Details for: CLNS1AP1

Gene ID: 1204

Symbol: CLNS1AP1

Ensembl ID: ENSG00000213335

Description: chloride nucleotide-sensitive channel 1A pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0404
    Cell Significance Index: 0.6000
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.0346
    Cell Significance Index: 0.3100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0190
    Cell Significance Index: 0.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0181
    Cell Significance Index: 0.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0067
    Cell Significance Index: 0.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0083
    Cell Significance Index: -0.2700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0089
    Cell Significance Index: -0.2200
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0101
    Cell Significance Index: -0.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0128
    Cell Significance Index: -0.2700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0132
    Cell Significance Index: -0.1200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0135
    Cell Significance Index: -0.2700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0142
    Cell Significance Index: -0.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0151
    Cell Significance Index: -0.3300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0159
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0166
    Cell Significance Index: -0.3300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0230
    Cell Significance Index: -0.2100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0236
    Cell Significance Index: -0.2900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0254
    Cell Significance Index: -0.3000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0268
    Cell Significance Index: -0.3400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0275
    Cell Significance Index: -0.3300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0280
    Cell Significance Index: -0.3100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0287
    Cell Significance Index: -0.3200
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0299
    Cell Significance Index: -0.3800
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0307
    Cell Significance Index: -0.3500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0311
    Cell Significance Index: -0.3600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0316
    Cell Significance Index: -0.3800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0318
    Cell Significance Index: -0.4200
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0323
    Cell Significance Index: -0.3900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0339
    Cell Significance Index: -0.3100
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0354
    Cell Significance Index: -0.3800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0382
    Cell Significance Index: -0.4100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0461
    Cell Significance Index: -0.3800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0469
    Cell Significance Index: -0.4400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0472
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0473
    Cell Significance Index: -0.3600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0584
    Cell Significance Index: -0.3800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0640
    Cell Significance Index: -0.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLNS1AP1 is a pseudogene, meaning that it lacks a functional coding sequence and is thought to be a non-functional copy of the CLNS1 gene. Despite this, CLNS1AP1 is significantly expressed in a wide range of cell types, including plasma cells, neurons, and hematopoietic stem cells. This expression is not limited to specific tissues or developmental stages, indicating that CLNS1AP1 may play a role in maintaining cellular homeostasis or regulating cellular behavior. Interestingly, CLNS1AP1 is also expressed in cells of the immune system, including leukocytes and neutrophils. This expression raises questions about the potential role of CLNS1AP1 in immune function and disease. **Pathways and Functions:** While the exact mechanisms of CLNS1AP1's function are unclear, several pathways and processes are thought to be involved: 1. **Cell signaling:** CLNS1AP1 may modulate cell signaling pathways, influencing cellular behavior and differentiation. For example, its expression in neurons suggests that CLNS1AP1 may play a role in regulating neuronal development and function. 2. **Gene regulation:** CLNS1AP1 may act as a regulator of gene expression, influencing the expression of other genes in its vicinity. This could have implications for cellular differentiation and development. 3. **Stem cell maintenance:** CLNS1AP1's expression in hematopoietic stem cells and other stem cell types suggests that it may play a role in maintaining stem cell homeostasis and promoting cellular self-renewal. **Clinical Significance:** The clinical significance of CLNS1AP1 is an area of ongoing research. While the gene's pseudogenic status makes it unlikely to be a direct contributor to human disease, its expression in immune cells and other tissues raises questions about its potential role in immune function and disease. Specifically, CLNS1AP1's expression in leukocytes and neutrophils suggests that it may be involved in regulating immune cell function and responding to pathogens. Further investigation is needed to determine the functional significance of CLNS1AP1 in immune cells and to explore its potential as a therapeutic target. In addition, CLNS1AP1's expression in other cell types, including neurons and epithelial cells, suggests that it may play a role in maintaining cellular homeostasis and regulating cellular behavior. Further research is needed to elucidate the functional significance of CLNS1AP1 in these cell types and to explore its potential as a biomarker or therapeutic target. In conclusion, CLNS1AP1 is a fascinating gene with multifaceted roles in immune and non-immune cells. While its pseudogenic status makes it unlikely to be a direct contributor to human disease, its expression in multiple cell types and potential involvement in cellular signaling, gene regulation, and stem cell maintenance make it an attractive subject for further investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.