Genular: Defining Cellular Identity and Function

Details for: Bdnf

Gene ID: 12064

Symbol: Bdnf

Ensembl ID: ENSMUSG00000048482

Description: brain derived neurotrophic factor

Associated with

Activated ntrk2 signals through frs2 and frs3
(R-MMU-9028731)
Activated ntrk2 signals through fyn
(R-MMU-9032500)
Activated ntrk2 signals through plcg1
(R-MMU-9026527)
Ntrk2 activates rac1
(R-MMU-9032759)
Signaling by ntrk2 (trkb)
(R-MMU-9006115)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Axon
(GO:0030424)
Axon extension
(GO:0048675)
Axon guidance
(GO:0007411)
Axon target recognition
(GO:0007412)
Behavioral fear response
(GO:0001662)
Behavioral response to cocaine
(GO:0048148)
Cellular response to acid chemical
(GO:0071229)
Circadian rhythm
(GO:0007623)
Collateral sprouting
(GO:0048668)
Conditioned place preference
(GO:1990708)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Dendrite development
(GO:0016358)
Dendrite extension
(GO:0097484)
Endoplasmic reticulum lumen
(GO:0005788)
Excitatory postsynaptic potential
(GO:0060079)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fear response
(GO:0042596)
Feeding behavior
(GO:0007631)
Gamma-aminobutyric acid signaling pathway
(GO:0007214)
Glutamate secretion
(GO:0014047)
Growth factor activity
(GO:0008083)
Inhibitory postsynaptic potential
(GO:0060080)
Inner ear development
(GO:0048839)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Mechanoreceptor differentiation
(GO:0042490)
Memory
(GO:0007613)
Mitochondrial crista
(GO:0030061)
Mitochondrial electron transport, nadh to ubiquinone
(GO:0006120)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of myotube differentiation
(GO:0010832)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of programmed cell death
(GO:0043069)
Negative regulation of striated muscle tissue development
(GO:0045843)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Nerve development
(GO:0021675)
Nerve growth factor receptor binding
(GO:0005163)
Nerve growth factor signaling pathway
(GO:0038180)
Nervous system development
(GO:0007399)
Neuronal cell body
(GO:0043025)
Neuron apoptotic process
(GO:0051402)
Neuron projection extension
(GO:1990138)
Neuron projection morphogenesis
(GO:0048812)
Neuron recognition
(GO:0008038)
Neurotrophin trkb receptor binding
(GO:0005169)
Peptidyl-serine phosphorylation
(GO:0018105)
Peripheral nervous system development
(GO:0007422)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of collateral sprouting
(GO:0048672)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of glucocorticoid receptor signaling pathway
(GO:2000324)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of receptor binding
(GO:1900122)
Positive regulation of synapse assembly
(GO:0051965)
Protein binding
(GO:0005515)
Regeneration
(GO:0031099)
Regulation of axon extension
(GO:0030516)
Regulation of collateral sprouting
(GO:0048670)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of neuron differentiation
(GO:0045664)
Regulation of retinal cell programmed cell death
(GO:0046668)
Regulation of short-term neuronal synaptic plasticity
(GO:0048172)
Regulation of synaptic plasticity
(GO:0048167)
Response to xenobiotic stimulus
(GO:0009410)
Retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission
(GO:0099083)
Secretory granule
(GO:0030141)
Signaling receptor binding
(GO:0005102)
Synapse assembly
(GO:0007416)
Synaptic vesicle
(GO:0008021)
Taste bud development
(GO:0061193)
Terminal bouton
(GO:0043195)
Trans-synaptic signaling by bdnf, modulating synaptic transmission
(GO:0099183)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

BDNF_MOUSE

Genular Protein ID: 2712879305

Symbol: BDNF_MOUSE

Name: N/A

UniProtKB Accession Codes:

P21237 A2AII2 Q8CCH9

Database IDs:

Citations:

PubMed ID: 2369898

Title: Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain.

PubMed ID: 2369898

DOI: 10.1002/j.1460-2075.1990.tb07423.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7957235

Title: Characterisation of neurotrophin dimers and monomers.

PubMed ID: 7957235

DOI: 10.1111/j.1432-1033.1994.0995b.x

PubMed ID: 8139657

Title: Mice lacking brain-derived neurotrophic factor develop with sensory deficits.

PubMed ID: 8139657

DOI: 10.1038/368147a0

PubMed ID: 15486301

Title: Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.

PubMed ID: 15486301

DOI: 10.1126/science.1100135

PubMed ID: 17023662

Title: Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior.

PubMed ID: 17023662

DOI: 10.1126/science.1129663

PubMed ID: 23785138

Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.

PubMed ID: 23785138

DOI: 10.1523/jneurosci.2757-12.2013

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 27457814

Title: SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

PubMed ID: 27457814

DOI: 10.1038/mp.2016.108

PubMed ID: 28111162

Title: HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury.

PubMed ID: 28111162

DOI: 10.1016/j.brainres.2017.01.019

PubMed ID: 29909994

Title: The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior.

PubMed ID: 29909994

DOI: 10.1016/j.neuron.2018.05.024

Sequence Information:

Length: 249
Mass: 28123
Checksum: 90CE1F16BB235C97
Sequence:

MTILFLTMVI SYFGCMKAAP MKEVNVHGQG NLAYPGVRTH GTLESVNGPR AGSRGLTTTS 
LADTFEHVIE ELLDEDQKVR PNEENHKDAD LYTSRVMLSS QVPLEPPLLF LLEEYKNYLD 
AANMSMRVRR HSDPARRGEL SVCDSISEWV TAADKKTAVD MSGGTVTVLE KVPVSKGQLK 
QYFYETKCNP MGYTKEGCRG IDKRHWNSQC RTTQSYVRAL TMDSKKRIGW RFIRIDTSCV 
CTLTIKRGR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bdnf

Associated with

Other Information

Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. PubMed ID: 2369898

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterisation of neurotrophin dimers and monomers. PubMed ID: 7957235

Mice lacking brain-derived neurotrophic factor develop with sensory deficits. PubMed ID: 8139657

Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. PubMed ID: 15486301

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. PubMed ID: 17023662

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. PubMed ID: 23785138

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

SorCS2 is required for BDNF-dependent plasticity in the hippocampus. PubMed ID: 27457814

HuD-mediated distinct BDNF regulatory pathways promote regeneration after nerve injury. PubMed ID: 28111162

The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. PubMed ID: 29909994