Details for: CMA1

Gene ID: 1215

Symbol: CMA1

Ensembl ID: ENSG00000092009

Description: chymase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.39
    Marker Score: 879
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7694
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 805
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.04
    Marker Score: 993
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251819
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.88
    Marker Score: 1423
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.8
    Marker Score: 469
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1511
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 509
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 183
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 531
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.64
    Marker Score: 1028
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.57
    Marker Score: 1168
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 152
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.57
    Marker Score: 390
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.5
    Marker Score: 449
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 483
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 266
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6801
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.41
    Marker Score: 370
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 379
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 172
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.26
    Marker Score: 443
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 141
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.08
    Marker Score: 84
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.08
    Marker Score: 163
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.07
    Marker Score: 429
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 46
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.05
    Marker Score: 13.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 14.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.04
    Marker Score: 124
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 23
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.04
    Marker Score: 13.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.03
    Marker Score: 15
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.03
    Marker Score: 51
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.03
    Marker Score: 13.5
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.03
    Marker Score: 14.5
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.03
    Marker Score: 38
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.03
    Marker Score: 24
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.03
    Marker Score: 9.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.03
    Marker Score: 12.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.02
    Marker Score: 14.5
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 45
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.02
    Marker Score: 13.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.02
    Marker Score: 10.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.02
    Marker Score: 8.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.01
    Marker Score: 11.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.01
    Marker Score: 9.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.01
    Marker Score: 14.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.01
    Marker Score: 8.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.01
    Marker Score: 35
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 20
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.01
    Marker Score: 9
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 11.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 13.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.01
    Marker Score: 36
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.01
    Marker Score: 9

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Other Information

**Key characteristics** * The CMA1 gene is located on chromosome 1q21.1. * It is a member of the chymase family of serine proteases. * It is expressed in high levels in the gastrointestinal tract and is involved in the remodeling of the ECM during development. **Pathways and functions** * The CMA1 gene is involved in the activation of matrix metalloproteinases, which are enzymes that break down ECM proteins. * It is also involved in the maturation of angiotensinogen, a protein that is converted to angiotensin I, which is a potent vasoconstrictor. * It is involved in the degradation of the extracellular matrix (ECM), which is essential for the proper function of cells in the body. * It is involved in the regulation of angiogenesis (the growth of new blood vessels). **Clinical significance** * Mutations in the CMA1 gene have been linked to a number of human diseases, including Marfan syndrome, which is characterized by a defective ECM. * CMA1 inhibitors are being investigated as potential treatments for these diseases. **Additional notes** * The CMA1 gene is also involved in the regulation of inflammation. * It is a key regulator of cell migration and differentiation.

Genular Protein ID: 3819100519

Symbol: CMA1_HUMAN

Name: Chymase

UniProtKB Accession Codes:

P23946 B5BUM8 Q16018 Q3SY36 Q3SY37 Q9UDH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2071582

Title: Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.

PubMed ID: 2071582

DOI: 10.1016/s0021-9258(18)98788-0

PubMed ID: 1894611

Title: Cloning of the gene and cDNA for human heart chymase.

PubMed ID: 1894611

DOI: 10.1016/s0021-9258(19)47355-9

PubMed ID: 8144971

Title: Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.

PubMed ID: 8144971

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8495723

Title: Purification and molecular cloning of chymase from human tonsils.

PubMed ID: 8495723

DOI: 10.1016/0014-5793(93)81461-8

PubMed ID: 2049082

Title: Angiotensin II-forming heart chymase is a mast-cell-specific enzyme.

PubMed ID: 2049082

DOI: 10.1042/bj2760567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9400368

Title: Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A.

PubMed ID: 9400368

DOI: 10.1021/bi971403n

PubMed ID: 9931257

Title: The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.

PubMed ID: 9931257

DOI: 10.1006/jmbi.1998.2462

PubMed ID: 10208809

Title:

PubMed ID: 10208809

DOI: 10.1006/jmbi.1999.2691

Sequence Information:

  • Length: 247
  • Mass: 27325
  • Checksum: DC1464A049ED6B00
  • Sequence:
    • MLLLPLPLLL FLLCSRAEAG EIIGGTECKP HSRPYMAYLE IVTSNGPSKF CGGFLIRRNF 
VLTAAHCAGR SITVTLGAHN ITEEEDTWQK LEVIKQFRHP KYNTSTLHHD IMLLKLKEKA 
SLTLAVGTLP FPSQFNFVPP GRMCRVAGWG RTGVLKPGSD TLQEVKLRLM DPQACSHFRD 
FDHNLQLCVG NPRKTKSAFK GDSGGPLLCA GVAQGIVSYG RSDAKPPAVF TRISHYRPWI 
NQILQAN

Genular Protein ID: 2024982562

Symbol: Q4FEB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4FEB3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 16400609

Title: Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.

PubMed ID: 16400609

DOI: 10.1086/500151

Sequence Information:

  • Length: 148
  • Mass: 16416
  • Checksum: 607FDDB27803BB43
  • Sequence:
    • LLLFLLCSRA EAGEIIGGTE CKPHSRPYMA YLEIVTSNGP SKFCGGFLIR RNFVLTAAHC 
AGSRSITVTL GAHNITEEED TWQKLEVIKQ FRHPKYNTST LHHDIMLLKL KEKASLTLAV 
GTLPFPSQFN FVPPGRMCRV AGWGRTGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.