Genular: Defining Cellular Identity and Function

Details for: Btc

Gene ID: 12223

Symbol: Btc

Ensembl ID: ENSMUSG00000082361

Description: betacellulin, epidermal growth factor family member

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Egfr downregulation
(R-MMU-182971)
Egfr interacts with phospholipase c-gamma
(R-MMU-212718)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gab1 signalosome
(R-MMU-180292)
Grb2 events in egfr signaling
(R-MMU-179812)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Membrane trafficking
(R-MMU-199991)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi3k events in erbb4 signaling
(R-MMU-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Apoptotic process
(GO:0006915)
Cell population proliferation
(GO:0008283)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell apoptotic process
(GO:1904019)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Membrane
(GO:0016020)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Plasma membrane
(GO:0005886)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of urine volume
(GO:0035810)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Other Information

Proteins

Probetacellulin
Q3TP84_MOUSE

Genular Protein ID: 1297721526

Symbol: BTC_MOUSE

Name: Probetacellulin

UniProtKB Accession Codes:

Q05928

Database IDs:

Citations:

PubMed ID: 8456283

Title: Betacellulin: a mitogen from pancreatic beta cell tumors.

PubMed ID: 8456283

DOI: 10.1126/science.8456283

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 21897861

Title: Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors.

PubMed ID: 21897861

DOI: 10.1371/journal.pone.0023894

Sequence Information:

Length: 177
Mass: 19664
Checksum: 066BB34F0E13F82B
Sequence:

MDPTAPGSSV SSLPLLLVLA LGLAILHCVV ADGNTTRTPE TNGSLCGAPG ENCTGTTPRQ 
KVKTHFSRCP KQYKHYCIHG RCRFVVDEQT PSCICEKGYF GARCERVDLF YLQQDRGQIL 
VVCLIVVMVV FIILVIGVCT CCHPLRKHRK KKKEEKMETL DKDKTPISED IQETNIA

Genular Protein ID: 856577102

Symbol: Q3TP84_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TP84

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 148
Mass: 16235
Checksum: E40154B0CFE610B5
Sequence:

MDPTAPGSSV SSLPLLLVLA LGLAILHCVV ADGNTTRTPE TNGSLCGAPG ENCTGTTPRQ 
KVKTHFSRCP KQYKHYCIHG RCRFVVDEQT PSCICEKGYF GARCERVDLF YLQQDRGQIL 
VVCLIVVMVV FIILVIGVCT CCHPLRKH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Btc

Associated with

Other Information

Betacellulin: a mitogen from pancreatic beta cell tumors. PubMed ID: 8456283

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Betacellulin-induced beta cell proliferation and regeneration is mediated by activation of ErbB-1 and ErbB-2 receptors. PubMed ID: 21897861

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073