Details for: Bad

Gene ID: 12015

Symbol: Bad

Ensembl ID: ENSMUSG00000024959

Description: BCL2-associated agonist of cell death

Associated with

  • Activation of bad and translocation to mitochondria
    (R-MMU-111447)
  • Activation of bh3-only proteins
    (R-MMU-114452)
  • Apoptosis
    (R-MMU-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-MMU-111453)
  • Cell death signalling via nrage, nrif and nade
    (R-MMU-204998)
  • Death receptor signaling
    (R-MMU-73887)
  • Intrinsic pathway for apoptosis
    (R-MMU-109606)
  • Nrage signals death through jnk
    (R-MMU-193648)
  • P75 ntr receptor-mediated signalling
    (R-MMU-193704)
  • Programmed cell death
    (R-MMU-5357801)
  • Signal transduction
    (R-MMU-162582)
  • 14-3-3 protein binding
    (GO:0071889)
  • Activation of cysteine-type endopeptidase activity
    (GO:0097202)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Adp metabolic process
    (GO:0046031)
  • Apoptotic process
    (GO:0006915)
  • Apoptotic signaling pathway
    (GO:0097190)
  • Atp metabolic process
    (GO:0046034)
  • Bad-bcl-2 complex
    (GO:0097138)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to lipid
    (GO:0071396)
  • Cellular response to nicotine
    (GO:0071316)
  • Cellular response to organic substance
    (GO:0071310)
  • Cysteine-type endopeptidase activator activity involved in apoptotic process
    (GO:0008656)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Epithelial cell proliferation
    (GO:0050673)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Glucose catabolic process
    (GO:0006007)
  • Glucose homeostasis
    (GO:0042593)
  • Induction by virus of host apoptotic process
    (GO:0019051)
  • Intrinsic apoptotic signaling pathway
    (GO:0097193)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Lipid binding
    (GO:0008289)
  • Membrane
    (GO:0016020)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Phospholipid binding
    (GO:0005543)
  • Pore complex assembly
    (GO:0046931)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of glucokinase activity
    (GO:0033133)
  • Positive regulation of granulosa cell apoptotic process
    (GO:1904710)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
    (GO:1902220)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of proteolysis
    (GO:0045862)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of type b pancreatic cell development
    (GO:2000078)
  • Protein binding
    (GO:0005515)
  • Protein kinase b binding
    (GO:0043422)
  • Protein kinase binding
    (GO:0019901)
  • Protein phosphatase 2b binding
    (GO:0030346)
  • Protein phosphatase binding
    (GO:0019903)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043281)
  • Regulation of mitochondrial membrane permeability
    (GO:0046902)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Suppression by virus of host apoptotic process
    (GO:0019050)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 704736560

Symbol: BAD_MOUSE

Name: Bcl2-associated agonist of cell death

UniProtKB Accession Codes:

Q61337

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisProt 1 ELM 1 EMBL 2 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 GeneTree 1 Genevisible 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 7834748

Title: Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.

PubMed ID: 7834748

DOI: 10.1016/0092-8674(95)90411-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9381178

Title: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

PubMed ID: 9381178

DOI: 10.1126/science.278.5338.687

PubMed ID: 10679322

Title: Rsk1 mediates a MEK-MAP kinase cell survival signal.

PubMed ID: 10679322

DOI: 10.1016/s0960-9822(00)00310-9

PubMed ID: 10949026

Title: 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.

PubMed ID: 10949026

DOI: 10.1016/s1097-2765(05)00012-2

PubMed ID: 10611223

Title: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.

PubMed ID: 10611223

DOI: 10.1128/mcb.20.2.453-461.2000

PubMed ID: 11278362

Title: p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts.

PubMed ID: 11278362

DOI: 10.1074/jbc.m007753200

PubMed ID: 11342610

Title: Protein kinase C-theta mediates a selective T cell survival signal via phosphorylation of BAD.

PubMed ID: 11342610

DOI: 10.4049/jimmunol.166.10.5955

PubMed ID: 11493700

Title: p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD.

PubMed ID: 11493700

DOI: 10.1073/pnas.171301998

PubMed ID: 11717309

Title: Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity.

PubMed ID: 11717309

DOI: 10.1074/jbc.m109990200

PubMed ID: 12954615

Title: The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.

PubMed ID: 12954615

DOI: 10.1074/jbc.m307933200

PubMed ID: 15849194

Title: p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association.

PubMed ID: 15849194

DOI: 10.1074/jbc.m413374200

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21546903

Title: Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.

PubMed ID: 21546903

DOI: 10.1038/cdd.2011.47

Sequence Information:

  • Length: 204
  • Mass: 22080
  • Checksum: 6C2BA910205053F7
  • Sequence:
    • MGTPKQPSLA PAHALGLRKS DPGIRSLGSD AGGRRWRPAA QSMFQIPEFE PSEQEDASAT 
DRGLGPSLTE DQPGPYLAPG LLGSNIHQQG RAATNSHHGG AGAMETRSRH SSYPAGTEED 
EGMEEELSPF RGRSRSAPPN LWAAQRYGRE LRRMSDEFEG SFKGLPRPKS AGTATQMRQS 
AGWTRIIQSW WDRNLGKGGS TPSQ

Genular Protein ID: 1996351759

Symbol: Q3U9H3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U9H3

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 1 GeneTree 1 HOGENOM 1 InterPro 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 162
  • Mass: 17745
  • Checksum: 7EA7F45E96EDA64F
  • Sequence:
    • MFQIPEFEPS EQEDASATDR GLGPSLTEDQ PGPYLAPGLL GSNIHQQGRA ATNSHHGGAG 
AMETRSRHSS YPAGTEEDEG MEEELSPFRG RSRSAPPNLW AAQRYGRELR RMSDEFEGSF 
KGLPRPKSAG TATQMRQSAG WTRIIQSWWD RNLGKGGSTP SQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.