CMA1 | ENSG00000092009 | NCBI 1215

Details for: CMA1

Gene ID: 1215

Symbol: CMA1

Ensembl ID: ENSG00000092009

Description: chymase 1

Associated with

Activation of matrix metalloproteinases
(R-HSA-1592389)
Degradation of the extracellular matrix
(R-HSA-1474228)
Extracellular matrix organization
(R-HSA-1474244)
Metabolism of angiotensinogen to angiotensins
(R-HSA-2022377)
Metabolism of proteins
(R-HSA-392499)
Peptide hormone metabolism
(R-HSA-2980736)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signal transduction
(R-HSA-162582)
Angiotensin maturation
(GO:0002003)
Basement membrane disassembly
(GO:0034769)
Cellular response to glucose stimulus
(GO:0071333)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine precursor processing
(GO:0140447)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytosol
(GO:0005829)
Endopeptidase activity
(GO:0004175)
Extracellular matrix disassembly
(GO:0022617)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Intracellular membrane-bounded organelle
(GO:0043231)
Midbrain development
(GO:0030901)
Peptide binding
(GO:0042277)
Positive regulation of angiogenesis
(GO:0045766)
Protein catabolic process
(GO:0030163)
Regulation of inflammatory response
(GO:0050727)
Secretory granule
(GO:0030141)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)

Other Information

Proteins

Chymase
Q4FEB3_HUMAN

Genular Protein ID: 3819100519

Symbol: CMA1_HUMAN

Name: Chymase

UniProtKB Accession Codes:

P23946 B5BUM8 Q16018 Q3SY36 Q3SY37 Q9UDH5

Database IDs:

Citations:

PubMed ID: 2071582

Title: Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.

PubMed ID: 2071582

DOI: 10.1016/s0021-9258(18)98788-0

PubMed ID: 1894611

Title: Cloning of the gene and cDNA for human heart chymase.

PubMed ID: 1894611

DOI: 10.1016/s0021-9258(19)47355-9

PubMed ID: 8144971

Title: Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.

PubMed ID: 8144971

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8495723

Title: Purification and molecular cloning of chymase from human tonsils.

PubMed ID: 8495723

DOI: 10.1016/0014-5793(93)81461-8

PubMed ID: 2049082

Title: Angiotensin II-forming heart chymase is a mast-cell-specific enzyme.

PubMed ID: 2049082

DOI: 10.1042/bj2760567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9400368

Title: Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A.

PubMed ID: 9400368

DOI: 10.1021/bi971403n

PubMed ID: 9931257

Title: The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.

PubMed ID: 9931257

DOI: 10.1006/jmbi.1998.2462

PubMed ID: 10208809

Title:

PubMed ID: 10208809

DOI: 10.1006/jmbi.1999.2691

Sequence Information:

Length: 247
Mass: 27325
Checksum: DC1464A049ED6B00
Sequence:

MLLLPLPLLL FLLCSRAEAG EIIGGTECKP HSRPYMAYLE IVTSNGPSKF CGGFLIRRNF 
VLTAAHCAGR SITVTLGAHN ITEEEDTWQK LEVIKQFRHP KYNTSTLHHD IMLLKLKEKA 
SLTLAVGTLP FPSQFNFVPP GRMCRVAGWG RTGVLKPGSD TLQEVKLRLM DPQACSHFRD 
FDHNLQLCVG NPRKTKSAFK GDSGGPLLCA GVAQGIVSYG RSDAKPPAVF TRISHYRPWI 
NQILQAN

Genular Protein ID: 2024982562

Symbol: Q4FEB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4FEB3

Database IDs:

Citations:

PubMed ID: 16400609

Title: Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.

PubMed ID: 16400609

DOI: 10.1086/500151

Sequence Information:

Length: 148
Mass: 16416
Checksum: 607FDDB27803BB43
Sequence:

LLLFLLCSRA EAGEIIGGTE CKPHSRPYMA YLEIVTSNGP SKFCGGFLIR RNFVLTAAHC 
AGSRSITVTL GAHNITEEED TWQKLEVIKQ FRHPKYNTST LHHDIMLLKL KEKASLTLAV 
GTLPFPSQFN FVPPGRMCRV AGWGRTGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CMA1

Associated with

Other Information

Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase. PubMed ID: 2071582

Cloning of the gene and cDNA for human heart chymase. PubMed ID: 1894611

Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions. PubMed ID: 8144971

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification and molecular cloning of chymase from human tonsils. PubMed ID: 8495723

Angiotensin II-forming heart chymase is a mast-cell-specific enzyme. PubMed ID: 2049082

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A. PubMed ID: 9400368

The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity. PubMed ID: 9931257