Genular: Defining Cellular Identity and Function

Details for: Slc7a2

Gene ID: 11988

Symbol: Slc7a2

Ensembl ID: ENSMUSG00000031596

Description: solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

Associated with

Amino acid import across plasma membrane
(GO:0089718)
Amino acid transmembrane transporter activity
(GO:0015171)
Amino acid transport
(GO:0006865)
Cell junction
(GO:0030054)
Establishment of localization in cell
(GO:0051649)
L-alpha-amino acid transmembrane transport
(GO:1902475)
L-amino acid transmembrane transporter activity
(GO:0015179)
L-amino acid transport
(GO:0015807)
L-arginine import across plasma membrane
(GO:0097638)
L-arginine transmembrane transport
(GO:1903826)
L-arginine transmembrane transporter activity
(GO:0061459)
L-lysine transmembrane transporter activity
(GO:0015189)
L-ornithine transmembrane transport
(GO:1903352)
L-ornithine transmembrane transporter activity
(GO:0000064)
Macrophage activation
(GO:0042116)
Membrane
(GO:0016020)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide production involved in inflammatory response
(GO:0002537)
Plasma membrane
(GO:0005886)
Regulation of inflammatory response
(GO:0050727)
Regulation of macrophage activation
(GO:0043030)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)

Other Information

Proteins

20.5

Genular Protein ID: 368912688

Symbol: CTR2_MOUSE

Name: 20.5

UniProtKB Accession Codes:

P18581 E9QPL9 Q38RA6 Q3TB99 Q3U3R5

Database IDs:

Citations:

PubMed ID: 1694015

Title: Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor.

PubMed ID: 1694015

DOI: 10.1128/mcb.10.7.3663-3674.1990

PubMed ID: 8385111

Title: Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver.

PubMed ID: 8385111

DOI: 10.1016/s0021-9258(18)53209-9

PubMed ID: 8195186

Title: Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family.

PubMed ID: 8195186

DOI: 10.1016/s0021-9258(17)40699-5

PubMed ID: 16239143

Title: Regulating gene expression through RNA nuclear retention.

PubMed ID: 16239143

DOI: 10.1016/j.cell.2005.08.033

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9174363

Title: Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.

PubMed ID: 9174363

DOI: 10.1021/bi962829p

PubMed ID: 16670299

Title: Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages.

PubMed ID: 16670299

DOI: 10.4049/jimmunol.176.10.5918

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28642498

Title: Uptake and metabolism of arginine impact Plasmodium development in the liver.

PubMed ID: 28642498

DOI: 10.1038/s41598-017-04424-y

Sequence Information:

Length: 657
Mass: 71856
Checksum: 140CC99D3AB96082
Sequence:

MIPCRAVLTF ARCLIRRKIV TLDSLEDSKL CRCLTTVDLI ALGVGSTLGA GVYVLAGEVA 
KADSGPSIVV SFLIAALASV MAGLCYAEFG ARVPKTGSAY LYTYVTVGEL WAFITGWNLI 
LSYVIGTSSV ARAWSGTFDE LLNKQIGQFF KTYFKMNYTG LAEYPDFFAV CLVLLLAGLL 
SFGVKESAWV NKFFTAINIL VLLFVMVAGF VKGNVANWKI SEEFLKNISA SAREPPSENG 
TSIYGAGGFM PYGFTGTLAG AATCFYAFVG FDCIATTGEE VRNPQKAIPI GIVTSLLVCF 
MAYFGVSAAL TLMMPYYLLD EKSPLPVAFE YVRWSPAKYV VSAGSLCALS TSLLGSMFPL 
PRILFAMARD GLLFRFLARV SKRQSPVAAT MTAGVISAVM AFLFDLKALV DMMSIGTLMA 
YSLVAACVLI LRYQPGLCYD QPKYTPEKET LESCTNATLK SESQVTMLQG QGFSLRTLFS 
PSALPTRQSA SLVSFLVGFL AFLILGLSIL TTYGVQAIAR LEAWSLALLA LFLVLCVAVI 
LTIWRQPQNQ QKVAFMVPFL PFLPAFSILV NIYLMVQLSA DTWIRFSIWM ALGFLIYFAY 
GIRHSLEGNP RDEEDDEDAF SDNINAATEE KSAMQANDHH QRNLSLPFIL HEKTSEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc7a2

Associated with

Other Information

Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. PubMed ID: 1694015

Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver. PubMed ID: 8385111

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family. PubMed ID: 8195186

Regulating gene expression through RNA nuclear retention. PubMed ID: 16239143

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties. PubMed ID: 9174363

Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. PubMed ID: 16670299

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Uptake and metabolism of arginine impact Plasmodium development in the liver. PubMed ID: 28642498