Genular: Defining Cellular Identity and Function

Details for: Tspo

Gene ID: 12257

Symbol: Tspo

Ensembl ID: ENSMUSG00000041736

Description: translocator protein

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroid hormones
(R-MMU-196071)
Metabolism of steroids
(R-MMU-8957322)
Pregnenolone biosynthesis
(R-MMU-196108)
Androgen binding
(GO:0005497)
Behavioral response to pain
(GO:0048266)
Benzodiazepine receptor activity
(GO:0008503)
Chloride transport
(GO:0006821)
Cholesterol binding
(GO:0015485)
Cholesterol homeostasis
(GO:0042632)
Contact inhibition
(GO:0060242)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Establishment of protein localization to mitochondrion
(GO:0072655)
Glial cell migration
(GO:0008347)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid transport
(GO:0006869)
Maintenance of protein location in mitochondrion
(GO:0072656)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Monoatomic ion transport
(GO:0006811)
Negative regulation of atp metabolic process
(GO:1903579)
Negative regulation of corticosterone secretion
(GO:2000853)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of mitochondrion organization
(GO:0010823)
Negative regulation of mitophagy
(GO:1901525)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of programmed necrotic cell death
(GO:0062100)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to acetylcholine
(GO:1905144)
Steroid biosynthetic process
(GO:0006694)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Translocator protein

Genular Protein ID: 968738751

Symbol: TSPO_MOUSE

Name: Translocator protein

UniProtKB Accession Codes:

P50637 Q541E3 Q62118 Q6LCZ0 Q99M32

Database IDs:

Citations:

PubMed ID: 8114671

Title: In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells.

PubMed ID: 8114671

PubMed ID: 8125973

Title: Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis.

PubMed ID: 8125973

DOI: 10.1016/s0021-9258(17)37318-0

PubMed ID: 11471062

Title: High-throughput sequence identification of gene coding variants within alcohol-related QTLs.

PubMed ID: 11471062

DOI: 10.1007/s00335-001-1001-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7721091

Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.

PubMed ID: 7721091

DOI: 10.1016/0378-1119(94)00817-c

PubMed ID: 9832438

Title: Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern.

PubMed ID: 9832438

DOI: 10.1210/endo.139.12.6390

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24814875

Title: Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

PubMed ID: 24814875

DOI: 10.1042/cs20140047

PubMed ID: 24174323

Title: Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.

PubMed ID: 24174323

DOI: 10.1210/en.2013-1556

PubMed ID: 24936060

Title: Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis.

PubMed ID: 24936060

DOI: 10.1074/jbc.m114.578286

PubMed ID: 24653034

Title: Structure of the mitochondrial translocator protein in complex with a diagnostic ligand.

PubMed ID: 24653034

DOI: 10.1126/science.1248725

PubMed ID: 25974690

Title: Structural Integrity of the A147T Polymorph of Mammalian TSPO.

PubMed ID: 25974690

DOI: 10.1002/cbic.201500217

Sequence Information:

Length: 169
Mass: 18841
Checksum: 2EF93420C3842A85
Sequence:

MPESWVPAVG LTLVPSLGGF MGAYFVRGEG LRWYASLQKP SWHPPRWTLA PIWGTLYSAM 
GYGSYIVWKE LGGFTEDAMV PLGLYTGQLA LNWAWPPIFF GARQMGWALA DLLLVSGVAT 
ATTLAWHRVS PPAARLLYPY LAWLAFATVL NYYVWRDNSG RRGGSRLPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tspo

Associated with

Other Information

In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. PubMed ID: 8114671

Induction of peripheral-type benzodiazepine receptors during differentiation of mouse erythroleukemia cells. A possible involvement of these receptors in heme biosynthesis. PubMed ID: 8125973

High-throughput sequence identification of gene coding variants within alcohol-related QTLs. PubMed ID: 11471062

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes. PubMed ID: 7721091

Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. PubMed ID: 9832438

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype. PubMed ID: 24814875

Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. PubMed ID: 24174323

Peripheral benzodiazepine receptor/translocator protein global knockout mice are viable with no effects on steroid hormone biosynthesis. PubMed ID: 24936060

Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. PubMed ID: 24653034

Structural Integrity of the A147T Polymorph of Mammalian TSPO. PubMed ID: 25974690