Genular: Defining Cellular Identity and Function

Details for: Axin2

Gene ID: 12006

Symbol: Axin2

Ensembl ID: ENSMUSG00000000142

Description: axin 2

Associated with

Degradation of axin
(R-MMU-4641257)
Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Ub-specific processing proteases
(R-MMU-5689880)
Aortic valve morphogenesis
(GO:0003180)
Beta-catenin binding
(GO:0008013)
Beta-catenin destruction complex
(GO:0030877)
Bone mineralization
(GO:0030282)
Canonical wnt signaling pathway
(GO:0060070)
Cell development
(GO:0048468)
Cell population proliferation
(GO:0008283)
Centrosome
(GO:0005813)
Chondrocyte differentiation involved in endochondral bone morphogenesis
(GO:0003413)
Cytoplasm
(GO:0005737)
Dorsal/ventral axis specification
(GO:0009950)
Enzyme binding
(GO:0019899)
I-smad binding
(GO:0070411)
Intramembranous ossification
(GO:0001957)
Maintenance of dna repeat elements
(GO:0043570)
Mitral valve morphogenesis
(GO:0003183)
Molecular adaptor activity
(GO:0060090)
Mrna stabilization
(GO:0048255)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of osteoblast differentiation
(GO:0045668)
Negative regulation of osteoblast proliferation
(GO:0033689)
Negative regulation of wnt signaling pathway
(GO:0030178)
Nucleus
(GO:0005634)
Odontogenesis
(GO:0042476)
Osteoblast differentiation
(GO:0001649)
Osteoblast proliferation
(GO:0033687)
Plasma membrane
(GO:0005886)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization
(GO:0008104)
Regulation of centromeric sister chromatid cohesion
(GO:0070602)
Regulation of chondrocyte development
(GO:0061181)
Regulation of extracellular matrix organization
(GO:1903053)
Regulation of mismatch repair
(GO:0032423)
Regulation of wnt signaling pathway
(GO:0030111)
Secondary heart field specification
(GO:0003139)
Somitogenesis
(GO:0001756)
Stem cell proliferation
(GO:0072089)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Axin-like protein
Q3UQK5_MOUSE

Genular Protein ID: 3252074358

Symbol: AXIN2_MOUSE

Name: Axin-like protein

UniProtKB Accession Codes:

O88566 Q6PFZ9 Q9QXJ6

Database IDs:

Citations:

PubMed ID: 9554852

Title: Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta.

PubMed ID: 9554852

DOI: 10.1126/science.280.5363.596

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12183362

Title: The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling.

PubMed ID: 12183362

DOI: 10.1101/gad.230402

PubMed ID: 23562159

Title: A network of high-mobility group box transcription factors programs innate interleukin-17 production.

PubMed ID: 23562159

DOI: 10.1016/j.immuni.2013.01.010

PubMed ID: 27713059

Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

PubMed ID: 27713059

DOI: 10.1016/j.ydbio.2016.10.001

Sequence Information:

Length: 840
Mass: 92906
Checksum: 53D7D33128879298
Sequence:

MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP VSSNARRNED 
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 
NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK PATKTYIRDG IKKQQIGSVM FDQAQTEIQA 
VMEENAYQVF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK 
CKLSPTVVGL SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 
EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGSEQA LSSRDGAPVQ 
HPLALLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH 
TLLPTGGKLP PVAACPLLGG KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL 
CPGGTDYYCY SKCKSHPKAP EPLPGEQFCG SRGGTLPKRN AKGTEPGLAL SARDGGMSSA 
AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSAQSIRK SYPLESACAA PGERVSRHHL 
LGASGHSRSV ARAHPFTQDP AMPPLTPPNT LAQLEEACRR LAEVSKPQKQ RCCVASQQRD 
RNHSAAGQAG ASPFANPSLA PEDHKEPKKL ASVHALQASE LVVTYFFCGE EIPYRRMLKA 
QSLTLGHFKE QLSKKGNYRY YFKKASDEFA CGAVFEEIWD DETVLPMYEG RILGKVERID

Genular Protein ID: 3237039633

Symbol: Q3UQK5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UQK5

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 793
Mass: 87342
Checksum: 14785708E16DC5EC
Sequence:

MSSAVLVTLL PDPSSSFRED APRPPVPGEE GETPPCQPSV GKVQSTKPMP VSSNARRNED 
GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE REKCVDTLDF WFACNGFRQM 
NLKDTKTLRV AKAIYKRYIE NNSVVSKQLK PATKTYIRDG IKKQQIGSVM FDQAQTEIQA 
VMEENAYQVF LTSDIYLEYV RSGGENTAYM SNGGLGSLKV LCGYLPTLNE EEEWTCADLK 
CKLSPTVVGL SSKTLRATAS VRSTETAENG FRSFKRSDPV NPYHVGSGYV FAPATSANDS 
ELSSDALTDD SMSMTDSSVD GVPPYRMGSK KQLQREMHRS VKANGQVSLP HFPRTHRLPK 
EMTPVEPAAF AAELISRLEK LKLELESRHS LEERLQQIRE DEEKEGSEQA LSSRDGAPVQ 
HPLALLPSGS YEEDPQTILD DHLSRVLKTP GCQSPGVGRY SPRSRSPDHH HQHHHHQQCH 
TLLPTGGKLP PVAACPLLGG KSFLTKQTTK HVHHHYIHHH AVPKTKEEIE AEATQRVRCL 
CPGGTDYYCY SKCKSHPKAP EPLPGEQFCG SRGGTLPKRN AKGTEPGLAL SARDGGMSSA 
AGAPQLPGEE GDRSQDVWQW MLESERQSKS KPHSAQSIRK SYPLESACAA PGERVSRHHL 
LGASGHSRSV ARAHPFTQDP AMPPLTPPNT LAQLEEACRR LAEVSKPQKQ RCCVASQQRD 
RNHSAAGQAG ASPFANPSLA PEDHKEPKKL ASVHALQASE LVVTYFFCGE EIPYRRMLKA 
QSLTLGHFKE QLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Axin2

Associated with

Other Information

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. PubMed ID: 9554852

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The ankyrin repeat protein diversin recruits casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. PubMed ID: 12183362

A network of high-mobility group box transcription factors programs innate interleukin-17 production. PubMed ID: 23562159

Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. PubMed ID: 27713059

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073