Genular: Defining Cellular Identity and Function

Details for: Bax

Gene ID: 12028

Symbol: Bax

Ensembl ID: ENSMUSG00000003873

Description: BCL2-associated X protein

Associated with

Activation, translocation and oligomerization of bax
(R-MMU-114294)
Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Programmed cell death
(R-MMU-5357801)
Pyroptosis
(R-MMU-5620971)
Regulated necrosis
(R-MMU-5218859)
Release of apoptotic factors from the mitochondria
(R-MMU-111457)
Rna polymerase ii transcription
(R-MMU-73857)
Tp53 regulates transcription of cell cycle genes
(R-MMU-6791312)
Tp53 regulates transcription of genes involved in g2 cell cycle arrest
(R-MMU-6804114)
Transcriptional regulation by tp53
(R-MMU-3700989)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
(GO:0008635)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process
(GO:0006915)
B cell apoptotic process
(GO:0001783)
B cell homeostasis
(GO:0001782)
B cell homeostatic proliferation
(GO:0002358)
B cell negative selection
(GO:0002352)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Blood vessel remodeling
(GO:0001974)
Cell population proliferation
(GO:0008283)
Cerebral cortex development
(GO:0021987)
Channel activity
(GO:0015267)
Dna damage response
(GO:0006974)
Establishment or maintenance of transmembrane electrochemical gradient
(GO:0010248)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Glycosphingolipid metabolic process
(GO:0006687)
Heat shock protein binding
(GO:0031072)
Hsp70 protein binding
(GO:0030544)
Hypothalamus development
(GO:0021854)
Identical protein binding
(GO:0042802)
Inner mitochondrial membrane organization
(GO:0007007)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Kidney development
(GO:0001822)
Leukocyte homeostasis
(GO:0001776)
Lipid binding
(GO:0008289)
Male gonad development
(GO:0008584)
Mitochondrial fusion
(GO:0008053)
Mitochondrion organization
(GO:0007005)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endoplasmic reticulum calcium ion concentration
(GO:0032471)
Negative regulation of mitochondrial membrane potential
(GO:0010917)
Negative regulation of protein binding
(GO:0032091)
Nervous system development
(GO:0007399)
Neuron migration
(GO:0001764)
Outer mitochondrial membrane organization
(GO:0007008)
Ovarian follicle development
(GO:0001541)
Peptidyl-serine phosphorylation
(GO:0018105)
Positive regulation of b cell apoptotic process
(GO:0002904)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Post-embryonic development
(GO:0009791)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of nitrogen utilization
(GO:0006808)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to gamma radiation
(GO:0010332)
Response to ionizing radiation
(GO:0010212)
Response to salt stress
(GO:0009651)
Response to toxic substance
(GO:0009636)
Response to wounding
(GO:0009611)
Sex differentiation
(GO:0007548)
Spermatogenesis
(GO:0007283)
T cell homeostatic proliferation
(GO:0001777)

Other Information

Proteins

Apoptosis regulator BAX

Genular Protein ID: 1123889226

Symbol: BAX_MOUSE

Name: Apoptosis regulator BAX

UniProtKB Accession Codes:

Q07813

Database IDs:

Citations:

PubMed ID: 8358790

Title: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

PubMed ID: 8358790

DOI: 10.1016/0092-8674(93)90509-o

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15383280

Title: Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions.

PubMed ID: 15383280

DOI: 10.1016/j.molcel.2004.08.020

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 18248095

Title: Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68.

PubMed ID: 18248095

DOI: 10.1371/journal.ppat.0040025

PubMed ID: 21060336

Title: Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX.

PubMed ID: 21060336

DOI: 10.1038/cr.2010.149

Sequence Information:

Length: 192
Mass: 21395
Checksum: D2E0B3566579FAFF
Sequence:

MDGSGEQLGS GGPTSSEQIM KTGAFLLQGF IQDRAGRMAG ETPELTLEQP PQDASTKKLS 
ECLRRIGDEL DSNMELQRMI ADVDTDSPRE VFFRVAADMF ADGNFNWGRV VALFYFASKL 
VLKALCTKVP ELIRTIMGWT LDFLRERLLV WIQDQGGWEG LLSYFGTPTW QTVTIFVAGV 
LTASLTIWKK MG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bax

Associated with

Other Information

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. PubMed ID: 8358790

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. PubMed ID: 15383280

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural and biochemical bases for the inhibition of autophagy and apoptosis by viral BCL-2 of murine gamma-herpesvirus 68. PubMed ID: 18248095

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. PubMed ID: 21060336