Genular: Defining Cellular Identity and Function

Details for: Bglap

Gene ID: 12096

Symbol: Bglap

Ensembl ID: ENSMUSG00000074483

Description: bone gamma carboxyglutamate protein

Associated with

Biomineral tissue development
(GO:0031214)
Bone development
(GO:0060348)
Brain development
(GO:0007420)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cellular response to bmp stimulus
(GO:0071773)
Cellular response to insulin stimulus
(GO:0032869)
Cognition
(GO:0050890)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dephosphorylation
(GO:0016311)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glucose homeostasis
(GO:0042593)
Hormone activity
(GO:0005179)
Hydroxyapatite binding
(GO:0046848)
Learning or memory
(GO:0007611)
Metal ion binding
(GO:0046872)
Negative regulation of bone development
(GO:1903011)
Osteoblast differentiation
(GO:0001649)
Perikaryon
(GO:0043204)
Positive regulation of neurotransmitter secretion
(GO:0001956)
Regulation of bone mineralization
(GO:0030500)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of testosterone biosynthetic process
(GO:2000224)
Response to vitamin k
(GO:0032571)
Structural constituent of bone
(GO:0008147)
Type b pancreatic cell proliferation
(GO:0044342)
Vesicle
(GO:0031982)

Other Information

Proteins

Gamma-carboxyglutamic acid-containing protein

Genular Protein ID: 2876747154

Symbol: OSTCN_MOUSE

Name: Gamma-carboxyglutamic acid-containing protein

UniProtKB Accession Codes:

P86546 P04641

Database IDs:

Citations:

PubMed ID: 8288580

Title: The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

PubMed ID: 8288580

DOI: 10.1016/s0021-9258(17)42240-x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8684484

Title: Increased bone formation in osteocalcin-deficient mice.

PubMed ID: 8684484

DOI: 10.1038/382448a0

PubMed ID: 17693256

Title: Endocrine regulation of energy metabolism by the skeleton.

PubMed ID: 17693256

DOI: 10.1016/j.cell.2007.05.047

PubMed ID: 20655470

Title: Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.

PubMed ID: 20655470

DOI: 10.1016/j.cell.2010.06.003

PubMed ID: 20655471

Title: Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.

PubMed ID: 20655471

DOI: 10.1016/j.cell.2010.06.002

PubMed ID: 21333348

Title: Endocrine regulation of male fertility by the skeleton.

PubMed ID: 21333348

DOI: 10.1016/j.cell.2011.02.004

PubMed ID: 24074871

Title: Maternal and offspring pools of osteocalcin influence brain development and functions.

PubMed ID: 24074871

DOI: 10.1016/j.cell.2013.08.042

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 28851741

Title: Gpr158 mediates osteocalcin's regulation of cognition.

PubMed ID: 28851741

DOI: 10.1084/jem.20171320

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

Sequence Information:

Length: 95
Mass: 10549
Checksum: ADCE40516ECEF971
Sequence:

MRTIFLLTLL TLAALCLSDL TDAKPSGPES DKAFMSKQEG NKVVNRLRRY LGASVPSPDP 
LEPTREQCEL NPACDELSDQ YGLKTAYKRI YGITI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bglap

Associated with

Other Information

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. PubMed ID: 8288580

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Increased bone formation in osteocalcin-deficient mice. PubMed ID: 8684484

Endocrine regulation of energy metabolism by the skeleton. PubMed ID: 17693256

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. PubMed ID: 20655470

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. PubMed ID: 20655471

Endocrine regulation of male fertility by the skeleton. PubMed ID: 21333348

Maternal and offspring pools of osteocalcin influence brain development and functions. PubMed ID: 24074871

Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. PubMed ID: 24028588

Gpr158 mediates osteocalcin's regulation of cognition. PubMed ID: 28851741

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101