Genular: Defining Cellular Identity and Function

Details for: Bmpr1a

Gene ID: 12166

Symbol: Bmpr1a

Ensembl ID: ENSMUSG00000021796

Description: bone morphogenetic protein receptor, type 1A

Associated with

Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Angiogenesis
(GO:0001525)
Anterior/posterior pattern specification
(GO:0009952)
Atp binding
(GO:0005524)
Atrioventricular valve development
(GO:0003171)
Bmp binding
(GO:0036122)
Bmp receptor activity
(GO:0098821)
Bmp signaling pathway
(GO:0030509)
Cardiac conduction system development
(GO:0003161)
Cardiac right ventricle morphogenesis
(GO:0003215)
Cartilage development
(GO:0051216)
Central nervous system neuron differentiation
(GO:0021953)
Chondrocyte differentiation
(GO:0002062)
Developmental growth
(GO:0048589)
Dorsal/ventral axis specification
(GO:0009950)
Dorsal/ventral pattern formation
(GO:0009953)
Dorsal aorta morphogenesis
(GO:0035912)
Ectoderm development
(GO:0007398)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic morphogenesis
(GO:0048598)
Embryonic organ development
(GO:0048568)
Endocardial cushion formation
(GO:0003272)
Endocardial cushion morphogenesis
(GO:0003203)
Endoderm development
(GO:0007492)
Epithelial cell proliferation
(GO:0050673)
Heart development
(GO:0007507)
Heart morphogenesis
(GO:0003007)
Hindlimb morphogenesis
(GO:0035137)
Immune response
(GO:0006955)
In utero embryonic development
(GO:0001701)
Kinase activity
(GO:0016301)
Lateral mesoderm development
(GO:0048368)
Lung development
(GO:0030324)
Mesendoderm development
(GO:0048382)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Mitral valve morphogenesis
(GO:0003183)
Mullerian duct regression
(GO:0001880)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of muscle cell differentiation
(GO:0051148)
Negative regulation of neurogenesis
(GO:0050768)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Nervous system development
(GO:0007399)
Neural crest cell development
(GO:0014032)
Neural plate mediolateral regionalization
(GO:0021998)
Nucleotide binding
(GO:0000166)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Osteoblast differentiation
(GO:0001649)
Outflow tract morphogenesis
(GO:0003151)
Outflow tract septum morphogenesis
(GO:0003148)
Paraxial mesoderm development
(GO:0048339)
Paraxial mesoderm structural organization
(GO:0048352)
Pattern specification process
(GO:0007389)
Phosphorylation
(GO:0016310)
Pituitary gland development
(GO:0021983)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of smad protein signal transduction
(GO:0060391)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta2 production
(GO:0032915)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cardiac muscle cell apoptotic process
(GO:0010665)
Regulation of cardiac muscle cell proliferation
(GO:0060043)
Regulation of endothelial cell differentiation
(GO:0045601)
Regulation of endothelial cell proliferation
(GO:0001936)
Regulation of lateral mesodermal cell fate specification
(GO:0048378)
Roof of mouth development
(GO:0060021)
Smad binding
(GO:0046332)
Somatic stem cell population maintenance
(GO:0035019)
Somitogenesis
(GO:0001756)
Transferase activity
(GO:0016740)
Transforming growth factor beta receptor activity, type i
(GO:0005025)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Transmembrane receptor protein serine/threonine kinase activity
(GO:0004675)
Transmembrane receptor protein serine/threonine kinase signaling pathway
(GO:0007178)
Tricuspid valve morphogenesis
(GO:0003186)
Ventricular compact myocardium morphogenesis
(GO:0003223)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Other Information

Proteins

Bone morphogenetic protein receptor type-1A

Genular Protein ID: 2134667326

Symbol: BMR1A_MOUSE

Name: Bone morphogenetic protein receptor type-1A

UniProtKB Accession Codes:

P36895

Database IDs:

Citations:

PubMed ID: 7750489

Title: Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

PubMed ID: 7750489

DOI: 10.1210/endo.136.6.7750489

PubMed ID: 7937936

Title: A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

PubMed ID: 7937936

DOI: 10.1073/pnas.91.22.10255

PubMed ID: 8065329

Title: Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells.

PubMed ID: 8065329

DOI: 10.1128/mcb.14.9.5961

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23527555

Title: Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage.

PubMed ID: 23527555

DOI: 10.1111/febs.12256

PubMed ID: 24098149

Title: A GDF5 point mutation strikes twice--causing BDA1 and SYNS2.

PubMed ID: 24098149

DOI: 10.1371/journal.pgen.1003846

PubMed ID: 29415997

Title: Downregulation of beta1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation.

PubMed ID: 29415997

DOI: 10.1038/s41419-017-0239-5

PubMed ID: 31800957

Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.

PubMed ID: 31800957

DOI: 10.1182/blood.2019002620

Sequence Information:

Length: 532
Mass: 60063
Checksum: 70CC83CFB07CE9D5
Sequence:

MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDLD QKKPENGVTL APEDTLPFLK 
CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR 
TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVVLISM AVCIVAMIIF SSCFCYKHYC 
KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV 
GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG 
SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH 
RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTKRYMAP EVLDESLNKN 
HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR 
PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bmpr1a

Associated with

Other Information

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. PubMed ID: 7750489

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. PubMed ID: 7937936

Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. PubMed ID: 8065329

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. PubMed ID: 23527555

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2. PubMed ID: 24098149

Downregulation of beta1,4-galactosyltransferase 5 improves insulin resistance by promoting adipocyte commitment and reducing inflammation. PubMed ID: 29415997

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3. PubMed ID: 31800957