Bglap2 | ENSMUSG00000074486 | NCBI 12097

Details for: Bglap2

Gene ID: 12097

Symbol: Bglap2

Ensembl ID: ENSMUSG00000074486

Description: bone gamma-carboxyglutamate protein 2

Associated with

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
(R-MMU-159854)
Gamma-carboxylation of protein precursors
(R-MMU-159740)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-MMU-163841)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Removal of aminoterminal propeptides from gamma-carboxylated proteins
(R-MMU-159782)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
(R-MMU-159763)
Biomineral tissue development
(GO:0031214)
Bone development
(GO:0060348)
Brain development
(GO:0007420)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cellular lipid catabolic process
(GO:0044242)
Cellular response to insulin stimulus
(GO:0032869)
Cognition
(GO:0050890)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dephosphorylation
(GO:0016311)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glucose homeostasis
(GO:0042593)
Hormone activity
(GO:0005179)
Hydroxyapatite binding
(GO:0046848)
Learning or memory
(GO:0007611)
Metal ion binding
(GO:0046872)
Negative regulation of bone development
(GO:1903011)
Osteoblast differentiation
(GO:0001649)
Pancreas development
(GO:0031016)
Perikaryon
(GO:0043204)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of neurotransmitter secretion
(GO:0001956)
Regulation of bone mineralization
(GO:0030500)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of testosterone biosynthetic process
(GO:2000224)
Response to vitamin k
(GO:0032571)
Structural constituent of bone
(GO:0008147)
Type b pancreatic cell proliferation
(GO:0044342)
Vesicle
(GO:0031982)

Other Information

Proteins

Osteocalcin-2

Genular Protein ID: 2731421248

Symbol: OSTC2_MOUSE

Name: Osteocalcin-2

UniProtKB Accession Codes:

P86547 P04641

Database IDs:

Citations:

PubMed ID: 3019668

Title: Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.

PubMed ID: 3019668

DOI: 10.1002/j.1460-2075.1986.tb04440.x

PubMed ID: 8243336

Title: Multiple copies of the bone-specific osteocalcin gene in mouse and rat.

PubMed ID: 8243336

DOI: 10.1210/endo.133.6.8243336

PubMed ID: 8288580

Title: The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

PubMed ID: 8288580

DOI: 10.1016/s0021-9258(17)42240-x

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8684484

Title: Increased bone formation in osteocalcin-deficient mice.

PubMed ID: 8684484

DOI: 10.1038/382448a0

PubMed ID: 17693256

Title: Endocrine regulation of energy metabolism by the skeleton.

PubMed ID: 17693256

DOI: 10.1016/j.cell.2007.05.047

PubMed ID: 20655470

Title: Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.

PubMed ID: 20655470

DOI: 10.1016/j.cell.2010.06.003

PubMed ID: 20655471

Title: Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition.

PubMed ID: 20655471

DOI: 10.1016/j.cell.2010.06.002

PubMed ID: 21333348

Title: Endocrine regulation of male fertility by the skeleton.

PubMed ID: 21333348

DOI: 10.1016/j.cell.2011.02.004

PubMed ID: 24074871

Title: Maternal and offspring pools of osteocalcin influence brain development and functions.

PubMed ID: 24074871

DOI: 10.1016/j.cell.2013.08.042

PubMed ID: 28851741

Title: Gpr158 mediates osteocalcin's regulation of cognition.

PubMed ID: 28851741

DOI: 10.1084/jem.20171320

Sequence Information:

Length: 95
Mass: 10459
Checksum: D4AA611134805D9B
Sequence:

MRTLSLLTLL ALAALCLSDL TDAKPSGPES DKAFMSKQEG NKVVNRLRRY LGASVPSPDP 
LEPTREQCEL NPACDELSDQ YGLKTAYKRI YGITI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bglap2

Associated with

Other Information

Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. PubMed ID: 3019668

Multiple copies of the bone-specific osteocalcin gene in mouse and rat. PubMed ID: 8243336

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. PubMed ID: 8288580

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Increased bone formation in osteocalcin-deficient mice. PubMed ID: 8684484

Endocrine regulation of energy metabolism by the skeleton. PubMed ID: 17693256

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. PubMed ID: 20655470

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. PubMed ID: 20655471

Endocrine regulation of male fertility by the skeleton. PubMed ID: 21333348

Maternal and offspring pools of osteocalcin influence brain development and functions. PubMed ID: 24074871

Gpr158 mediates osteocalcin's regulation of cognition. PubMed ID: 28851741