Genular: Defining Cellular Identity and Function

Details for: Bub3

Gene ID: 12237

Symbol: Bub3

Ensembl ID: ENSMUSG00000066979

Description: BUB3 mitotic checkpoint protein

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176814)
Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Apc-cdc20 mediated degradation of nek2a
(R-MMU-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-MMU-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-MMU-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-MMU-174184)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-MMU-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-MMU-141405)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of mitotic cell cycle
(R-MMU-453276)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Attachment of spindle microtubules to kinetochore
(GO:0008608)
Bub1-bub3 complex
(GO:1990298)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Chromosome segregation
(GO:0007059)
Kinetochore
(GO:0000776)
Meiotic cell cycle
(GO:0051321)
Mitotic checkpoint complex
(GO:0033597)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein localization to kinetochore
(GO:0034501)
Regulation of chromosome segregation
(GO:0051983)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Mitotic checkpoint protein BUB3

Genular Protein ID: 2328874146

Symbol: BUB3_MOUSE

Name: Mitotic checkpoint protein BUB3

UniProtKB Accession Codes:

Q9WVA3 P97397 Q6ZWM5

Database IDs:

Citations:

PubMed ID: 10411903

Title: Retention of the BUB3 checkpoint protein on lagging chromosomes.

PubMed ID: 10411903

DOI: 10.1073/pnas.96.15.8493

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12011073

Title: Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated.

PubMed ID: 12011073

DOI: 10.1074/jbc.m200620200

PubMed ID: 19888327

Title: Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis.

PubMed ID: 19888327

DOI: 10.1371/journal.pone.0007701

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 326
Mass: 36955
Checksum: F1EA57368E5A6345
Sequence:

MTGSNEFKLN QPPEDGISSV KFSPNTSQFL LVSSWDTSVR LYDVPANSMR LKYQHTGAVL 
DCAFYDPTHA WSGGLDHQLK MHDLNTDQEN LVGTHDAPIR CVEYCPEVNV MVTGSWDQTV 
KLWDPRTPCN AGTFSQPEKV YTLSVSGDRL IVGTAGRRVL VWDLRNMGYV QQRRESSLKY 
QTRCIRAFPN KQGYVLSSIE GRVAVEYLDP SPEVQKKKYA FKCHRLKENN IEQIYPVNAI 
SFHNIHNTFA TGGSDGFVNI WDPFNKKRLC QFHRYPTSIA SLAFSNDGTT LAIASSYMYE 
MDDTEHPEDG IFIRQVTDAE TKPKST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bub3

Associated with

Other Information

Retention of the BUB3 checkpoint protein on lagging chromosomes. PubMed ID: 10411903

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. PubMed ID: 12011073

Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. PubMed ID: 19888327