Genular: Defining Cellular Identity and Function

Details for: Bub1b

Gene ID: 12236

Symbol: Bub1b

Ensembl ID: ENSMUSG00000040084

Description: BUB1B, mitotic checkpoint serine/threonine kinase

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Apc-cdc20 mediated degradation of nek2a
(R-MMU-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-MMU-174184)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-MMU-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-MMU-141405)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Kinase activity
(GO:0016301)
Kinetochore
(GO:0000776)
Meiotic sister chromatid cohesion, centromeric
(GO:0051754)
Metaphase/anaphase transition of mitotic cell cycle
(GO:0007091)
Mitotic checkpoint complex
(GO:0033597)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to chromosome, centromeric region
(GO:0071459)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Spindle
(GO:0005819)
Transferase activity
(GO:0016740)

Other Information

Proteins

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Q3UZD6_MOUSE

Genular Protein ID: 2591543049

Symbol: BUB1B_MOUSE

Name: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

UniProtKB Accession Codes:

Q9Z1S0 A2ARS1

Database IDs:

Citations:

PubMed ID: 9889005

Title: The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner.

PubMed ID: 9889005

DOI: 10.1006/geno.1998.5629

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 12925705

Title: Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.

PubMed ID: 12925705

DOI: 10.1083/jcb.200303167

PubMed ID: 14744753

Title: Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency.

PubMed ID: 14744753

DOI: 10.1158/0008-5472.can-03-3119

PubMed ID: 15208629

Title: BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice.

PubMed ID: 15208629

DOI: 10.1038/ng1382

PubMed ID: 17925231

Title: Bub1 maintains centromeric cohesion by activation of the spindle checkpoint.

PubMed ID: 17925231

DOI: 10.1016/j.devcel.2007.08.008

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1052
Mass: 118392
Checksum: 9EF1ECF3735DD1F4
Sequence:

MAEASEAMCL EGAEWELSKE NIQPLRHGRV MSTLQGALAK QESAGHTALQ QQKRAFESEI 
RFYSGDDPLD VWDRYINWTE QNYPQGGKES NMSALVERAI EALQGETRYY NDPRFLSLWI 
KLGHLCNEPL DMYSYLQSQG IGVSLAQFYI SWAEEYEARE NFKKADIIFQ EGIERKAEPL 
DRLQSQHRQF QSRVSRQAFL ALGNEEEEAL EPSEPQRSSL AELKSRGKKM ARAPISRVGG 
ALKAPGQSRG FLNAVPQPVH GNRRITVFDE NADTASRTEL SKPVAQPWMA PPVPRAKENE 
LQPGPWSTDR PAGRRPHDNP ASVTSIPSVL PSFTPYVEES AQQTVMTPCK IEPSINHVLS 
TRKPGREEGD PLQRVQSHQQ GCEEKKEKMM YCKEKIYAGV GEFSFEEIRA EVFRKKLKER 
REAELLTSAK KREEMQKQIE EMERRLKAMQ AVQQEGAGGQ QEEKMPTEDP ARLQIASGPQ 
EMSGVPLSCS ICPLSSNPRE ISPAENILQE QPDSKGSSMP FSIFDESLSD KKDKSPATGG 
PQVLNAQRRP LSVLKTTEVG TTNEDVSPDI CDELTELEPL SEDAIITGFR NVTLCPNPED 
TCDFARAARL ASTPFHEILS SKGIAADPEG LLQEEDLDGK AAEAHHTVHH QALIIKKLSP 
IIEESREATH SSGFSRSSSS APSTSSIKGF QLLEKLELTN DGAEDAIQSP WCSQYRLQLL 
KSLLELSAFA EFSVEDRPMP VLEIGKEIEL GPEDYVIKQE HLTCDDYRLF WVAPRSSAEL 
TMIKASSQPI PWDFYINLKL KERLNEDYDQ LCSCCQYQDG HVVWYQYINC STLQNLLQHS 
EFVTHEIIVL IIYNLLTIVE KLHRAEIVHG DLSPRSLILR NRIHDPYDYV NKDDHAVRIM 
DFSYSVDLRV QLDAFAYSGF RTAQILEGQK ILANCSSPYH VDLLGIADLA HLLLFKEHLH 
VFWDGLLWKL SQSTSELKDS ELWNKFFVRI LNASDKSTVS VLGELAAEMG GAFDATFHSH 
LNRALWKLGK TISPEALLTQ QDKQPGGSQS PA

Genular Protein ID: 3033979715

Symbol: Q3UZD6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UZD6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 1052
Mass: 118391
Checksum: 9EF1ECF06C7A809E
Sequence:

MAEASEAMCL EGAEWELSKE NIQPLRHGRV MSTLQGALAK QESAGHTALQ QQKRAFESEI 
RFYSGDDPLD VWDRYINWTE QNYPQGGKES NMSALVERAI EALQGETRYY NDPRFLSLWI 
KLGHLCNEPL DMYSYLQSQG IGVSLAQFYI SWAEEYEARE NFKKADIIFQ EGIERKAEPL 
DRLQSQHRQF QSRVSRQAFL ALGNEEEEAL EPSEPQRSSL AELKSRGKKM ARAPISRVGG 
ALKAPGQSRG FLNAVPQPVH GNRRITVFDE NADTASRTEL SKPVAQPWMA PPVPRAKENE 
LQPGPWSTDR PAGRRPHDNP ASVTSIPSVL PSFTPYVEES AQQTVMTPCK IEPSINHVLS 
TRKPGREEGD PLQRVQSHQQ GCEEKKEKMM YCKEKIYAGV GEFSFEEIRA EVFRKKLKER 
REAELLTSAK KREEMQKQIE EMERRLKAMQ AVQQEGAGGQ QEEKMPTEDP ARLQIASGPQ 
EMSGVPLSCS ICPLSSNPRE ISPAENILQE QPNSKGSSMP FSIFDESLSD KKDKSPATGG 
PQVLNAQRRP LSVLKTTEVG TTNEDVSPDI CDELTELEPL SEDAIITGFR NVTLCPNPED 
TCDFARAARL ASTPFHEILS SKGIAADPEG LLQEEDLDGK AAEAHHTVHH QALIIKKLSP 
IIEESREATH SSGFSRSSSS APSTSSIKGF QLLEKLELTN DGAEDAIQSP WCSQYRLQLL 
KSLLELSAFA EFSVEDRPMP VLEIGKEIEL GPEDYVIKQE HLTCDDYRLF WVAPRSSAEL 
TMIKASSQPI PWDFYINLKL KERLNEDYDQ LCSCCQYQDG HVVWYQYINC STLQNLLQHS 
EFVTHEIIVL IIYNLLTIVE KLHRAEIVHG DLSPRSLILR NRIHDPYDYV NKDDHAVRIM 
DFSYSVDLRV QLDAFAYSGF RTAQILEGQK ILANCSSPYH VDLLGIADLA HLLLFKEHLH 
VFWDGLLWKL SQSTSELKDS ELWNKFFVRI LNASDKSTVS VLGELAAEMG GAFDATFHSH 
LNRALWKLGK TISPEALLTQ QDKQPGGSQS PA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bub1b

Associated with

Other Information

The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. PubMed ID: 9889005

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. PubMed ID: 12925705

Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. PubMed ID: 14744753

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. PubMed ID: 15208629

Bub1 maintains centromeric cohesion by activation of the spindle checkpoint. PubMed ID: 17925231

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073