Details for: CLTC

Gene ID: 1213

Symbol: CLTC

Ensembl ID: ENSG00000141367

Description: clathrin heavy chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 450.0299
    Cell Significance Index: -70.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 316.5468
    Cell Significance Index: -80.2900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 214.5661
    Cell Significance Index: -88.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 183.2786
    Cell Significance Index: -86.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 179.9353
    Cell Significance Index: -73.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 157.7028
    Cell Significance Index: -81.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 76.9527
    Cell Significance Index: -73.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.2659
    Cell Significance Index: -80.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.8747
    Cell Significance Index: -80.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.1242
    Cell Significance Index: -71.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.1211
    Cell Significance Index: -83.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.2446
    Cell Significance Index: -39.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.2058
    Cell Significance Index: 112.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2998
    Cell Significance Index: 461.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2156
    Cell Significance Index: 439.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8687
    Cell Significance Index: 1687.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8589
    Cell Significance Index: 96.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6806
    Cell Significance Index: 602.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6582
    Cell Significance Index: 298.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4841
    Cell Significance Index: 182.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3733
    Cell Significance Index: 105.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3100
    Cell Significance Index: 715.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1718
    Cell Significance Index: 810.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8574
    Cell Significance Index: 39.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8540
    Cell Significance Index: 138.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7808
    Cell Significance Index: 107.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7417
    Cell Significance Index: 21.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7161
    Cell Significance Index: 136.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7133
    Cell Significance Index: 84.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6678
    Cell Significance Index: 29.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6434
    Cell Significance Index: 43.2600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5918
    Cell Significance Index: 5.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5809
    Cell Significance Index: 26.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5292
    Cell Significance Index: 20.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5250
    Cell Significance Index: 32.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4812
    Cell Significance Index: 212.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4736
    Cell Significance Index: 51.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3240
    Cell Significance Index: 16.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3021
    Cell Significance Index: 14.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2745
    Cell Significance Index: 7.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2587
    Cell Significance Index: 6.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2236
    Cell Significance Index: 38.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1857
    Cell Significance Index: 5.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1696
    Cell Significance Index: 319.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1657
    Cell Significance Index: 4.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1526
    Cell Significance Index: 96.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1132
    Cell Significance Index: 6.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0998
    Cell Significance Index: 45.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0613
    Cell Significance Index: 3.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0358
    Cell Significance Index: 55.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0342
    Cell Significance Index: 63.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0264
    Cell Significance Index: 19.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0099
    Cell Significance Index: 0.1700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0061
    Cell Significance Index: 0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0008
    Cell Significance Index: 1.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0076
    Cell Significance Index: -5.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0207
    Cell Significance Index: -12.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0380
    Cell Significance Index: -28.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0515
    Cell Significance Index: -5.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0631
    Cell Significance Index: -8.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1117
    Cell Significance Index: -12.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1134
    Cell Significance Index: -63.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1267
    Cell Significance Index: -12.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1848
    Cell Significance Index: -38.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1986
    Cell Significance Index: -5.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2259
    Cell Significance Index: -11.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2300
    Cell Significance Index: -17.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2564
    Cell Significance Index: -9.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2610
    Cell Significance Index: -75.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2629
    Cell Significance Index: -6.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2801
    Cell Significance Index: -19.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2846
    Cell Significance Index: -41.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2888
    Cell Significance Index: -18.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2945
    Cell Significance Index: -38.0500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4109
    Cell Significance Index: -8.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4217
    Cell Significance Index: -49.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4460
    Cell Significance Index: -51.1000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5298
    Cell Significance Index: -10.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5395
    Cell Significance Index: -14.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5854
    Cell Significance Index: -10.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5921
    Cell Significance Index: -14.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6452
    Cell Significance Index: -67.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6986
    Cell Significance Index: -20.0300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6990
    Cell Significance Index: -11.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7410
    Cell Significance Index: -10.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7473
    Cell Significance Index: -59.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7969
    Cell Significance Index: -25.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9211
    Cell Significance Index: -15.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9493
    Cell Significance Index: -11.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.9765
    Cell Significance Index: -5.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9864
    Cell Significance Index: -21.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0330
    Cell Significance Index: -22.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1161
    Cell Significance Index: -23.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2367
    Cell Significance Index: -33.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2549
    Cell Significance Index: -76.9400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.2944
    Cell Significance Index: -15.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3603
    Cell Significance Index: -28.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3676
    Cell Significance Index: -29.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.4346
    Cell Significance Index: -21.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4389
    Cell Significance Index: -42.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics** 1. **Structural role**: The clathrin heavy chain is a key component of the clathrin-coated vesicle (CCV) machinery, which plays a crucial role in endocytosis and exocytosis. 2. **Assembly and disassembly**: The clathrin heavy chain contributes to the assembly and disassembly of the CCV, ensuring efficient and regulated endocytosis. 3. **Cellular localization**: The CLTC gene is significantly expressed in various cell types, including myeloid leukocytes, kidney cells, and epithelial cells. 4. **Regulatory function**: The clathrin heavy chain regulates the internalization of cargo into the cell, influencing cellular homeostasis and responding to external stimuli. **Pathways and functions** 1. **Adaptive immune system**: The clathrin-coated vesicle (CCV) machinery plays a crucial role in the internalization of pathogens and antigens, facilitating the adaptive immune response. 2. **Endocytosis and exocytosis**: The CCV machinery is involved in the endocytosis and exocytosis of various molecules, including proteins, lipids, and receptors. 3. ** cargo recognition**: The clathrin heavy chain recognizes and binds to specific cargo molecules, facilitating their internalization into the cell. 4. **Cell signaling**: The clathrin-coated vesicle (CCV) machinery is involved in cell signaling pathways, including those mediated by growth factor receptors and second messengers. **Clinical significance** 1. **Infectious diseases**: The clathrin-coated vesicle (CCV) machinery plays a crucial role in the internalization of pathogens, such as influenza viruses, into host cells. 2. **Cancer**: Altered expression and function of the clathrin heavy chain have been implicated in cancer development and progression. 3. **Neurological disorders**: The clathrin-coated vesicle (CCV) machinery is involved in the transport of neurotransmitters and other molecules in the nervous system, and alterations in its function have been linked to neurological disorders, such as Alzheimer's disease. 4. **Lipid metabolism**: The clathrin-coated vesicle (CCV) machinery is involved in the transport of lipids, including low-density lipoproteins, and alterations in its function have been linked to lipid metabolism disorders. In conclusion, the CLTC gene encodes for the clathrin heavy chain, a crucial component of the clathrin-coated vesicle (CCV) machinery, which plays a pivotal role in endocytosis and exocytosis of various molecules. The clathrin heavy chain regulates the internalization of cargo into the cell, influencing cellular homeostasis and responding to external stimuli. Its dysregulation has been implicated in various diseases, including infectious diseases, cancer, neurological disorders, and lipid metabolism disorders.

Genular Protein ID: 3451335350

Symbol: CLH1_HUMAN

Name: Clathrin heavy chain on chromosome 17

UniProtKB Accession Codes:

Q00610 D3DU00 Q6N0A0 Q86TF2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 19 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1765375

Title: Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter.

PubMed ID: 1765375

DOI: 10.1016/0888-7543(91)90115-u

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16314522

Title: Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor.

PubMed ID: 16314522

DOI: 10.1128/mcb.25.24.11005-11018.2005

PubMed ID: 15858577

Title: Clathrin is required for the function of the mitotic spindle.

PubMed ID: 15858577

DOI: 10.1038/nature03502

PubMed ID: 16968737

Title: Trimerisation is important for the function of clathrin at the mitotic spindle.

PubMed ID: 16968737

DOI: 10.1242/jcs.03192

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18529014

Title: FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.

PubMed ID: 18529014

DOI: 10.1021/bi8001506

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20639872

Title: Plasma membrane contributes to the formation of pre-autophagosomal structures.

PubMed ID: 20639872

DOI: 10.1038/ncb2078

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21297582

Title: A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

PubMed ID: 21297582

DOI: 10.1038/emboj.2011.15

PubMed ID: 21266579

Title: Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

PubMed ID: 21266579

DOI: 10.1074/jbc.m110.185793

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23918938

Title: Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.

PubMed ID: 23918938

DOI: 10.1083/jcb.201211127

PubMed ID: 23532825

Title: Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

PubMed ID: 23532825

DOI: 10.1242/jcs.124834

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25066864

Title: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.

PubMed ID: 25066864

DOI: 10.1016/j.mcn.2014.07.006

PubMed ID: 25596274

Title: TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation.

PubMed ID: 25596274

DOI: 10.1242/bio.201410843

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27022195

Title: Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.

PubMed ID: 27022195

DOI: 10.4049/jimmunol.1501734

PubMed ID: 21816279

Title: Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

PubMed ID: 21816279

DOI: 10.1016/j.cell.2011.06.025

PubMed ID: 26756164

Title: USP2-45 is a circadian clock output effector regulating calcium absorption at the post-translational level.

PubMed ID: 26756164

DOI: 10.1371/journal.pone.0145155

PubMed ID: 29735704

Title: LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson's disease.

PubMed ID: 29735704

DOI: 10.1073/pnas.1717590115

PubMed ID: 26822784

Title: CLTC as a clinically novel gene associated with multiple malformations and developmental delay.

PubMed ID: 26822784

DOI: 10.1002/ajmg.a.37506

PubMed ID: 29100083

Title: High rate of recurrent de novo mutations in developmental and epileptic encephalopathies.

PubMed ID: 29100083

DOI: 10.1016/j.ajhg.2017.09.008

Sequence Information:

  • Length: 1675
  • Mass: 191615
  • Checksum: 6C4F2D54950079E2
  • Sequence:
    • MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 
PIRRPISADS AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHTMTDDVTF WKWISLNTVA 
LVTDNAVYHW SMEGESQPVK MFDRHSSLAG CQIINYRTDA KQKWLLLTGI SAQQNRVVGA 
MQLYSVDRKV SQPIEGHAAS FAQFKMEGNA EESTLFCFAV RGQAGGKLHI IEVGTPPTGN 
QPFPKKAVDV FFPPEAQNDF PVAMQISEKH DVVFLITKYG YIHLYDLETG TCIYMNRISG 
ETIFVTAPHE ATAGIIGVNR KGQVLSVCVE EENIIPYITN VLQNPDLALR MAVRNNLAGA 
EELFARKFNA LFAQGNYSEA AKVAANAPKG ILRTPDTIRR FQSVPAQPGQ TSPLLQYFGI 
LLDQGQLNKY ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKSV DPTLALSVYL 
RANVPNKVIQ CFAETGQVQK IVLYAKKVGY TPDWIFLLRN VMRISPDQGQ QFAQMLVQDE 
EPLADITQIV DVFMEYNLIQ QCTAFLLDAL KNNRPSEGPL QTRLLEMNLM HAPQVADAIL 
GNQMFTHYDR AHIAQLCEKA GLLQRALEHF TDLYDIKRAV VHTHLLNPEW LVNYFGSLSV 
EDSLECLRAM LSANIRQNLQ ICVQVASKYH EQLSTQSLIE LFESFKSFEG LFYFLGSIVN 
FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYDPERVK NFLKEAKLTD QLPLIIVCDR 
FDFVHDLVLY LYRNNLQKYI EIYVQKVNPS RLPVVIGGLL DVDCSEDVIK NLILVVRGQF 
STDELVAEVE KRNRLKLLLP WLEARIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY 
DSRVVGKYCE KRDPHLACVA YERGQCDLEL INVCNENSLF KSLSRYLVRR KDPELWGSVL 
LESNPYRRPL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE 
HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELFEEAFA IFRKFDVNTS 
AVQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LAKAQLQKGM VKEAIDSYIK ADDPSSYMEV 
VQAANTSGNW EELVKYLQMA RKKARESYVE TELIFALAKT NRLAELEEFI NGPNNAHIQQ 
VGDRCYDEKM YDAAKLLYNN VSNFGRLAST LVHLGEYQAA VDGARKANST RTWKEVCFAC 
VDGKEFRLAQ MCGLHIVVHA DELEELINYY QDRGYFEELI TMLEAALGLE RAHMGMFTEL 
AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN 
HPTDAWKEGQ FKDIITKVAN VELYYRAIQF YLEFKPLLLN DLLMVLSPRL DHTRAVNYFS 
KVKQLPLVKP YLRSVQNHNN KSVNESLNNL FITEEDYQAL RTSIDAYDNF DNISLAQRLE 
KHELIEFRRI AAYLFKGNNR WKQSVELCKK DSLYKDAMQY ASESKDTELA EELLQWFLQE 
EKRECFGACL FTCYDLLRPD VVLETAWRHN IMDFAMPYFI QVMKEYLTKV DKLDASESLR 
KEEEQATETQ PIVYGQPQLM LTAGPSVAVP PQAPFGYGYT APPYGQPQPG FGYSM

Genular Protein ID: 2424466130

Symbol: A0A087WVQ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVQ6 J3KSQ2

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 10 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 7 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SUPFAM 2 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1679
  • Mass: 192058
  • Checksum: 9E4E36D1E25FB0DA
  • Sequence:
    • MAQILPIRFQ EHLQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMNDPSN 
PIRRPISADS AIMNPASKVI ALKGIKESGK TLQIFNIEMK SKMKAHTMTD DVTFWKWISL 
NTVALVTDNA VYHWSMEGES QPVKMFDRHS SLAGCQIINY RTDAKQKWLL LTGISAQQNR 
VVGAMQLYSV DRKVSQPIEG HAASFAQFKM EGNAEESTLF CFAVRGQAGG KLHIIEVGTP 
PTGNQPFPKK AVDVFFPPEA QNDFPVAMQI SEKHDVVFLI TKYGYIHLYD LETGTCIYMN 
RISGETIFVT APHEATAGII GVNRKGQVLS VCVEEENIIP YITNVLQNPD LALRMAVRNN 
LAGAEELFAR KFNALFAQGN YSEAAKVAAN APKGILRTPD TIRRFQSVPA QPGQTSPLLQ 
YFGILLDQGQ LNKYESLELC RPVLQQGRKQ LLEKWLKEDK LECSEELGDL VKSVDPTLAL 
SVYLRANVPN KVIQCFAETG QVQKIVLYAK KVGYTPDWIF LLRNVMRISP DQGQQFAQML 
VQDEEPLADI TQIVDVFMEY NLIQQCTAFL LDALKNNRPS EGPLQTRLLE MNLMHAPQVA 
DAILGNQMFT HYDRAHIAQL CEKAGLLQRA LEHFTDLYDI KRAVVHTHLL NPEWLVNYFG 
SLSVEDSLEC LRAMLSANIR QNLQICVQVA SKYHEQLSTQ SLIELFESFK SFEGLFYFLG 
SIVNFSQDPD VHFKYIQAAC KTGQIKEVER ICRESNCYDP ERVKNFLKEA KLTDQLPLII 
VCDRFDFVHD LVLYLYRNNL QKYIEIYVQK VNPSRLPVVI GGLLDVDCSE DVIKNLILVV 
RGQFSTDELV AEVEKRNRLK LLLPWLEARI HEGCEEPATH NALAKIYIDS NNNPERFLRE 
NPYYDSRVVG KYCEKRDPHL ACVAYERGQC DLELINVCNE NSLFKSLSRY LVRRKDPELW 
GSVLLESNPY RRPLIDQVVQ TALSETQDPE EVSVTVKAFM TADLPNELIE LLEKIVLDNS 
VFSEHRNLQN LLILTAIKAD RTRVMEYINR LDNYDAPDIA NIAISNELFE EAFAIFRKFD 
VNTSAVQVLI EHIGNLDRAY EFAERCNEPA VWSQLAKAQL QKGMVKEAID SYIKADDPSS 
YMEVVQAANT SGNWEELVKY LQMARKKARE SYVETELIFA LAKTNRLAEL EEFINGPNNA 
HIQQVGDRCY DEKMYDAAKL LYNNVSNFGR LASTLVHLGE YQAAVDGARK ANSTRTWKEV 
CFACVDGKEF RLAQMCGLHI VVHADELEEL INYYQDRGYF EELITMLEAA LGLERAHMGM 
FTELAILYSK FKPQKMREHL ELFWSRVNIP KVLRAAEQAH LWAELVFLYD KYEEYDNAII 
TMMNHPTDAW KEGQFKDIIT KVANVELYYR AIQFYLEFKP LLLNDLLMVL SPRLDHTRAV 
NYFSKVKQLP LVKPYLRSVQ NHNNKSVNES LNNLFITEED YQALRTSIDA YDNFDNISLA 
QRLEKHELIE FRRIAAYLFK GNNRWKQSVE LCKKDSLYKD AMQYASESKD TELAEELLQW 
FLQEEKRECF GACLFTCYDL LRPDVVLETA WRHNIMDFAM PYFIQVMKEY LTKVDKLDAS 
ESLRKEEEQA TETQPIVYGQ PQLMLTAGPS VAVPPQAPFG YGYTAPPYGQ PQPGFGYSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.