Details for: PLIN2

Gene ID: 123

Symbol: PLIN2

Ensembl ID: ENSG00000147872

Description: perilipin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 241.3446
    Cell Significance Index: -37.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 177.8876
    Cell Significance Index: -45.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 124.1056
    Cell Significance Index: -51.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.2412
    Cell Significance Index: -44.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 106.3707
    Cell Significance Index: -50.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.5922
    Cell Significance Index: -50.2000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.1540
    Cell Significance Index: -50.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.7896
    Cell Significance Index: -45.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.6041
    Cell Significance Index: -44.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.0247
    Cell Significance Index: -47.4500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0697
    Cell Significance Index: -34.0000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.1226
    Cell Significance Index: 136.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.6166
    Cell Significance Index: 189.6700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.4432
    Cell Significance Index: 60.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.5806
    Cell Significance Index: 62.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.3380
    Cell Significance Index: 165.3600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.2323
    Cell Significance Index: 13.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1225
    Cell Significance Index: 345.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7411
    Cell Significance Index: 46.4900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6831
    Cell Significance Index: 49.4300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.6076
    Cell Significance Index: 2.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.5752
    Cell Significance Index: 94.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4669
    Cell Significance Index: 291.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3889
    Cell Significance Index: 151.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2875
    Cell Significance Index: 1162.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0818
    Cell Significance Index: 69.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9313
    Cell Significance Index: 127.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8697
    Cell Significance Index: 384.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8165
    Cell Significance Index: 38.0700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8147
    Cell Significance Index: 5.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8079
    Cell Significance Index: 37.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8064
    Cell Significance Index: 41.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7563
    Cell Significance Index: 14.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7087
    Cell Significance Index: 91.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6886
    Cell Significance Index: 18.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5406
    Cell Significance Index: 14.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5181
    Cell Significance Index: 23.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5152
    Cell Significance Index: 66.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4289
    Cell Significance Index: 6.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3923
    Cell Significance Index: 7.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3754
    Cell Significance Index: 67.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3692
    Cell Significance Index: 28.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3683
    Cell Significance Index: 12.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3191
    Cell Significance Index: 39.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2982
    Cell Significance Index: 4.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2487
    Cell Significance Index: 2.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1939
    Cell Significance Index: 3.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1832
    Cell Significance Index: 18.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1400
    Cell Significance Index: 4.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1287
    Cell Significance Index: 14.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1235
    Cell Significance Index: 67.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1040
    Cell Significance Index: 195.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0785
    Cell Significance Index: 14.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0711
    Cell Significance Index: 4.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0560
    Cell Significance Index: 42.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0502
    Cell Significance Index: 1.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0231
    Cell Significance Index: 14.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0137
    Cell Significance Index: 1.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0101
    Cell Significance Index: 1.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -11.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0076
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0172
    Cell Significance Index: -12.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0183
    Cell Significance Index: -28.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0232
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0281
    Cell Significance Index: -17.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0283
    Cell Significance Index: -4.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0393
    Cell Significance Index: -53.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0394
    Cell Significance Index: -28.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0409
    Cell Significance Index: -0.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0641
    Cell Significance Index: -36.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0763
    Cell Significance Index: -27.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0853
    Cell Significance Index: -38.7400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1090
    Cell Significance Index: -5.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1283
    Cell Significance Index: -14.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1315
    Cell Significance Index: -37.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1642
    Cell Significance Index: -32.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1784
    Cell Significance Index: -37.5800
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2274
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2640
    Cell Significance Index: -30.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2735
    Cell Significance Index: -20.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3213
    Cell Significance Index: -18.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3771
    Cell Significance Index: -5.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4401
    Cell Significance Index: -45.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4512
    Cell Significance Index: -9.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4631
    Cell Significance Index: -12.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4763
    Cell Significance Index: -11.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5005
    Cell Significance Index: -39.6400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.5085
    Cell Significance Index: -4.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5313
    Cell Significance Index: -27.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5432
    Cell Significance Index: -15.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5569
    Cell Significance Index: -5.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5807
    Cell Significance Index: -35.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5849
    Cell Significance Index: -35.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6326
    Cell Significance Index: -18.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6957
    Cell Significance Index: -46.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6975
    Cell Significance Index: -18.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7529
    Cell Significance Index: -47.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7672
    Cell Significance Index: -19.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7724
    Cell Significance Index: -24.7400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.8017
    Cell Significance Index: -3.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lipid droplet association:** PLIN2 is known to associate with lipid droplets, where it regulates the storage and mobilization of lipids. 2. **Autophagy regulation:** PLIN2 modulates autophagy, a process by which cells recycle damaged or dysfunctional components, including lipids. 3. **Metabolic regulation:** PLIN2 is involved in regulating lipid metabolism, including the transport of long-chain fatty acids and the metabolism of lipids. 4. **Cell type-specific expression:** PLIN2 is expressed in various cell types, including fibroblasts, macrophages, and skeletal muscle fibers. 5. **Regulation by PPARα:** PLIN2 is a target gene of Peroxisome Proliferator-Activated Receptor alpha (PPARα), a transcription factor that regulates lipid metabolism. **Pathways and Functions:** 1. **Autophagy:** PLIN2 regulates autophagy by modulating the activity of autophagy-related proteins, such as LC3 and ATG7. 2. **Lipid metabolism:** PLIN2 regulates lipid metabolism by controlling the storage and mobilization of lipids within lipid droplets. 3. **Long-chain fatty acid transport:** PLIN2 is involved in the transport of long-chain fatty acids, which is essential for lipid metabolism. 4. **Metabolism of lipids:** PLIN2 regulates the metabolism of lipids, including the breakdown of triglycerides and the synthesis of phospholipids. 5. **Response to glucose starvation:** PLIN2 is upregulated in response to glucose starvation, which is a critical event in the regulation of lipid metabolism. **Clinical Significance:** 1. **Metabolic disorders:** PLIN2 dysregulation has been implicated in various metabolic disorders, including obesity, type 2 diabetes, and dyslipidemia. 2. **Cancer:** PLIN2 has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 3. **Autophagy-related diseases:** PLIN2 dysregulation has been implicated in autophagy-related diseases, including neurodegenerative diseases and metabolic disorders. 4. **Therapeutic targeting:** PLIN2 is a potential therapeutic target for the treatment of metabolic disorders and autophagy-related diseases. In conclusion, PLIN2 is a complex protein that plays a critical role in regulating lipid metabolism and autophagy. Its dysregulation has been implicated in various metabolic disorders and autophagy-related diseases, making it a potential therapeutic target for the treatment of these conditions. Further studies are needed to fully elucidate the mechanisms by which PLIN2 regulates lipid metabolism and autophagy, and to explore its potential as a therapeutic target.

Genular Protein ID: 1304122457

Symbol: PLIN2_HUMAN

Name: Adipophilin

UniProtKB Accession Codes:

Q99541 Q9BSC3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9003395

Title: Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane.

PubMed ID: 9003395

DOI: 10.1042/bj3201025

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26357594

Title: Perilipin-related protein regulates lipid metabolism in C. elegans.

PubMed ID: 26357594

DOI: 10.7717/peerj.1213

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

Sequence Information:

  • Length: 437
  • Mass: 48075
  • Checksum: 36411341619E53BF
  • Sequence:
    • MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA ENGVKTITSV 
AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP STQIVANAKG AVTGAKDAVT 
TTVTGAKDSV ASTITGVMDK TKGAVTGSVE KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL 
TKSELLVEQY LPLTEEELEK EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK 
EAKQKSQQTI SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES 
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA GDIYSVFRNA 
ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW LVGPFYPQLT ESQNAQDQGA 
EMDKSSQETQ RSEHKTH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.