Details for: CLTA

Gene ID: 1211

Symbol: CLTA

Ensembl ID: ENSG00000122705

Description: clathrin light chain A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.27
    Marker Score: 43148
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.13
    Marker Score: 106663
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.98
    Marker Score: 103353
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 18983
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.91
    Marker Score: 4776.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.83
    Marker Score: 10042
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.77
    Marker Score: 5789
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.76
    Marker Score: 24009.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.75
    Marker Score: 2938
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.75
    Marker Score: 5581
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.74
    Marker Score: 20406
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.74
    Marker Score: 3308
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.72
    Marker Score: 4511
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.68
    Marker Score: 2525
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.68
    Marker Score: 149613
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.67
    Marker Score: 2673.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.65
    Marker Score: 2769
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.65
    Marker Score: 20708
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.62
    Marker Score: 6389.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.59
    Marker Score: 22343
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.58
    Marker Score: 2952
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.57
    Marker Score: 4376.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.57
    Marker Score: 4083
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.55
    Marker Score: 4792
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.55
    Marker Score: 25648
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6905
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.51
    Marker Score: 64290
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.5
    Marker Score: 16295
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.47
    Marker Score: 1551
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1943
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.46
    Marker Score: 3540
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.46
    Marker Score: 2647
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.46
    Marker Score: 10607
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.46
    Marker Score: 2760
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.45
    Marker Score: 1163
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.45
    Marker Score: 6181
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.45
    Marker Score: 5584
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6553
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.44
    Marker Score: 4453
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.43
    Marker Score: 4731
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.43
    Marker Score: 7618
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.42
    Marker Score: 2157
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.42
    Marker Score: 1244
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.4
    Marker Score: 5454
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27037
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.4
    Marker Score: 8868
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.39
    Marker Score: 4243
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.39
    Marker Score: 2554
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.37
    Marker Score: 5579
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.37
    Marker Score: 2403
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.37
    Marker Score: 2765.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.37
    Marker Score: 15095
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.35
    Marker Score: 9629
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.35
    Marker Score: 1569
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.34
    Marker Score: 2488
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.33
    Marker Score: 2190
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.33
    Marker Score: 1328
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.32
    Marker Score: 2445
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.32
    Marker Score: 4627
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.31
    Marker Score: 2794
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.31
    Marker Score: 12149
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.31
    Marker Score: 11081
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.3
    Marker Score: 1526
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3
    Marker Score: 8849
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.29
    Marker Score: 2056
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.29
    Marker Score: 2421
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.28
    Marker Score: 8950
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.28
    Marker Score: 1550
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.27
    Marker Score: 2807
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.27
    Marker Score: 2660
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.27
    Marker Score: 542
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.26
    Marker Score: 804
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.26
    Marker Score: 2718
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.26
    Marker Score: 3478
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.25
    Marker Score: 5605
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.24
    Marker Score: 14340
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.23
    Marker Score: 3231
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.23
    Marker Score: 1228
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.22
    Marker Score: 2871
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.22
    Marker Score: 3273
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.22
    Marker Score: 5813
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.21
    Marker Score: 904
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.21
    Marker Score: 547
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.21
    Marker Score: 2082
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.21
    Marker Score: 707
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.2
    Marker Score: 2369
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.2
    Marker Score: 1303
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.19
    Marker Score: 5213
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.19
    Marker Score: 3713
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.18
    Marker Score: 4150.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.18
    Marker Score: 6461
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.18
    Marker Score: 2992
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.18
    Marker Score: 1817
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.17
    Marker Score: 2188
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.17
    Marker Score: 10665
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.16
    Marker Score: 5502
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.16
    Marker Score: 2067.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.15
    Marker Score: 1013.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.14
    Marker Score: 1248
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.14
    Marker Score: 12673.5

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Other Information

**Key characteristics:** - CLTA is a type IV transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including epithelial cells, fibroblasts, and immune cells. - CLTA is involved in the assembly and trafficking of membrane vesicles, and it is also involved in the regulation of cell adhesion. **Pathways and functions:** - CLTA is involved in the assembly of clathrin vesicles from precursors in the endoplasmic reticulum. - It is also involved in the sorting and trafficking of clathrin vesicles to their final destination. - CLTA is also involved in the regulation of cell adhesion by binding to cadherins, which are cell adhesion molecules. - It is involved in the formation of cell contacts with neighboring cells, which is essential for cell adhesion and signaling. **Clinical significance:** Mutations in CLTA have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. In one study, mutations in CLTA were found in 25% of patients with breast cancer. This suggests that CLTA is a potential target for cancer therapy. **Additional information:** - CLTA is a highly conserved protein, with a similar protein found in other mammals. - It is expressed in a variety of cell types, including epithelial cells, fibroblasts, and immune cells. - CLTA is a relatively new protein, with the first sequence being identified in 1994.

Genular Protein ID: 1207154028

Symbol: CLCA_HUMAN

Name: Clathrin light chain A

UniProtKB Accession Codes:

P09496 A8K4W3 B4DIN1 F5H6N3 Q2XPN5 Q53XZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 26 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 15 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3267234

Title: Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.

PubMed ID: 3267234

DOI: 10.1016/s0021-9258(18)37445-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15858577

Title: Clathrin is required for the function of the mitotic spindle.

PubMed ID: 15858577

DOI: 10.1038/nature03502

PubMed ID: 16595675

Title: Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.

PubMed ID: 16595675

DOI: 10.1074/jbc.m600265200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21297582

Title: A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

PubMed ID: 21297582

DOI: 10.1038/emboj.2011.15

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 248
  • Mass: 27077
  • Checksum: 8D8A3B49E6353D93
  • Sequence:
    • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER 
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV 
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS 
LKQAPLVH

Genular Protein ID: 3659377560

Symbol: C9J8P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J8P9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 196
  • Mass: 21102
  • Checksum: 5944F7C112985930
  • Sequence:
    • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
GPQPHGEPPG GPDANSRKQE AEWKEKAIKE LEEWYARQDE QLQKTKANNR VADEAFYKQP 
FADVIGYVTN INHPCYSLEQ AAEEAFVNDI DESSPGTEWE RVARLCDFNP KSSKQAKDVS 
RMRSVLISLK QAPLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.