Genular: Defining Cellular Identity and Function

Details for: B2m

Gene ID: 12010

Symbol: B2m

Ensembl ID: ENSMUSG00000060802

Description: beta-2 microglobulin

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-MMU-983170)
Antigen processing-cross presentation
(R-MMU-1236975)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Endosomal/vacuolar pathway
(R-MMU-1236977)
Er-phagosome pathway
(R-MMU-1236974)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Amyloid fibril formation
(GO:1990000)
Antibacterial humoral response
(GO:0019731)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of exogenous peptide antigen via mhc class ii
(GO:0019886)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Antigen processing and presentation of peptide antigen via mhc class i
(GO:0002474)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Cellular defense response
(GO:0006968)
Cellular response to iron(iii) ion
(GO:0071283)
Cellular response to iron ion
(GO:0071281)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to nicotine
(GO:0071316)
Cytosol
(GO:0005829)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Hfe-transferrin receptor complex
(GO:1990712)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion transport
(GO:0006826)
Late endosome membrane
(GO:0031902)
Learning or memory
(GO:0007611)
Lysosomal membrane
(GO:0005765)
Mhc class ii protein complex
(GO:0042613)
Mhc class ii protein complex binding
(GO:0023026)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein complex
(GO:0042612)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of forebrain neuron differentiation
(GO:2000978)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of receptor binding
(GO:1900121)
Peptide antigen assembly with mhc class ii protein complex
(GO:0002503)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide antigen binding
(GO:0042605)
Phagocytic vesicle membrane
(GO:0030670)
Plasma membrane
(GO:0005886)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of ferrous iron binding
(GO:1904434)
Positive regulation of immune response
(GO:0050778)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell cytokine production
(GO:0002726)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of transferrin receptor binding
(GO:1904437)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein homotetramerization
(GO:0051289)
Protein refolding
(GO:0042026)
Regulation of erythrocyte differentiation
(GO:0045646)
Regulation of iron ion transport
(GO:0034756)
Regulation of membrane depolarization
(GO:0003254)
Response to molecule of bacterial origin
(GO:0002237)
Sensory perception of smell
(GO:0007608)
Structural molecule activity
(GO:0005198)
T cell differentiation in thymus
(GO:0033077)
T cell mediated cytotoxicity
(GO:0001913)

Other Information

Proteins

Beta-2-microglobulin

Genular Protein ID: 2134960163

Symbol: B2MG_MOUSE

Name: Beta-2-microglobulin

UniProtKB Accession Codes:

P01887 Q91XJ8

Database IDs:

Citations:

PubMed ID: 6354707

Title: Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells.

PubMed ID: 6354707

DOI: 10.1002/j.1460-2075.1983.tb01546.x

PubMed ID: 6180834

Title: Structure of wild-type and mutant mouse beta 2-microglobulin genes.

PubMed ID: 6180834

DOI: 10.1016/0092-8674(82)90182-9

PubMed ID: 8482575

Title: Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection.

PubMed ID: 8482575

DOI: 10.1007/bf00190898

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6165997

Title: Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism.

PubMed ID: 6165997

DOI: 10.1073/pnas.78.1.554

PubMed ID: 6166005

Title: Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs.

PubMed ID: 6166005

DOI: 10.1073/pnas.78.4.2253

PubMed ID: 3510743

Title: Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression.

PubMed ID: 3510743

DOI: 10.1016/0092-8674(86)90760-9

PubMed ID: 59595

Title: Partial amino acid sequence of mouse beta2-microglobulin.

PubMed ID: 59595

DOI: 10.1016/0006-291x(76)91063-9

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 1323877

Title: Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb.

PubMed ID: 1323877

DOI: 10.1126/science.1323877

PubMed ID: 7506996

Title: The three-dimensional structure of H-2Db at 2.4-A resolution: implications for antigen-determinant selection.

PubMed ID: 7506996

DOI: 10.1016/0092-8674(94)90171-6

PubMed ID: 9192660

Title: The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide.

PubMed ID: 9192660

DOI: 10.1073/pnas.94.13.6880

PubMed ID: 9729040

Title: The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK cell recognition.

PubMed ID: 9729040

DOI: 10.1016/s1074-7613(00)80602-0

Sequence Information:

Length: 119
Mass: 13779
Checksum: 94F649EBCF1D7A4E
Sequence:

MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF HPPHIEIQML 
KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC RVKHASMAEP KTVYWDRDM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: B2m

Associated with

Other Information

Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells. PubMed ID: 6354707

Structure of wild-type and mutant mouse beta 2-microglobulin genes. PubMed ID: 6180834

Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection. PubMed ID: 8482575

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism. PubMed ID: 6165997

Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs. PubMed ID: 6166005

Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression. PubMed ID: 3510743

Partial amino acid sequence of mouse beta2-microglobulin. PubMed ID: 59595

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. PubMed ID: 1323877

The three-dimensional structure of H-2Db at 2.4-A resolution: implications for antigen-determinant selection. PubMed ID: 7506996

The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide. PubMed ID: 9192660

The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK cell recognition. PubMed ID: 9729040