Genular: Defining Cellular Identity and Function

Details for: C4b

Gene ID: 12268

Symbol: C4b

Ensembl ID: ENSMUSG00000073418

Description: complement C4B (Chido blood group)

Associated with

Activation of c3 and c5
(R-MMU-174577)
Complement cascade
(R-MMU-166658)
Immune system
(R-MMU-168256)
Initial triggering of complement
(R-MMU-166663)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Post-translational protein phosphorylation
(R-MMU-8957275)
Regulation of complement cascade
(R-MMU-977606)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-MMU-381426)
Axon
(GO:0030424)
Carbohydrate binding
(GO:0030246)
Complement activation
(GO:0006956)
Complement binding
(GO:0001848)
Complement component c1q complex binding
(GO:0001849)
Dendrite
(GO:0030425)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immunoglobulin mediated immune response
(GO:0016064)
Neuronal cell body
(GO:0043025)
Symbiont cell surface
(GO:0106139)
Synapse
(GO:0045202)

Other Information

Proteins

Complement C4-B
Q3TYN1_MOUSE

Genular Protein ID: 2961233893

Symbol: CO4B_MOUSE

Name: Complement C4-B

UniProtKB Accession Codes:

P01029 E9QKK7 O70346 Q31201 Q3TYY1 Q3TZC9 Q61372 Q61859 Q62353 Q6NWV8

Database IDs:

Citations:

PubMed ID: 2993295

Title: Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

PubMed ID: 2993295

DOI: 10.1016/s0021-9258(17)39125-1

PubMed ID: 3862104

Title: Complete cDNA sequence of the fourth component of murine complement.

PubMed ID: 3862104

DOI: 10.1073/pnas.82.17.5895

PubMed ID: 2777798

Title: Sequence of the gene for murine complement component C4.

PubMed ID: 2777798

DOI: 10.1016/s0021-9258(19)84744-0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2997024

Title: Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.

PubMed ID: 2997024

DOI: 10.1111/j.1600-065x.1985.tb01146.x

PubMed ID: 3464002

Title: Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.

PubMed ID: 3464002

DOI: 10.1073/pnas.83.20.7883

PubMed ID: 3008092

Title: Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).

PubMed ID: 3008092

DOI: 10.1093/nar/14.6.2539

PubMed ID: 6208559

Title: Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.

PubMed ID: 6208559

DOI: 10.1073/pnas.81.21.6822

PubMed ID: 2459207

Title: Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

PubMed ID: 2459207

PubMed ID: 2387317

Title: C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

PubMed ID: 2387317

DOI: 10.1002/eji.1830200730

PubMed ID: 3856857

Title: Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp.

PubMed ID: 3856857

DOI: 10.1073/pnas.82.6.1746

PubMed ID: 6149581

Title: Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

PubMed ID: 6149581

DOI: 10.1098/rstb.1984.0099

PubMed ID: 6192448

Title: cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).

PubMed ID: 6192448

DOI: 10.1073/pnas.80.16.5061

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1738
Mass: 192915
Checksum: FCC7580209029E88
Sequence:

MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ EVKGSVFLRN 
PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL RRAPHIQLVA QSPWLRNTAF 
KATETQGVNL LFSSRRGHIF VQTDQPIYNP GQRVRYRVFA LDQKMRPSTD FLTITVENSH 
GLRVLKKEIF TSTSIFQDAF TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE 
VKITPWKPYI LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ 
AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM EEAELTSWRF 
VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP VKVSATLVSG SDSQVLDIQQ 
STNGIGQVSI SFPIPPTVTE LRLLVSAGSL YPAIARLTVQ APPSRGTGFL SIEPLDPRSP 
SVGDTFILNL QPVGIPAPTF SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY 
FVAYFYHQGH PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG 
AVDMALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL AFSDGDRLTQ 
TREDLSCPKE KKSRQKRNVN FQKAVSEKLG QYSSPDAKRC CQDGMTKLPM KRTCEQRAAR 
VPQQACREPF LSCCKFAEDL RRNQTRSQAH LARNNHNMLQ EEDLIDEDDI LVRTSFPENW 
LWRVEPVDSS KLLTVWLPDS MTTWEIHGVS LSKSKGLCVA KPTRVRVFRK FHLHLRLPIS 
IRRFEQFELR PVLYNYLNDD VAVSVHVTPV EGLCLAGGGM MAQQVTVPAG SARPVAFSVV 
PTAAANVPLK VVARGVFDLG DAVSKILQIE KEGAIHREEL VYNLDPLNNL GRTLEIPGSS 
DPNIVPDGDF SSLVRVTASE PLETMGSEGA LSPGGVASLL RLPQGCAEQT MIYLAPTLTA 
SNYLDRTEQW SKLSPETKDH AVDLIQKGYM RIQQFRKNDG SFGAWLHRDS STWLTAFVLK 
ILSLAQEQVG NSPEKLQETA SWLLAQQLGD GSFHDPCPVI HRAMQGGLVG SDETVALTAF 
VVIALHHGLD VFQDDDAKQL KNRVEASITK ANSFLGQKAS AGLLGAHAAA ITAYALTLTK 
ASEDLRNVAH NSLMAMAEET GEHLYWGLVL GSQDKVVLRP TAPRSPTEPV PQAPALWIET 
TAYALLHLLL REGKGKMADK AASWLTHQGS FHGAFRSTQD TVVTLDALSA YWIASHTTEE 
KALNVTLSSM GRNGLKTHGL HLNNHQVKGL EEELKFSLGS TISVKVEGNS KGTLKILRTY 
NVLDMKNTTC QDLQIEVKVT GAVEYAWDAN EDYEDYYDMP AADDPSVPLQ PVTPLQLFEG 
RRSRRRREAP KVVEEQESRV QYTVCIWRNG KLGLSGMAIA DITLLSGFHA LRADLEKLTS 
LSDRYVSHFE TDGPHVLLYF DSVPTTRECV GFGASQEVVV GLVQPSSAVL YDYYSPDHKC 
SVFYAAPTKS QLLATLCSGD VCQCAEGKCP RLLRSLERRV EDKDGYRMRF ACYYPRVEYG 
FTVKVLREDG RAAFRLFESK ITQVLHFRKD TMASIGQTRN FLSRASCRLR LEPNKEYLIM 
GMDGETSDNK GDPQYLLDSN TWIEEMPSEQ MCKSTRHRAA CFQLKDFLME FSSRGCQV

Genular Protein ID: 3610837818

Symbol: Q3TYN1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TYN1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 674
Mass: 74429
Checksum: 26050993EEC61B78
Sequence:

MRLLWGLAWV FSFCASSLQK PRLLLFSPSV VNLGTPLSVG VQLLDAPPGQ EVKGSVFLRN 
PKGGSCSPKK DFKLSSGDDF VLLSLEVPLE DVRSCGLFDL RRAPHIQLVA QSPWLRNTAF 
KATETQGVNL LFSSRRGHIF VQTDQPIYNP GQRVRYRVFA LDQKMRPSTD FLTITVENSH 
GLRVLKKEIF TSTSIFQDAF TIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE 
VKITPWKPYI LMVPSNSDEI QLDIQARYIY GKPVQGVAYT RFALMDEQGK RTFLRGLETQ 
AKLVEGRTHI SISKDQFQAA LDKINIGVRD LEGLRLYAAT AVIESPGGEM EEAELTSWRF 
VSSAFSLDLS RTKRHLVPGA HFLLQALVQE MSGSEASNVP VKVSATLVSG SDSQVLDIQQ 
STNGIGQVSI SFPIPPTVTE LRLLVSAGSL YPAIARLTVQ APPSRGTGFL SIEPLDPRSP 
SVGDTFILNL QPVGIPAPTF SHYYYMIISR GQIMAMGREP RKTVTSVSVL VDHQLAPSFY 
FVAYFYHQGH PVANSLLINI QSRDCEGKLQ LKVDGAKEYR NADMMKLRIQ TDSKALVALG 
AVDMALYAVG GRSHKPLDMS KVFEVINSYN VGCGPGGGDD ALQVFQDAGL AFSDGDRLTQ 
TREDLSCPKE KKSR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C4b

Associated with

Other Information

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects. PubMed ID: 2993295

Complete cDNA sequence of the fourth component of murine complement. PubMed ID: 3862104

Sequence of the gene for murine complement component C4. PubMed ID: 2777798

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. PubMed ID: 14656967

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp. PubMed ID: 2997024

Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes. PubMed ID: 3464002

Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp). PubMed ID: 3008092

Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein. PubMed ID: 6208559

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4. PubMed ID: 2459207

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4. PubMed ID: 2387317

Multiple duplications of complement C4 gene correlate with H-2-controlled testosterone-independent expression of its sex-limited isoform, C4-Slp. PubMed ID: 3856857

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component. PubMed ID: 6149581

cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4). PubMed ID: 6192448

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. PubMed ID: 17330941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073