SERPINA3 - ENSG00000196136

Details for: SERPINA3

Gene ID: 12

Symbol: SERPINA3

Ensembl ID: ENSG00000196136

Description: serpin family A member 3

Associated with

Hemostasis (R-HSA-109582)
Immune system (R-HSA-168256)
Innate immune system (R-HSA-168249)
Neutrophil degranulation (R-HSA-6798695)
Platelet activation, signaling and aggregation (R-HSA-76002)
Platelet degranulation (R-HSA-114608)
Response to elevated platelet cytosolic ca2+ (R-HSA-76005)
Acute-phase response (GO:0006953)
Azurophil granule lumen (GO:0035578)
Blood microparticle (GO:0072562)
Collagen-containing extracellular matrix (GO:0062023)
Dna binding (GO:0003677)
Extracellular exosome (GO:0070062)
Extracellular region (GO:0005576)
Extracellular space (GO:0005615)
Inflammatory response (GO:0006954)
Maintenance of gastrointestinal epithelium (GO:0030277)
Negative regulation of endopeptidase activity (GO:0010951)
Nucleus (GO:0005634)
Platelet alpha granule lumen (GO:0031093)
Protein binding (GO:0005515)
Regulation of lipid metabolic process (GO:0019216)
Secretory granule lumen (GO:0034774)
Serine-type endopeptidase inhibitor activity (GO:0004867)

Cells (max top 100)

Cell Name: progenitor cell (CL0011026)
Fold Change: 7.15
Marker Score: 46069.5
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 3.04
Marker Score: 1181
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.02
Marker Score: 2008
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.9
Marker Score: 14269
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.72
Marker Score: 965
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.59
Marker Score: 2207
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.85
Marker Score: 3277
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.67
Marker Score: 696
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1169
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4
Marker Score: 5414
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.39
Marker Score: 354
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.39
Marker Score: 1383
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 855
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.23
Marker Score: 501
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4814
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.11
Marker Score: 2099
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 502
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251809
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71827
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48052
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.97
Marker Score: 15193
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 372
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.87
Marker Score: 2863
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.86
Marker Score: 1740
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.84
Marker Score: 28733
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.84
Marker Score: 385
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.78
Marker Score: 1787
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.75
Marker Score: 192
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.73
Marker Score: 181
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.66
Marker Score: 14153
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.62
Marker Score: 490
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.6
Marker Score: 917
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.53
Marker Score: 3157.5
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.5
Marker Score: 220
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.49
Marker Score: 295
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.48
Marker Score: 548
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.44
Marker Score: 1143
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.43
Marker Score: 290.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.38
Marker Score: 182
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.36
Marker Score: 107
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.35
Marker Score: 378
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.31
Marker Score: 324
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.3
Marker Score: 305.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.3
Marker Score: 138
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 89
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.26
Marker Score: 727
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.25
Marker Score: 72
Cell Name: acinar cell (CL0000622)
Fold Change: 0.25
Marker Score: 174
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.24
Marker Score: 133
Cell Name: secretory cell (CL0000151)
Fold Change: 0.23
Marker Score: 428
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74
Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.21
Marker Score: 191.5
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.21
Marker Score: 93
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.2
Marker Score: 122
Cell Name: malignant cell (CL0001064)
Fold Change: 0.19
Marker Score: 2618
Cell Name: club cell (CL0000158)
Fold Change: 0.18
Marker Score: 211
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.18
Marker Score: 102
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.17
Marker Score: 497
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.17
Marker Score: 154
Cell Name: astrocyte (CL0000127)
Fold Change: 0.16
Marker Score: 142
Cell Name: granulocyte (CL0000094)
Fold Change: 0.16
Marker Score: 72
Cell Name: erythroid lineage cell (CL0000764)
Fold Change: 0.16
Marker Score: 80
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.16
Marker Score: 73
Cell Name: keratocyte (CL0002363)
Fold Change: 0.15
Marker Score: 34
Cell Name: interneuron (CL0000099)
Fold Change: 0.15
Marker Score: 67
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.15
Marker Score: 369
Cell Name: stromal cell (CL0000499)
Fold Change: 0.14
Marker Score: 164
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.14
Marker Score: 67
Cell Name: erythroblast (CL0000765)
Fold Change: 0.13
Marker Score: 83
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.13
Marker Score: 215
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.13
Marker Score: 126
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.13
Marker Score: 60
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.12
Marker Score: 148
Cell Name: tracheobronchial serous cell (CL0019001)
Fold Change: 0.12
Marker Score: 44
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.12
Marker Score: 81
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.12
Marker Score: 116
Cell Name: lactocyte (CL0002325)
Fold Change: 0.12
Marker Score: 1856
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 0.12
Marker Score: 104
Cell Name: neural cell (CL0002319)
Fold Change: 0.1
Marker Score: 50.5
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1
Marker Score: 215
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.1
Marker Score: 84
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.1
Marker Score: 156
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.1
Marker Score: 34
Cell Name: pericyte (CL0000669)
Fold Change: 0.1
Marker Score: 56
Cell Name: PP cell (CL0000696)
Fold Change: 0.1
Marker Score: 21.5
Cell Name: macrophage (CL0000235)
Fold Change: 0.09
Marker Score: 104
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.09
Marker Score: 37
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.09
Marker Score: 22
Cell Name: basal cell (CL0000646)
Fold Change: 0.09
Marker Score: 114
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 0.09
Marker Score: 59
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.09
Marker Score: 762

## Summary SERPINA3 is a serpin family A member with a diverse expression pattern across different cell types. It is significantly expressed in progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate. ## Key characteristics * Serpin family A member * Ensembl ID: ENSG00000196136 * Protein: AACT_HUMAN (Alpha-1-antichymotrypsin) * Expression pattern: Progenitor cells, prostate gland microvascular endothelial cells, hematopoietic cells, myoepithelial cells of the mammary gland, mammary gland epithelial cells, fibroblasts of connective tissue of the nonglandular part of the prostate, luminal epithelial cells of the mammary gland, and fibroblasts of connective tissue of the glandular part of the prostate ## Pathways and functions * Acute-phase response * DNA binding * Extracellular region * Extracellular space * Hemostasis * Immune system * Inflammatory response * Innate immune system * Maintenance of gastrointestinal epithelium * Negative regulation of endopeptidase activity * Neutrophil degranulation * Platelet activation * Signaling and aggregation * Platelet degranulation * Protein binding * Regulation of lipid metabolic process * Response to elevated platelet cytosolic ca2+ ## Clinical significance SERPINA3 is a potential therapeutic target for various diseases. It has been implicated in a variety of conditions, including prostate cancer, breast cancer, and heart failure. By targeting SERPINA3, it may be possible to inhibit the activity of platelet-activating factor (PAF), a protein that is involved in platelet activation. This could lead to a reduction in platelet aggregation and inflammation, which may be beneficial in the treatment of these diseases.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.