Genular: Defining Cellular Identity and Function

Details for: Bmp10

Gene ID: 12154

Symbol: Bmp10

Ensembl ID: ENSMUSG00000030046

Description: bone morphogenetic protein 10

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Molecules associated with elastic fibres
(R-MMU-2129379)
Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Activin receptor signaling pathway
(GO:0032924)
Adult heart development
(GO:0007512)
Atrial cardiac muscle tissue morphogenesis
(GO:0055009)
Bmp signaling pathway
(GO:0030509)
Cardiac muscle cell proliferation
(GO:0060038)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart trabecula formation
(GO:0060347)
Hormone activity
(GO:0005179)
Kidney development
(GO:0001822)
Multicellular organism development
(GO:0007275)
Negative regulation of cardiac muscle hypertrophy
(GO:0010614)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of endothelial cell migration
(GO:0010596)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cartilage development
(GO:0061036)
Positive regulation of cell proliferation involved in heart morphogenesis
(GO:2000138)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of sarcomere organization
(GO:0060298)
Positive regulation of smad protein signal transduction
(GO:0060391)
Receptor serine/threonine kinase binding
(GO:0033612)
Regulation of cardiac muscle contraction
(GO:0055117)
Regulation of cardiac muscle hypertrophy in response to stress
(GO:1903242)
Sarcomere organization
(GO:0045214)
Telethonin binding
(GO:0031433)
Ventricular cardiac muscle cell development
(GO:0055015)
Ventricular cardiac muscle tissue morphogenesis
(GO:0055010)
Z disc
(GO:0030018)

Other Information

Proteins

Bone morphogenetic protein 10

Genular Protein ID: 955072546

Symbol: BMP10_MOUSE

Name: Bone morphogenetic protein 10

UniProtKB Accession Codes:

Q9R229 A6H6S5 Q9Z1V8

Database IDs:

Citations:

PubMed ID: 10072785

Title: Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily.

PubMed ID: 10072785

DOI: 10.1016/s0925-4773(98)00221-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15109497

Title: Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.

PubMed ID: 15109497

DOI: 10.1016/s0092-8674(04)00405-2

PubMed ID: 15073151

Title: BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.

PubMed ID: 15073151

DOI: 10.1242/dev.01094

PubMed ID: 16798733

Title: Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.

PubMed ID: 16798733

DOI: 10.1074/jbc.m604818200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21737454

Title: Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

PubMed ID: 21737454

DOI: 10.1074/jbc.m111.260133

Sequence Information:

Length: 421
Mass: 47888
Checksum: 770AF401A64C3F49
Sequence:

MGSLVLPLSA VFCLVAHSAS GSPIMGLEQS PLEEDMPFFD DIFTEQDGID FNTLLQSMKN 
EFLKTLNLSD IPVQDTGRVD PPEYMLELYN KFATDRTSMP SANIIRSFKN EDLFSQPVTF 
NGLRKYPLLF NVSIPHHEEV VMAELRLYTL VQRDRMMYDG VDRKITIFEV LESADGSEEE 
RSMLVLVSTE IYGTNSEWET FDVTDATRRW QKSGPSTHQL EIHIESRQNQ AEDTGRGQLE 
IDMSAQNKHD PLLVVFSDDQ SNDKEQKEEL NELITHEQDL DLDSDAFFSG PDEEALLQMR 
SNMIDDSSAR IRRNAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR GVCNYPLAEH 
LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD KGVVTYKFKY EGMAVSECGC 
R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmp10

Associated with

Other Information

Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. PubMed ID: 10072785

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nkx2-5 pathways and congenital heart disease: loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block. PubMed ID: 15109497

BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. PubMed ID: 15073151

Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. PubMed ID: 16798733

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. PubMed ID: 21737454