Details for: SERPINA3

Gene ID: 12

Symbol: SERPINA3

Ensembl ID: ENSG00000196136

Description: serpin family A member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 7.15
    Marker Score: 46069.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 3.04
    Marker Score: 1181
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.02
    Marker Score: 2008
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.9
    Marker Score: 14269
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.72
    Marker Score: 965
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.59
    Marker Score: 2207
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.85
    Marker Score: 3277
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.67
    Marker Score: 696
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4
    Marker Score: 5414
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.39
    Marker Score: 354
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.39
    Marker Score: 1383
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.23
    Marker Score: 501
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.11
    Marker Score: 2099
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15193
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.87
    Marker Score: 2863
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1740
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.84
    Marker Score: 28733
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.84
    Marker Score: 385
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.78
    Marker Score: 1787
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.75
    Marker Score: 192
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.73
    Marker Score: 181
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.66
    Marker Score: 14153
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.62
    Marker Score: 490
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.6
    Marker Score: 917
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.53
    Marker Score: 3157.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.5
    Marker Score: 220
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 295
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.48
    Marker Score: 548
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.44
    Marker Score: 1143
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.43
    Marker Score: 290.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.38
    Marker Score: 182
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.36
    Marker Score: 107
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.35
    Marker Score: 378
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 324
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.3
    Marker Score: 305.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.3
    Marker Score: 138
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.26
    Marker Score: 727
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.25
    Marker Score: 72
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.25
    Marker Score: 174
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.24
    Marker Score: 133
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 428
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.21
    Marker Score: 191.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 93
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.19
    Marker Score: 2618
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.18
    Marker Score: 211
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.17
    Marker Score: 497
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.17
    Marker Score: 154
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.16
    Marker Score: 80
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.15
    Marker Score: 34
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.15
    Marker Score: 369
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.14
    Marker Score: 164
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.13
    Marker Score: 83
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.13
    Marker Score: 215
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.13
    Marker Score: 126
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 148
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.12
    Marker Score: 116
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.12
    Marker Score: 1856
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.12
    Marker Score: 104
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.1
    Marker Score: 50.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1
    Marker Score: 215
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.1
    Marker Score: 84
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.1
    Marker Score: 156
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.1
    Marker Score: 21.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.09
    Marker Score: 104
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.09
    Marker Score: 59
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.09
    Marker Score: 762

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Other Information

## Summary SERPINA3 is a serpin family A member with a diverse expression pattern across different cell types. It is significantly expressed in progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate. ## Key characteristics * Serpin family A member * Ensembl ID: ENSG00000196136 * Protein: AACT_HUMAN (Alpha-1-antichymotrypsin) * Expression pattern: Progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate ## Pathways and functions * Acute-phase response * DNA binding * Extracellular region * Extracellular space * Hemostasis * Immune system * Inflammatory response * Innate immune system * Maintenance of gastrointestinal epithelium * Negative regulation of endopeptidase activity * Neutrophil degranulation * Platelet activation * Signaling and aggregation * Platelet degranulation * Protein binding * Regulation of lipid metabolic process * Response to elevated platelet cytosolic ca2+ ## Clinical significance SERPINA3 is a potential therapeutic target for various diseases. It has been implicated in a variety of conditions, including prostate cancer, breast cancer, and heart failure. By targeting SERPINA3, it may be possible to inhibit the activity of platelet-activating factor (PAF), a protein that is involved in platelet activation. This could lead to a reduction in platelet aggregation and inflammation, which may be beneficial in the treatment of these diseases.

Genular Protein ID: 3596112924

Symbol: AACT_HUMAN

Name: Alpha-1-antichymotrypsin

UniProtKB Accession Codes:

P01011 B3KVQ7 Q13703 Q2TU87 Q2TU88 Q59GP9 Q6LBY8 Q6LDT7 Q6NSC9 Q8N177 Q96DW8 Q9UC47 Q9UNU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 4 EMBL 19 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 2 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6606438

Title: Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III.

PubMed ID: 6606438

DOI: 10.1021/bi00291a001

PubMed ID: 8244391

Title: A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.

PubMed ID: 8244391

DOI: 10.1006/geno.1993.1396

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3257719

Title: Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.

PubMed ID: 3257719

DOI: 10.1016/0092-8674(88)90462-x

PubMed ID: 9880565

Title: Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver.

PubMed ID: 9880565

DOI: 10.1074/jbc.274.3.1821

PubMed ID: 2787670

Title: The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.

PubMed ID: 2787670

DOI: 10.1016/0167-4838(89)90139-8

PubMed ID: 7521171

Title: Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose.

PubMed ID: 7521171

DOI: 10.1515/bchm3.1994.375.5.335

PubMed ID: 6687683

Title: Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma.

PubMed ID: 6687683

DOI: 10.1016/0006-291x(83)90325-x

PubMed ID: 8647626

Title: Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3.

PubMed ID: 8647626

DOI: 10.1002/(sici)1097-0215(19960529)66:5<636::aid-ijc10>3.0.co;2-2

PubMed ID: 2404007

Title: Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.

PubMed ID: 2404007

DOI: 10.1016/s0021-9258(19)40178-6

PubMed ID: 6547997

Title: Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions.

PubMed ID: 6547997

DOI: 10.1038/311175a0

PubMed ID: 6556193

Title: Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin.

PubMed ID: 6556193

DOI: 10.1016/s0021-9258(17)44026-9

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14668352

Title: The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.

PubMed ID: 14668352

DOI: 10.1074/jbc.m310903200

PubMed ID: 15638460

Title: Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.

PubMed ID: 15638460

DOI: 10.1007/s00239-004-2640-9

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 2016749

Title: Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins.

PubMed ID: 2016749

DOI: 10.1016/0022-2836(91)90704-a

PubMed ID: 8836107

Title: Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement.

PubMed ID: 8836107

DOI: 10.1038/nsb1096-888

PubMed ID: 9521649

Title: Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction.

PubMed ID: 9521649

DOI: 10.1021/bi972359e

PubMed ID: 10618372

Title: Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

PubMed ID: 10618372

DOI: 10.1073/pnas.97.1.67

PubMed ID: 1618300

Title: Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease.

PubMed ID: 1618300

DOI: 10.1016/0014-5793(92)80590-d

PubMed ID: 1351206

Title: Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease.

PubMed ID: 1351206

DOI: 10.1016/0140-6736(92)91301-n

PubMed ID: 11289720

Title: Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.

PubMed ID: 11289720

DOI: 10.1007/s100380170125

Sequence Information:

  • Length: 423
  • Mass: 47651
  • Checksum: B002F946C86A8951
  • Sequence:
    • MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL 
YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ 
HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI 
NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM 
VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR 
DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK 
AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP 
KQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.