Genular: Defining Cellular Identity and Function

Details for: Zfp36l1

Gene ID: 12192

Symbol: Zfp36l1

Ensembl ID: ENSMUSG00000021127

Description: zinc finger protein 36, C3H type-like 1

Associated with

Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-MMU-450385)
Metabolism of rna
(R-MMU-8953854)
Regulation of mrna stability by proteins that bind au-rich elements
(R-MMU-450531)
3'-utr-mediated mrna destabilization
(GO:0061158)
14-3-3 protein binding
(GO:0071889)
Apoptotic process
(GO:0006915)
Cell population proliferation
(GO:0008283)
Cellular response to camp
(GO:0071320)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cellular response to raffinose
(GO:0097403)
Cellular response to salt stress
(GO:0071472)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Chorio-allantoic fusion
(GO:0060710)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Embryonic organ development
(GO:0048568)
Erk1 and erk2 cascade
(GO:0070371)
Heart development
(GO:0007507)
Mapk cascade
(GO:0000165)
Mesendoderm development
(GO:0048382)
Metal ion binding
(GO:0046872)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna binding
(GO:0003729)
Mrna catabolic process
(GO:0006402)
Mrna processing
(GO:0006397)
Mrna transport
(GO:0051028)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of mitotic cell cycle phase transition
(GO:1901991)
Neural tube development
(GO:0021915)
Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:0000288)
Nuclear-transcribed mrna catabolic process, deadenylation-independent decay
(GO:0031086)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
P38mapk cascade
(GO:0038066)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of intracellular mrna localization
(GO:1904582)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Proepicardium development
(GO:0003342)
Protein binding
(GO:0005515)
Regulation of b cell differentiation
(GO:0045577)
Regulation of gene expression
(GO:0010468)
Regulation of keratinocyte apoptotic process
(GO:1902172)
Regulation of keratinocyte differentiation
(GO:0045616)
Regulation of keratinocyte proliferation
(GO:0010837)
Regulation of mrna 3'-end processing
(GO:0031440)
Regulation of mrna stability
(GO:0043488)
Regulation of myoblast differentiation
(GO:0045661)
Regulation of stem cell proliferation
(GO:0072091)
Regulation of translation
(GO:0006417)
Response to wounding
(GO:0009611)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Spongiotrophoblast layer development
(GO:0060712)
T cell differentiation in thymus
(GO:0033077)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

TISB_MOUSE

Genular Protein ID: 3098779950

Symbol: TISB_MOUSE

Name: N/A

UniProtKB Accession Codes:

P23950

Database IDs:

Citations:

PubMed ID: 1996120

Title: The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat.

PubMed ID: 1996120

DOI: 10.1128/mcb.11.3.1754-1758.1991

PubMed ID: 11796723

Title: Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling.

PubMed ID: 11796723

DOI: 10.1074/jbc.m111457200

PubMed ID: 15465005

Title: Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.

PubMed ID: 15465005

DOI: 10.1016/j.bbrc.2004.09.030

PubMed ID: 15226444

Title: Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family.

PubMed ID: 15226444

DOI: 10.1128/mcb.24.14.6445-6455.2004

PubMed ID: 17013884

Title: The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression.

PubMed ID: 17013884

DOI: 10.1002/dvdy.20949

PubMed ID: 17889962

Title: Strong induction of the Tis11B gene in myogenic differentiation.

PubMed ID: 17889962

DOI: 10.1016/j.ejcb.2007.07.005

PubMed ID: 19179481

Title: cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b.

PubMed ID: 19179481

DOI: 10.1210/me.2008-0296

PubMed ID: 20622884

Title: Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia.

PubMed ID: 20622884

DOI: 10.1038/ni.1901

PubMed ID: 22701344

Title: Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes.

PubMed ID: 22701344

DOI: 10.7150/ijbs.4036

PubMed ID: 23046558

Title: A role for RNA post-transcriptional regulation in satellite cell activation.

PubMed ID: 23046558

DOI: 10.1186/2044-5040-2-21

PubMed ID: 24700863

Title: Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.

PubMed ID: 24700863

DOI: 10.1681/asn.2013091023

PubMed ID: 24733888

Title: Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.

PubMed ID: 24733888

DOI: 10.1073/pnas.1320873111

PubMed ID: 25815583

Title: Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay.

PubMed ID: 25815583

DOI: 10.7554/elife.03390

PubMed ID: 27102483

Title: RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.

PubMed ID: 27102483

DOI: 10.1126/science.aad5978

Sequence Information:

Length: 338
Mass: 36385
Checksum: A28F2C8BF476496C
Sequence:

MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP TQKQPGSGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGGRD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Zfp36l1

Associated with

Other Information

The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. PubMed ID: 1996120

Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. PubMed ID: 11796723

Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. PubMed ID: 15465005

Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. PubMed ID: 15226444

The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. PubMed ID: 17013884

Strong induction of the Tis11B gene in myogenic differentiation. PubMed ID: 17889962

cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. PubMed ID: 19179481

Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. PubMed ID: 20622884

Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. PubMed ID: 22701344

A role for RNA post-transcriptional regulation in satellite cell activation. PubMed ID: 23046558

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control. PubMed ID: 24700863

Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase. PubMed ID: 24733888

Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. PubMed ID: 25815583

RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. PubMed ID: 27102483