Details for: CLPS

Gene ID: 1208

Symbol: CLPS

Ensembl ID: ENSG00000137392

Description: colipase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 220.4649
    Cell Significance Index: 110.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 18.8068
    Cell Significance Index: 3211.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 10.3838
    Cell Significance Index: 1185.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.7262
    Cell Significance Index: 228.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8629
    Cell Significance Index: 62.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6285
    Cell Significance Index: 52.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3699
    Cell Significance Index: 62.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3223
    Cell Significance Index: 251.6300
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.2237
    Cell Significance Index: 12.4400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.9263
    Cell Significance Index: 11.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6016
    Cell Significance Index: 59.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5482
    Cell Significance Index: 494.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4566
    Cell Significance Index: 9.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4149
    Cell Significance Index: 5.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3444
    Cell Significance Index: 56.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2598
    Cell Significance Index: 29.7700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.2071
    Cell Significance Index: 2.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2000
    Cell Significance Index: 148.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1968
    Cell Significance Index: 13.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1572
    Cell Significance Index: 17.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1106
    Cell Significance Index: 69.0600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.0993
    Cell Significance Index: 0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0812
    Cell Significance Index: 17.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0760
    Cell Significance Index: 1.9000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.0222
    Cell Significance Index: 0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0075
    Cell Significance Index: 4.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0085
    Cell Significance Index: -4.6500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0103
    Cell Significance Index: -0.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0141
    Cell Significance Index: -0.1400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0292
    Cell Significance Index: -0.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0299
    Cell Significance Index: -0.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0305
    Cell Significance Index: -6.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0311
    Cell Significance Index: -8.9600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0313
    Cell Significance Index: -0.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0321
    Cell Significance Index: -1.6700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0338
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0378
    Cell Significance Index: -0.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0402
    Cell Significance Index: -5.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0422
    Cell Significance Index: -8.4600
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0491
    Cell Significance Index: -0.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0500
    Cell Significance Index: -2.3500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0503
    Cell Significance Index: -0.5400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0532
    Cell Significance Index: -0.4700
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.0551
    Cell Significance Index: -0.4600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0635
    Cell Significance Index: -0.6700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0714
    Cell Significance Index: -0.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0791
    Cell Significance Index: -5.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0800
    Cell Significance Index: -4.8000
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0923
    Cell Significance Index: -0.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0927
    Cell Significance Index: -0.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0946
    Cell Significance Index: -2.5400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1026
    Cell Significance Index: -1.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1050
    Cell Significance Index: -1.7300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.1058
    Cell Significance Index: -0.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1064
    Cell Significance Index: -5.5400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1064
    Cell Significance Index: -1.5300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1195
    Cell Significance Index: -1.5100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.1223
    Cell Significance Index: -1.3100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1397
    Cell Significance Index: -1.9000
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.1466
    Cell Significance Index: -1.6400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1470
    Cell Significance Index: -1.6700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1554
    Cell Significance Index: -2.0400
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.1633
    Cell Significance Index: -1.6300
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1765
    Cell Significance Index: -1.8600
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: -0.1807
    Cell Significance Index: -1.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1825
    Cell Significance Index: -2.3500
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1831
    Cell Significance Index: -1.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1845
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1917
    Cell Significance Index: -5.4700
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.2011
    Cell Significance Index: -2.1300
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.2032
    Cell Significance Index: -1.9900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2098
    Cell Significance Index: -2.1900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2106
    Cell Significance Index: -6.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2126
    Cell Significance Index: -5.5900
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.2184
    Cell Significance Index: -2.0200
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.2190
    Cell Significance Index: -1.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2193
    Cell Significance Index: -8.0500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2235
    Cell Significance Index: -3.1000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2246
    Cell Significance Index: -1.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2301
    Cell Significance Index: -8.0600
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2311
    Cell Significance Index: -2.5600
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: -0.2337
    Cell Significance Index: -2.1700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2340
    Cell Significance Index: -2.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2355
    Cell Significance Index: -7.7100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2446
    Cell Significance Index: -6.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2510
    Cell Significance Index: -6.2600
  • Cell Name: memory T cell (CL0000813)
    Fold Change: -0.2522
    Cell Significance Index: -2.0900
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: -0.2538
    Cell Significance Index: -1.6900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2653
    Cell Significance Index: -4.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2659
    Cell Significance Index: -8.4700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2690
    Cell Significance Index: -2.1400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.2720
    Cell Significance Index: -2.8800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.2721
    Cell Significance Index: -3.3100
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.2729
    Cell Significance Index: -1.3000
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2775
    Cell Significance Index: -3.4900
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.2791
    Cell Significance Index: -3.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Colipase is a secreted enzyme that plays a pivotal role in the digestion of dietary lipids. It is a serine protease that is activated by calcium ions and works in concert with lipase enzymes to break down triglycerides into monoglycerides and free fatty acids. The CLPS gene encodes a 34-kDa protein with a molecular weight of 34 kDa, and its expression is predominantly found in the pancreas, where it is secreted into the pancreatic juice to facilitate lipid digestion. **Pathways and Functions:** The CLPS gene is involved in various biological pathways, including digestion, lipid catabolic process, lipid metabolic process, and metabolism of fat-soluble vitamins. Colipase plays a critical role in the following pathways: 1. **Digestion of dietary lipid:** Colipase works in tandem with lipase enzymes to break down triglycerides into monoglycerides and free fatty acids, enabling the absorption of dietary lipids. 2. **Lipid catabolic process:** Colipase facilitates the breakdown of triglycerides into glycerol and free fatty acids, which are then metabolized by other enzymes. 3. **Lipid metabolic process:** Colipase is involved in the regulation of lipid metabolism, influencing the production of energy and the synthesis of lipids. 4. **Metabolism of fat-soluble vitamins:** Colipase plays a role in the metabolism of fat-soluble vitamins, including vitamins A, D, E, and K. **Clinical Significance:** Dysregulation of colipase function has been implicated in various diseases, including: 1. **Pancreatitis:** Colipase deficiency has been linked to pancreatitis, a condition characterized by inflammation of the pancreas. 2. **Malabsorption:** Impaired colipase function can lead to malabsorption of dietary lipids, resulting in symptoms such as steatorrhea (excess fat in the stool). 3. **Celiac disease:** Colipase has been shown to play a role in the immune response to gluten, and its dysfunction may contribute to the development of celiac disease. 4. **Atherosclerosis:** Colipase has been implicated in the regulation of lipid metabolism, and its dysregulation may contribute to the development of atherosclerosis. In conclusion, colipase is a vital enzyme involved in lipid digestion and metabolism. Its dysregulation can have significant clinical implications, highlighting the importance of understanding the functions and pathways of this enzyme in the context of human disease.

Genular Protein ID: 187913816

Symbol: COL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P04118 Q5T9G7 Q5U809

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2337598

Title: Cloning and characterization of the human colipase cDNA.

PubMed ID: 2337598

DOI: 10.1021/bi00455a032

PubMed ID: 1643046

Title: The human colipase gene: isolation, chromosomal location, and tissue-specific expression.

PubMed ID: 1643046

DOI: 10.1021/bi00146a013

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6691986

Title: The primary sequence of human pancreatic colipase.

PubMed ID: 6691986

DOI: 10.1016/0167-4838(84)90175-4

PubMed ID: 17401110

Title: Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.

PubMed ID: 17401110

DOI: 10.1194/jlr.m600486-jlr200

PubMed ID: 26494624

Title: The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2).

PubMed ID: 26494624

DOI: 10.1074/jbc.m115.683375

PubMed ID: 8479519

Title: Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography.

PubMed ID: 8479519

DOI: 10.1038/362814a0

PubMed ID: 16189801

Title: Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.

PubMed ID: 16189801

DOI: 10.1002/mnfr.200500087

Sequence Information:

  • Length: 112
  • Mass: 11954
  • Checksum: 772872EBBE7C4DF8
  • Sequence:
    • MEKILILLLV ALSVAYAAPG PRGIIINLEN GELCMNSAQC KSNCCQHSSA LGLARCTSMA 
SENSECSVKT LYGIYYKCPC ERGLTCEGDK TIVGSITNTN FGICHDAGRS KQ

Genular Protein ID: 2687511438

Symbol: A0A087WZW1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZW1

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 98
  • Mass: 10567
  • Checksum: 2F917259DECF1357
  • Sequence:
    • MILLPQPPKK LGLQENGELC MNSAQCKSNC CQHSSALGLA RCTSMASENS ECSVKTLYGI 
YYKCPCERGL TCEGDKTIVG SITNTNFGIC HDAGRSKQ

Genular Protein ID: 3853189722

Symbol: A0A087X0Q7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X0Q7

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 71
  • Mass: 7659
  • Checksum: 6E0A64E851AE6A56
  • Sequence:
    • MEKILILLLV ALSVAYAAPG PRGIIINLTL YGIYYKCPCE RGLTCEGDKT IVGSITNTNF 
GICHDAGRSK Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.