Genular: Defining Cellular Identity and Function

Details for: Bcl3

Gene ID: 12051

Symbol: Bcl3

Ensembl ID: ENSMUSG00000053175

Description: B cell leukemia/lymphoma 3

Associated with

Antimicrobial humoral response
(GO:0019730)
Bcl3-bcl10 complex
(GO:0032996)
Bcl3/nf-kappab2 complex
(GO:0033257)
Canonical nf-kappab signal transduction
(GO:0007249)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to protozoan
(GO:0042832)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Extracellular matrix organization
(GO:0030198)
Follicular dendritic cell differentiation
(GO:0002268)
Germinal center formation
(GO:0002467)
Histone deacetylase binding
(GO:0042826)
Humoral immune response mediated by circulating immunoglobulin
(GO:0002455)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Marginal zone b cell differentiation
(GO:0002315)
Midbody
(GO:0030496)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of t cell apoptotic process
(GO:0070233)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Positive regulation of type ii interferon production
(GO:0032729)
Protein-containing complex
(GO:0032991)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Regulation of apoptotic process
(GO:0042981)
Response to uv-c
(GO:0010225)
Response to virus
(GO:0009615)
Spleen development
(GO:0048536)
T-helper 1 type immune response
(GO:0042088)
T-helper 2 cell differentiation
(GO:0045064)
T cell apoptotic process
(GO:0070231)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
Type ii interferon production
(GO:0032609)

Other Information

Proteins

B-cell lymphoma 3 protein homolog

Genular Protein ID: 4135405691

Symbol: BCL3_MOUSE

Name: B-cell lymphoma 3 protein homolog

UniProtKB Accession Codes:

Q9Z2F6

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10361130

Title: Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction.

PubMed ID: 10361130

PubMed ID: 16713561

Title: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.

PubMed ID: 16713561

DOI: 10.1016/j.cell.2006.03.041

PubMed ID: 19893491

Title: CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.

PubMed ID: 19893491

DOI: 10.1038/emboj.2009.317

Sequence Information:

Length: 448
Mass: 47216
Checksum: 7665D28BBC3EE194
Sequence:

MPRCPAGAMD EGPVDLRTRP KGTPGAALPL RKRPLRPASP EPATTRSPAG PLDALRSGCD 
VPVVPGPPHC VARPEALYYQ GPLMPIYSTP TMAPHFPLLN LPTHPYSMIC PMEHPLSADI 
AMATRVDEDG DTPLHIAVVQ NNIAAVYRIL SLFKLGSREV DVHNNLRQTP LHLAVITTLP 
DMVRLLVTAG ASPMALDRHG QTAIHLACEH RSPSCLQALL DSATSGSVDL EVRNYEGLTA 
LHVAVNTGCQ EAVLLLLERG ADIDAVDIKS GRSPLIHAVE NNSLNMVQLL LLHGANVNAQ 
MYSGSSALHS ASGRGLLPLV RTLVRSGADS GLKNCHNDTP LMVARSRRVI DILRGKASRA 
ASGSQPEPSP DQSATNSPES SSRLSSNGLQ SSPSSSPSLS PPKDAPGFPA TPQNFFLPTT 
STPAFLPFPG VLRGPGRPVP PSPAPGSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl3

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction. PubMed ID: 10361130

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. PubMed ID: 16713561

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin. PubMed ID: 19893491

Database document:

PubMed ID: 19468303

PubMed ID: 10361130

PubMed ID: 16713561

PubMed ID: 19893491