Details for: CMA1

Gene ID: 1215

Symbol: CMA1

Ensembl ID: ENSG00000092009

Description: chymase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.7875
    Cell Significance Index: -5.2000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.5813
    Cell Significance Index: 6.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3238
    Cell Significance Index: 5.0100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1344
    Cell Significance Index: 1.5800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0017
    Cell Significance Index: 0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0014
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0084
    Cell Significance Index: -0.3900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0230
    Cell Significance Index: -0.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0234
    Cell Significance Index: -0.6300
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0263
    Cell Significance Index: -0.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0312
    Cell Significance Index: -4.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0328
    Cell Significance Index: -6.5000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0374
    Cell Significance Index: -0.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0377
    Cell Significance Index: -7.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0386
    Cell Significance Index: -0.9600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0401
    Cell Significance Index: -0.4600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0480
    Cell Significance Index: -0.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0557
    Cell Significance Index: -9.5100
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.0581
    Cell Significance Index: -0.4900
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: -0.0700
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0748
    Cell Significance Index: -8.5700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0839
    Cell Significance Index: -0.6400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0887
    Cell Significance Index: -1.0200
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.0893
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1026
    Cell Significance Index: -1.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1137
    Cell Significance Index: -6.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1262
    Cell Significance Index: -6.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1269
    Cell Significance Index: -6.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1353
    Cell Significance Index: -7.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1370
    Cell Significance Index: -0.9800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1581
    Cell Significance Index: -2.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1838
    Cell Significance Index: -2.6900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1902
    Cell Significance Index: -1.0000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2043
    Cell Significance Index: -1.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2111
    Cell Significance Index: -7.7500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.2116
    Cell Significance Index: -2.4400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2121
    Cell Significance Index: -7.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2269
    Cell Significance Index: -7.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2372
    Cell Significance Index: -5.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2383
    Cell Significance Index: -7.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2398
    Cell Significance Index: -7.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2470
    Cell Significance Index: -6.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2535
    Cell Significance Index: -6.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2736
    Cell Significance Index: -7.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2855
    Cell Significance Index: -7.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2935
    Cell Significance Index: -7.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2994
    Cell Significance Index: -14.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3119
    Cell Significance Index: -7.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3119
    Cell Significance Index: -6.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3157
    Cell Significance Index: -9.0500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3199
    Cell Significance Index: -3.5800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3474
    Cell Significance Index: -5.9000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3533
    Cell Significance Index: -5.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3548
    Cell Significance Index: -7.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3560
    Cell Significance Index: -7.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3586
    Cell Significance Index: -7.6100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3603
    Cell Significance Index: -8.7900
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3619
    Cell Significance Index: -3.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3696
    Cell Significance Index: -7.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3786
    Cell Significance Index: -8.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3828
    Cell Significance Index: -5.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3839
    Cell Significance Index: -7.5900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3841
    Cell Significance Index: -7.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4072
    Cell Significance Index: -3.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4077
    Cell Significance Index: -9.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4258
    Cell Significance Index: -5.5100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4396
    Cell Significance Index: -7.1200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.4415
    Cell Significance Index: -5.3300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.4432
    Cell Significance Index: -5.8900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4434
    Cell Significance Index: -7.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4468
    Cell Significance Index: -4.7900
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.4468
    Cell Significance Index: -5.2800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4550
    Cell Significance Index: -6.2400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4616
    Cell Significance Index: -6.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4619
    Cell Significance Index: -7.7300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4797
    Cell Significance Index: -5.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4928
    Cell Significance Index: -8.5200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4950
    Cell Significance Index: -6.6800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.4977
    Cell Significance Index: -6.5500
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.5016
    Cell Significance Index: -6.3000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.5064
    Cell Significance Index: -5.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5220
    Cell Significance Index: -7.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5222
    Cell Significance Index: -7.7100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5285
    Cell Significance Index: -7.5900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.5356
    Cell Significance Index: -6.2200
  • Cell Name: basophil (CL0000767)
    Fold Change: -0.5379
    Cell Significance Index: -4.9500
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.5399
    Cell Significance Index: -6.7500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5425
    Cell Significance Index: -6.6000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.5438
    Cell Significance Index: -4.4100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5442
    Cell Significance Index: -7.6100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.5442
    Cell Significance Index: -8.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.5529
    Cell Significance Index: -7.3700
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.5560
    Cell Significance Index: -6.5700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.5564
    Cell Significance Index: -7.5700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.5572
    Cell Significance Index: -7.0400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5578
    Cell Significance Index: -6.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5590
    Cell Significance Index: -6.6900
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.5603
    Cell Significance Index: -6.6600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5675
    Cell Significance Index: -7.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CMA1 is a serine-type endopeptidase that belongs to the chymase family, which also includes matripatide and prolyl endopeptidase. CMA1 is characterized by its ability to degrade various peptides, including angiotensinogen, growth factors, and cytokines. Its expression is regulated by multiple transcription factors, including NF-κB, AP-1, and STAT3. CMA1 is also known to interact with other enzymes, such as matrix metalloproteinases (MMPs), to modulate its activity. **Pathways and Functions:** CMA1 is involved in various signaling pathways, including: 1. **Angiotensin maturation:** CMA1 is responsible for the degradation of angiotensinogen to angiotensin I, which is then converted to angiotensin II by angiotensin-converting enzyme (ACE). 2. **Cellular response to glucose stimulus:** CMA1 is involved in the regulation of glucose metabolism in cells, particularly in the pancreas and liver. 3. **Inflammation:** CMA1 is a key player in the regulation of inflammatory responses, particularly in the context of immune cell activation and cytokine production. 4. **Angiogenesis:** CMA1 is involved in the regulation of angiogenesis, particularly through its interaction with MMPs and the degradation of extracellular matrix proteins. 5. **Extracellular matrix organization:** CMA1 is involved in the degradation of extracellular matrix proteins, which is crucial for cell migration, invasion, and tissue remodeling. **Clinical Significance:** CMA1 has been implicated in various immune-related disorders, including: 1. **Atherosclerosis:** CMA1 has been shown to play a role in the development of atherosclerosis, particularly through its involvement in the regulation of inflammatory responses and angiogenesis. 2. **Autoimmune diseases:** CMA1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, particularly through its involvement in the regulation of cytokine production and immune cell activation. 3. **Cancer:** CMA1 has been shown to play a role in cancer progression, particularly through its involvement in the regulation of angiogenesis and extracellular matrix organization. 4. **Diabetes:** CMA1 has been implicated in the regulation of glucose metabolism in diabetes, particularly through its involvement in the regulation of pancreatic islet cell function. In conclusion, CMA1 is a multifunctional enzyme that plays a crucial role in various biological processes, including immune regulation, angiogenesis, and inflammation. Its dysregulation has been implicated in various immune-related disorders, highlighting the importance of CMA1 in human health and disease. Further research is needed to fully elucidate the mechanisms by which CMA1 regulates these processes and to explore its therapeutic potential in the treatment of these disorders.

Genular Protein ID: 3819100519

Symbol: CMA1_HUMAN

Name: Chymase

UniProtKB Accession Codes:

P23946 B5BUM8 Q16018 Q3SY36 Q3SY37 Q9UDH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 2 EMBL 13 Ensembl 2 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 20 PDBsum 20 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2071582

Title: Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.

PubMed ID: 2071582

DOI: 10.1016/s0021-9258(18)98788-0

PubMed ID: 1894611

Title: Cloning of the gene and cDNA for human heart chymase.

PubMed ID: 1894611

DOI: 10.1016/s0021-9258(19)47355-9

PubMed ID: 8144971

Title: Determination of the primary structures of human skin chymase and cathepsin G from cutaneous mast cells of urticaria pigmentosa lesions.

PubMed ID: 8144971

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8495723

Title: Purification and molecular cloning of chymase from human tonsils.

PubMed ID: 8495723

DOI: 10.1016/0014-5793(93)81461-8

PubMed ID: 2049082

Title: Angiotensin II-forming heart chymase is a mast-cell-specific enzyme.

PubMed ID: 2049082

DOI: 10.1042/bj2760567

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9400368

Title: Crystal structure of phenylmethanesulfonyl fluoride-treated human chymase at 1.9 A.

PubMed ID: 9400368

DOI: 10.1021/bi971403n

PubMed ID: 9931257

Title: The 2.2-A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity.

PubMed ID: 9931257

DOI: 10.1006/jmbi.1998.2462

PubMed ID: 10208809

Title:

PubMed ID: 10208809

DOI: 10.1006/jmbi.1999.2691

Sequence Information:

  • Length: 247
  • Mass: 27325
  • Checksum: DC1464A049ED6B00
  • Sequence:
    • MLLLPLPLLL FLLCSRAEAG EIIGGTECKP HSRPYMAYLE IVTSNGPSKF CGGFLIRRNF 
VLTAAHCAGR SITVTLGAHN ITEEEDTWQK LEVIKQFRHP KYNTSTLHHD IMLLKLKEKA 
SLTLAVGTLP FPSQFNFVPP GRMCRVAGWG RTGVLKPGSD TLQEVKLRLM DPQACSHFRD 
FDHNLQLCVG NPRKTKSAFK GDSGGPLLCA GVAQGIVSYG RSDAKPPAVF TRISHYRPWI 
NQILQAN

Genular Protein ID: 2024982562

Symbol: Q4FEB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4FEB3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 16400609

Title: Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing.

PubMed ID: 16400609

DOI: 10.1086/500151

Sequence Information:

  • Length: 148
  • Mass: 16416
  • Checksum: 607FDDB27803BB43
  • Sequence:
    • LLLFLLCSRA EAGEIIGGTE CKPHSRPYMA YLEIVTSNGP SKFCGGFLIR RNFVLTAAHC 
AGSRSITVTL GAHNITEEED TWQKLEVIKQ FRHPKYNTST LHHDIMLLKL KEKASLTLAV 
GTLPFPSQFN FVPPGRMCRV AGWGRTGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.