Details for: SERPINA3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 31.2222
Cell Significance Index: 179.8000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 25.1073
Cell Significance Index: -10.2000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 22.0909
Cell Significance Index: 372.1200 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 10.4740
Cell Significance Index: -10.0000 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 10.0000
Cell Significance Index: 98.6600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 5.4775
Cell Significance Index: 113.6300 - Cell Name: peg cell (CL4033014)
Fold Change: 3.4631
Cell Significance Index: 80.0100 - Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
Fold Change: 3.2332
Cell Significance Index: 22.6900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.3282
Cell Significance Index: 74.5700 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2.2599
Cell Significance Index: 38.0100 - Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
Fold Change: 2.0943
Cell Significance Index: 13.9900 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.9596
Cell Significance Index: 12.0600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8060
Cell Significance Index: 134.6000 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.7632
Cell Significance Index: 26.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.4760
Cell Significance Index: 189.2100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 1.4237
Cell Significance Index: 162.5100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0532
Cell Significance Index: 30.1900 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.9722
Cell Significance Index: 14.3500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8925
Cell Significance Index: 19.3400 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.6111
Cell Significance Index: 6.6700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.3899
Cell Significance Index: 4.4300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2966
Cell Significance Index: 48.2500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2735
Cell Significance Index: 16.4200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2672
Cell Significance Index: 166.8400 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.2656
Cell Significance Index: 3.4200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2461
Cell Significance Index: 46.8400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.2353
Cell Significance Index: 3.6400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2329
Cell Significance Index: 6.3400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1835
Cell Significance Index: 23.7100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1483
Cell Significance Index: 25.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1027
Cell Significance Index: 4.6600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0838
Cell Significance Index: 1.7900 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0570
Cell Significance Index: 0.4500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0564
Cell Significance Index: 10.1700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0311
Cell Significance Index: 3.5600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0066
Cell Significance Index: 0.3100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0048
Cell Significance Index: 0.2300 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0007
Cell Significance Index: 0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0050
Cell Significance Index: -3.7200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0065
Cell Significance Index: -12.1500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0066
Cell Significance Index: -0.3300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0069
Cell Significance Index: -3.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0144
Cell Significance Index: -7.8800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0157
Cell Significance Index: -11.8900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0197
Cell Significance Index: -4.1400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0213
Cell Significance Index: -2.9300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0236
Cell Significance Index: -8.4500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0256
Cell Significance Index: -1.0500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0326
Cell Significance Index: -14.7900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0367
Cell Significance Index: -4.0000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.0375
Cell Significance Index: -3.7100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0464
Cell Significance Index: -5.7000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0516
Cell Significance Index: -14.8500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0610
Cell Significance Index: -12.2300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0620
Cell Significance Index: -3.2300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0779
Cell Significance Index: -2.2500 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: -0.0826
Cell Significance Index: -0.5000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0836
Cell Significance Index: -9.7400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0872
Cell Significance Index: -12.6800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0878
Cell Significance Index: -6.0800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1248
Cell Significance Index: -9.5800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1280
Cell Significance Index: -13.0800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1287
Cell Significance Index: -3.2100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1524
Cell Significance Index: -3.1000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1663
Cell Significance Index: -10.4800 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1705
Cell Significance Index: -2.8100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1957
Cell Significance Index: -12.0000 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: -0.2360
Cell Significance Index: -3.5300 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2435
Cell Significance Index: -4.2100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2452
Cell Significance Index: -6.1300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2502
Cell Significance Index: -15.3800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2784
Cell Significance Index: -7.4600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2906
Cell Significance Index: -10.1800 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.3124
Cell Significance Index: -2.7000 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.3334
Cell Significance Index: -5.2900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3429
Cell Significance Index: -19.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3493
Cell Significance Index: -18.1500 - Cell Name: T-helper 17 cell (CL0000899)
Fold Change: -0.3495
Cell Significance Index: -2.6700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3629
Cell Significance Index: -11.8800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3790
Cell Significance Index: -12.0700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3845
Cell Significance Index: -6.4400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3915
Cell Significance Index: -11.5300 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: -0.4157
Cell Significance Index: -4.1600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4160
Cell Significance Index: -10.9400 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: -0.4264
Cell Significance Index: -4.7100 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: -0.4549
Cell Significance Index: -5.5000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.4670
Cell Significance Index: -12.4700 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.4678
Cell Significance Index: -3.3600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4687
Cell Significance Index: -20.7300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4735
Cell Significance Index: -4.3600 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4867
Cell Significance Index: -12.1400 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4913
Cell Significance Index: -12.2700 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: -0.4961
Cell Significance Index: -6.8600 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.5160
Cell Significance Index: -7.4100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5314
Cell Significance Index: -11.0900 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.5371
Cell Significance Index: -5.1100 - Cell Name: progenitor cell (CL0011026)
Fold Change: -0.5450
Cell Significance Index: -5.7900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5453
Cell Significance Index: -20.6500 - Cell Name: secretory cell (CL0000151)
Fold Change: -0.5480
Cell Significance Index: -3.8000 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.5509
Cell Significance Index: -7.6400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3596112924
Symbol: AACT_HUMAN
Name: Alpha-1-antichymotrypsin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6606438
Title: Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III.
PubMed ID: 6606438
DOI: 10.1021/bi00291a001
PubMed ID: 8244391
Title: A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.
PubMed ID: 8244391
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3257719
Title: Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.
PubMed ID: 3257719
PubMed ID: 9880565
Title: Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver.
PubMed ID: 9880565
PubMed ID: 2787670
Title: The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.
PubMed ID: 2787670
PubMed ID: 7521171
Title: Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose.
PubMed ID: 7521171
PubMed ID: 6687683
Title: Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma.
PubMed ID: 6687683
PubMed ID: 8647626
Title: Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3.
PubMed ID: 8647626
DOI: 10.1002/(sici)1097-0215(19960529)66:5<636::aid-ijc10>3.0.co;2-2
PubMed ID: 2404007
Title: Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.
PubMed ID: 2404007
PubMed ID: 6547997
Title: Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions.
PubMed ID: 6547997
DOI: 10.1038/311175a0
PubMed ID: 6556193
Title: Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin.
PubMed ID: 6556193
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14668352
Title: The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.
PubMed ID: 14668352
PubMed ID: 15638460
Title: Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.
PubMed ID: 15638460
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 2016749
Title: Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins.
PubMed ID: 2016749
PubMed ID: 8836107
Title: Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement.
PubMed ID: 8836107
DOI: 10.1038/nsb1096-888
PubMed ID: 9521649
Title: Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction.
PubMed ID: 9521649
DOI: 10.1021/bi972359e
PubMed ID: 10618372
Title: Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.
PubMed ID: 10618372
DOI: 10.1073/pnas.97.1.67
PubMed ID: 1618300
Title: Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease.
PubMed ID: 1618300
PubMed ID: 1351206
Title: Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease.
PubMed ID: 1351206
PubMed ID: 11289720
Title: Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.
PubMed ID: 11289720
Sequence Information:
- Length: 423
- Mass: 47651
- Checksum: B002F946C86A8951
- Sequence:
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP KQA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.