Genular: Defining Cellular Identity and Function

Details for: Brca1

Gene ID: 12189

Symbol: Brca1

Ensembl ID: ENSMUSG00000017146

Description: breast cancer 1, early onset

Associated with

Cell cycle checkpoints
(R-MMU-69620)
Deubiquitination
(R-MMU-5688426)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
Metabolism of proteins
(R-MMU-392499)
Metalloprotease dubs
(R-MMU-5689901)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Post-translational protein modification
(R-MMU-597592)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Resolution of d-loop structures
(R-MMU-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-MMU-5693568)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cell cycle
(GO:0007049)
Cellular response to indole-3-methanol
(GO:0071681)
Cellular response to ionizing radiation
(GO:0071479)
Cellular response to tumor necrosis factor
(GO:0071356)
Centrosome cycle
(GO:0007098)
Centrosome duplication
(GO:0051298)
Chordate embryonic development
(GO:0043009)
Chromatin binding
(GO:0003682)
Chromosome segregation
(GO:0007059)
Damaged dna binding
(GO:0003684)
Dna-binding transcription activator activity
(GO:0001216)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna recombination
(GO:0006310)
Dna repair
(GO:0006281)
Dna strand resection involved in replication fork processing
(GO:0110025)
Double-strand break repair
(GO:0006302)
Double-strand break repair via homologous recombination
(GO:0000724)
Enzyme binding
(GO:0019899)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid metabolic process
(GO:0006631)
Homologous recombination
(GO:0035825)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Lipid metabolic process
(GO:0006629)
Localization
(GO:0051179)
Metal ion binding
(GO:0046872)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic g2/m transition checkpoint
(GO:0044818)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fatty acid biosynthetic process
(GO:0045717)
Negative regulation of gene expression via cpg island methylation
(GO:0044027)
Negative regulation of intracellular estrogen receptor signaling pathway
(GO:0033147)
P53 binding
(GO:0002039)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna repair
(GO:0045739)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Postreplication repair
(GO:0006301)
Protein autoubiquitination
(GO:0051865)
Protein k6-linked ubiquitination
(GO:0085020)
Protein ubiquitination
(GO:0016567)
Random inactivation of x chromosome
(GO:0060816)
Regulation of cell cycle
(GO:0051726)
Regulation of dna repair
(GO:0006282)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to ionizing radiation
(GO:0010212)
Rna binding
(GO:0003723)
Rna polymerase binding
(GO:0070063)
Sex-chromosome dosage compensation
(GO:0007549)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator activity
(GO:0003713)
Transferase activity
(GO:0016740)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Breast cancer type 1 susceptibility protein homolog
Q6NV63_MOUSE

Genular Protein ID: 1771189547

Symbol: BRCA1_MOUSE

Name: Breast cancer type 1 susceptibility protein homolog

UniProtKB Accession Codes:

P48754 A2A4Q4 Q60957 Q60983

Database IDs:

Citations:

PubMed ID: 8634697

Title: Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains.

PubMed ID: 8634697

DOI: 10.1093/hmg/4.12.2265

PubMed ID: 8634698

Title: Murine Brca1: sequence and significance for human missense mutations.

PubMed ID: 8634698

DOI: 10.1093/hmg/4.12.2275

PubMed ID: 8575748

Title: Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11.

PubMed ID: 8575748

DOI: 10.1006/geno.1995.9963

PubMed ID: 7590247

Title: Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice.

PubMed ID: 7590247

DOI: 10.1101/gad.9.21.2712

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 7550308

Title: The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues.

PubMed ID: 7550308

DOI: 10.1038/ng0995-17

PubMed ID: 8566965

Title: The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.

PubMed ID: 8566965

DOI: 10.1007/bf02265277

PubMed ID: 12360400

Title: BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains.

PubMed ID: 12360400

DOI: 10.1038/sj.onc.1205915

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23039116

Title: HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity.

PubMed ID: 23039116

DOI: 10.1111/gtc.12005

PubMed ID: 22549958

Title: Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.

PubMed ID: 22549958

DOI: 10.1101/gad.187559.112

Sequence Information:

Length: 1812
Mass: 198795
Checksum: 2B47FB55B149FD71
Sequence:

MDLSAVQIQE VQNVLHAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 
CPLCKNEITK RSLQGSTRFS QLAEELLRIM AAFELDTGMQ LTNGFSFSKK RNNSCERLNE 
EASIIQSVGY RNRVRRLPQV EPGNATLKDS LGVQLSNLGI VRSVKKNRQT QPRKKSVYIE 
LDSDSSEETV TKPGDCSVRD QELLQTAPQE AGDEGKLHSA EEAACEFSEG IRNIEHHQCS 
DDLNPTENHA TERHPEKCQS ISISNVCVEP CGTDAHASSL QPETSSLLLI EDRMNAEKAE 
FCNKSKQPGI AVSQQSRWAA SKGTCNDRQV PSTGEKVGPN ADSLSDREKW THPQSLCPEN 
SGATTDVPWI TLNSSVQKVN EWFSRTGEML TSDSASARRH ESNAEAAVVL EVSNEVDGGF 
SSSRKTDLVT PDPHHTLMCK SGRDFSKPVE DNISDKIFGK SYQRKGSRPH LNHVTEIIGT 
FITEPQITQE QPFTNKLKRK RSTSLQPEDF IKKADSAGVQ RTPDNINQGT DLMEPNEQAV 
STTSNCQENK IAGSNLQKEK SAHPTESLRK EPASTAGAKS ISNSVSDLEV ELNVHSSKAP 
KKNRLRRKSS IRCALPLEPI SRNPSPPTCA ELQIDSCGSS EETKKNHSNQ QPAGHLREPQ 
LIEDTEPAAD AKKNEPNEHI RKRRASDAFP EEKLMNKAGL LTSCSSPRKS QGPVNPSPQR 
TGTEQLETRQ MSDSAKELGD RVLGGEPSGK TTDRSEESTS VSLVSDTDYD TQNSVSVLDA 
HTVRYARTGS AQCMTQFVAS ENPKELVHGS NNAGSGTEGL KPPLRHALNL SQEKVEMEDS 
ELDTQYLQNT FQVSKRQSFA LFSKPRSPQK DCAHSVPSKE LSPKVTAKGK QKERQGQEEF 
EISHVQAVAA TVGLPVPCQE GKLAADTMCD RGCRLCPSSH YRSGENGLSA TGKSGISQNS 
HFKQSVSPIR SSIKTDNRKP LTEGRFERHT SSTEMAVGNE NILQSTVHTV SLNNRGNACQ 
EAGSGSIHEV CSTGDSFPGQ LGRNRGPKVN TVPPLDSMQP GVCQQSVPVS DKYLEIKKQE 
GEAVCADFSP CLFSDHLEQS MSGKVFQVCS ETPDDLLDDV EIQGHTSFGE GDIMERSAVF 
NGSILRRESS RSPSPVTHAS KSQSLHRASR KLESSEESDS TEDEDLPCFQ HLLSRISNTP 
ELTRCSSAVT QRMPEKAEGT QAPWKGSSSD CNNEVIMIEA SQEHQFSEDP RCSGSMFSSQ 
HSAAQGSTAN ANSQDSNFIP PSKQRSHQCG NEEAFLSDKE LISDNEEMAT CLEEDNDQEE 
DSIIPDSEAS GYESETNLSE DCSQSDILTT QQRATMKYNL IKLQQEMAHL EAVLEQRGNQ 
PSGHSPSLLA DPCALEDLPD LEPNMSGAAI LTSKNINENP VSQNLKSACD DKFQLQHLEG 
PTSGDDESGM GRPSPFKSPL AGSRGSAHGC SRHLQKRNSP SQEELLQPAG SEASSEPHNS 
TGQSCLPRRE LEGTPYLGSG ISLFSSRDPE SESPKEPAHI GTTPASTSAL KIPQGQVAFR 
SAAAAGADKA VVGIVSKIKP ELTSSEERAD RDISMVVSGL TPKEVMTVQK FAEKYRLTLT 
DAITEETTHV IIKTDAEFVC ERTLKYFLGI AGGKWIVSYS WVVRSIQERR LLNVHEFEVK 
GDVVTGRNHQ GPRRSRESRE KLFKGLQVYC CEPFTNMPKD ELERMLQLCG ASVVKELPSL 
THDTGAHLVV IVQPSAWTED SNCPDIGQLC KARLVMWDWV LDSLSSYRCR DLDAYLVQNI 
TCDSSEPQDS ND

Genular Protein ID: 104752626

Symbol: Q6NV63_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6NV63

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 1811
Mass: 198615
Checksum: 76197BA09B8DEC86
Sequence:

MDLSAVQIQE VQNVLHAMQK ILECPICLEL IKEPVSTKCD HIFCKFCMLK LLNQKKGPSQ 
CPLCKNEITK RSLQGSTRFS QLAEELLRIM AAFELDTGMQ LTNGFSFSKK RNNSCERLNE 
EASIIQSVGY RNRVRRLPQV EPGNATLKDS LGVQLSNLGI VRSVKKNRQT QPRKKSVYIE 
LDSDSSEETV TKPGDCSVRD QELLQTAPQE AGDEGKLHSA EEAACEFSGG IRNIEHHQCS 
DDLNPTENHA TERHPEKCQS ISISNVCVEP CGTDAHASSL QPETSSLLLI EDRMNAEKAE 
FCNKSKQPGI AVSQQSRWAA SKGTCNDRQV PSTGEKVGPN ADSLSDREKW THPQSLCPEN 
SGATTDVPWI TLNSSVQKVN EWFSRTGEML TSDSASARRH ESNAEAAVVL EVSNEVDGGF 
SSSRKTDLVT PDPHHTLMCK RGRDFSKPVE DNISDKIFGK SYQRKGSRPH LNHVTEIIGT 
FITEPQITQE QPFTNKLKRK RSTSLQPEDF IKKADSAGVQ RTPDNINQGT DLMEPNEQAV 
STTSNCQENK IAGSNLQKEK SAHPTESLRK EPASTAGAKS ISNSVSDLEV ELNVHSSKAP 
KKNRLRRKSS IRCALPLEPI SRNPSPPTCA ELQIDSCGSS EETKKNHSNQ QPAGHLREPQ 
LIEDTEPAAD AKKNEPNEHI RKRRASDAFP EEKLMNKAGL LTSCSSPRKS QGPVNPSPQR 
TGTEQLETRQ MSDSAKELGD RVLGGEPSGK TTDRSEESTS VSLVSDTDYD TQNSVSVLDA 
HTVRYARTGS AQCMTQFVAS ENPKELVHGS NNAGSGTEGL KPPLRHALNL SQEKVEMEDS 
ELDTQYLQNT FQVSKRQSFA LFSKPRSPQK DCAHSVPSKE LSPKVTAKGK QKERQGQEEF 
EISHVQAVAA TVGLPVPCQE GKLAADTMCD RGCRLCPSSH YRSGENGLSA TGKSGISQNS 
HFKQSVSPIR SSIKTDNRKP LTEGRFERHT PSTEMAVGNE NILQSTVHTV SLNNRGNACQ 
EAGSGSIHEV CSTGDSFPGQ LGRNRGPKVN TVPPLDSMQP GVCQQSVPVS DKYLEIKKQE 
GEAVCADFSP CLFSDHLEQS MSGKVFQVCS ETPDDLLDDV EIQGHTSFGE GDIMERSAVF 
NGSILRRESS RSPSPVTHAS KSQSLHRASR KLESSEESDS TEDEDLPCFQ HLLSRISNTP 
ELTKCSSAVA QRMPEKAEGT QAPWKGSSSD CNNEVIMIEA SQEHQFSEDP RCSGSMFSSQ 
HSAAQGSTAN ANSQDSNFIP PSKQRSHQCG NEEAFLSDKE LISDNEEMAT CLEEDNDQEE 
DSIIPDSEAS GYESETNLSE DCSQSDILTT QQRATMKYNL IKLQQEMAHL EAVLEQRGNQ 
PSGHSPSLLA DPCALEDLPD LEPNMSGAAI LTSKNINENP VSQNLKSACD DKFQLQHLEG 
PTSGDDESGM GRPSPFKSPL AGSRGSAHGC SRHLQKRNSP SQEELLQPAG SEASSEPHNS 
TGQSCLPRRE LGTPYLGSGI SLFSSRDPES ESPKEPAHIG TTPASTSALK IPQGQVAFRS 
AAAAGADKAV VGIVSKIKPE LTSSEERADR DISMVVSGLT PKEVMTVQKF AEKYRLTLTD 
AITEETTHVI IKTDAEFVCE RTLKYFLGIA GGKWIVSYSW VVRSIQERRL LNVHEFEVKG 
DVVTGRNHQG PRRSRESREK LFKGLQVYCC EPFTNMPKDE LERMLQLCGA SVVKELPSLT 
HDTGAHLVVI VQPSAWTEDS NCPDIGQLCK ARLVMWDWVL DSLSSYRCRD LDAYLVQNIT 
CDSSEPQDSN D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Brca1

Associated with

Other Information

Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains. PubMed ID: 8634697

Murine Brca1: sequence and significance for human missense mutations. PubMed ID: 8634698

Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11. PubMed ID: 8575748

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. PubMed ID: 7590247

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. PubMed ID: 7550308

The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D. PubMed ID: 8566965

BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. PubMed ID: 12360400

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

HORMAD2 is essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. PubMed ID: 23039116

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. PubMed ID: 22549958

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334