Genular: Defining Cellular Identity and Function

Details for: Bche

Gene ID: 12038

Symbol: Bche

Ensembl ID: ENSMUSG00000027792

Description: butyrylcholinesterase

Associated with

Aspirin adme
(R-MMU-9749641)
Drug adme
(R-MMU-9748784)
Metabolism of proteins
(R-MMU-392499)
Peptide hormone metabolism
(R-MMU-2980736)
Synthesis, secretion, and deacylation of ghrelin
(R-MMU-422085)
Acetylcholine catabolic process
(GO:0006581)
Acetylcholinesterase activity
(GO:0003990)
Carboxylic ester hydrolase activity
(GO:0052689)
Choline binding
(GO:0033265)
Choline metabolic process
(GO:0019695)
Cholinesterase activity
(GO:0004104)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Learning
(GO:0007612)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of synaptic transmission
(GO:0050805)
Neuroblast differentiation
(GO:0014016)
Nuclear envelope lumen
(GO:0005641)
Plasma membrane
(GO:0005886)
Response to alkaloid
(GO:0043279)
Response to folic acid
(GO:0051593)
Response to glucocorticoid
(GO:0051384)
Response to nutrient
(GO:0007584)
Response to xenobiotic stimulus
(GO:0009410)

Other Information

Proteins

Cholinesterase

Genular Protein ID: 1740584319

Symbol: CHLE_MOUSE

Name: Cholinesterase

UniProtKB Accession Codes:

Q03311 Q543J3

Database IDs:

Citations:

PubMed ID: 2400605

Title: Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species.

PubMed ID: 2400605

DOI: 10.1016/0896-6273(90)90168-f

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2016308

Title: Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates.

PubMed ID: 2016308

DOI: 10.1016/s0021-9258(20)89597-0

PubMed ID: 17212694

Title: Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity.

PubMed ID: 17212694

DOI: 10.1111/j.1471-4159.2006.04347.x

PubMed ID: 17467011

Title: Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice.

PubMed ID: 17467011

DOI: 10.1016/j.lfs.2007.03.011

PubMed ID: 17194517

Title: Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.

PubMed ID: 17194517

DOI: 10.1016/j.tox.2006.11.069

PubMed ID: 18056867

Title: The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency.

PubMed ID: 18056867

DOI: 10.1124/jpet.107.133330

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 603
Mass: 68462
Checksum: 2CB79C46797B3713
Sequence:

MQTQHTKVTQ THFLLWILLL CMPFGKSHTE EDFIITTKTG RVRGLSMPVL GGTVTAFLGI 
PYAQPPLGSL RFKKPQPLNK WPDIHNATQY ANSCYQNIDQ AFPGFQGSEM WNPNTNLSED 
CLYLNVWIPV PKPKNATVMV WIYGGGFQTG TSSLPVYDGK FLARVERVIV VSMNYRVGAL 
GFLAFPGNPD APGNMGLFDQ QLALQWVQRN IAAFGGNPKS ITIFGESAGA ASVSLHLLCP 
QSYPLFTRAI LESGSSNAPW AVKHPEEARN RTLTLAKFTG CSKENEMEMI KCLRSKDPQE 
ILRNERFVLP SDSILSINFG PTVDGDFLTD MPHTLLQLGK VKKAQILVGV NKDEGTAFLV 
YGAPGFSKDN DSLITRKEFQ EGLNMYFPGV SRLGKEAVLF YYVDWLGEQS PEVYRDALDD 
VIGDYNIICP ALEFTKKFAE LENNAFFYFF EHRSSKLPWP EWMGVMHGYE IEFVFGLPLG 
RRVNYTRAEE IFSRSIMKTW ANFAKYGHPN GTQGNSTMWP VFTSTEQKYL TLNTEKSKIY 
SKLRAPQCQF WRLFFPKVLE MTGDIDETEQ EWKAGFHRWS NYMMDWQNQF NDYTSKKESC 
TAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bche

Associated with

Other Information

Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. PubMed ID: 2400605

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Use of the polymerase chain reaction for homology probing of butyrylcholinesterase from several vertebrates. PubMed ID: 2016308

Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. PubMed ID: 17212694

Butyrylcholinesterase and the control of synaptic responses in acetylcholinesterase knockout mice. PubMed ID: 17467011

Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. PubMed ID: 17194517

The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency. PubMed ID: 18056867

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079