Details for: CLTA

Gene ID: 1211

Symbol: CLTA

Ensembl ID: ENSG00000122705

Description: clathrin light chain A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.27
    Marker Score: 43,148
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.13
    Marker Score: 106,663
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.98
    Marker Score: 103,353
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 18,983
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.91
    Marker Score: 4,777
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.83
    Marker Score: 10,042
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.77
    Marker Score: 5,789
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.76
    Marker Score: 24,010
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.75
    Marker Score: 2,938
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.75
    Marker Score: 5,581
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.74
    Marker Score: 20,406
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.74
    Marker Score: 3,308
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.72
    Marker Score: 4,511
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.68
    Marker Score: 2,525
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.68
    Marker Score: 149,613
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.67
    Marker Score: 2,674
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.65
    Marker Score: 2,769
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.65
    Marker Score: 20,708
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.62
    Marker Score: 6,390
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.59
    Marker Score: 22,343
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.58
    Marker Score: 2,952
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.57
    Marker Score: 4,377
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.57
    Marker Score: 4,083
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.55
    Marker Score: 4,792
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.55
    Marker Score: 25,648
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6,905
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.51
    Marker Score: 64,290
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.5
    Marker Score: 16,295
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.47
    Marker Score: 1,551
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.47
    Marker Score: 1,943
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.46
    Marker Score: 3,540
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.46
    Marker Score: 2,647
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.46
    Marker Score: 10,607
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.46
    Marker Score: 2,760
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.45
    Marker Score: 1,163
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.45
    Marker Score: 6,181
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.45
    Marker Score: 5,584
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6,553
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.44
    Marker Score: 4,453
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.43
    Marker Score: 4,731
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.43
    Marker Score: 7,618
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.42
    Marker Score: 2,157
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.42
    Marker Score: 1,244
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.4
    Marker Score: 5,454
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4
    Marker Score: 27,037
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.4
    Marker Score: 8,868
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.39
    Marker Score: 4,243
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.39
    Marker Score: 2,554
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.37
    Marker Score: 5,579
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.37
    Marker Score: 2,403
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.37
    Marker Score: 2,766
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.37
    Marker Score: 15,095
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.35
    Marker Score: 9,629
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.35
    Marker Score: 1,569
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.34
    Marker Score: 2,488
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.33
    Marker Score: 2,190
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.33
    Marker Score: 1,328
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.32
    Marker Score: 2,445
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.32
    Marker Score: 4,627
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.31
    Marker Score: 2,794
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.31
    Marker Score: 12,149
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.31
    Marker Score: 11,081
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.3
    Marker Score: 1,526
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3
    Marker Score: 8,849
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.29
    Marker Score: 2,056
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.29
    Marker Score: 2,421
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.28
    Marker Score: 8,950
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.28
    Marker Score: 1,550
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.27
    Marker Score: 2,807
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.27
    Marker Score: 2,660
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.27
    Marker Score: 542
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.26
    Marker Score: 804
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.26
    Marker Score: 2,718
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.26
    Marker Score: 3,478
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.25
    Marker Score: 5,605
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.24
    Marker Score: 14,340
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.23
    Marker Score: 3,231
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.23
    Marker Score: 1,228
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.22
    Marker Score: 2,871
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.22
    Marker Score: 3,273
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.22
    Marker Score: 5,813
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.21
    Marker Score: 904
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.21
    Marker Score: 547
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.21
    Marker Score: 2,082
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.21
    Marker Score: 707
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.2
    Marker Score: 2,369
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.2
    Marker Score: 1,303
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.19
    Marker Score: 5,213
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.19
    Marker Score: 3,713
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.18
    Marker Score: 4,151
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.18
    Marker Score: 6,461
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.18
    Marker Score: 2,992
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.18
    Marker Score: 1,817
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.17
    Marker Score: 2,188
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.17
    Marker Score: 10,665
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.16
    Marker Score: 5,502
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.16
    Marker Score: 2,068
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.15
    Marker Score: 1,014
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.14
    Marker Score: 1,248
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.14
    Marker Score: 12,674

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: CLTA is expressed in a variety of cell types, including mesodermal cells, fibroblasts, epithelial cells, and skeletal muscle satellite stem cells. 2. **Function**: CLTA plays a critical role in the assembly and function of the clathrin coat, which is essential for clathrin-mediated endocytosis. 3. **Pathways**: CLTA is involved in various cellular pathways, including adaptive immune system, axon guidance, beta-catenin-independent Wnt signaling, cargo recognition for clathrin-mediated endocytosis, and cell cycle regulation. 4. **Cellular Localization**: CLTA is primarily localized to the cytosol and associated with the clathrin coat. **Pathways and Functions** 1. **Clathrin-Mediated Endocytosis**: CLTA is essential for the assembly and function of the clathrin coat, which facilitates the formation and scission of vesicles from the plasma membrane. 2. **Adaptive Immune System**: CLTA is involved in the regulation of immune responses, including antigen presentation and cytokine signaling. 3. **Axon Guidance**: CLTA plays a role in axon guidance and neuronal development, likely through its involvement in the regulation of cytoskeletal dynamics. 4. **Wnt Signaling**: CLTA is involved in beta-catenin-independent Wnt signaling, which regulates various cellular processes, including cell proliferation and differentiation. 5. **Cargo Recognition**: CLTA recognizes cargo molecules, such as proteins and lipids, for clathrin-mediated endocytosis, ensuring the efficient uptake of essential molecules. **Clinical Significance** 1. **Infectious Diseases**: CLTA is involved in the entry of influenza virions into host cells via endocytosis, highlighting its potential as a target for therapeutic interventions against influenza. 2. **Cancer**: CLTA expression has been linked to various types of cancer, including breast and lung cancer, suggesting its potential as a biomarker or therapeutic target. 3. **Neurological Disorders**: CLTA is involved in axon guidance and neuronal development, which may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders**: CLTA is involved in the regulation of lipid metabolism, which may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, the Clathrin Light Chain A gene plays a critical role in various cellular processes, including clathrin-mediated endocytosis, adaptive immune system, axon guidance, and Wnt signaling. Its dysregulation has been implicated in various diseases, including infectious diseases, cancer, neurological disorders, and metabolic disorders. Further research is needed to fully elucidate the functions and clinical significance of CLTA.

Genular Protein ID: 1207154028

Symbol: CLCA_HUMAN

Name: Clathrin light chain A

UniProtKB Accession Codes:

P09496 A8K4W3 B4DIN1 F5H6N3 Q2XPN5 Q53XZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 26 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 15 RefSeq 5 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3267234

Title: Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.

PubMed ID: 3267234

DOI: 10.1016/s0021-9258(18)37445-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15858577

Title: Clathrin is required for the function of the mitotic spindle.

PubMed ID: 15858577

DOI: 10.1038/nature03502

PubMed ID: 16595675

Title: Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.

PubMed ID: 16595675

DOI: 10.1074/jbc.m600265200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21297582

Title: A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

PubMed ID: 21297582

DOI: 10.1038/emboj.2011.15

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 248
  • Mass: 27077
  • Checksum: 8D8A3B49E6353D93
  • Sequence:
    • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER 
LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV 
TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS 
LKQAPLVH

Genular Protein ID: 3659377560

Symbol: C9J8P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9J8P9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 5 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 196
  • Mass: 21102
  • Checksum: 5944F7C112985930
  • Sequence:
    • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
GPQPHGEPPG GPDANSRKQE AEWKEKAIKE LEEWYARQDE QLQKTKANNR VADEAFYKQP 
FADVIGYVTN INHPCYSLEQ AAEEAFVNDI DESSPGTEWE RVARLCDFNP KSSKQAKDVS 
RMRSVLISLK QAPLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.