Details for: CLTA

Gene ID: 1211

Symbol: CLTA

Ensembl ID: ENSG00000122705

Description: clathrin light chain A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 616.3481
    Cell Significance Index: -95.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 344.4994
    Cell Significance Index: -87.3800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 275.6661
    Cell Significance Index: -113.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 237.4171
    Cell Significance Index: -112.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 230.9621
    Cell Significance Index: -93.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 204.4577
    Cell Significance Index: -105.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 167.3417
    Cell Significance Index: -112.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 98.7072
    Cell Significance Index: -94.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 87.6268
    Cell Significance Index: -108.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.7896
    Cell Significance Index: -85.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.0939
    Cell Significance Index: -110.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.8845
    Cell Significance Index: -73.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.4953
    Cell Significance Index: -38.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.9201
    Cell Significance Index: 205.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.6654
    Cell Significance Index: 37.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.9855
    Cell Significance Index: 275.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5606
    Cell Significance Index: 166.0100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3686
    Cell Significance Index: 158.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2443
    Cell Significance Index: 445.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1749
    Cell Significance Index: 1733.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1651
    Cell Significance Index: 66.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.0661
    Cell Significance Index: 377.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0172
    Cell Significance Index: 543.9100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9298
    Cell Significance Index: 78.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6752
    Cell Significance Index: 140.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.3784
    Cell Significance Index: 307.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3735
    Cell Significance Index: 62.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3267
    Cell Significance Index: 63.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.3045
    Cell Significance Index: 53.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1313
    Cell Significance Index: 23.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9501
    Cell Significance Index: 137.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9494
    Cell Significance Index: 861.8600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9298
    Cell Significance Index: 55.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8708
    Cell Significance Index: 220.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6575
    Cell Significance Index: 86.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6479
    Cell Significance Index: 15.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5260
    Cell Significance Index: 195.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4816
    Cell Significance Index: 18.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4276
    Cell Significance Index: 106.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3410
    Cell Significance Index: 266.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3257
    Cell Significance Index: 38.9400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2531
    Cell Significance Index: 23.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2438
    Cell Significance Index: 249.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1503
    Cell Significance Index: 74.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1069
    Cell Significance Index: 109.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9876
    Cell Significance Index: 11.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7297
    Cell Significance Index: 12.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7074
    Cell Significance Index: 10.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6384
    Cell Significance Index: 228.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6009
    Cell Significance Index: 102.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2741
    Cell Significance Index: 52.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1165
    Cell Significance Index: 1.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1095
    Cell Significance Index: 80.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0837
    Cell Significance Index: 63.3300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0583
    Cell Significance Index: 109.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0268
    Cell Significance Index: 18.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0109
    Cell Significance Index: -20.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0161
    Cell Significance Index: -24.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0342
    Cell Significance Index: -2.1500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0369
    Cell Significance Index: -23.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0391
    Cell Significance Index: -53.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0418
    Cell Significance Index: -30.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1035
    Cell Significance Index: -64.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1058
    Cell Significance Index: -48.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1380
    Cell Significance Index: -77.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1588
    Cell Significance Index: -9.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1739
    Cell Significance Index: -4.8600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1939
    Cell Significance Index: -31.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2385
    Cell Significance Index: -50.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3042
    Cell Significance Index: -87.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3637
    Cell Significance Index: -27.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4217
    Cell Significance Index: -48.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4299
    Cell Significance Index: -62.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5077
    Cell Significance Index: -8.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5425
    Cell Significance Index: -28.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5885
    Cell Significance Index: -68.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5940
    Cell Significance Index: -39.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5999
    Cell Significance Index: -47.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6293
    Cell Significance Index: -35.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6337
    Cell Significance Index: -38.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6927
    Cell Significance Index: -17.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6992
    Cell Significance Index: -9.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7278
    Cell Significance Index: -20.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7701
    Cell Significance Index: -27.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9135
    Cell Significance Index: -104.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9195
    Cell Significance Index: -29.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9236
    Cell Significance Index: -5.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.9385
    Cell Significance Index: -42.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9753
    Cell Significance Index: -101.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2574
    Cell Significance Index: -55.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2887
    Cell Significance Index: -27.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3268
    Cell Significance Index: -35.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.5560
    Cell Significance Index: -58.9200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.6665
    Cell Significance Index: -14.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.7084
    Cell Significance Index: -17.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.7364
    Cell Significance Index: -33.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8090
    Cell Significance Index: -110.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8547
    Cell Significance Index: -54.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.0039
    Cell Significance Index: -51.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: CLTA is expressed in a variety of cell types, including mesodermal cells, fibroblasts, epithelial cells, and skeletal muscle satellite stem cells. 2. **Function**: CLTA plays a critical role in the assembly and function of the clathrin coat, which is essential for clathrin-mediated endocytosis. 3. **Pathways**: CLTA is involved in various cellular pathways, including adaptive immune system, axon guidance, beta-catenin-independent Wnt signaling, cargo recognition for clathrin-mediated endocytosis, and cell cycle regulation. 4. **Cellular Localization**: CLTA is primarily localized to the cytosol and associated with the clathrin coat. **Pathways and Functions** 1. **Clathrin-Mediated Endocytosis**: CLTA is essential for the assembly and function of the clathrin coat, which facilitates the formation and scission of vesicles from the plasma membrane. 2. **Adaptive Immune System**: CLTA is involved in the regulation of immune responses, including antigen presentation and cytokine signaling. 3. **Axon Guidance**: CLTA plays a role in axon guidance and neuronal development, likely through its involvement in the regulation of cytoskeletal dynamics. 4. **Wnt Signaling**: CLTA is involved in beta-catenin-independent Wnt signaling, which regulates various cellular processes, including cell proliferation and differentiation. 5. **Cargo Recognition**: CLTA recognizes cargo molecules, such as proteins and lipids, for clathrin-mediated endocytosis, ensuring the efficient uptake of essential molecules. **Clinical Significance** 1. **Infectious Diseases**: CLTA is involved in the entry of influenza virions into host cells via endocytosis, highlighting its potential as a target for therapeutic interventions against influenza. 2. **Cancer**: CLTA expression has been linked to various types of cancer, including breast and lung cancer, suggesting its potential as a biomarker or therapeutic target. 3. **Neurological Disorders**: CLTA is involved in axon guidance and neuronal development, which may contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders**: CLTA is involved in the regulation of lipid metabolism, which may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, the Clathrin Light Chain A gene plays a critical role in various cellular processes, including clathrin-mediated endocytosis, adaptive immune system, axon guidance, and Wnt signaling. Its dysregulation has been implicated in various diseases, including infectious diseases, cancer, neurological disorders, and metabolic disorders. Further research is needed to fully elucidate the functions and clinical significance of CLTA.

Genular Protein ID: 1207154028

Symbol: CLCA_HUMAN

Name: Clathrin light chain A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3267234

Title: Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.

PubMed ID: 3267234

DOI: 10.1016/s0021-9258(18)37445-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15858577

Title: Clathrin is required for the function of the mitotic spindle.

PubMed ID: 15858577

DOI: 10.1038/nature03502

PubMed ID: 16595675

Title: Calcyon, a novel partner of clathrin light chain, stimulates clathrin-mediated endocytosis.

PubMed ID: 16595675

DOI: 10.1074/jbc.m600265200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21297582

Title: A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

PubMed ID: 21297582

DOI: 10.1038/emboj.2011.15

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 248
  • Mass: 27077
  • Checksum: 8D8A3B49E6353D93
  • Sequence:
  • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
    GPQPHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISQV DRLQSEPESI RKWREEQMER 
    LEALDANSRK QEAEWKEKAI KELEEWYARQ DEQLQKTKAN NRVADEAFYK QPFADVIGYV 
    TNINHPCYSL EQAAEEAFVN DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS 
    LKQAPLVH

Genular Protein ID: 3659377560

Symbol: C9J8P9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 196
  • Mass: 21102
  • Checksum: 5944F7C112985930
  • Sequence:
  • MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE AFAILDGGAP 
    GPQPHGEPPG GPDANSRKQE AEWKEKAIKE LEEWYARQDE QLQKTKANNR VADEAFYKQP 
    FADVIGYVTN INHPCYSLEQ AAEEAFVNDI DESSPGTEWE RVARLCDFNP KSSKQAKDVS 
    RMRSVLISLK QAPLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.