Genular: Defining Cellular Identity and Function

Details for: Bcl2

Gene ID: 12043

Symbol: Bcl2

Ensembl ID: ENSMUSG00000057329

Description: B cell leukemia/lymphoma 2

Associated with

Activation of bad and translocation to mitochondria
(R-MMU-111447)
Activation of bh3-only proteins
(R-MMU-114452)
Apoptosis
(R-MMU-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-MMU-111453)
Immune system
(R-MMU-168256)
Inflammasomes
(R-MMU-622312)
Innate immune system
(R-MMU-168249)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Programmed cell death
(R-MMU-5357801)
The nlrp1 inflammasome
(R-MMU-844455)
Actin filament organization
(GO:0007015)
Animal organ morphogenesis
(GO:0009887)
Apoptotic mitochondrial changes
(GO:0008637)
Apoptotic process
(GO:0006915)
Axonogenesis
(GO:0007409)
B cell apoptotic process
(GO:0001783)
B cell homeostasis
(GO:0001782)
B cell lineage commitment
(GO:0002326)
Behavioral fear response
(GO:0001662)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Channel activity
(GO:0015267)
Channel inhibitor activity
(GO:0016248)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
G1/s transition of mitotic cell cycle
(GO:0000082)
Identical protein binding
(GO:0042802)
Immune system development
(GO:0002520)
Intracellular calcium ion homeostasis
(GO:0006874)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Kidney development
(GO:0001822)
Leukocyte homeostasis
(GO:0001776)
Lymphocyte homeostasis
(GO:0002260)
Lymphoid progenitor cell differentiation
(GO:0002320)
Male gonad development
(GO:0008584)
Melanin metabolic process
(GO:0006582)
Mesenchymal cell development
(GO:0014031)
Metanephros development
(GO:0001656)
Mitotic cell cycle
(GO:0000278)
Molecular adaptor activity
(GO:0060090)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of calcium ion transport into cytosol
(GO:0010523)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cell population proliferation
(GO:0008285)
Ossification
(GO:0001503)
Ovarian follicle development
(GO:0001541)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of neuron maturation
(GO:0014042)
Post-embryonic development
(GO:0009791)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dephosphorylation
(GO:0006470)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein phosphatase 2a binding
(GO:0051721)
Protein phosphatase binding
(GO:0019903)
Protein polyubiquitination
(GO:0000209)
Regulation of autophagy
(GO:0010506)
Regulation of cell-matrix adhesion
(GO:0001952)
Regulation of gene expression
(GO:0010468)
Regulation of glycoprotein biosynthetic process
(GO:0010559)
Regulation of nitrogen utilization
(GO:0006808)
Release of cytochrome c from mitochondria
(GO:0001836)
Renal system process
(GO:0003014)
Response to acid chemical
(GO:0001101)
Response to gamma radiation
(GO:0010332)
Response to iron ion
(GO:0010039)
Response to ischemia
(GO:0002931)
Response to oxidative stress
(GO:0006979)
Response to toxic substance
(GO:0009636)
Response to uv-b
(GO:0010224)
Response to xenobiotic stimulus
(GO:0009410)
Smooth muscle cell migration
(GO:0014909)
T cell lineage commitment
(GO:0002360)
Transcription factor binding
(GO:0008134)
Ubiquitin protein ligase binding
(GO:0031625)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Genular Protein ID: 2025413160

Symbol: BCL2_MOUSE

Name: Apoptosis regulator Bcl-2

UniProtKB Accession Codes:

P10417 P10418 Q4VBF6

Database IDs:

Citations:

PubMed ID: 3032455

Title: Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma.

PubMed ID: 3032455

DOI: 10.1016/0092-8674(87)90448-x

PubMed ID: 1508712

Title: Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo.

PubMed ID: 1508712

DOI: 10.1093/nar/20.16.4187

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115213

Title: Bcl-2 phosphorylation required for anti-apoptosis function.

PubMed ID: 9115213

DOI: 10.1074/jbc.272.18.11671

PubMed ID: 9852076

Title: Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A.

PubMed ID: 9852076

DOI: 10.1074/jbc.273.51.34157

PubMed ID: 15781622

Title: Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness.

PubMed ID: 15781622

DOI: 10.1158/0008-5472.can-04-3377

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 17418785

Title: Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1.

PubMed ID: 17418785

DOI: 10.1016/j.cell.2007.01.045

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21502331

Title: Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells.

PubMed ID: 21502331

DOI: 10.1084/jem.20101192

PubMed ID: 29020630

Title: Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.

PubMed ID: 29020630

DOI: 10.1016/j.celrep.2017.09.052

Sequence Information:

Length: 236
Mass: 26407
Checksum: 80FDCFE78C735092
Sequence:

MAQAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDADAAPL GAAPTPGIFS FQPESNPMPA 
VHRDMAARTS PLRPLVATAG PALSPVPPVV HLTLRRAGDD FSRRYRRDFA EMSSQLHLTP 
FTARGRFATV VEELFRDGVN WGRIVAFFEF GGVMCVESVN REMSPLVDNI ALWMTEYLNR 
HLHTWIQDNG GWDAFVELYG PSMRPLFDFS WLSLKTLLSL ALVGACITLG AYLGHK

Genular Protein ID: 2192186326

Symbol: Q6NTH7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6NTH7

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 199
Mass: 22281
Checksum: F13C8037262BA955
Sequence:

MAQAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDADAAPL GAAPTPGIFS FQPESNPMPA 
VHRDMAARTS PLRPLVATAG PALSPVPPVV HLTLRRAGDD FSRRYRRDFA EMSSQLHLTP 
FTARGRFATV VEELFRDGVN WGRIVAFFEF GGVMCVESVN REMSPLVDNI ALWMTEYLNR 
HLHTWIQDNG GWVGACLVE

Genular Protein ID: 3534389171

Symbol: Q8BQK4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BQK4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 236
Mass: 26437
Checksum: B726BFFA3AA1C718
Sequence:

MAQAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDADAAPL GAAPTPGIFS FQPESNPMPA 
VHRDMAARTS PLRPLVATTG PALSPVPPVV HLTLRRAGDD FSRRYRRDFA EMSSQLHLTP 
FTARGRFATV VEELFRDGVN WGRIVAFFEF GGVMCVESVN REMSPLVDNI ALWMTEYLNR 
HLHTWIQDNG GWDAFVELYG PSMRPLFDFS WLSLKTLLSL ALVGACITLG AYLGHK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl2

Associated with

Other Information

Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. PubMed ID: 3032455

Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. PubMed ID: 1508712

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Bcl-2 phosphorylation required for anti-apoptosis function. PubMed ID: 9115213

Reversible phosphorylation of Bcl2 following interleukin 3 or bryostatin 1 is mediated by direct interaction with protein phosphatase 2A. PubMed ID: 9852076

Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness. PubMed ID: 15781622

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1. PubMed ID: 17418785

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. PubMed ID: 21502331

Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis. PubMed ID: 29020630

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Database document:

PubMed ID: 3032455

PubMed ID: 1508712

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 9115213

PubMed ID: 9852076

PubMed ID: 15781622

PubMed ID: 16509771

PubMed ID: 17418785

PubMed ID: 21183079

PubMed ID: 21502331

PubMed ID: 29020630

PubMed ID: 15489334

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073