Genular: Defining Cellular Identity and Function

Details for: Bcl2l11

Gene ID: 12125

Symbol: Bcl2l11

Ensembl ID: ENSMUSG00000027381

Description: BCL2 like 11

Associated with

Activation of bh3-only proteins
(R-MMU-114452)
Activation of bim and translocation to mitochondria
(R-MMU-111446)
Apoptosis
(R-MMU-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-MMU-111453)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Nrage signals death through jnk
(R-MMU-193648)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Programmed cell death
(R-MMU-5357801)
Signal transduction
(R-MMU-162582)
Activation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0006919)
Apoptotic process
(GO:0006915)
Apoptotic process involved in embryonic digit morphogenesis
(GO:1902263)
B cell homeostasis
(GO:0001782)
Bcl-2 family protein complex
(GO:0097136)
Bim-bcl-2 complex
(GO:0097141)
Bim-bcl-xl complex
(GO:0097140)
Cell-matrix adhesion
(GO:0007160)
Cell cycle
(GO:0007049)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Developmental pigmentation
(GO:0048066)
Ear development
(GO:0043583)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Induction by virus of host apoptotic process
(GO:0019051)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Leukocyte homeostasis
(GO:0001776)
Lymphocyte apoptotic process
(GO:0070227)
Lymphocyte homeostasis
(GO:0002260)
Male gonad development
(GO:0008584)
Mammary gland development
(GO:0030879)
Meiosis i
(GO:0007127)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Mitochondrion
(GO:0005739)
Molecular adaptor activity
(GO:0060090)
Myeloid cell homeostasis
(GO:0002262)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of autophagy in response to er overload
(GO:0034263)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of fibroblast apoptotic process
(GO:2000271)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of lymphocyte apoptotic process
(GO:0070230)
Positive regulation of mitochondrial membrane permeability involved in apoptotic process
(GO:1902110)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of release of cytochrome c from mitochondria
(GO:0090200)
Positive regulation of t cell apoptotic process
(GO:0070234)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of developmental pigmentation
(GO:0048070)
Regulation of organ growth
(GO:0046620)
Response to endoplasmic reticulum stress
(GO:0034976)
Spermatogenesis
(GO:0007283)
Spleen development
(GO:0048536)
T cell apoptotic process
(GO:0070231)
T cell homeostasis
(GO:0043029)
Thymocyte apoptotic process
(GO:0070242)
Thymus development
(GO:0048538)
Tube formation
(GO:0035148)

Other Information

Proteins

Genular Protein ID: 3203997682

Symbol: B2L11_MOUSE

Name: Bcl-2-like protein 11

UniProtKB Accession Codes:

O54918 A2ALQ6 O54919 O54920

Database IDs:

Citations:

PubMed ID: 9430630

Title: Bim: a novel member of the Bcl-2 family that promotes apoptosis.

PubMed ID: 9430630

DOI: 10.1093/emboj/17.2.384

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16543145

Title: Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1.

PubMed ID: 16543145

DOI: 10.1016/j.molcel.2006.02.009

PubMed ID: 16509771

Title: IAN family critically regulates survival and development of T lymphocytes.

PubMed ID: 16509771

DOI: 10.1371/journal.pbio.0040103

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21159964

Title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.

PubMed ID: 21159964

DOI: 10.1523/jneurosci.1598-10.2010

PubMed ID: 21478148

Title: Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection.

PubMed ID: 21478148

DOI: 10.1074/jbc.m110.197707

PubMed ID: 27013495

Title: The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis.

PubMed ID: 27013495

DOI: 10.15252/embr.201541392

PubMed ID: 14499110

Title: The structure of a Bcl-xL/Bim fragment complex: implications for Bim function.

PubMed ID: 14499110

DOI: 10.1016/s1074-7613(03)00234-6

Sequence Information:

Length: 196
Mass: 22067
Checksum: 531C176E5F1AC9AA
Sequence:

MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QGNPDGEGDR CPHGSPQGPL 
APPASPGPFA TRSPLFIFVR RSSLLSRSSS GYFSFDTDRS PAPMSCDKST QTPSPPCQAF 
NHYLSAMASI RQSQEEPEDL RPEIRIAQEL RRIGDEFNET YTRRVFANDY REAEDHPQMV 
ILQLLRFIFR LVWRRH

Genular Protein ID: 1422482461

Symbol: Q3TR86_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TR86

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 150
Mass: 15715
Checksum: 022FC4A25177A485
Sequence:

TSLPAGTGSP AGWSSAVLAI VAVTGFLQPL CELCSTWIHT TSAAPAATAS GPFPWPSSTQ 
CLTLILGLRN ARKKDQMAKQ PSDVSSECDR EGGQLQPAER PPQLRPGAPT SLQTEPQDRS 
PAPMSCDKST QTPSPPCQAF NHYLSAMGKP

Genular Protein ID: 558815347

Symbol: Q3U7X3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U7X3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 110
Mass: 12954
Checksum: 67AB421AC1E4D2CA
Sequence:

MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QASIRQSQEE PEDLRPEIRI 
AQELRRIGDE FNETYTRRVF ANDYREAEDH PQMVILQLLR FIFRLVWRRH

Genular Protein ID: 1431609223

Symbol: Q6PEB3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6PEB3

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 91
Mass: 9993
Checksum: 7B9ADE6F0667AAF8
Sequence:

MAKQPSDVSS ECDREGGQLQ PAERPPQLRP GAPTSLQTEP QDRSPAPMSC DKSTQTPSPP 
CQAFNHYLSA MDQLENLNQV AQNIHGDAWY N

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl2l11

Associated with

Other Information

Bim: a novel member of the Bcl-2 family that promotes apoptosis. PubMed ID: 9430630

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. PubMed ID: 16543145

IAN family critically regulates survival and development of T lymphocytes. PubMed ID: 16509771

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA. PubMed ID: 21159964

Identification of a novel Bcl-2-interacting mediator of cell death (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and its role in rapid ischemic tolerance-induced neuroprotection. PubMed ID: 21478148

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis. PubMed ID: 27013495

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function. PubMed ID: 14499110

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 9430630

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 16543145

PubMed ID: 16509771

PubMed ID: 21183079

PubMed ID: 21159964

PubMed ID: 21478148

PubMed ID: 27013495

PubMed ID: 14499110

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 15489334

PubMed ID: 19468303