Details for: CLPS

Gene ID: 1208

Symbol: CLPS

Ensembl ID: ENSG00000137392

Description: colipase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 8.45
    Marker Score: 5960
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.95
    Marker Score: 2227
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.98
    Marker Score: 3593
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.78
    Marker Score: 1439
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.57
    Marker Score: 5428
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 2.53
    Marker Score: 908
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.1
    Marker Score: 472
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1993
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.95
    Marker Score: 2178.5
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.73
    Marker Score: 1090
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.71
    Marker Score: 1779
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.54
    Marker Score: 2234
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.54
    Marker Score: 1327
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.23
    Marker Score: 479
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4807
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.14
    Marker Score: 247
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.07
    Marker Score: 442
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6980
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Marker Score: 456.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.89
    Marker Score: 1228
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 805
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1333
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.79
    Marker Score: 780
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 701
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.73
    Marker Score: 406
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.72
    Marker Score: 474
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1111
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.69
    Marker Score: 432
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.68
    Marker Score: 294
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.62
    Marker Score: 320
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 481
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.58
    Marker Score: 243
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 333.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 255
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.46
    Marker Score: 462.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 249
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 735
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 368
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.4
    Marker Score: 496
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.4
    Marker Score: 346
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.33
    Marker Score: 366
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.3
    Marker Score: 207
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 186
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.27
    Marker Score: 499
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 557
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.27
    Marker Score: 108
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.25
    Marker Score: 238
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.23
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.23
    Marker Score: 77
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.22
    Marker Score: 87
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.2
    Marker Score: 311
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 97
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.16
    Marker Score: 134
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.14
    Marker Score: 449
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.13
    Marker Score: 149
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.13
    Marker Score: 239
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 71
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.12
    Marker Score: 62
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.11
    Marker Score: 32
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.1
    Marker Score: 110
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.1
    Marker Score: 73
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1
    Marker Score: 175
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.1
    Marker Score: 40
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.09
    Marker Score: 193
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.09
    Marker Score: 35

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Other Information

**Key characteristics:** * CLPS is a serine protease that is expressed in the plasma membrane. * It is a glycoprotein with a molecular weight of approximately 140 kDa. * It is a key enzyme in the hydrolysis of phospholipids in the plasma membrane. * It is involved in a variety of cellular processes, including digestion, absorption, and metabolism. **Pathways and functions:** * CLPS is involved in the digestion of dietary lipids. * It is also involved in the hydrolysis of phospholipids in the plasma membrane, which is essential for the uptake of fatty acids from the lumen of the intestine. * It is involved in the metabolism of fat-soluble vitamins, including vitamins A and E. * It is also involved in the metabolism of vitamins and cofactors. **Clinical significance:** * Mutations in CLPS have been linked to several human diseases, including pancreatitis, which is inflammation of the pancreas. * CLPS is a potential therapeutic target for diseases that are characterized by abnormal lipid metabolism, such as pancreatitis. **Additional notes:** * CLPS is a highly conserved enzyme that is found in organisms from yeast to humans. * It is a key enzyme in the regulation of lipid metabolism. * It is a target for a variety of drugs, including bile acid resins.

Genular Protein ID: 187913816

Symbol: COL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P04118 Q5T9G7 Q5U809

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2337598

Title: Cloning and characterization of the human colipase cDNA.

PubMed ID: 2337598

DOI: 10.1021/bi00455a032

PubMed ID: 1643046

Title: The human colipase gene: isolation, chromosomal location, and tissue-specific expression.

PubMed ID: 1643046

DOI: 10.1021/bi00146a013

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6691986

Title: The primary sequence of human pancreatic colipase.

PubMed ID: 6691986

DOI: 10.1016/0167-4838(84)90175-4

PubMed ID: 17401110

Title: Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.

PubMed ID: 17401110

DOI: 10.1194/jlr.m600486-jlr200

PubMed ID: 26494624

Title: The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).

PubMed ID: 26494624

DOI: 10.1074/jbc.m115.683375

PubMed ID: 8479519

Title: Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography.

PubMed ID: 8479519

DOI: 10.1038/362814a0

PubMed ID: 16189801

Title: Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.

PubMed ID: 16189801

DOI: 10.1002/mnfr.200500087

Sequence Information:

  • Length: 112
  • Mass: 11954
  • Checksum: 772872EBBE7C4DF8
  • Sequence:
    • MEKILILLLV ALSVAYAAPG PRGIIINLEN GELCMNSAQC KSNCCQHSSA LGLARCTSMA 
SENSECSVKT LYGIYYKCPC ERGLTCEGDK TIVGSITNTN FGICHDAGRS KQ

Genular Protein ID: 2687511438

Symbol: A0A087WZW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZW1

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 98
  • Mass: 10567
  • Checksum: 2F917259DECF1357
  • Sequence:
    • MILLPQPPKK LGLQENGELC MNSAQCKSNC CQHSSALGLA RCTSMASENS ECSVKTLYGI 
YYKCPCERGL TCEGDKTIVG SITNTNFGIC HDAGRSKQ

Genular Protein ID: 3853189722

Symbol: A0A087X0Q7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X0Q7

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 71
  • Mass: 7659
  • Checksum: 6E0A64E851AE6A56
  • Sequence:
    • MEKILILLLV ALSVAYAAPG PRGIIINLTL YGIYYKCPCE RGLTCEGDKT IVGSITNTNF 
GICHDAGRSK Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.