Genular: Defining Cellular Identity and Function

Details for: Phb2

Gene ID: 12034

Symbol: Phb2

Ensembl ID: ENSMUSG00000004264

Description: prohibitin 2

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to mitochondrial stress
(R-MMU-9840373)
Mitochondrial calcium ion transport
(R-MMU-8949215)
Processing of smdt1
(R-MMU-8949664)
Transport of small molecules
(R-MMU-382551)
Activation of phospholipase c activity
(GO:0007202)
Activation of protein kinase c activity
(GO:1990051)
Amide binding
(GO:0033218)
Antiviral innate immune response
(GO:0140374)
Axon
(GO:0030424)
B cell activation
(GO:0042113)
Cd40 signaling pathway
(GO:0023035)
Cell migration
(GO:0016477)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Gaba-ergic synapse
(GO:0098982)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Inner mitochondrial membrane protein complex
(GO:0098800)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Mammary gland alveolus development
(GO:0060749)
Mammary gland branching involved in thelarche
(GO:0060744)
Mammary gland epithelial cell proliferation
(GO:0033598)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial prohibitin complex
(GO:0035632)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Mitophagy
(GO:0000423)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of intracellular estrogen receptor signaling pathway
(GO:0033147)
Negative regulation of mammary gland epithelial cell proliferation
(GO:0033600)
Nuclear matrix
(GO:0016363)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell cycle g1/s phase transition
(GO:1902808)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of exit from mitosis
(GO:0031536)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Postsynaptic density
(GO:0014069)
Presynaptic active zone
(GO:0048786)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein stabilization
(GO:0050821)
Regulation of branching involved in mammary gland duct morphogenesis
(GO:0060762)
Regulation of cardiolipin metabolic process
(GO:1900208)
Regulation of cytochrome-c oxidase activity
(GO:1904959)
Rig-i signaling pathway
(GO:0039529)
Sister chromatid cohesion
(GO:0007062)
Sphingolipid binding
(GO:0046625)

Other Information

Proteins

B-cell receptor-associated protein BAP37

Genular Protein ID: 968529121

Symbol: PHB2_MOUSE

Name: B-cell receptor-associated protein BAP37

UniProtKB Accession Codes:

O35129 O89075 Q61336

Database IDs:

Citations:

PubMed ID: 8070406

Title: The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein.

PubMed ID: 8070406

DOI: 10.1002/j.1460-2075.1994.tb06689.x

PubMed ID: 12878603

Title: Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins.

PubMed ID: 12878603

DOI: 10.1074/jbc.m303882200

PubMed ID: 15140878

Title: Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.

PubMed ID: 15140878

DOI: 10.1074/jbc.m312300200

PubMed ID: 9445485

Title: Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.

PubMed ID: 9445485

PubMed ID: 9798653

Title: Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis.

PubMed ID: 9798653

DOI: 10.1016/s0161-5890(98)00031-5

PubMed ID: 11302691

Title: Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence.

PubMed ID: 11302691

DOI: 10.1006/excr.2001.5166

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20959514

Title: Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

PubMed ID: 20959514

DOI: 10.1096/fj.10-167502

PubMed ID: 23241883

Title: Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes.

PubMed ID: 23241883

DOI: 10.4049/jimmunol.1201646

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 24856930

Title: DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling.

PubMed ID: 24856930

DOI: 10.1016/j.cmet.2014.04.016

PubMed ID: 28017329

Title: Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.

PubMed ID: 28017329

DOI: 10.1016/j.cell.2016.11.042

PubMed ID: 31819158

Title: Prohibitin levels regulate OMA1 activity and turnover in neurons.

PubMed ID: 31819158

DOI: 10.1038/s41418-019-0469-4

PubMed ID: 31522117

Title: Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region.

PubMed ID: 31522117

DOI: 10.1016/j.isci.2019.08.056

Sequence Information:

Length: 299
Mass: 33296
Checksum: A887CC982BF85C80
Sequence:

MAQNLKDLAG RLPAGPRGMG TALKLLLGAG AVAYGVRESV FTVEGGHRAI FFNRIGGVQQ 
DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ MVNISLRVLS RPNAQELPSM 
YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA SQLITQRAQV SLLIRRELTE RAKDFSLILD 
DVAITELSFS REYTAAVEAK QVAQQEAQRA QFLVEKAKQE QRQKIVQAEG EAEAAKMLGE 
ALSKNPGYIK LRKIRAAQNI SKTIATSQNR IYLTADNLVL NLQDESFTRG SDSLIKGKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Phb2

Associated with

Other Information

The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. PubMed ID: 8070406

Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins. PubMed ID: 12878603

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. PubMed ID: 15140878

Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. PubMed ID: 9445485

Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. PubMed ID: 9798653

Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. PubMed ID: 11302691

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. PubMed ID: 20959514

Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. PubMed ID: 23241883

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. PubMed ID: 24856930

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. PubMed ID: 28017329

Prohibitin levels regulate OMA1 activity and turnover in neurons. PubMed ID: 31819158

Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region. PubMed ID: 31522117