Genular: Defining Cellular Identity and Function

Details for: Bmp4

Gene ID: 12159

Symbol: Bmp4

Ensembl ID: ENSMUSG00000021835

Description: bone morphogenetic protein 4

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Metabolism of proteins
(R-MMU-392499)
Molecules associated with elastic fibres
(R-MMU-2129379)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Angiogenesis
(GO:0001525)
Anterior/posterior axis specification
(GO:0009948)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process involved in endocardial cushion morphogenesis
(GO:0003277)
Blood vessel development
(GO:0001568)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:0002043)
Bmp receptor binding
(GO:0070700)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cell population proliferation
(GO:0008283)
Chemoattractant activity
(GO:0042056)
Chondrocyte differentiation
(GO:0002062)
Co-receptor binding
(GO:0039706)
Cytokine activity
(GO:0005125)
Dorsal/ventral neural tube patterning
(GO:0021904)
Endocardial cushion development
(GO:0003197)
Endochondral ossification
(GO:0001958)
Endoderm development
(GO:0007492)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Eye development
(GO:0001654)
Gene expression
(GO:0010467)
Germ cell development
(GO:0007281)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heart induction
(GO:0003129)
Heart morphogenesis
(GO:0003007)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Kidney development
(GO:0001822)
Lymphoid progenitor cell differentiation
(GO:0002320)
Membranous septum morphogenesis
(GO:0003149)
Mesodermal cell fate determination
(GO:0007500)
Mesoderm formation
(GO:0001707)
Metanephros development
(GO:0001656)
Multicellular organism development
(GO:0007275)
Muscular septum morphogenesis
(GO:0003150)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Organ induction
(GO:0001759)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Ovarian follicle development
(GO:0001541)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of protein phosphorylation
(GO:0001934)
Post-embryonic development
(GO:0009791)
Programmed cell death
(GO:0012501)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of cell fate commitment
(GO:0010453)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of gene expression
(GO:0010468)
Renal system process
(GO:0003014)
Secondary heart field specification
(GO:0003139)
Skeletal system development
(GO:0001501)
Specification of animal organ position
(GO:0010159)
Telencephalon development
(GO:0021537)
Telencephalon regionalization
(GO:0021978)
Transcription by rna polymerase ii
(GO:0006366)
Type b pancreatic cell development
(GO:0003323)
Ureteric bud development
(GO:0001657)
Vasculature development
(GO:0001944)

Other Information

Proteins

BMP4_MOUSE

Genular Protein ID: 2084216552

Symbol: BMP4_MOUSE

Name: N/A

UniProtKB Accession Codes:

P21275

Database IDs:

Citations:

PubMed ID: 8507180

Title: Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region.

PubMed ID: 8507180

DOI: 10.1006/bbrc.1993.1523

PubMed ID: 8358941

Title: Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma.

PubMed ID: 8358941

PubMed ID: 7499338

Title: The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor.

PubMed ID: 7499338

DOI: 10.1074/jbc.270.47.28364

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1970330

Title: Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.

PubMed ID: 1970330

DOI: 10.1016/0888-7543(90)90480-i

PubMed ID: 8898217

Title: Msx1 controls inductive signaling in mammalian tooth morphogenesis.

PubMed ID: 8898217

DOI: 10.1242/dev.122.10.3035

PubMed ID: 10049358

Title: Bmp4 is required for the generation of primordial germ cells in the mouse embryo.

PubMed ID: 10049358

DOI: 10.1101/gad.13.4.424

PubMed ID: 11260715

Title: Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.

PubMed ID: 11260715

DOI: 10.1038/35068572

PubMed ID: 14623234

Title: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.

PubMed ID: 14623234

DOI: 10.1016/j.ydbio.2003.08.011

PubMed ID: 15206957

Title: Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling.

PubMed ID: 15206957

DOI: 10.1111/j.1440-169x.2004.00743.x

PubMed ID: 14973287

Title: HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins.

PubMed ID: 14973287

DOI: 10.1242/dev.00999

PubMed ID: 15039429

Title: Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation.

PubMed ID: 15039429

DOI: 10.1074/jbc.m402376200

PubMed ID: 15671031

Title: DRAGON, a bone morphogenetic protein co-receptor.

PubMed ID: 15671031

DOI: 10.1074/jbc.m410034200

PubMed ID: 15975920

Title: Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.

PubMed ID: 15975920

DOI: 10.1074/jbc.m503511200

PubMed ID: 16604073

Title: Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.

PubMed ID: 16604073

DOI: 10.1038/ng1777

PubMed ID: 17301089

Title: BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

PubMed ID: 17301089

DOI: 10.1242/dev.000182

PubMed ID: 17472960

Title: Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4.

PubMed ID: 17472960

DOI: 10.1074/jbc.m701679200

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 27713059

Title: Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists.

PubMed ID: 27713059

DOI: 10.1016/j.ydbio.2016.10.001

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

PubMed ID: 32127020

Title: Tsukushi is essential for the development of the inner ear.

PubMed ID: 32127020

DOI: 10.1186/s13041-020-00570-z

PubMed ID: 34995814

Title: The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells.

PubMed ID: 34995814

DOI: 10.1016/j.cdev.2021.203763

Sequence Information:

Length: 408
Mass: 46497
Checksum: 35053D844624EF9D
Sequence:

MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT 
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEEQS QGTGLEYPER PASRANTVRS 
FHHEEHLENI PGTSESSAFR FLFNLSSIPE NEVISSAELR LFREQVDQGP DWEQGFHRIN 
IYEVMKPPAE MVPGHLITRL LDTRLVHHNV TRWETFDVSP AVLRWTREKQ PNYGLAIEVT 
HLHQTRTHQG QHVRISRSLP QGSGDWAQLR PLLVTFGHDG RGHTLTRRRA KRSPKHHPQR 
SRKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL 
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmp4

Associated with

Other Information

Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region. PubMed ID: 8507180

Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma. PubMed ID: 8358941

The mouse bone morphogenetic protein-4 gene. Analysis of promoter utilization in fetal rat calvarial osteoblasts and regulation by COUP-TFI orphan receptor. PubMed ID: 7499338

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. PubMed ID: 1970330

Msx1 controls inductive signaling in mammalian tooth morphogenesis. PubMed ID: 8898217

Bmp4 is required for the generation of primordial germ cells in the mouse embryo. PubMed ID: 10049358

Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. PubMed ID: 11260715

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. PubMed ID: 14623234

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. PubMed ID: 15206957

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. PubMed ID: 14973287

Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. PubMed ID: 15039429

DRAGON, a bone morphogenetic protein co-receptor. PubMed ID: 15671031

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. PubMed ID: 15975920

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. PubMed ID: 16604073

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. PubMed ID: 17301089

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. PubMed ID: 17472960

Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. PubMed ID: 24028588

Bmp4-Msx1 signaling and Osr2 control tooth organogenesis through antagonistic regulation of secreted Wnt antagonists. PubMed ID: 27713059

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101

Tsukushi is essential for the development of the inner ear. PubMed ID: 32127020

The regulation of Msx1 by BMP4/pSmad1/5 signaling is mediated by importin7 in dental mesenchymal cells. PubMed ID: 34995814