Genular: Defining Cellular Identity and Function

Details for: Btk

Gene ID: 12229

Symbol: Btk

Ensembl ID: ENSMUSG00000031264

Description: Bruton agammaglobulinemia tyrosine kinase

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen activates b cell receptor (bcr) leading to generation of second messengers
(R-MMU-983695)
Dap12 interactions
(R-MMU-2172127)
Dap12 signaling
(R-MMU-2424491)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated ca+2 mobilization
(R-MMU-2871809)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G-protein beta:gamma signalling
(R-MMU-397795)
G alpha (12/13) signalling events
(R-MMU-416482)
G alpha (q) signalling events
(R-MMU-416476)
G beta:gamma signalling through btk
(R-MMU-8964315)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate wasps and waves
(R-MMU-5663213)
Signaling by gpcr
(R-MMU-372790)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
B cell affinity maturation
(GO:0002344)
B cell receptor signaling pathway
(GO:0050853)
Cell maturation
(GO:0048469)
Cellular response to interleukin-7
(GO:0098761)
Cellular response to molecule of fungal origin
(GO:0071226)
Cellular response to reactive oxygen species
(GO:0034614)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Eosinophil homeostasis
(GO:1990959)
Histamine secretion by mast cell
(GO:0002553)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Monocyte proliferation
(GO:0061516)
Negative regulation of b cell activation
(GO:0050869)
Negative regulation of b cell proliferation
(GO:0030889)
Negative regulation of cytokine production
(GO:0001818)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of leukocyte proliferation
(GO:0070664)
Neutrophil homeostasis
(GO:0001780)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phospholipase activator activity
(GO:0016004)
Phospholipase binding
(GO:0043274)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-17a production
(GO:0150153)
Positive regulation of nlrp3 inflammasome complex assembly
(GO:1900227)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of synoviocyte proliferation
(GO:1901647)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of type i hypersensitivity
(GO:0001812)
Positive regulation of type iii hypersensitivity
(GO:0001805)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Proteoglycan catabolic process
(GO:0030167)
Response to lipopolysaccharide
(GO:0032496)
Response to organic substance
(GO:0010033)
T cell receptor signaling pathway
(GO:0050852)
Transferase activity
(GO:0016740)

Other Information

Proteins

Tyrosine-protein kinase BTK

Genular Protein ID: 3633603144

Symbol: BTK_MOUSE

Name: Tyrosine-protein kinase BTK

UniProtKB Accession Codes:

P35991 Q61365

Database IDs:

Citations:

PubMed ID: 8425221

Title: Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.

PubMed ID: 8425221

DOI: 10.1016/0092-8674(93)90667-f

PubMed ID: 8476425

Title: Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells.

PubMed ID: 8476425

DOI: 10.1006/bbrc.1993.1404

PubMed ID: 7989760

Title: Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci.

PubMed ID: 7989760

PubMed ID: 7626884

Title: Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.

PubMed ID: 7626884

DOI: 10.1007/bf00364796

PubMed ID: 8630736

Title: Regulation of Btk function by a major autophosphorylation site within the SH3 domain.

PubMed ID: 8630736

DOI: 10.1016/s1074-7613(00)80417-3

PubMed ID: 7538439

Title: Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain.

PubMed ID: 7538439

DOI: 10.1016/1074-7613(95)90026-8

PubMed ID: 8629002

Title: Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.

PubMed ID: 8629002

DOI: 10.1126/science.271.5250.822

PubMed ID: 9240435

Title: Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain.

PubMed ID: 9240435

DOI: 10.1006/bbrc.1997.6947

PubMed ID: 10811867

Title: Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement.

PubMed ID: 10811867

DOI: 10.1084/jem.191.10.1745

PubMed ID: 11120822

Title: The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease.

PubMed ID: 11120822

DOI: 10.4049/jimmunol.165.12.6956

PubMed ID: 10852954

Title: Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk.

PubMed ID: 10852954

DOI: 10.1073/pnas.120175097

PubMed ID: 16738337

Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.

PubMed ID: 16738337

DOI: 10.1128/mcb.02009-05

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17725607

Title: Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice.

PubMed ID: 17725607

DOI: 10.1111/j.1365-2567.2007.02693.x

PubMed ID: 9751072

Title: Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.

PubMed ID: 9751072

DOI: 10.1016/s0006-2952(98)00122-1

PubMed ID: 19290921

Title: Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.

PubMed ID: 19290921

DOI: 10.1111/j.1600-065x.2008.00741.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23478294

Title: Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis.

PubMed ID: 23478294

DOI: 10.1038/cr.2013.33

PubMed ID: 34554188

Title: BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.

PubMed ID: 34554188

DOI: 10.1084/jem.20201656

PubMed ID: 8332901

Title: Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice.

PubMed ID: 8332901

DOI: 10.1126/science.8332901

Sequence Information:

Length: 659
Mass: 76437
Checksum: E502B798BC36E223
Sequence:

MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK 
ITCVETVIPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL 
RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS 
HRKTKKPLPP TPEEDQILKK PLPPEPTAAP ISTTELKKVV ALYDYMPMNA NDLQLRKGEE 
YFILEESNLP WWRARDKNGQ EGYIPSNYIT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 
EGGFIVRDSS KAGKYTVSVF AKSTGEPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN 
YHQHNSAGLI SRLKYPVSKQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK 
WRGQYDVAIK MIREGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG 
CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF 
GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 
FTNSETAEHI AQGLRLYRPH LASERVYTIM YSCWHEKADE RPSFKILLSN ILDVMDEES

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Btk

Associated with

Other Information

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. PubMed ID: 8425221

Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells. PubMed ID: 8476425

Genomic organization of mouse and human Bruton's agammaglobulinemia tyrosine kinase (Btk) loci. PubMed ID: 7989760

Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci. PubMed ID: 7626884

Regulation of Btk function by a major autophosphorylation site within the SH3 domain. PubMed ID: 8630736

Activation of Bruton's tyrosine kinase (BTK) by a point mutation in its pleckstrin homology (PH) domain. PubMed ID: 7538439

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. PubMed ID: 8629002

Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain. PubMed ID: 9240435

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement. PubMed ID: 10811867

The transcription factor Bright associates with Bruton's tyrosine kinase, the defective protein in immunodeficiency disease. PubMed ID: 11120822

Regulation of protein kinase CbetaI by two protein-tyrosine kinases, Btk and Syk. PubMed ID: 10852954

Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. PubMed ID: 16738337

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Defective Toll-like receptor 9-mediated cytokine production in B cells from Bruton's tyrosine kinase-deficient mice. PubMed ID: 17725607

Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis. PubMed ID: 9751072

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. PubMed ID: 19290921

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis. PubMed ID: 23478294

BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. PubMed ID: 34554188

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice. PubMed ID: 8332901