51.79
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CSI 1.34rCSI 1.29%PRS 54.36
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CSI 1.32rCSI 2.63%PRS 72.4
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CSI 1.31rCSI 2.24%PRS 73.31
-
CSI 1.3rCSI 1.12%PRS 58.72
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CSI 1.24rCSI 2.78%PRS 37.49
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CSI 1.24rCSI 1.08%PRS 64.58
-
CSI 1.15rCSI 1.45%PRS 64.35
-
CSI 1.15rCSI 2.21%PRS 81.61
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CSI 1.14rCSI 1.84%PRS 44.02
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CSI 1.13rCSI 1.74%PRS 52.1
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CSI 1.1rCSI 1.58%PRS 59.38
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CSI 1.09rCSI 2.44%PRS 61.42
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CSI 1.09rCSI 1.4%PRS 37.82
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CSI 0.2rCSI 1.4%PRS 64.6%
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CSI 0.3rCSI 1.5%PRS 64.5%
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CSI 0.5rCSI 1.4%PRS 44.2%
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CSI 0.5rCSI 2.8%PRS 68.1%
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CSI 0.8rCSI 3.4%PRS 53.1%
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CSI 0.8rCSI 1.5%PRS 42.8%
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CSI 0.8rCSI 2.3%PRS 67.6%
-
CSI 0.9rCSI 2.3%PRS 49.0%
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CSI 0.9rCSI 1.2%PRS 59.6%
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CSI 1.0rCSI 1.8%PRS 63.5%
-
CSI 1.1rCSI 3.3%PRS 38.2%
-
CSI 1.1rCSI 1.4%PRS 37.8%
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CSI 1.1rCSI 2.4%PRS 61.4%
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CSI 1.1rCSI 1.6%PRS 59.4%
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CSI 1.1rCSI 1.7%PRS 52.1%
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CSI 1.1rCSI 1.8%PRS 44.0%
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CSI 1.2rCSI 2.2%PRS 81.6%
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CSI 1.2rCSI 1.5%PRS 64.4%
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CSI 1.2rCSI 1.1%PRS 64.6%
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CSI 1.2rCSI 2.8%PRS 37.5%
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CSI 1.3rCSI 1.1%PRS 58.7%
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CSI 1.3rCSI 2.2%PRS 73.3%
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CSI 1.3rCSI 2.6%PRS 72.4%
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CSI 1.3rCSI 1.3%PRS 54.4%
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CSI 1.3rCSI 3.0%PRS 51.8%
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CSI 1.4rCSI 2.2%PRS 47.2%
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CSI 1.4rCSI 2.1%PRS 54.7%
-
CSI 1.4rCSI 2.0%PRS 44.2%
-
CSI 1.4rCSI 3.5%PRS 52.0%
-
CSI 1.4rCSI 1.9%PRS 51.7%
-
CSI 1.5rCSI 2.0%PRS 62.4%
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CSI 1.5rCSI 2.3%PRS 63.4%
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CSI 1.5rCSI 9.8%PRS 73.8%
-
CSI 1.5rCSI 1.8%PRS 47.8%
-
CSI 1.6rCSI 4.5%PRS 55.9%
-
CSI 1.6rCSI 2.4%PRS 62.3%
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CSI 1.6rCSI 4.1%PRS 62.4%
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CSI 1.6rCSI 1.6%PRS 44.6%
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CSI 1.7rCSI 2.5%PRS 57.1%
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CSI 1.7rCSI 1.7%PRS 67.6%
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CSI 1.7rCSI 1.4%PRS 55.2%
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CSI 1.7rCSI 1.5%PRS 42.4%
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CSI 1.7rCSI 2.3%PRS 62.9%
-
CSI 1.7rCSI 2.4%PRS 74.3%
-
CSI 1.8rCSI 4.2%PRS 58.9%
-
CSI 1.8rCSI 2.4%PRS 56.3%
-
CSI 1.8rCSI 2.6%PRS 57.8%
-
CSI 1.8rCSI 3.8%PRS 67.1%
-
CSI 1.8rCSI 3.2%PRS 35.8%
-
CSI 1.9rCSI 1.8%PRS 69.8%
-
CSI 1.9rCSI 2.3%PRS 35.0%
-
CSI 1.9rCSI 1.5%PRS 41.1%
-
CSI 1.9rCSI 2.9%PRS 59.4%
-
CSI 1.9rCSI 2.4%PRS 49.9%
-
CSI 1.9rCSI 1.4%PRS 56.6%
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CSI 2.0rCSI 5.0%PRS 43.7%
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CSI 2.0rCSI 2.6%PRS 59.0%
-
CSI 2.0rCSI 1.8%PRS 52.4%
-
CSI 2.0rCSI 1.7%PRS 54.5%
-
CSI 2.0rCSI 2.1%PRS 50.7%
-
CSI 2.1rCSI 3.1%PRS 50.4%
-
CSI 2.1rCSI 3.1%PRS 56.2%
-
CSI 2.1rCSI 1.8%PRS 58.9%
-
CSI 2.2rCSI 1.6%PRS 46.7%
-
CSI 2.2rCSI 4.9%PRS 59.1%
-
CSI 2.2rCSI 1.6%PRS 58.7%
-
CSI 2.2rCSI 1.6%PRS 68.0%
-
CSI 2.2rCSI 2.0%PRS 74.1%
-
CSI 2.2rCSI 6.5%PRS 57.7%
-
CSI 2.2rCSI 3.0%PRS 59.6%
-
CSI 2.2rCSI 1.7%PRS 53.6%
-
CSI 2.3rCSI 2.7%PRS 70.2%
-
CSI 2.3rCSI 2.6%PRS 70.4%
-
CSI 2.3rCSI 2.1%PRS 53.8%
-
CSI 2.3rCSI 2.1%PRS 55.1%
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CSI 2.3rCSI 3.3%PRS 63.8%
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CSI 2.3rCSI 4.2%PRS 47.2%
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CSI 2.3rCSI 4.7%PRS 43.3%
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CSI 2.4rCSI 1.8%PRS 67.6%
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CSI 2.4rCSI 4.6%PRS 69.8%
-
CSI 2.5rCSI 1.8%PRS 68.0%
-
CSI 2.5rCSI 1.5%PRS 70.8%
-
CSI 2.6rCSI 2.0%PRS 71.8%
-
CSI 2.6rCSI 1.8%PRS 68.2%
-
CSI 2.6rCSI 4.5%PRS 44.2%
-
CSI 2.7rCSI 2.1%PRS 76.1%
-
CSI 2.7rCSI 2.2%PRS 55.7%
-
CSI 2.7rCSI 2.4%PRS 64.1%
-
CSI 2.8rCSI 2.8%PRS 56.6%
-
CSI 2.9rCSI 2.2%PRS 60.7%
-
CSI 2.9rCSI 3.1%PRS 52.7%
-
CSI 2.9rCSI 3.5%PRS 52.2%
-
CSI 3.0rCSI 8.7%PRS 73.3%
-
CSI 3.1rCSI 2.1%PRS 66.3%
-
CSI 3.1rCSI 2.2%PRS 64.2%
-
CSI 3.2rCSI 2.1%PRS 57.6%
-
CSI 3.4rCSI 16.9%PRS 66.3%
-
CSI 3.4rCSI 2.9%PRS 71.8%
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CSI 3.5rCSI 4.0%PRS 44.0%
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CSI 3.6rCSI 2.8%PRS 66.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 632523565
Symbol: CLK3_HUMAN
Name: Dual specificity protein kinase CLK3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7990150
Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
PubMed ID: 7990150
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9637771
Title: The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing.
PubMed ID: 9637771
PubMed ID: 14759258
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19168442
Title: Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.
PubMed ID: 19168442
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 21615147
Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.
PubMed ID: 21615147
DOI: 10.1021/jm200274d
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 490
- Mass: 58588
- Checksum: 86A342ABB8AB24CA
- Sequence:
MHHCKRYRSP EPDPYLSYRW KRRRSYSREH EGRLRYPSRR EPPPRRSRSR SHDRLPYQRR YRERRDSDTY RCEERSPSFG EDYYGPSRSR HRRRSRERGP YRTRKHAHHC HKRRTRSCSS ASSRSQQSSK RSSRSVEDDK EGHLVCRIGD WLQERYEIVG NLGEGTFGKV VECLDHARGK SQVALKIIRN VGKYREAARL EINVLKKIKE KDKENKFLCV LMSDWFNFHG HMCIAFELLG KNTFEFLKEN NFQPYPLPHV RHMAYQLCHA LRFLHENQLT HTDLKPENIL FVNSEFETLY NEHKSCEEKS VKNTSIRVAD FGSATFDHEH HTTIVATRHY RPPEVILELG WAQPCDVWSI GCILFEYYRG FTLFQTHENR EHLVMMEKIL GPIPSHMIHR TRKQKYFYKG GLVWDENSSD GRYVKENCKP LKSYMLQDSL EHVQLFDLMR RMLEFDPAQR ITLAEALLHP FFAGLTPEER SFHTSRNPSR
Genular Protein ID: 3637432907
Symbol: B3KRI8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
Sequence Information:
- Length: 638
- Mass: 73534
- Checksum: 833402BD33883073
- Sequence:
MPVLSARRRE LADHAGSGRR SGPSPTARSG PHLSALRAQP ARAAHLSGRG TYVRRDTAGG GPGQARPLGP PGTSLLGRGA RRSGEGWCPG AFESGARAAR PPSRVEPRLA TAASREGAGL PRAEVAAGSG RGARSGEWGL AAAGAWETMH HCKRYRSPEP DPYLSYRWKR RRSYSREHEG RLRYPSRREP PPRRSRSRSH DRLPYQRRYR ERRDSDTYRC EERSPSFGED YYGPSRSRHR RRSRERGPYR TRKHAHHCHK RRTRSCSSAS SRSQQSSKRS SRSVEDDKEG HLVCRIGDWL QERYEIVGNL GEGTFGKVVE CLDHARGKSQ VALKIIRNVG KYREAARLEI NVLKKIKEKD KENKFLCVLM SDWFNFHGHM CIAFELLGKN TFEFLKENNF QPYPLPHVRR MAYQLCHALR FLHENQLTHT DLKPENILFV NSEFETLYNE HKSCEEKSVK NTSIRVADFG SATFDHEHHT TIVATRHYRP PEVILELGWA QPCDVWSIGC ILFEYYRGFT LFQTHENREH LVMMEKILGP IPSHMIHRTR KQKYFYKGGL VWDENSSDGR YVKENCKPLK SYMLQDSLEH VQLFDLMRRM LEFDPAQRIT LAEALLHPFF AGLTPEERSF HTSRNPSR