Genular: Defining Cellular Identity and Function

Details for: Bmp7

Gene ID: 12162

Symbol: Bmp7

Ensembl ID: ENSMUSG00000008999

Description: bone morphogenetic protein 7

Associated with

Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Molecules associated with elastic fibres
(R-MMU-2129379)
Allantois development
(GO:1905069)
Ameloblast differentiation
(GO:0036305)
Anatomical structure formation involved in morphogenesis
(GO:0048646)
Animal organ morphogenesis
(GO:0009887)
Axon guidance
(GO:0007411)
Bmp receptor binding
(GO:0070700)
Bmp signaling pathway
(GO:0030509)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Camera-type eye morphogenesis
(GO:0048593)
Cardiac muscle tissue development
(GO:0048738)
Cardiac septum morphogenesis
(GO:0060411)
Cartilage development
(GO:0051216)
Cell development
(GO:0048468)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cellular response to bmp stimulus
(GO:0071773)
Chorio-allantoic fusion
(GO:0060710)
Collagen-containing extracellular matrix
(GO:0062023)
Cytokine activity
(GO:0005125)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic limb morphogenesis
(GO:0030326)
Embryonic pattern specification
(GO:0009880)
Embryonic skeletal joint morphogenesis
(GO:0060272)
Endocardial cushion formation
(GO:0003272)
Epithelial cell differentiation
(GO:0030855)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Eye development
(GO:0001654)
Growth factor activity
(GO:0008083)
Heart trabecula morphogenesis
(GO:0061384)
Heparin binding
(GO:0008201)
Hindbrain development
(GO:0030902)
Kidney development
(GO:0001822)
Mesenchymal cell apoptotic process involved in nephron morphogenesis
(GO:1901145)
Mesenchymal cell differentiation
(GO:0048762)
Mesenchyme development
(GO:0060485)
Mesoderm formation
(GO:0001707)
Metanephric mesenchymal cell proliferation involved in metanephros development
(GO:0072136)
Metanephric mesenchyme morphogenesis
(GO:0072133)
Monocyte aggregation
(GO:0070487)
Multicellular organism development
(GO:0007275)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of glomerular mesangial cell proliferation
(GO:0072125)
Negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
(GO:0072040)
Negative regulation of mitotic nuclear division
(GO:0045839)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of prostatic bud formation
(GO:0060686)
Nephrogenic mesenchyme morphogenesis
(GO:0072134)
Neural fold elevation formation
(GO:0021502)
Neuron projection morphogenesis
(GO:0048812)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Ossification
(GO:0001503)
Pattern specification process
(GO:0007389)
Pericardium morphogenesis
(GO:0003344)
Pharyngeal system development
(GO:0060037)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of brown fat cell differentiation
(GO:0090336)
Positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
(GO:1905312)
Positive regulation of dendrite development
(GO:1900006)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell differentiation
(GO:0030858)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of heterotypic cell-cell adhesion
(GO:0034116)
Positive regulation of hyaluranon cable assembly
(GO:1900106)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of branching involved in prostate gland morphogenesis
(GO:0060687)
Regulation of phosphorylation
(GO:0042325)
Salivary gland morphogenesis
(GO:0007435)
Tube morphogenesis
(GO:0035239)
Ureteric bud development
(GO:0001657)
Vesicle
(GO:0031982)

Other Information

Proteins

Bone morphogenetic protein 7

Genular Protein ID: 1491118572

Symbol: BMP7_MOUSE

Name: Bone morphogenetic protein 7

UniProtKB Accession Codes:

P23359 Q91XF7

Database IDs:

Citations:

PubMed ID: 1715687

Title: Murine osteogenic protein (OP-1): high levels of mRNA in kidney.

PubMed ID: 1715687

DOI: 10.1016/0006-291x(91)91342-a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9013703

Title: BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye.

PubMed ID: 9013703

DOI: 10.1006/excr.1996.3411

PubMed ID: 15843411

Title: Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm.

PubMed ID: 15843411

DOI: 10.1242/dev.01822

PubMed ID: 14623234

Title: Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.

PubMed ID: 14623234

DOI: 10.1016/j.ydbio.2003.08.011

PubMed ID: 22461901

Title: Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse.

PubMed ID: 22461901

DOI: 10.1371/journal.pone.0034088

PubMed ID: 30097509

Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

PubMed ID: 30097509

DOI: 10.1182/blood-2018-06-857995

Sequence Information:

Length: 430
Mass: 49199
Checksum: 464F36D5D2E54041
Sequence:

MHVRSLRAAA PHSFVALWAP LFLLRSALAD FSLDNEVHSS FIHRRLRSQE RREMQREILS 
ILGLPHRPRP HLQGKHNSAP MFMLDLYNAM AVEESGPDGQ GFSYPYKAVF STQGPPLASL 
QDSHFLTDAD MVMSFVNLVE HDKEFFHPRY HHREFRFDLS KIPEGEAVTA AEFRIYKDYI 
RERFDNETFQ ITVYQVLQEH SGRESDLFLL DSRTIWASEE GWLVFDITAT SNHWVVNPRH 
NLGLQLSVET LDGQSINPKL AGLIGRHGPQ NKQPFMVAFF KATEVHLRSI RSTGGKQRSQ 
NRSKTPKNQE ALRMASVAEN SSSDQRQACK KHELYVSFRD LGWQDWIIAP EGYAAYYCEG 
ECAFPLNSYM NATNHAIVQT LVHFINPDTV PKPCCAPTQL NAISVLYFDD SSNVILKKYR 
NMVVRACGCH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmp7

Associated with

Other Information

Murine osteogenic protein (OP-1): high levels of mRNA in kidney. PubMed ID: 1715687

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BMP7 null mutation in mice: developmental defects in skeleton, kidney, and eye. PubMed ID: 9013703

Sirenomelia in Bmp7 and Tsg compound mutant mice: requirement for Bmp signaling in the development of ventral posterior mesoderm. PubMed ID: 15843411

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. PubMed ID: 14623234

Bmp7 regulates the survival, proliferation, and neurogenic properties of neural progenitor cells during corticogenesis in the mouse. PubMed ID: 22461901

Erythroferrone inhibits the induction of hepcidin by BMP6. PubMed ID: 30097509