Gene PLIN2 - ENSG00000147872 | NCBI Gene ID: 123

Details for: PLIN2

Gene ID: 123

Symbol: PLIN2

Ensembl ID: ENSG00000147872

Description: perilipin 2

Associated with

Autophagy
(R-HSA-9612973)
Chaperone mediated autophagy
(R-HSA-9613829)
Late endosomal microautophagy
(R-HSA-9615710)
Lipophagy
(R-HSA-9613354)
Macroautophagy
(R-HSA-1632852)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Ppara activates gene expression
(R-HSA-1989781)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Selective autophagy
(R-HSA-9663891)
Cellular response to glucose starvation
(GO:0042149)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Lipid droplet
(GO:0005811)
Lipid droplet disassembly
(GO:1905691)
Lipid storage
(GO:0019915)
Long-chain fatty acid transport
(GO:0015909)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of sequestering of triglyceride
(GO:0010890)
Protein binding
(GO:0005515)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.25
Marker Score: 110437.5
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.71
Marker Score: 69430
Cell Name: basophil (CL0000767)
Fold Change: 2.7
Marker Score: 1285
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.69
Marker Score: 1535
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.63
Marker Score: 6592
Cell Name: decidual cell (CL2000002)
Fold Change: 2.33
Marker Score: 10045
Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.26
Marker Score: 13735
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.19
Marker Score: 2185.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.96
Marker Score: 7274
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.92
Marker Score: 2193
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.91
Marker Score: 2311
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.91
Marker Score: 463.5
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.9
Marker Score: 1198.5
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.9
Marker Score: 2797
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 1.87
Marker Score: 1955
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.83
Marker Score: 20555
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 1.76
Marker Score: 2714
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.76
Marker Score: 4002
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.75
Marker Score: 9430.5
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.73
Marker Score: 11135.5
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.7
Marker Score: 2466
Cell Name: granulocyte (CL0000094)
Fold Change: 1.7
Marker Score: 763
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.7
Marker Score: 1066
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.7
Marker Score: 10860
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.7
Marker Score: 707
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.68
Marker Score: 1326
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.68
Marker Score: 6605
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.62
Marker Score: 5748
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6
Marker Score: 1682
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.59
Marker Score: 397
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.59
Marker Score: 2688
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.59
Marker Score: 3830
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.58
Marker Score: 6829
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.58
Marker Score: 397
Cell Name: Unknown (CL0002371)
Fold Change: 1.57
Marker Score: 1665.5
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.56
Marker Score: 2772.5
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.56
Marker Score: 484
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.55
Marker Score: 3012
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.52
Marker Score: 736
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.51
Marker Score: 3754
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.51
Marker Score: 372
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.5
Marker Score: 827
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.5
Marker Score: 549
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.5
Marker Score: 1016.5
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.48
Marker Score: 1262
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.48
Marker Score: 3609
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.46
Marker Score: 3046
Cell Name: keratocyte (CL0002363)
Fold Change: 1.46
Marker Score: 335
Cell Name: enterocyte (CL0000584)
Fold Change: 1.45
Marker Score: 6980
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166229
Cell Name: mature T cell (CL0002419)
Fold Change: 1.4
Marker Score: 13878
Cell Name: fat cell (CL0000136)
Fold Change: 1.4
Marker Score: 782
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.4
Marker Score: 583
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.38
Marker Score: 2218
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.38
Marker Score: 466
Cell Name: stromal cell (CL0000499)
Fold Change: 1.37
Marker Score: 1600.5
Cell Name: macrophage (CL0000235)
Fold Change: 1.37
Marker Score: 1519
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.36
Marker Score: 13832
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.35
Marker Score: 4242
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.33
Marker Score: 74491
Cell Name: blood cell (CL0000081)
Fold Change: 1.33
Marker Score: 15429
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.32
Marker Score: 2636
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.3
Marker Score: 2214.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.3
Marker Score: 2135
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.3
Marker Score: 861
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.29
Marker Score: 17068
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.29
Marker Score: 3352
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.29
Marker Score: 1360
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.28
Marker Score: 3360
Cell Name: monocyte (CL0000576)
Fold Change: 1.28
Marker Score: 1667
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.28
Marker Score: 875
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 1.28
Marker Score: 1813
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.28
Marker Score: 496
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.28
Marker Score: 1363
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.27
Marker Score: 8297
Cell Name: classical monocyte (CL0000860)
Fold Change: 1.27
Marker Score: 5273
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.27
Marker Score: 1068
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 1.25
Marker Score: 433
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.24
Marker Score: 2929
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.22
Marker Score: 1879.5
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.2
Marker Score: 852
Cell Name: reticular cell (CL0000432)
Fold Change: 1.19
Marker Score: 433.5
Cell Name: kidney cell (CL1000497)
Fold Change: 1.19
Marker Score: 792
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.18
Marker Score: 680
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.18
Marker Score: 1285
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.18
Marker Score: 3310.5
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.17
Marker Score: 267
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.16
Marker Score: 372
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 1.15
Marker Score: 861
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 17940
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.15
Marker Score: 672
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.14
Marker Score: 728.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.13
Marker Score: 1016
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.13
Marker Score: 269
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.12
Marker Score: 1610.5
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.11
Marker Score: 1190
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 1.11
Marker Score: 320
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.1
Marker Score: 1601
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.1
Marker Score: 414
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.09
Marker Score: 444.5

Hover over a box to see details here...

**Key characteristics:** * PLIN2 is a multi-functional protein that is involved in both macro- and microautophagy. * It is a key regulator of lipid metabolism and is highly expressed in tissues that are involved in energy production, such as muscle and fat cells. * PLIN2 is also involved in the regulation of inflammation and cell death. **Pathways and functions:** * PLIN2 is a key regulator of autophagy. It is recruited to the lysosome in a phosphorylation-dependent manner and then undergoes a conformational change that allows it to interact with the LC3-family of autophagy receptors. * Once bound to LC3, PLIN2 recruits the LC3-family of autophagy receptors to the lysosome, which then fuses with an autolysosome and is degraded. * PLIN2 also plays a role in the regulation of cellular response to glucose starvation. It is expressed in the liver and skeletal muscle and is induced by high-fat diet and fasting. * PLIN2 is also involved in the regulation of inflammation and cell death. It is expressed in macrophages and is activated by inflammatory stimuli. * PLIN2 is involved in the metabolism of lipids and is a key regulator of lipid storage in adipose tissue. **Clinical significance:** * Mutations in PLIN2 have been linked to several human diseases, including obesity, diabetes, and cancer. * PLIN2 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** * PLIN2 is a highly conserved protein, with a similar protein found in mammals, birds, and fish. * PLIN2 is a relatively new protein, with the gene first identified in 2004.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Perilipin-2

Genular Protein ID: 1304122457

Symbol: PLIN2_HUMAN

Name: Perilipin-2

UniProtKB Accession Codes:

Q99541 Q9BSC3

Database IDs:

Citations:

PubMed ID: 9003395

Title: Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane.

PubMed ID: 9003395

DOI: 10.1042/bj3201025

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26357594

Title: Perilipin-related protein regulates lipid metabolism in C. elegans.

PubMed ID: 26357594

DOI: 10.7717/peerj.1213

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

Sequence Information:

Length: 437
Mass: 48075
Checksum: 36411341619E53BF
Sequence:

MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 
AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 
TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 
TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 
EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 
ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 
EMDKSSQETQ RSEHKTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: PLIN2

Associated with

Cells (max top 100)

Other Information

Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. PubMed ID: 9003395

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Perilipin-related protein regulates lipid metabolism in C. elegans. PubMed ID: 26357594

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. PubMed ID: 34077757