Details for: Bid

Gene ID: 12122

Symbol: Bid

Ensembl ID: ENSMUSG00000004446

Description: BH3 interacting domain death agonist

Associated with

  • Activation, myristolyation of bid and translocation to mitochondria
    (R-MMU-75108)
  • Activation, translocation and oligomerization of bax
    (R-MMU-114294)
  • Activation and oligomerization of bak protein
    (R-MMU-111452)
  • Activation of bad and translocation to mitochondria
    (R-MMU-111447)
  • Activation of bh3-only proteins
    (R-MMU-114452)
  • Apoptosis
    (R-MMU-109581)
  • Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
    (R-MMU-111453)
  • Intrinsic pathway for apoptosis
    (R-MMU-109606)
  • Programmed cell death
    (R-MMU-5357801)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic mitochondrial changes
    (GO:0008637)
  • Apoptotic process
    (GO:0006915)
  • Cytosol
    (GO:0005829)
  • Establishment of protein localization to membrane
    (GO:0090150)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Hepatocyte apoptotic process
    (GO:0097284)
  • Membrane
    (GO:0016020)
  • Mitochondrial atp synthesis coupled electron transport
    (GO:0042775)
  • Mitochondrial membrane
    (GO:0031966)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrial outer membrane permeabilization
    (GO:0097345)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
    (GO:1902230)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of autophagy in response to er overload
    (GO:0034263)
  • Positive regulation of extrinsic apoptotic signaling pathway
    (GO:2001238)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial membrane potential
    (GO:0010918)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein targeting to mitochondrion
    (GO:0006626)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of epithelial cell proliferation
    (GO:0050678)
  • Regulation of g1/s transition of mitotic cell cycle
    (GO:2000045)
  • Regulation of mitochondrial membrane permeability involved in apoptotic process
    (GO:1902108)
  • Regulation of t cell proliferation
    (GO:0042129)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signal transduction in response to dna damage
    (GO:0042770)
  • Supramolecular fiber organization
    (GO:0097435)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 1170859447

Symbol: BID_MOUSE

Name: BH3-interacting domain death agonist

UniProtKB Accession Codes:

P70444 Q99M39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisProt 1 ELM 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIRSF 1 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 4 SAM 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8918887

Title: BID: a novel BH3 domain-only death agonist.

PubMed ID: 8918887

DOI: 10.1101/gad.10.22.2859

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9873064

Title: Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death.

PubMed ID: 9873064

DOI: 10.1074/jbc.274.2.1156

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20392206

Title: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid.

PubMed ID: 20392206

DOI: 10.1111/j.1742-4658.2010.07562.x

PubMed ID: 10089878

Title: Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.

PubMed ID: 10089878

DOI: 10.1016/s0092-8674(00)80573-5

PubMed ID: 15899861

Title: Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.

PubMed ID: 15899861

DOI: 10.1128/mcb.25.11.4579-4590.2005

Sequence Information:

  • Length: 195
  • Mass: 21952
  • Checksum: 52F412714FB867F3
  • Sequence:
    • MDSEVSNGSG LGAEHITDLL VFGFLQSSGC TRQELEVLGR ELPVQAYWEA DLEDELQTDG 
SQASRSFNQG RIEPDSESQE EIIHNIARHL AQIGDEMDHN IQPTLVRQLA AQFMNGSLSE 
EDKRNCLAKA LDEVKTAFPR DMENDKAMLI MTMLLAKKVA SHAPSLLRDV FHTTVNFINQ 
NLFSYVRNLV RNEMD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.