Details for: CCR1

Gene ID: 1230

Symbol: CCR1

Ensembl ID: ENSG00000163823

Description: C-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1988
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.96
    Marker Score: 1959
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.81
    Marker Score: 997
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1164
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.51
    Marker Score: 3064
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.44
    Marker Score: 80755
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.44
    Marker Score: 600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.32
    Marker Score: 8025
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.28
    Marker Score: 1470
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 691
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.15
    Marker Score: 469
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.13
    Marker Score: 2807
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.08
    Marker Score: 537
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 369
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.9
    Marker Score: 2336
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.83
    Marker Score: 848
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.83
    Marker Score: 21250
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1512
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.8
    Marker Score: 3314
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.73
    Marker Score: 8456
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456.5
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.69
    Marker Score: 554
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1106
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.62
    Marker Score: 1722
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.58
    Marker Score: 1130
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.56
    Marker Score: 1355
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.55
    Marker Score: 200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.54
    Marker Score: 600
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.53
    Marker Score: 340
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.53
    Marker Score: 635
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7604
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.47
    Marker Score: 234
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.45
    Marker Score: 821.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.45
    Marker Score: 144
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.43
    Marker Score: 150
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.41
    Marker Score: 537
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.35
    Marker Score: 183
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.35
    Marker Score: 2337
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.35
    Marker Score: 308
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 91
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.32
    Marker Score: 87
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.31
    Marker Score: 3072
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.3
    Marker Score: 76
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 163
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.27
    Marker Score: 182
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.26
    Marker Score: 266
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.26
    Marker Score: 284
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.25
    Marker Score: 205
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.25
    Marker Score: 143
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.25
    Marker Score: 169
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 116
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 293
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.22
    Marker Score: 1395
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 87
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.19
    Marker Score: 182.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.18
    Marker Score: 53
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.17
    Marker Score: 145
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.17
    Marker Score: 86
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 157
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.16
    Marker Score: 176
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.16
    Marker Score: 114
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.16
    Marker Score: 34
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.16
    Marker Score: 33

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Other Information

**Key characteristics:** * CCR1 is a transmembrane protein with a single extracellular domain that binds to chemokines and a cytoplasmic domain that is involved in signaling. * It is a member of the C-C chemokine receptor family, which are a large group of receptors that are expressed in various immune cells. * CCR1 is a key regulator of inflammation and immune responses. * It is expressed in high levels in the epithelium of the large intestine, suggesting a role in maintaining intestinal homeostasis. **Pathways and functions:** * CCR1 binds to various chemokines, including CCL-1, CCL-3, and CCL-5. * Upon binding to a chemokine, CCR1 undergoes a conformational change that activates its cytoplasmic domain. * The activated CCR1 recruits and activates GPCRs, which are coupled to intracellular signaling pathways. * These pathways can lead to the production of cytokines and chemokines, which can amplify and regulate inflammatory responses. * CCR1 also plays a role in regulating immune cell migration and trafficking. **Clinical significance:** * Mutations in the CCR1 gene have been linked to inflammatory diseases, including inflammatory bowel disease (IBD), asthma, and cancer. * CCR1 inhibitors are being investigated as potential therapeutics for these diseases. * Understanding the role of CCR1 in inflammation and immune responses could lead to the development of new treatments for inflammatory diseases. **Additional notes:** * CCR1 is a highly conserved protein, with a similar sequence found in mammals, birds, and fish. * It is a key regulator of innate immunity and is expressed in high levels in the mucosa of the large intestine. * CCR1 is also expressed in some tumor cells, where it can promote tumor growth and metastasis.

Genular Protein ID: 843499110

Symbol: CCR1_HUMAN

Name: C-C chemokine receptor type 1

UniProtKB Accession Codes:

P32246 Q86VA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7679328

Title: Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.

PubMed ID: 7679328

DOI: 10.1016/0092-8674(93)90118-a

PubMed ID: 7683036

Title: Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.

PubMed ID: 7683036

DOI: 10.1084/jem.177.5.1421

PubMed ID: 7505609

Title: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.

PubMed ID: 7505609

DOI: 10.1093/intimm/5.10.1239

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15001559

Title: Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.

PubMed ID: 15001559

DOI: 10.1096/fj.03-0867fje

PubMed ID: 18587271

Title: Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration.

PubMed ID: 18587271

DOI: 10.3858/emm.2008.40.3.332

Sequence Information:

  • Length: 355
  • Mass: 41173
  • Checksum: B2C100FFED275985
  • Sequence:
    • METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV 
QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH 
HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL 
IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.