Genular: Defining Cellular Identity and Function

Details for: Bak1

Gene ID: 12018

Symbol: Bak1

Ensembl ID: ENSMUSG00000057789

Description: BCL2-antagonist/killer 1

Associated with

Activation and oligomerization of bak protein
(R-MMU-111452)
Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Programmed cell death
(R-MMU-5357801)
Pyroptosis
(R-MMU-5620971)
Regulated necrosis
(R-MMU-5218859)
Release of apoptotic factors from the mitochondria
(R-MMU-111457)
Activation of cysteine-type endopeptidase activity
(GO:0097202)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
(GO:0008635)
Apoptotic process
(GO:0006915)
Apoptotic process involved in blood vessel morphogenesis
(GO:1902262)
Apoptotic signaling pathway
(GO:0097190)
Bak complex
(GO:0097145)
B cell apoptotic process
(GO:0001783)
B cell homeostasis
(GO:0001782)
B cell negative selection
(GO:0002352)
Bcl-2 family protein complex
(GO:0097136)
Bh domain binding
(GO:0051400)
Blood vessel remodeling
(GO:0001974)
Calcium ion transport into cytosol
(GO:0060402)
Cellular response to uv
(GO:0034644)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell proliferation
(GO:0050673)
Establishment of localization in cell
(GO:0051649)
Establishment or maintenance of transmembrane electrochemical gradient
(GO:0010248)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fibroblast apoptotic process
(GO:0044346)
Heat shock protein binding
(GO:0031072)
Homeostasis of number of cells
(GO:0048872)
Identical protein binding
(GO:0042802)
Intracellular anatomical structure
(GO:0005622)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Leukocyte homeostasis
(GO:0001776)
Limb morphogenesis
(GO:0035108)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial fusion
(GO:0008053)
Mitochondrial membrane
(GO:0031966)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endoplasmic reticulum calcium ion concentration
(GO:0032471)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of peptidyl-serine phosphorylation
(GO:0033137)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Peptidyl-serine phosphorylation
(GO:0018105)
Pore complex
(GO:0046930)
Porin activity
(GO:0015288)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of endoplasmic reticulum unfolded protein response
(GO:1900103)
Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901030)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Post-embryonic camera-type eye morphogenesis
(GO:0048597)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to fungus
(GO:0009620)
Response to gamma radiation
(GO:0010332)
Response to mycotoxin
(GO:0010046)
Thymocyte apoptotic process
(GO:0070242)
Transmembrane transporter binding
(GO:0044325)
Vagina development
(GO:0060068)

Other Information

Proteins

Bcl-2 homologous antagonist/killer

Genular Protein ID: 3681828321

Symbol: BAK_MOUSE

Name: Bcl-2 homologous antagonist/killer

UniProtKB Accession Codes:

O08734 E9QM21 Q8C264

Database IDs:

Citations:

PubMed ID: 9299236

Title: Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member.

PubMed ID: 9299236

DOI: 10.1006/geno.1997.4858

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 18248095

Title: Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68.

PubMed ID: 18248095

DOI: 10.1371/journal.ppat.0040025

PubMed ID: 18462686

Title: Structural plasticity underpins promiscuous binding of the prosurvival protein A1.

PubMed ID: 18462686

DOI: 10.1016/j.str.2008.02.009

Sequence Information:

Length: 209
Mass: 23295
Checksum: 49972D3CA21F4218
Sequence:

MASGQGPGPP KVGCDESPSP SEQQVAQDTE EVFRSYVFYL HQQEQETQGA AAPANPEMDN 
LPLEPNSILG QVGRQLALIG DDINRRYDTE FQNLLEQLQP TAGNAYELFT KIASSLFKSG 
ISWGRVVALL GFGYRLALYV YQRGLTGFLG QVTCFLADII LHHYIARWIA QRGGWVAALN 
FRRDPILTVM VIFGVVLLGQ FVVHRFFRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bak1

Associated with

Other Information

Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. PubMed ID: 9299236

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PubMed ID: 18248095

Structural plasticity underpins promiscuous binding of the prosurvival protein A1. PubMed ID: 18462686