Details for: CLTB
Gene ID: 1212
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CLTB
Ensembl ID: ENSG00000175416
Description: clathrin light chain B
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 78.23rCSI 65.58%PRS 15.88
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CSI 65.15rCSI 69.22%PRS 23.47
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CSI 58.55rCSI 80.06%PRS 21.54
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CSI 42.74rCSI 68.91%PRS 21.17
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CSI 42.42rCSI 60.8%PRS 18.23
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CSI 42.41rCSI 52.46%PRS 11.65
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CSI 42.31rCSI 40.79%PRS 9.2
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CSI 36.78rCSI 78.3%PRS 21.37
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CSI 36.03rCSI 44.82%PRS 14.02
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CSI 35.32rCSI 41.49%PRS 15.59
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CSI 34.97rCSI 47.65%PRS 11.84
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CSI 32.14rCSI 57.32%PRS 22.45
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CSI 29.69rCSI 31.1%PRS 12.37
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CSI 29.56rCSI 30.97%PRS 14.19
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CSI 28.65rCSI 43.67%PRS 12.42
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CSI 28.33rCSI 29.56%PRS 13.59
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CSI 24.61rCSI 53.73%PRS 26.63
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CSI 24.16rCSI 21.44%PRS 13.28
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CSI 24.06rCSI 30.86%PRS 15.33
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CSI 23.39rCSI 34.77%PRS 16.18
-
CSI 23.3rCSI 36.01%PRS 12.43
-
CSI 22.58rCSI 23.6%PRS 13.95
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CSI 22.37rCSI 29.74%PRS 14.51
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CSI 21.9rCSI 21.54%PRS 14.44
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CSI 20.95rCSI 49.73%PRS 16.79
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CSI 20.86rCSI 31.91%PRS 21.55
-
CSI 18.96rCSI 45.06%PRS 19.93
-
CSI 18.44rCSI 53.37%PRS 15.06
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CSI 16.53rCSI 15.91%PRS 13.75
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CSI 16.42rCSI 47.3%PRS 25.67
-
CSI 15.71rCSI 55.11%PRS 23.95
-
CSI 15.07rCSI 23.02%PRS 13.28
-
CSI 13.92rCSI 13.15%PRS 13.86
-
CSI 13.28rCSI 15.4%PRS 19.6
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CSI 13.22rCSI 27.15%PRS 30.57
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CSI 13rCSI 19.98%PRS 18.84
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CSI 11.87rCSI 34.36%PRS 29.48
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CSI 11.78rCSI 16.97%PRS 21.32
-
CSI 11.69rCSI 15.98%PRS 15.09
-
CSI 11.65rCSI 61.19%PRS 23.49
-
CSI 11.49rCSI 31.58%PRS 21.85
-
CSI 11.06rCSI 37.89%PRS 11.73
-
CSI 11.01rCSI 24.37%PRS 12.35
-
CSI 10.94rCSI 31.7%PRS 10.33
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CSI 10.06rCSI 16.2%PRS 10.22
-
CSI 9.29rCSI 20.52%PRS 9.56
-
CSI 8.48rCSI 12.17%PRS 10.32
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CSI 8.45rCSI 16.44%PRS 13.55
-
CSI 8.42rCSI 27.11%PRS 14.08
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CSI 8.31rCSI 8.16%PRS 20.87
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CSI 8.23rCSI 47.91%PRS 19.92
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CSI 8.12rCSI 6.6%PRS 14.01
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CSI 7.58rCSI 8.13%PRS 12.22
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CSI 7.56rCSI 74.26%PRS 37.24
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CSI 7.55rCSI 5.59%PRS 11.75
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CSI 7.19rCSI 10.37%PRS 18.46
-
CSI 7.09rCSI 28.32%PRS 28.96
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CSI 7.06rCSI 19.04%PRS 17.1
-
CSI 7.05rCSI 6.08%PRS 21.37
-
CSI 6.72rCSI 31.53%PRS 35.22
-
CSI 6.48rCSI 12.26%PRS 28.67
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CSI 6.27rCSI 8.89%PRS 12.37
-
CSI 6.2rCSI 4.78%PRS 12.04
-
CSI 6.16rCSI 60.88%PRS 45.84
-
CSI 6.16rCSI 14.05%PRS 11.63
-
CSI 6.1rCSI 4.64%PRS 17.37
-
CSI 6.05rCSI 8.31%PRS 27.36
-
CSI 5.92rCSI 25.57%PRS 25.32
-
CSI 5.81rCSI 8.05%PRS 19.06
-
CSI 5.81rCSI 43.63%PRS 24.3
-
CSI 5.8rCSI 4.56%PRS 15.78
-
CSI 5.62rCSI 9.11%PRS 13.51
-
CSI 5.6rCSI 4.64%PRS 12.51
-
CSI 5.5rCSI 8.05%PRS 15.48
-
CSI 5.49rCSI 7.5%PRS 14.72
-
CSI 5.3rCSI 57.62%PRS 25.5
-
CSI 5.27rCSI 5.93%PRS 21.28
-
CSI 5.25rCSI 3.93%PRS 37.8
-
CSI 5.15rCSI 10.22%PRS 39.02
-
CSI 5.11rCSI 6.96%PRS 31.78
-
CSI 5.06rCSI 3.63%PRS 18.05
-
CSI 5.06rCSI 11.48%PRS 18.46
-
CSI 4.97rCSI 6.65%PRS 14.52
-
CSI 4.9rCSI 21.56%PRS 12.9
-
CSI 4.87rCSI 3.9%PRS 24.04
-
CSI 4.86rCSI 4.77%PRS 37.52
-
CSI 4.8rCSI 13.73%PRS 23.56
-
CSI 4.76rCSI 4.4%PRS 24.13
-
CSI 4.72rCSI 15.95%PRS 22.22
-
CSI 4.6rCSI 6.75%PRS 17.42
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CSI 4.56rCSI 3.41%PRS 21.5
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CSI 4.52rCSI 3.51%PRS 19.12
-
CSI 4.5rCSI 8.18%PRS 20.31
-
CSI 4.49rCSI 2.99%PRS 34.46
-
CSI 4.47rCSI 13.19%PRS 16.23
-
CSI 4.47rCSI 2.97%PRS 15.82
-
CSI 4.43rCSI 12.09%PRS 50.27
-
CSI 4.39rCSI 3.67%PRS 38
-
CSI 4.38rCSI 3.06%PRS 13.91
-
CSI 4.33rCSI 8.98%PRS 13.26
-
CSI -9.7rCSI -12.8%PRS 18.6%
-
CSI -4.1rCSI -6.0%PRS 15.3%
-
CSI -4.0rCSI -3.7%PRS 20.1%
-
CSI -3.5rCSI -10.0%PRS 19.3%
-
CSI -1.3rCSI -8.3%PRS 10.3%
-
CSI -0.4rCSI -1.0%PRS 14.7%
-
CSI 0.0rCSI 0.1%PRS 24.0%
-
CSI 0.1rCSI 1.0%PRS 38.5%
-
CSI 0.1rCSI 0.3%PRS 7.4%
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CSI 0.2rCSI 4.8%PRS 44.0%
-
CSI 0.2rCSI 0.4%PRS 15.4%
-
CSI 0.2rCSI 0.6%PRS 12.4%
-
CSI 0.3rCSI 4.0%PRS 33.1%
-
CSI 0.3rCSI 6.6%PRS 23.9%
-
CSI 0.3rCSI 4.3%PRS 9.4%
-
CSI 0.3rCSI 1.8%PRS 19.4%
-
CSI 0.3rCSI 1.2%PRS 11.2%
-
CSI 0.3rCSI 2.9%PRS 61.8%
-
CSI 0.3rCSI 0.6%PRS 7.8%
-
CSI 0.4rCSI 3.0%PRS 13.7%
-
CSI 0.4rCSI 2.2%PRS 24.8%
-
CSI 0.4rCSI 1.6%PRS 18.6%
-
CSI 0.4rCSI 9.0%PRS 11.2%
-
CSI 0.5rCSI 3.2%PRS 12.6%
-
CSI 0.5rCSI 2.6%PRS 8.2%
-
CSI 0.5rCSI 2.4%PRS 44.1%
-
CSI 0.5rCSI 2.8%PRS 29.5%
-
CSI 0.5rCSI 0.6%PRS 22.8%
-
CSI 0.5rCSI 9.9%PRS 10.2%
-
CSI 0.5rCSI 2.5%PRS 17.3%
-
CSI 0.6rCSI 1.6%PRS 22.9%
-
CSI 0.6rCSI 1.5%PRS 21.0%
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CSI 0.6rCSI 1.2%PRS 34.2%
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CSI 0.6rCSI 1.2%PRS 22.0%
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CSI 0.6rCSI 1.6%PRS 16.5%
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CSI 0.7rCSI 0.6%PRS 11.8%
-
CSI 0.7rCSI 2.4%PRS 21.7%
-
CSI 0.7rCSI 1.8%PRS 10.1%
-
CSI 0.7rCSI 1.1%PRS 15.5%
-
CSI 0.7rCSI 3.5%PRS 14.4%
-
CSI 0.7rCSI 9.7%PRS 57.9%
-
CSI 0.8rCSI 3.8%PRS 18.0%
-
CSI 0.8rCSI 2.8%PRS 7.2%
-
CSI 0.8rCSI 2.1%PRS 12.4%
-
CSI 0.8rCSI 2.5%PRS 8.3%
-
CSI 0.9rCSI 3.1%PRS 22.8%
-
CSI 0.9rCSI 2.1%PRS 19.9%
-
CSI 0.9rCSI 1.4%PRS 11.4%
-
CSI 0.9rCSI 1.3%PRS 18.5%
-
CSI 0.9rCSI 1.5%PRS 7.8%
-
CSI 0.9rCSI 3.7%PRS 30.9%
-
CSI 1.0rCSI 1.2%PRS 13.1%
-
CSI 1.0rCSI 3.8%PRS 7.9%
-
CSI 1.0rCSI 1.6%PRS 15.2%
-
CSI 1.0rCSI 8.0%PRS 28.5%
-
CSI 1.0rCSI 7.6%PRS 35.9%
-
CSI 1.1rCSI 5.7%PRS 23.9%
-
CSI 1.1rCSI 1.6%PRS 13.1%
-
CSI 1.1rCSI 1.9%PRS 11.1%
-
CSI 1.1rCSI 8.6%PRS 51.2%
-
CSI 1.1rCSI 0.9%PRS 16.4%
-
CSI 1.1rCSI 2.5%PRS 8.2%
-
CSI 1.1rCSI 1.3%PRS 23.0%
-
CSI 1.1rCSI 1.5%PRS 25.3%
-
CSI 1.1rCSI 1.4%PRS 7.6%
-
CSI 1.2rCSI 0.9%PRS 22.3%
-
CSI 1.2rCSI 0.9%PRS 13.1%
-
CSI 1.2rCSI 4.5%PRS 18.5%
-
CSI 1.2rCSI 6.4%PRS 32.7%
-
CSI 1.2rCSI 3.1%PRS 25.9%
-
CSI 1.2rCSI 2.2%PRS 26.2%
-
CSI 1.2rCSI 2.9%PRS 7.6%
-
CSI 1.2rCSI 3.6%PRS 32.6%
-
CSI 1.2rCSI 5.7%PRS 31.5%
-
CSI 1.3rCSI 1.6%PRS 7.3%
-
CSI 1.4rCSI 2.2%PRS 8.5%
-
CSI 1.4rCSI 3.5%PRS 13.5%
-
CSI 1.4rCSI 15.6%PRS 42.4%
-
CSI 1.4rCSI 3.3%PRS 13.9%
-
CSI 1.5rCSI 8.5%PRS 17.5%
-
CSI 1.5rCSI 2.6%PRS 17.6%
-
CSI 1.6rCSI 1.3%PRS 23.5%
-
CSI 1.7rCSI 2.1%PRS 20.3%
-
CSI 1.7rCSI 6.8%PRS 23.4%
-
CSI 1.7rCSI 7.2%PRS 33.8%
-
CSI 1.7rCSI 3.0%PRS 12.7%
-
CSI 1.8rCSI 2.9%PRS 10.3%
-
CSI 1.8rCSI 1.6%PRS 14.8%
-
CSI 1.8rCSI 2.5%PRS 13.7%
-
CSI 1.8rCSI 34.8%PRS 40.9%
-
CSI 1.8rCSI 4.3%PRS 27.8%
-
CSI 1.9rCSI 1.4%PRS 13.8%
-
CSI 1.9rCSI 5.2%PRS 20.5%
-
CSI 1.9rCSI 4.3%PRS 31.4%
-
CSI 1.9rCSI 5.8%PRS 8.9%
-
CSI 1.9rCSI 4.1%PRS 20.4%
-
CSI 1.9rCSI 11.6%PRS 42.4%
-
CSI 1.9rCSI 3.8%PRS 9.8%
-
CSI 1.9rCSI 2.3%PRS 16.7%
-
CSI 1.9rCSI 5.3%PRS 18.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 3200289978
Symbol: CLCB_HUMAN
Name: Clathrin light chain B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3267234
Title: Structure of human clathrin light chains. Conservation of light chain polymorphism in three mammalian species.
PubMed ID: 3267234
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11889126
Title: HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain.
PubMed ID: 11889126
PubMed ID: 15533940
Title: Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo.
PubMed ID: 15533940
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 229
- Mass: 25190
- Checksum: 07DBA19D44648F6F
- Sequence:
MADDFGFFSS SESGAPEAAE EDPAAAFLAQ QESEIAGIEN DEGFGAPAGS HAAPAQPGPT SGAGSEDMGT TVNGDVFQEA NGPADGYAAI AQADRLTQEP ESIRKWREEQ RKRLQELDAA SKVTEQEWRE KAKKDLEEWN QRQSEQVEKN KINNRIADKA FYQQPDADII GYVASEEAFV KESKEETPGT EWEKVAQLCD FNPKSSKQCK DVSRLRSVLM SLKQTPLSR