Genular: Defining Cellular Identity and Function

Details for: Bcl10

Gene ID: 12042

Symbol: Bcl10

Ensembl ID: ENSMUSG00000028191

Description: B cell leukemia/lymphoma 10

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
E3 ubiquitin ligases ubiquitinate target proteins
(R-MMU-8866654)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Protein ubiquitination
(R-MMU-8852135)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Tcr signaling
(R-MMU-202403)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Adaptive immune response
(GO:0002250)
Antifungal innate immune response
(GO:0061760)
Apoptotic process
(GO:0006915)
B cell apoptotic process
(GO:0001783)
Card domain binding
(GO:0050700)
Cbm complex
(GO:0032449)
Cellular defense response
(GO:0006968)
Cysteine-type endopeptidase activator activity involved in apoptotic process
(GO:0008656)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule
(GO:0005881)
Cytosol
(GO:0005829)
Fibroblast apoptotic process
(GO:0044346)
General transcription initiation factor binding
(GO:0140296)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Immunological synapse
(GO:0001772)
Innate immune response
(GO:0045087)
Kinase activator activity
(GO:0019209)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lysosome
(GO:0005764)
Mast cell activation
(GO:0045576)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Negative regulation of mature b cell apoptotic process
(GO:0002906)
Neural tube closure
(GO:0001843)
Nf-kappab binding
(GO:0051059)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Polkadots
(GO:0002096)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of execution phase of apoptosis
(GO:1900119)
Positive regulation of extrinsic apoptotic signaling pathway
(GO:2001238)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell receptor signaling pathway
(GO:0050862)
Programmed cell death
(GO:0012501)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein homooligomerization
(GO:0051260)
Protein kinase b binding
(GO:0043422)
Protein self-association
(GO:0043621)
Regulation of apoptotic process
(GO:0042981)
Regulation of t cell receptor signaling pathway
(GO:0050856)
Response to food
(GO:0032094)
Response to fungus
(GO:0009620)
Signaling adaptor activity
(GO:0035591)
T cell apoptotic process
(GO:0070231)
T cell receptor signaling pathway
(GO:0050852)
Thymocyte apoptotic process
(GO:0070242)
Toll-like receptor signaling pathway
(GO:0002224)
Transcription coactivator activity
(GO:0003713)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

B-cell lymphoma/leukemia 10

Genular Protein ID: 3702843868

Symbol: BCL10_MOUSE

Name: B-cell lymphoma/leukemia 10

UniProtKB Accession Codes:

Q9Z0H7 Q3UBN4

Database IDs:

Citations:

PubMed ID: 9989495

Title: Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types.

PubMed ID: 9989495

DOI: 10.1016/s0092-8674(00)80957-5

PubMed ID: 10187770

Title: CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10.

PubMed ID: 10187770

DOI: 10.1074/jbc.274.15.9955

PubMed ID: 10187771

Title: Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.

PubMed ID: 10187771

DOI: 10.1074/jbc.274.15.9962

PubMed ID: 10187815

Title: mE10, a novel caspase recruitment domain-containing proapoptotic molecule.

PubMed ID: 10187815

DOI: 10.1074/jbc.274.15.10287

PubMed ID: 10364242

Title: CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis.

PubMed ID: 10364242

DOI: 10.1074/jbc.274.25.17946

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15213237

Title: BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.

PubMed ID: 15213237

DOI: 10.1074/jbc.m400241200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22265677

Title: Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity.

PubMed ID: 22265677

DOI: 10.1016/j.immuni.2011.11.015

PubMed ID: 22880103

Title: Structural insights into the assembly of CARMA1 and BCL10.

PubMed ID: 22880103

DOI: 10.1371/journal.pone.0042775

Sequence Information:

Length: 233
Mass: 25948
Checksum: C0539BC97102DBB8
Sequence:

MEAPAPSLTE EDLTEVKKDA LENLRVYLCE KIIAERHFDH LRAKKILSRE DTEEISCRTS 
SRKRAGKLLD YLQENPRGLD TLVESIRREK TQSFLIQKIT DEVLKLRNIK LEHLKGLKCS 
SCEPFAAGAT NNLSRCNSDE SNLSEKQRAS TVMYHPEGES STAPFFSMAS SLNLPVLEVG 
RTENSSFSSA TLPRPGDPGA PPLPPDLRLE EGGSCGNSSE MFLPLRSRAL SRQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl10

Associated with

Other Information

Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. PubMed ID: 9989495

CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10. PubMed ID: 10187770

Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. PubMed ID: 10187771

mE10, a novel caspase recruitment domain-containing proapoptotic molecule. PubMed ID: 10187815

CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis. PubMed ID: 10364242

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. PubMed ID: 15213237

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Syk kinase-coupled C-type lectin receptors engage protein kinase C-delta to elicit Card9 adaptor-mediated innate immunity. PubMed ID: 22265677

Structural insights into the assembly of CARMA1 and BCL10. PubMed ID: 22880103