Genular: Defining Cellular Identity and Function

Details for: Bcl6

Gene ID: 12053

Symbol: Bcl6

Ensembl ID: ENSMUSG00000022508

Description: B cell leukemia/lymphoma 6

Associated with

Actin cytoskeleton organization
(GO:0030036)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Cell-matrix adhesion
(GO:0007160)
Cell morphogenesis
(GO:0000902)
Cell motility
(GO:0048870)
Cell population proliferation
(GO:0008283)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor binding
(GO:0140297)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Erythrocyte development
(GO:0048821)
Germinal center formation
(GO:0002467)
Golgi apparatus
(GO:0005794)
Heterochromatin formation
(GO:0031507)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Intronic transcription regulatory region sequence-specific dna binding
(GO:0001161)
Isotype switching to ige isotypes
(GO:0048289)
Mast cell cytokine production
(GO:0032762)
Metal ion binding
(GO:0046872)
Mononuclear cell proliferation
(GO:0032943)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell-matrix adhesion
(GO:0001953)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of isotype switching to ige isotypes
(GO:0048294)
Negative regulation of mast cell cytokine production
(GO:0032764)
Negative regulation of mononuclear cell proliferation
(GO:0032945)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of plasma cell differentiation
(GO:1900099)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of t-helper 2 cell differentiation
(GO:0045629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type 2 immune response
(GO:0002829)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Paraspeckles
(GO:0042382)
Plasma cell differentiation
(GO:0002317)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Pyramidal neuron differentiation
(GO:0021859)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cytokine production
(GO:0001817)
Regulation of gtpase activity
(GO:0043087)
Regulation of immune system process
(GO:0002682)
Regulation of inflammatory response
(GO:0050727)
Regulation of memory t cell differentiation
(GO:0043380)
Regulation of t cell proliferation
(GO:0042129)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Replication fork
(GO:0005657)
Rho protein signal transduction
(GO:0007266)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Spermatogenesis
(GO:0007283)
T-helper 2 cell differentiation
(GO:0045064)
Transcription by rna polymerase ii
(GO:0006366)
Transcription corepressor binding
(GO:0001222)
Type 2 immune response
(GO:0042092)

Other Information

Proteins

B-cell lymphoma 6 protein homolog

Genular Protein ID: 1240373753

Symbol: BCL6_MOUSE

Name: B-cell lymphoma 6 protein homolog

UniProtKB Accession Codes:

P41183 Q61065

Database IDs:

Citations:

PubMed ID: 7478591

Title: The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.

PubMed ID: 7478591

PubMed ID: 8652841

Title: BCL-6 expression during B-cell activation.

PubMed ID: 8652841

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9632807

Title: BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor.

PubMed ID: 9632807

DOI: 10.1128/mcb.18.7.4235

PubMed ID: 9927193

Title: Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene.

PubMed ID: 9927193

DOI: 10.1038/sj.onc.1202332

PubMed ID: 10981963

Title: BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control.

PubMed ID: 10981963

DOI: 10.1016/s1074-7613(00)00020-0

PubMed ID: 12021781

Title: Role for Bcl-6 in the generation and maintenance of memory CD8+ T-cells.

PubMed ID: 12021781

DOI: 10.1038/ni802

PubMed ID: 17828269

Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

PubMed ID: 17828269

DOI: 10.1038/ni1508

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23166356

Title: BCL6 positively regulates AID and germinal center gene expression via repression of miR-155.

PubMed ID: 23166356

DOI: 10.1084/jem.20121387

PubMed ID: 23160044

Title: BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets.

PubMed ID: 23160044

DOI: 10.1038/nn.3264

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 23455674

Title: Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.

PubMed ID: 23455674

DOI: 10.1038/ni.2543

Sequence Information:

Length: 707
Mass: 78982
Checksum: 2051DD808D32D5EC
Sequence:

MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI 
FTDQLKCNLS VINLDPEISP EGFCILLDFM YTSRLNLREG NIMAVMTTAM YLQMEHVVDT 
CRKFIKASEA EMAPALKPPR EEFLNSRMLM PHDIMAYRGR EVVENNMPLR NTPGCESRAF 
APPLYSGLST PPASYPMYSH LPLSTFLFSD EELRDAPRMP VANPFPKERA LPCDSARQVP 
NEYSRPAMEV SPSLCHSNIY SPKEAVPEEA RSDIHYSVPE GPKPAVPSAR NAPYFPCDKA 
SKEEERPSSE DEIALHFEPP NAPLNRKGLV SPQSPQKSDC QPNSPTESCS SKNACILQAS 
GSPPAKSPTD PKACNWKKYK FIVLNSLNQN AKPEGSEQAE LGRLSPRAYP APPACQPPME 
PANLDLQSPT KLSASGEDST IPQASRLNNL VNRSLAGSPR SSSESHSPLY MHPPKCTSCG 
SQSPQHTEMC LHTAGPTFPE EMGETQSEYS DSSCENGTFF CNECDCRFSE EASLKRHTLQ 
THSDKPYKCD RCQASFRYKG NLASHKTVHT GEKPYRCNIC GAQFNRPANL KTHTRIHSGE 
KPYKCETCGA RFVQVAHLRA HVLIHTGEKP YPCEICGTRF RHLQTLKSHL RIHTGEKPYH 
CEKCNLHFRH KSQLRLHLRQ KHGAITNTKV QYRVSAADLP PELPKAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl6

Associated with

Other Information

The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene. PubMed ID: 7478591

BCL-6 expression during B-cell activation. PubMed ID: 8652841

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BAZF, a novel Bcl6 homolog, functions as a transcriptional repressor. PubMed ID: 9632807

Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. PubMed ID: 9927193

BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. PubMed ID: 10981963

Role for Bcl-6 in the generation and maintenance of memory CD8+ T-cells. PubMed ID: 12021781

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. PubMed ID: 17828269

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. PubMed ID: 23166356

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets. PubMed ID: 23160044

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. PubMed ID: 23911289

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. PubMed ID: 23455674