Genular: Defining Cellular Identity and Function

Details for: Bmp2

Gene ID: 12156

Symbol: Bmp2

Ensembl ID: ENSMUSG00000027358

Description: bone morphogenetic protein 2

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Molecules associated with elastic fibres
(R-MMU-2129379)
Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Animal organ morphogenesis
(GO:0009887)
Aortic valve development
(GO:0003176)
Atrioventricular valve morphogenesis
(GO:0003181)
Bmp receptor binding
(GO:0070700)
Bmp signaling pathway
(GO:0030509)
Bone mineralization
(GO:0030282)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac atrium formation
(GO:0003210)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiocyte differentiation
(GO:0035051)
Cell differentiation
(GO:0030154)
Chondrocyte differentiation
(GO:0002062)
Co-receptor binding
(GO:0039706)
Cytokine activity
(GO:0005125)
Embryo development
(GO:0009790)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion morphogenesis
(GO:0003203)
Endodermal-mesodermal cell signaling
(GO:0003133)
Epithelial to mesenchymal transition
(GO:0001837)
Gene expression
(GO:0010467)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart induction
(GO:0003129)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
In utero embryonic development
(GO:0001701)
Multicellular organism development
(GO:0007275)
Negative regulation of aldosterone biosynthetic process
(GO:0032348)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of steroid biosynthetic process
(GO:0010894)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Notch signaling pathway
(GO:0007219)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Osteoclast differentiation
(GO:0030316)
Phosphatase activator activity
(GO:0019211)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell differentiation
(GO:0030858)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of extracellular matrix constituent secretion
(GO:0003331)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of phosphatase activity
(GO:0010922)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein domain specific binding
(GO:0019904)
Protein serine/threonine kinase activator activity
(GO:0043539)
Proteoglycan metabolic process
(GO:0006029)
Receptor ligand activity
(GO:0048018)
Regulation of dna-templated transcription
(GO:0006355)
Response to bacterium
(GO:0009617)
Response to hypoxia
(GO:0001666)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Transcription by rna polymerase ii
(GO:0006366)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)

Other Information

Proteins

Bone morphogenetic protein 2

Genular Protein ID: 3397756958

Symbol: BMP2_MOUSE

Name: Bone morphogenetic protein 2

UniProtKB Accession Codes:

P21274 Q497W8

Database IDs:

Citations:

PubMed ID: 8018727

Title: Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes.

PubMed ID: 8018727

DOI: 10.1016/0167-4781(94)90017-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1970330

Title: Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

PubMed ID: 1970330

DOI: 10.1016/0888-7543(90)90480-i

PubMed ID: 14623234

Title: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.

PubMed ID: 14623234

DOI: 10.1016/j.ydbio.2003.08.011

PubMed ID: 15039429

Title: Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation.

PubMed ID: 15039429

DOI: 10.1074/jbc.m402376200

PubMed ID: 15671031

Title: DRAGON, a bone morphogenetic protein co-receptor.

PubMed ID: 15671031

DOI: 10.1074/jbc.m410034200

PubMed ID: 15975920

Title: Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.

PubMed ID: 15975920

DOI: 10.1074/jbc.m503511200

PubMed ID: 16604073

Title: Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

PubMed ID: 16604073

DOI: 10.1038/ng1777

PubMed ID: 17472960

Title: Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.

PubMed ID: 17472960

DOI: 10.1074/jbc.m701679200

PubMed ID: 17522060

Title: PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization.

PubMed ID: 17522060

DOI: 10.1074/jbc.m611181200

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 23963447

Title: Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo.

PubMed ID: 23963447

DOI: 10.1074/jbc.m113.497727

PubMed ID: 29198724

Title: Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions.

PubMed ID: 29198724

DOI: 10.1016/j.ajhg.2017.10.006

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

Sequence Information:

Length: 394
Mass: 44525
Checksum: D0C03B63B1D5C4E2
Sequence:

MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAAASSRP LSRPSEDVLS EFELRLLSMF 
GLKQRPTPSK DVVVPPYMLD LYRRHSGQPG APAPDHRLER AASRANTVRS FHHEEAVEEL 
PEMSGKTARR FFFNLSSVPS DEFLTSAELQ IFREQIQEAL GNSSFQHRIN IYEIIKPAAA 
NLKFPVTRLL DTRLVNQNTS QWESFDVTPA VMRWTTQGHT NHGFVVEVAH LEENPGVSKR 
HVRISRSLHQ DEHSWSQIRP LLVTFGHDGK GHPLHKREKR QAKHKQRKRL KSSCKRHPLY 
VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV 
PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmp2

Associated with

Other Information

Structure and sequence of mouse bone morphogenetic protein-2 gene (BMP-2): comparison of the structures and promoter regions of BMP-2 and BMP-4 genes. PubMed ID: 8018727

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. PubMed ID: 1970330

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. PubMed ID: 14623234

Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. PubMed ID: 15039429

DRAGON, a bone morphogenetic protein co-receptor. PubMed ID: 15671031

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. PubMed ID: 15975920

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. PubMed ID: 16604073

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. PubMed ID: 17472960

PLAP-1/asporin, a novel negative regulator of periodontal ligament mineralization. PubMed ID: 17522060

Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. PubMed ID: 24028588

Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. PubMed ID: 23963447

Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions. PubMed ID: 29198724

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. PubMed ID: 31800957