Genular: Defining Cellular Identity and Function

Details for: Bckdk

Gene ID: 12041

Symbol: Bckdk

Ensembl ID: ENSMUSG00000030802

Description: branched chain ketoacid dehydrogenase kinase

Associated with

Branched-chain amino acid catabolism
(R-MMU-70895)
Metabolism
(R-MMU-1430728)
Metabolism of amino acids and derivatives
(R-MMU-71291)
Atp binding
(GO:0005524)
Branched-chain amino acid catabolic process
(GO:0009083)
Isoleucine catabolic process
(GO:0006550)
Kinase activity
(GO:0016301)
Leucine catabolic process
(GO:0006552)
Lipid biosynthetic process
(GO:0008610)
Mitochondrial alpha-ketoglutarate dehydrogenase complex
(GO:0005947)
Mitochondrion
(GO:0005739)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine/threonine phosphatase activity
(GO:0004722)
Pyruvate dehydrogenase (acetyl-transferring) kinase activity
(GO:0004740)
Regulation of glucose metabolic process
(GO:0010906)
Spermatogenesis
(GO:0007283)
Transferase activity
(GO:0016740)
Transferase activity, transferring phosphorus-containing groups
(GO:0016772)
Valine catabolic process
(GO:0006574)
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity
(GO:0047323)

Other Information

Proteins

[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

Genular Protein ID: 3051283971

Symbol: BCKD_MOUSE

Name: [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial

UniProtKB Accession Codes:

O55028

Database IDs:

Citations:

PubMed ID: 9611264

Title: Murine branched chain alpha ketoacid dehydrogenase kinase; cDNA cloning, tissue distribution, and temporal expression during embryonic development.

PubMed ID: 9611264

DOI: 10.1016/s0378-1119(98)00182-6

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16875466

Title: Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.

PubMed ID: 16875466

DOI: 10.1042/bj20060869

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22956686

Title: Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy.

PubMed ID: 22956686

DOI: 10.1126/science.1224631

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

Sequence Information:

Length: 412
Mass: 46588
Checksum: 80B3B173AAC8AAD3
Sequence:

MILTSVLGSG PRSWSSLWPL LGSSLSLRAR STSATDTHHV ELARERSKTV TSFYNQSAID 
VAAEKPSVRL TPTMMLYSGR SQDGSHLLKS GRYLQQELPV RIAHRIKGFR SLPFIIGCNP 
TILHVHELYI RAFQKLTDFP PIKDQADEAQ YCQLVRQLLD DHKDVVTLLA EGLRESRKHI 
QDEKLVRYFL DKTLTSRLGI RMLATHHLAL HEDKPDFVGI ICTRLSPKKI IEKWVDFARR 
LCEHKYGNAP RVRINGHVAA RFPFIPMPLD YILPELLKNA MRATMESHLD TPYNVPDVVI 
TIANNDIDLI IRISDRGGGI AHKDLDRVMD YHFTTAEAST QDPRINPLFG HLDMHSGGQS 
GPMHGFGFGL PTSRAYAEYL GGSLQLQSLQ GIGTDVYLRL RHIDGREESF RI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bckdk

Associated with

Other Information

Murine branched chain alpha ketoacid dehydrogenase kinase; cDNA cloning, tissue distribution, and temporal expression during embryonic development. PubMed ID: 9611264

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. PubMed ID: 16875466

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy. PubMed ID: 22956686

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753