SERPINA3 | ENSG00000196136 | NCBI 12

Details for: SERPINA3

Gene ID: 12

Symbol: SERPINA3

Ensembl ID: ENSG00000196136

Description: serpin family A member 3

Associated with

Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Acute-phase response
(GO:0006953)
Azurophil granule lumen
(GO:0035578)
Blood microparticle
(GO:0072562)
Collagen-containing extracellular matrix
(GO:0062023)
Dna binding
(GO:0003677)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Maintenance of gastrointestinal epithelium
(GO:0030277)
Negative regulation of endopeptidase activity
(GO:0010951)
Nucleus
(GO:0005634)
Platelet alpha granule lumen
(GO:0031093)
Protein binding
(GO:0005515)
Regulation of lipid metabolic process
(GO:0019216)
Secretory granule lumen
(GO:0034774)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Other Information

Proteins

Alpha-1-antichymotrypsin

Genular Protein ID: 3596112924

Symbol: AACT_HUMAN

Name: Alpha-1-antichymotrypsin

UniProtKB Accession Codes:

P01011 B3KVQ7 Q13703 Q2TU87 Q2TU88 Q59GP9 Q6LBY8 Q6LDT7 Q6NSC9 Q8N177 Q96DW8 Q9UC47 Q9UNU9

Database IDs:

Citations:

PubMed ID: 6606438

Title: Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III.

PubMed ID: 6606438

DOI: 10.1021/bi00291a001

PubMed ID: 8244391

Title: A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease.

PubMed ID: 8244391

DOI: 10.1006/geno.1993.1396

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3257719

Title: Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease.

PubMed ID: 3257719

DOI: 10.1016/0092-8674(88)90462-x

PubMed ID: 9880565

Title: Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver.

PubMed ID: 9880565

DOI: 10.1074/jbc.274.3.1821

PubMed ID: 2787670

Title: The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide.

PubMed ID: 2787670

DOI: 10.1016/0167-4838(89)90139-8

PubMed ID: 7521171

Title: Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose.

PubMed ID: 7521171

DOI: 10.1515/bchm3.1994.375.5.335

PubMed ID: 6687683

Title: Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma.

PubMed ID: 6687683

DOI: 10.1016/0006-291x(83)90325-x

PubMed ID: 8647626

Title: Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3.

PubMed ID: 8647626

DOI: 10.1002/(sici)1097-0215(19960529)66:5<636::aid-ijc10>3.0.co;2-2

PubMed ID: 2404007

Title: Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins.

PubMed ID: 2404007

DOI: 10.1016/s0021-9258(19)40178-6

PubMed ID: 6547997

Title: Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions.

PubMed ID: 6547997

DOI: 10.1038/311175a0

PubMed ID: 6556193

Title: Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin.

PubMed ID: 6556193

DOI: 10.1016/s0021-9258(17)44026-9

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14668352

Title: The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity.

PubMed ID: 14668352

DOI: 10.1074/jbc.m310903200

PubMed ID: 15638460

Title: Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.

PubMed ID: 15638460

DOI: 10.1007/s00239-004-2640-9

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 2016749

Title: Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins.

PubMed ID: 2016749

DOI: 10.1016/0022-2836(91)90704-a

PubMed ID: 8836107

Title: Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement.

PubMed ID: 8836107

DOI: 10.1038/nsb1096-888

PubMed ID: 9521649

Title: Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction.

PubMed ID: 9521649

DOI: 10.1021/bi972359e

PubMed ID: 10618372

Title: Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease.

PubMed ID: 10618372

DOI: 10.1073/pnas.97.1.67

PubMed ID: 1618300

Title: Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease.

PubMed ID: 1618300

DOI: 10.1016/0014-5793(92)80590-d

PubMed ID: 1351206

Title: Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease.

PubMed ID: 1351206

DOI: 10.1016/0140-6736(92)91301-n

PubMed ID: 11289720

Title: Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease.

PubMed ID: 11289720

DOI: 10.1007/s100380170125

Sequence Information:

Length: 423
Mass: 47651
Checksum: B002F946C86A8951
Sequence:

MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA SANVDFAFSL 
YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL KGLKFNLTET SEAEIHQSFQ 
HLLRTLNQSS DELQLSMGNA MFVKEQLSLL DRFTEDAKRL YGSEAFATDF QDSAAAKKLI 
NDYVKNGTRG KITDLIKDLD SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM 
VPMMSLHHLT IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR 
DSLEFREIGE LYLPKFSISR DYNLNDILLQ LGIEEAFTSK ADLSGITGAR NLAVSQVVHK 
AVLDVFEEGT EASAATAVKI TLLSALVETR TIVRFNRPFL MIIVPTDTQN IFFMSKVTNP 
KQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SERPINA3

Associated with

Other Information

Sequence homology between human alpha 1-antichymotrypsin, alpha 1-antitrypsin, and antithrombin III. PubMed ID: 6606438

A leucine-to-proline substitution causes a defective alpha 1-antichymotrypsin allele associated with familial obstructive lung disease. PubMed ID: 8244391

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. PubMed ID: 3257719

Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hippocampus and liver. PubMed ID: 9880565

The microheterogeneity of desialylated alpha 1-antichymotrypsin: the occurrence of two amino-terminal isoforms, one lacking a His-Pro dipeptide. PubMed ID: 2787670

Interactions of alpha-1-antichymotrypsin, alpha-1-proteinase inhibitor, and alpha-2-macroglobulin with the fungal enzyme, seaprose. PubMed ID: 7521171

Structural alterations in alpha 1-antichymotrypsin from normal and acute phase human plasma. PubMed ID: 6687683

Characterisation of the tumour-associated carbohydrate epitope recognised by monoclonal antibody 4D3. PubMed ID: 8647626

Cloning, expression, purification, and biological activity of recombinant native and variant human alpha 1-antichymotrypsins. PubMed ID: 2404007

Plasma protease inhibitors in mouse and man: divergence within the reactive centre regions. PubMed ID: 6547997

Amino acid sequence at the reactive site of human alpha 1-antichymotrypsin. PubMed ID: 6556193

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity. PubMed ID: 14668352

Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. PubMed ID: 15638460

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

Crystal structure of cleaved human alpha 1-antichymotrypsin at 2.7-A resolution and its comparison with other serpins. PubMed ID: 2016749

Arginine substitutions in the hinge region of antichymotrypsin affect serpin beta-sheet rearrangement. PubMed ID: 8836107

Engineering an anion-binding cavity in antichymotrypsin modulates the 'spring-loaded' serpin-protease interaction. PubMed ID: 9521649

Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. PubMed ID: 10618372

Detection of a new mutant alpha-1-antichymotrypsin in patients with occlusive-cerebrovascular disease. PubMed ID: 1618300

Mis-sense mutation of alpha 1-antichymotrypsin gene associated with chronic lung disease. PubMed ID: 1351206

Alpha-1-antichymotrypsin gene A1252G variant (ACT Isehara-1) is associated with a lacunar type of ischemic cerebrovascular disease. PubMed ID: 11289720