Genular: Defining Cellular Identity and Function

Details for: C5ar1

Gene ID: 12273

Symbol: C5ar1

Ensembl ID: ENSMUSG00000049130

Description: complement component 5a receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Complement cascade
(R-MMU-166658)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Peptide ligand-binding receptors
(R-MMU-375276)
Regulation of complement cascade
(R-MMU-977606)
Signaling by gpcr
(R-MMU-372790)
Amyloid-beta clearance
(GO:0097242)
Apical part of cell
(GO:0045177)
Astrocyte activation
(GO:0048143)
Basolateral plasma membrane
(GO:0016323)
Cell proliferation in hindbrain
(GO:0021534)
Cell surface
(GO:0009986)
Chemotaxis
(GO:0006935)
Cognition
(GO:0050890)
Complement component c5a binding
(GO:0001856)
Complement component c5a receptor activity
(GO:0004878)
Complement component c5a signaling pathway
(GO:0038178)
Complement receptor activity
(GO:0004875)
Complement receptor mediated signaling pathway
(GO:0002430)
Cytoplasmic vesicle
(GO:0031410)
Defense response to gram-positive bacterium
(GO:0050830)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Inflammatory response
(GO:0006954)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neutrophil chemotaxis
(GO:0030593)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Presynapse organization
(GO:0099172)
Regulation of tau-protein kinase activity
(GO:1902947)
Response to peptidoglycan
(GO:0032494)
Signal transduction
(GO:0007165)

Other Information

Proteins

C5a anaphylatoxin chemotactic receptor 1

Genular Protein ID: 2263485837

Symbol: C5AR1_MOUSE

Name: C5a anaphylatoxin chemotactic receptor 1

UniProtKB Accession Codes:

P30993 Q3TZ86

Database IDs:

Citations:

PubMed ID: 1401897

Title: Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor.

PubMed ID: 1401897

PubMed ID: 16230349

Title: Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.

PubMed ID: 16230349

DOI: 10.1074/jbc.m509245200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 351
Mass: 39023
Checksum: 1186314DBAECC8F2
Sequence:

MDPIDNSSFE INYDHYGTMD PNIPADGIHL PKRQPGDVAA LIIYSVVFLV GVPGNALVVW 
VTAFEARRAV NAIWFLNLAV ADLLSCLALP VLFTTVLNHN YWYFDATACI VLPSLILLNM 
YASILLLATI SADRFLLVFK PIWCQKVRGT GLAWMACGVA WVLALLLTIP SFVYREAYKD 
FYSEHTVCGI NYGGGSFPKE KAVAILRLMV GFVLPLLTLN ICYTFLLLRT WSRKATRSTK 
TLKVVMAVVI CFFIFWLPYQ VTGVMIAWLP PSSPTLKRVE KLNSLCVSLA YINCCVNPII 
YVMAGQGFHG RLLRSLPSII RNALSEDSVG RDSKTFTPST TDTSTRKSQA V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C5ar1

Associated with

Other Information

Structural diversity in the extracellular faces of peptidergic G-protein-coupled receptors. Molecular cloning of the mouse C5a anaphylatoxin receptor. PubMed ID: 1401897

Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction. PubMed ID: 16230349

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079