Genular: Defining Cellular Identity and Function

Details for: Axin1

Gene ID: 12005

Symbol: Axin1

Ensembl ID: ENSMUSG00000024182

Description: axin 1

Associated with

Beta-catenin phosphorylation cascade
(R-MMU-196299)
Degradation of axin
(R-MMU-4641257)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Deubiquitination
(R-MMU-5688426)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Ub-specific processing proteases
(R-MMU-5689880)
Activation of protein kinase activity
(GO:0032147)
Adult walking behavior
(GO:0007628)
Apoptotic process
(GO:0006915)
Armadillo repeat domain binding
(GO:0070016)
Axial mesoderm development
(GO:0048318)
Axial mesoderm formation
(GO:0048320)
Beta-catenin binding
(GO:0008013)
Canonical wnt signaling pathway
(GO:0060070)
Cell development
(GO:0048468)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule organization
(GO:0031122)
Cytosol
(GO:0005829)
Dorsal/ventral axis specification
(GO:0009950)
Dorsal/ventral pattern formation
(GO:0009953)
Embryonic skeletal joint morphogenesis
(GO:0060272)
Enzyme binding
(GO:0019899)
Epigenetic programming in the zygotic pronuclei
(GO:0044725)
Erythrocyte homeostasis
(GO:0034101)
Golgi apparatus
(GO:0005794)
Head development
(GO:0060322)
Hemoglobin metabolic process
(GO:0020027)
I-smad binding
(GO:0070411)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Molecular adaptor activity
(GO:0060090)
Multicellular organism development
(GO:0007275)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein metabolic process
(GO:0051248)
Negative regulation of transcription elongation by rna polymerase ii
(GO:0034244)
Negative regulation of wnt signaling pathway
(GO:0030178)
Nervous system process
(GO:0050877)
Nucleocytoplasmic transport
(GO:0006913)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Plasma membrane
(GO:0005886)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Post-anal tail morphogenesis
(GO:0036342)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein polyubiquitination
(GO:0000209)
Protein self-association
(GO:0043621)
R-smad binding
(GO:0070412)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of protein phosphorylation
(GO:0001932)
Sensory perception of sound
(GO:0007605)
Signaling receptor binding
(GO:0005102)
Smad binding
(GO:0046332)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Genular Protein ID: 381247341

Symbol: AXIN1_MOUSE

Name: Axin-1

UniProtKB Accession Codes:

O35625

Database IDs:

Citations:

PubMed ID: 9230313

Title: The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.

PubMed ID: 9230313

DOI: 10.1016/s0092-8674(00)80324-4

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10581160

Title: A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.

PubMed ID: 10581160

DOI: 10.1006/bbrc.1999.1760

PubMed ID: 11336703

Title: Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

PubMed ID: 11336703

DOI: 10.1016/s1097-2765(01)00224-6

PubMed ID: 12183362

Title: The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

PubMed ID: 12183362

DOI: 10.1101/gad.230402

PubMed ID: 12223491

Title: SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling.

PubMed ID: 12223491

DOI: 10.1074/jbc.m208099200

PubMed ID: 15063782

Title: Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin.

PubMed ID: 15063782

DOI: 10.1016/j.bbrc.2004.03.065

PubMed ID: 15526030

Title: Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

PubMed ID: 15526030

DOI: 10.1038/sj.emboj.7600475

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 16815997

Title: The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.

PubMed ID: 16815997

DOI: 10.1101/gad.1411206

PubMed ID: 17681137

Title: A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida.

PubMed ID: 17681137

DOI: 10.1016/j.devcel.2007.07.006

PubMed ID: 18632848

Title: SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability.

PubMed ID: 18632848

DOI: 10.1096/fj.08-113910

PubMed ID: 19141611

Title: Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.

PubMed ID: 19141611

DOI: 10.1074/jbc.m807753200

PubMed ID: 19581931

Title: Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

PubMed ID: 19581931

DOI: 10.1038/onc.2009.157

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 863
Mass: 96276
Checksum: 2216D66E92387B81
Sequence:

MNVQEQGFPL DLGASFTEDA PRPPVPGEEG ELVSTDSRPV NHSFCSGKGT SIKSETSTAT 
PRRSDLDLGY EPEGSASPTP PYLRWAESLH SLLDDQDGIS LFRTFLKQEG CADLLDFWFA 
CSGFRKLEPC DSNEEKRLKL ARAIYRKYIL DSNGIVSRQT KPATKSFIKD CVMKQQIDPA 
MFDQAQTEIQ STMEENTYPS FLKSDIYLEY TRTGSESPKV CSDQSSGSGT GKGMSGYLPT 
LNEDEEWKCD QDADEDDGRD PLPPSRLTQK LLLETAAPRA PSSRRYNEGR ELRYGSWREP 
VNPYYVNSGY ALAPATSAND SEQQSLSSDA DTLSLTDSSV DGIPPYRIRK QHRREMQESI 
QVNGRVPLPH IPRTYRMPKE IRVEPQKFAE ELIHRLEAVQ RTREAEEKLE ERLKRVRMEE 
EGEDGEMPSG PMASHKLPSV PAWHHFPPRY VDMGCSGLRD AHEENPESIL DEHVQRVMRT 
PGCQSPGPGH RSPDSGHVAK TAVLGGTASG HGKHVPKLGL KLDTAGLHHH RHVHHHVHHN 
SARPKEQMEA EVARRVQSSF SWGPETHGHA KPRSYSENAG TTLSAGDLAF GGKTSAPSKR 
NTKKAESGKN ANAEVPSTTE DAEKNQKIMQ WIIEGEKEIS RHRKAGHGSS GLRKQQAHES 
SRPLSIERPG AVHPWVSAQL RNSVQPSHLF IQDPTMPPNP APNPLTQLEE ARRRLEEEEK 
RANKLPSKQR YVQAVMQRGR TCVRPACAPV LSVVPAVSDL ELSETETKSQ RKAGGGSAPP 
CDSIVVAYYF CGEPIPYRTL VRGRAVTLGQ FKELLTKKGS YRYYFKKVSD EFDCGVVFEE 
VREDEAVLPV FEEKIIGKVE KVD

Genular Protein ID: 4197589830

Symbol: Q14DJ8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q14DJ8

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 832
Mass: 92990
Checksum: 020E1BB57C73CEBE
Sequence:

MQSPKMNVQE QGFPLDLGAS FTEDAPRPPV PGEEGELVST DSRPVNHSFC SGKGTSIKSE 
TSTATPRRSD LDLGYEPEGS ASPTPPYLRW AESLHSLLDD QDGISLFRTF LKQEGCADLL 
DFWFACSGFR KLEPCDSNEE KRLKLARAIY RKYILDSNGI VSRQTKPATK SFIKDCVMKQ 
QIDPAMFDQA QTEIQSTMEE NTYPSFLKSD IYLEYTRTGS ESPKVCSDQS SGSGTGKGMS 
GYLPTLNEDE EWKCDQDADE DDGRDPLPPS RLTQKLLLET AAPRAPSSRR YNEGRELRYG 
SWREPVNPYY VNSGYALAPA TSANDSEQQS LSSDADTLSL TDSSVDGIPP YRIRKQHRRE 
MQESIQVNGR VPLPHIPRTY RMPKEIRVEP QKFAEELIHR LEAVQRTREA EEKLEERLKR 
VRMEEEGEDG EMPSGPMASH KLPSVPAWHH FPPRYVDMGC SGLRDAHEEN PESILDEHVQ 
RVMRTPGCQS PGPGHRSPDS GHVAKTAVLG GTASGHGKHV PKLGLKLDTA GLHHHRHVHH 
HVHHNSARPK EQMEAEVARR VQSSFSWGPE THGHAKPRSY SENAGTTLSA GDLAFGGKTS 
APSKRNTKKA ESGKNANAEV PSTTEDAEKN QKIMQWIIEG EKEISRHRKA GHGSSGLRKQ 
QAHESSRPLS IERPGAVHPW VSAQLRNSVQ PSHLFIQDPT MPPNPAPNPL TQLEEARRRL 
EEEEKRANKL PSKQRTKSQR KAGGGSAPPC DSIVVAYYFC GEPIPYRTLV RGRAVTLGQF 
KELLTKKGSY RYYFKKVSDE FDCGVVFEEV REDEAVLPVF EEKIIGKVEK VD

Genular Protein ID: 3414598141

Symbol: E9QMJ8_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9QMJ8

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 868
Mass: 96847
Checksum: D9FD3C42F0B24F75
Sequence:

MQSPKMNVQE QGFPLDLGAS FTEDAPRPPV PGEEGELVST DSRPVNHSFC SGKGTSIKSE 
TSTATPRRSD LDLGYEPEGS ASPTPPYLRW AESLHSLLDD QDGISLFRTF LKQEGCADLL 
DFWFACSGFR KLEPCDSNEE KRLKLARAIY RKYILDSNGI VSRQTKPATK SFIKDCVMKQ 
QIDPAMFDQA QTEIQSTMEE NTYPSFLKSD IYLEYTRTGS ESPKVCSDQS SGSGTGKGMS 
GYLPTLNEDE EWKCDQDADE DDGRDPLPPS RLTQKLLLET AAPRAPSSRR YNEGRELRYG 
SWREPVNPYY VNSGYALAPA TSANDSEQQS LSSDADTLSL TDSSVDGIPP YRIRKQHRRE 
MQESIQVNGR VPLPHIPRTY RMPKEIRVEP QKFAEELIHR LEAVQRTREA EEKLEERLKR 
VRMEEEGEDG EMPSGPMASH KLPSVPAWHH FPPRYVDMGC SGLRDAHEEN PESILDEHVQ 
RVMRTPGCQS PGPGHRSPDS GHVAKTAVLG GTASGHGKHV PKLGLKLDTA GLHHHRHVHH 
HVHHNSARPK EQMEAEVARR VQSSFSWGPE THGHAKPRSY SENAGTTLSA GDLAFGGKTS 
APSKRNTKKA ESGKNANAEV PSTTEDAEKN QKIMQWIIEG EKEISRHRKA GHGSSGLRKQ 
QAHESSRPLS IERPGAVHPW VSAQLRNSVQ PSHLFIQDPT MPPNPAPNPL TQLEEARRRL 
EEEEKRANKL PSKQRYVQAV MQRGRTCVRP ACAPVLSVVP AVSDLELSET ETKSQRKAGG 
GSAPPCDSIV VAYYFCGEPI PYRTLVRGRA VTLGQFKELL TKKGSYRYYF KKVSDEFDCG 
VVFEEVREDE AVLPVFEEKI IGKVEKVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Axin1

Associated with

Other Information

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation. PubMed ID: 9230313

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. PubMed ID: 10581160

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. PubMed ID: 11336703

The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. PubMed ID: 12183362

SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. PubMed ID: 12223491

Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. PubMed ID: 15063782

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation. PubMed ID: 15526030

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms. PubMed ID: 15262978

The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. PubMed ID: 16815997

A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. PubMed ID: 17681137

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability. PubMed ID: 18632848

Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. PubMed ID: 19141611

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. PubMed ID: 19581931

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9230313

PubMed ID: 19468303

PubMed ID: 10581160

PubMed ID: 11336703

PubMed ID: 12183362

PubMed ID: 12223491

PubMed ID: 15063782

PubMed ID: 15526030

PubMed ID: 15262978

PubMed ID: 16815997

PubMed ID: 17681137

PubMed ID: 18632848

PubMed ID: 19141611

PubMed ID: 19581931

PubMed ID: 21183079

PubMed ID: 15489334

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 19468303

PubMed ID: 21183079