Details for: CLTB

Gene ID: 1212

Symbol: CLTB

Ensembl ID: ENSG00000175416

Description: clathrin light chain B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 361.6312
    Cell Significance Index: -56.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 239.4701
    Cell Significance Index: -60.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.6273
    Cell Significance Index: -61.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.0470
    Cell Significance Index: -52.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.4388
    Cell Significance Index: -59.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 91.7332
    Cell Significance Index: -61.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.0934
    Cell Significance Index: -52.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.7666
    Cell Significance Index: -61.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.0819
    Cell Significance Index: -63.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.1557
    Cell Significance Index: -46.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2486
    Cell Significance Index: -38.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.7760
    Cell Significance Index: -30.1500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 9.2434
    Cell Significance Index: 27.4900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 6.9382
    Cell Significance Index: 59.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.7022
    Cell Significance Index: 51.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.6193
    Cell Significance Index: 242.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1697
    Cell Significance Index: 959.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.0319
    Cell Significance Index: 95.5000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.9088
    Cell Significance Index: 142.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.9002
    Cell Significance Index: 54.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8218
    Cell Significance Index: 84.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7299
    Cell Significance Index: 237.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5122
    Cell Significance Index: 195.3600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.4815
    Cell Significance Index: 3.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3948
    Cell Significance Index: 137.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2018
    Cell Significance Index: 62.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1820
    Cell Significance Index: 237.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1277
    Cell Significance Index: 30.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8463
    Cell Significance Index: 23.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8039
    Cell Significance Index: 36.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7446
    Cell Significance Index: 91.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6394
    Cell Significance Index: 349.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6329
    Cell Significance Index: 114.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6292
    Cell Significance Index: 16.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5940
    Cell Significance Index: 8.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5782
    Cell Significance Index: 74.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5688
    Cell Significance Index: 29.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5590
    Cell Significance Index: 6.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5130
    Cell Significance Index: 33.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5057
    Cell Significance Index: 181.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4535
    Cell Significance Index: 32.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4460
    Cell Significance Index: 11.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4072
    Cell Significance Index: 7.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3198
    Cell Significance Index: 2.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3066
    Cell Significance Index: 212.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2994
    Cell Significance Index: 270.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1783
    Cell Significance Index: 33.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1190
    Cell Significance Index: 14.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0336
    Cell Significance Index: 25.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0150
    Cell Significance Index: 2.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0097
    Cell Significance Index: 17.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0059
    Cell Significance Index: -4.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0127
    Cell Significance Index: -23.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0226
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0278
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0290
    Cell Significance Index: -39.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0349
    Cell Significance Index: -0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0523
    Cell Significance Index: -33.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0593
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0692
    Cell Significance Index: -51.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0718
    Cell Significance Index: -2.1100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0731
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0754
    Cell Significance Index: -12.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0890
    Cell Significance Index: -40.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0976
    Cell Significance Index: -55.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1091
    Cell Significance Index: -68.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1293
    Cell Significance Index: -9.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1397
    Cell Significance Index: -2.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1562
    Cell Significance Index: -18.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1715
    Cell Significance Index: -2.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1797
    Cell Significance Index: -51.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2036
    Cell Significance Index: -13.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2161
    Cell Significance Index: -6.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2655
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2941
    Cell Significance Index: -33.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3181
    Cell Significance Index: -4.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3229
    Cell Significance Index: -68.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3266
    Cell Significance Index: -47.4800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3440
    Cell Significance Index: -3.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3531
    Cell Significance Index: -7.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3944
    Cell Significance Index: -7.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4470
    Cell Significance Index: -7.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4973
    Cell Significance Index: -30.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5402
    Cell Significance Index: -42.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5629
    Cell Significance Index: -19.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6022
    Cell Significance Index: -62.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7029
    Cell Significance Index: -16.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7412
    Cell Significance Index: -18.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8041
    Cell Significance Index: -49.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8262
    Cell Significance Index: -52.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8627
    Cell Significance Index: -21.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9283
    Cell Significance Index: -41.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9404
    Cell Significance Index: -52.7700
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.9444
    Cell Significance Index: -5.8500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0025
    Cell Significance Index: -25.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0026
    Cell Significance Index: -28.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0077
    Cell Significance Index: -29.6800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.0381
    Cell Significance Index: -6.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.0554
    Cell Significance Index: -8.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CLTB exhibits several key characteristics that underscore its importance in cellular biology. These include: 1. **Structural role in clathrin-mediated endocytosis**: CLTB forms a heterotetrameric complex with clathrin heavy chain A, B, and gamma chains to form a clathrin-coated vesicle, which is essential for the internalization of proteins and lipids. 2. **Regulation of cargo recognition**: CLTB interacts with various proteins to regulate cargo recognition, ensuring that the correct molecules are internalized and processed within the cell. 3. **Involvement in signaling pathways**: CLTB is implicated in several signaling pathways, including Wnt5a-dependent internalization of receptors, which modulate cellular responses to external stimuli. 4. **Expression in diverse cell types**: CLTB is expressed in stratified epithelial cells, epithelial cells, neural cells, and stem cells, highlighting its widespread importance in tissue development and maintenance. **Pathways and Functions:** The CLTB gene is involved in numerous cellular processes, including: 1. **Clathrin-dependent endocytosis**: CLTB facilitates the formation of clathrin-coated vesicles, which internalize proteins and lipids from the plasma membrane. 2. **Cargo recognition for clathrin-mediated endocytosis**: CLTB interacts with cargo receptors to regulate the recognition of specific molecules for internalization. 3. **Wnt signaling**: CLTB is involved in Wnt5a-dependent internalization of receptors, which modulate cellular responses to external stimuli. 4. **Axon guidance**: CLTB plays a role in axon guidance, a process critical for neural development and connectivity. 5. **Membrane trafficking**: CLTB is involved in the trafficking of vesicles and proteins within the cell, ensuring proper localization and function. **Clinical Significance:** Dysregulation of CLTB has been implicated in various diseases, including: 1. **Neurological disorders**: CLTB mutations have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer**: CLTB expression has been altered in various types of cancer, including colorectal and breast cancer. 3. **Neurodevelopmental disorders**: CLTB plays a critical role in neural development, and its dysregulation has been linked to neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, the CLTB gene plays a vital role in maintaining cellular homeostasis and regulating various cellular processes, including endocytosis, signaling, and membrane trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the molecular mechanisms underlying CLTB function.

Genular Protein ID: 3200289978

Symbol: CLCB_HUMAN

Name: Clathrin light chain B

UniProtKB Accession Codes:

P09497 Q53Y37 Q6FHW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3267234

Title: Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.

PubMed ID: 3267234

DOI: 10.1016/s0021-9258(18)37445-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11889126

Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.

PubMed ID: 11889126

DOI: 10.1074/jbc.m112310200

PubMed ID: 15533940

Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.

PubMed ID: 15533940

DOI: 10.1074/jbc.m408454200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 229
  • Mass: 25190
  • Checksum: 07DBA19D44648F6F
  • Sequence:
    • MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS HAAPAQPGPT 
SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP ESIRKWREEQ RKRLQELDAA 
SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN KINNRIADKA FYQQPDADII GYVASEEAFV 
KESKEETPGT EWEKVAQLCD FNPKSSKQCK DVSRLRSVLM SLKQTPLSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.