Genular: Defining Cellular Identity and Function

Details for: Bmi1

Gene ID: 12151

Symbol: Bmi1

Ensembl ID: ENSMUSG00000026739

Description: Bmi1 polycomb ring finger oncogene

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 interacts with co-factors whose precise effect on runx1 targets is not known
(R-MMU-8939243)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of chromatin organization proteins
(R-MMU-4551638)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Sumoylation of rna binding proteins
(R-MMU-4570464)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Transcriptional regulation by e2f6
(R-MMU-8953750)
Transcriptional regulation by runx1
(R-MMU-8878171)
Apoptotic signaling pathway
(GO:0097190)
Brain development
(GO:0007420)
Chromatin binding
(GO:0003682)
Chromatin organization
(GO:0006325)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna methylation
(GO:0006306)
Embryonic skeletal system development
(GO:0048706)
Embryonic skeletal system morphogenesis
(GO:0048704)
Hematopoietic stem cell homeostasis
(GO:0061484)
Heterochromatin
(GO:0000792)
Humoral immune response
(GO:0006959)
In utero embryonic development
(GO:0001701)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nucleus
(GO:0005634)
Pcg protein complex
(GO:0031519)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Prc1 complex
(GO:0035102)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of adaxial/abaxial pattern formation
(GO:2000011)
Ring-like zinc finger domain binding
(GO:0071535)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rostrocaudal neural tube patterning
(GO:0021903)
Sequence-specific dna binding
(GO:0043565)
Skeletal system development
(GO:0001501)
Somatic stem cell division
(GO:0048103)
Ubiquitin-protein transferase activator activity
(GO:0097027)
Ubiquitin ligase complex
(GO:0000151)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Polycomb complex protein BMI-1

Genular Protein ID: 1300501913

Symbol: BMI1_MOUSE

Name: Polycomb complex protein BMI-1

UniProtKB Accession Codes:

P25916

Database IDs:

Citations:

PubMed ID: 1904009

Title: Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

PubMed ID: 1904009

DOI: 10.1016/0092-8674(91)90383-a

PubMed ID: 1904008

Title: Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging.

PubMed ID: 1904008

DOI: 10.1016/0092-8674(91)90382-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16359901

Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.

PubMed ID: 16359901

DOI: 10.1016/j.molcel.2005.12.002

PubMed ID: 16710298

Title: Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.

PubMed ID: 16710298

DOI: 10.1038/sj.emboj.7601144

PubMed ID: 20808772

Title: A novel zinc finger protein Zfp277 mediates transcriptional repression of the Ink4a/arf locus through polycomb repressive complex 1.

PubMed ID: 20808772

DOI: 10.1371/journal.pone.0012373

Sequence Information:

Length: 324
Mass: 36708
Checksum: AD7DECDB6B29DCE5
Sequence:

MHRTTRIKIT ELNPHLMCVL CGGYFIDATT IIECLHSFCK TCIVRYLETS KYCPICDVQV 
HKTRPLLNIR SDKTLQDIVY KLVPGLFKNE MKRRRDFYAA HPSADAANGS NEDRGEVADE 
EKRIITDDEI ISLSIEFFDQ SRLDRKVNKE KPKEEVNDKR YLRCPAAMTV MHLRKFLRSK 
MDIPNTFQID VMYEEEPLKD YYTLMDIAYI YTWRRNGPLP LKYRVRPTCK RMKMSHQRDG 
LTNAGELESD SGSDKANSPA GGVPSTSSCL PSPSTPVQSP HPQFPHISST MNGTSNSPSA 
NHQSSFASRP RKSSLNGSSA TSSG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmi1

Associated with

Other Information

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice. PubMed ID: 1904009

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. PubMed ID: 1904008

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. PubMed ID: 16359901

Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. PubMed ID: 16710298