Genular: Defining Cellular Identity and Function

Details for: C3

Gene ID: 12266

Symbol: C3

Ensembl ID: ENSMUSG00000024164

Description: complement component 3

Associated with

Activation of c3 and c5
(R-MMU-174577)
Adaptive immune system
(R-MMU-1280218)
Alternative complement activation
(R-MMU-173736)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Complement cascade
(R-MMU-166658)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Initial triggering of complement
(R-MMU-166663)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Neutrophil degranulation
(R-MMU-6798695)
Peptide ligand-binding receptors
(R-MMU-375276)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of complement cascade
(R-MMU-977606)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Amyloid-beta clearance
(GO:0097242)
C5l2 anaphylatoxin chemotactic receptor binding
(GO:0031715)
Cell surface
(GO:0009986)
Complement-dependent cytotoxicity
(GO:0097278)
Complement-mediated synapse pruning
(GO:0150062)
Complement activation
(GO:0006956)
Complement activation, alternative pathway
(GO:0006957)
Complement activation, classical pathway
(GO:0006958)
Complement receptor mediated signaling pathway
(GO:0002430)
Endopeptidase inhibitor activity
(GO:0004866)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid metabolic process
(GO:0006631)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Neuron remodeling
(GO:0016322)
Oviduct epithelium development
(GO:0035846)
Positive regulation of activation of membrane attack complex
(GO:0001970)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic cell clearance
(GO:2000427)
Positive regulation of developmental growth
(GO:0048639)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of glucose transmembrane transport
(GO:0010828)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of lipid storage
(GO:0010884)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of type iia hypersensitivity
(GO:0001798)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of triglyceride biosynthetic process
(GO:0010866)
Response to bacterium
(GO:0009617)
Retina development in camera-type eye
(GO:0060041)
Vascular associated smooth muscle cell differentiation
(GO:0035886)
Vertebrate eye-specific patterning
(GO:0150064)

Other Information

Proteins

Complement C3

Genular Protein ID: 1663564745

Symbol: CO3_MOUSE

Name: Complement C3

UniProtKB Accession Codes:

P01027 Q61370 Q80XP1

Database IDs:

Citations:

PubMed ID: 6208565

Title: Nucleotide sequence of complementary DNA and derived amino acid sequence of murine complement protein C3.

PubMed ID: 6208565

DOI: 10.1098/rstb.1984.0094

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6548745

Title: Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain.

PubMed ID: 6548745

DOI: 10.1016/s0021-9258(18)89824-6

PubMed ID: 6985486

Title: Isolation and analysis of genomic DNA clones encoding the third component of mouse complement.

PubMed ID: 6985486

DOI: 10.1073/pnas.79.23.7077

PubMed ID: 2578664

Title: Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4.

PubMed ID: 2578664

DOI: 10.1073/pnas.82.1.9

PubMed ID: 6356427

Title: Structure and expression of the C3 gene.

PubMed ID: 6356427

DOI: 10.1007/bf00205869

PubMed ID: 8364938

Title: A paracrine migration-stimulating factor for metastatic tumor cells secreted by mouse hepatic sinusoidal endothelial cells: identification as complement component C3b.

PubMed ID: 8364938

PubMed ID: 2065778

Title: The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.

PubMed ID: 2065778

DOI: 10.1016/0014-5793(91)80715-f

PubMed ID: 6609661

Title: Amino acid sequences of mouse complement C3 derived from nucleotide sequences of cloned cDNA.

PubMed ID: 6609661

DOI: 10.1111/j.1749-6632.1983.tb18118.x

PubMed ID: 6094532

Title: Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain.

PubMed ID: 6094532

DOI: 10.1016/s0021-9258(18)89825-8

PubMed ID: 6961437

Title: Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement.

PubMed ID: 6961437

DOI: 10.1073/pnas.79.24.7619

PubMed ID: 7964485

Title: The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes.

PubMed ID: 7964485

DOI: 10.1084/jem.180.6.2079

PubMed ID: 12244109

Title: Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice.

PubMed ID: 12244109

DOI: 10.1074/jbc.m207281200

PubMed ID: 18160458

Title: Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice.

PubMed ID: 18160458

DOI: 10.1152/ajpendo.00590.2007

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1663
Mass: 186484
Checksum: 7E5546CC7C314779
Sequence:

MGPASGSQLL VLLLLLASSP LALGIPMYSI ITPNVLRLES EETIVLEAHD AQGDIPVTVT 
VQDFLKRQVL TSEKTVLTGA SGHLRSVSIK IPASKEFNSD KEGHKYVTVV ANFGETVVEK 
AVMVSFQSGY LFIQTDKTIY TPGSTVLYRI FTVDNNLLPV GKTVVILIET PDGIPVKRDI 
LSSNNQHGIL PLSWNIPELV NMGQWKIRAF YEHAPKQIFS AEFEVKEYVL PSFEVRVEPT 
ETFYYIDDPN GLEVSIIAKF LYGKNVDGTA FVIFGVQDGD KKISLAHSLT RVVIEDGVGD 
AVLTRKVLME GVRPSNADAL VGKSLYVSVT VILHSGSDMV EAERSGIPIV TSPYQIHFTK 
TPKFFKPAMP FDLMVFVTNP DGSPASKVLV VTQGSNAKAL TQDDGVAKLS INTPNSRQPL 
TITVRTKKDT LPESRQATKT MEAHPYSTMH NSNNYLHLSV SRMELKPGDN LNVNFHLRTD 
PGHEAKIRYY TYLVMNKGKL LKAGRQVREP GQDLVVLSLP ITPEFIPSFR LVAYYTLIGA 
SGQREVVADS VWVDVKDSCI GTLVVKGDPR DNHLAPGQQT TLRIEGNQGA RVGLVAVDKG 
VFVLNKKNKL TQSKIWDVVE KADIGCTPGS GKNYAGVFMD AGLAFKTSQG LQTEQRADLE 
CTKPAARRRR SVQLMERRMD KAGQYTDKGL RKCCEDGMRD IPMRYSCQRR ARLITQGENC 
IKAFIDCCNH ITKLREQHRR DHVLGLARSE LEEDIIPEED IISRSHFPQS WLWTIEELKE 
PEKNGISTKV MNIFLKDSIT TWEILAVSLS DKKGICVADP YEIRVMQDFF IDLRLPYSVV 
RNEQVEIRAV LFNYREQEEL KVRVELLHNP AFCSMATAKN RYFQTIKIPP KSSVAVPYVI 
VPLKIGQQEV EVKAAVFNHF ISDGVKKTLK VVPEGMRINK TVAIHTLDPE KLGQGGVQKV 
DVPAADLSDQ VPDTDSETRI ILQGSPVVQM AEDAVDGERL KHLIVTPAGC GEQNMIGMTP 
TVIAVHYLDQ TEQWEKFGIE KRQEALELIK KGYTQQLAFK QPSSAYAAFN NRPPSTWLTA 
YVVKVFSLAA NLIAIDSHVL CGAVKWLILE KQKPDGVFQE DGPVIHQEMI GGFRNAKEAD 
VSLTAFVLIA LQEARDICEG QVNSLPGSIN KAGEYIEASY MNLQRPYTVA IAGYALALMN 
KLEEPYLGKF LNTAKDRNRW EEPDQQLYNV EATSYALLAL LLLKDFDSVP PVVRWLNEQR 
YYGGGYGSTQ ATFMVFQALA QYQTDVPDHK DLNMDVSFHL PSRSSATTFR LLWENGNLLR 
SEETKQNEAF SLTAKGKGRG TLSVVAVYHA KLKSKVTCKK FDLRVSIRPA PETAKKPEEA 
KNTMFLEICT KYLGDVDATM SILDISMMTG FAPDTKDLEL LASGVDRYIS KYEMNKAFSN 
KNTLIIYLEK ISHTEEDCLT FKVHQYFNVG LIQPGSVKVY SYYNLEESCT RFYHPEKDDG 
MLSKLCHSEM CRCAEENCFM QQSQEKINLN VRLDKACEPG VDYVYKTELT NIELLDDFDE 
YTMTIQQVIK SGSDEVQAGQ QRKFISHIKC RNALKLQKGK KYLMWGLSSD LWGEKPNTSY 
IIGKDTWVEH WPEAEECQDQ KYQKQCEELG AFTESMVVYG CPN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C3

Associated with

Other Information

Nucleotide sequence of complementary DNA and derived amino acid sequence of murine complement protein C3. PubMed ID: 6208565

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain. PubMed ID: 6548745

Isolation and analysis of genomic DNA clones encoding the third component of mouse complement. PubMed ID: 6985486

Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4. PubMed ID: 2578664

Structure and expression of the C3 gene. PubMed ID: 6356427

A paracrine migration-stimulating factor for metastatic tumor cells secreted by mouse hepatic sinusoidal endothelial cells: identification as complement component C3b. PubMed ID: 8364938

The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3. PubMed ID: 2065778

Amino acid sequences of mouse complement C3 derived from nucleotide sequences of cloned cDNA. PubMed ID: 6609661

Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain. PubMed ID: 6094532

Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement. PubMed ID: 6961437

The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes. PubMed ID: 7964485

Acylation-stimulating protein (ASP) deficiency induces obesity resistance and increased energy expenditure in ob/ob mice. PubMed ID: 12244109

Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice. PubMed ID: 18160458

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079