Details for: CCR1

Gene ID: 1230

Symbol: CCR1

Ensembl ID: ENSG00000163823

Description: C-C motif chemokine receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 50.5962
    Cell Significance Index: -7.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.0278
    Cell Significance Index: -7.8700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 9.2799
    Cell Significance Index: 24.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.3911
    Cell Significance Index: -7.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.7672
    Cell Significance Index: 144.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 5.0816
    Cell Significance Index: 146.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.5213
    Cell Significance Index: 54.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.8635
    Cell Significance Index: 59.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4777
    Cell Significance Index: -7.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.3704
    Cell Significance Index: -6.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0672
    Cell Significance Index: 93.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6686
    Cell Significance Index: 30.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5627
    Cell Significance Index: 33.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4258
    Cell Significance Index: 271.3400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1533
    Cell Significance Index: 36.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1528
    Cell Significance Index: 114.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9355
    Cell Significance Index: 844.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5780
    Cell Significance Index: 8.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4922
    Cell Significance Index: 80.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4618
    Cell Significance Index: 9.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4478
    Cell Significance Index: 48.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3917
    Cell Significance Index: 82.5100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2961
    Cell Significance Index: 1.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2450
    Cell Significance Index: 16.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2107
    Cell Significance Index: 156.0900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0865
    Cell Significance Index: 1.0700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.0617
    Cell Significance Index: 0.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0606
    Cell Significance Index: 37.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0445
    Cell Significance Index: 2.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0067
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0083
    Cell Significance Index: -1.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0086
    Cell Significance Index: -11.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0098
    Cell Significance Index: -7.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0132
    Cell Significance Index: -0.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0148
    Cell Significance Index: -8.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0170
    Cell Significance Index: -3.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0194
    Cell Significance Index: -8.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0215
    Cell Significance Index: -7.7100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0239
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0241
    Cell Significance Index: -6.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0275
    Cell Significance Index: -2.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0392
    Cell Significance Index: -4.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0402
    Cell Significance Index: -8.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0414
    Cell Significance Index: -7.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0441
    Cell Significance Index: -6.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0485
    Cell Significance Index: -1.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0568
    Cell Significance Index: -8.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0630
    Cell Significance Index: -8.0700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: -0.0635
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0638
    Cell Significance Index: -7.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0698
    Cell Significance Index: -8.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0718
    Cell Significance Index: -9.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0721
    Cell Significance Index: -8.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0738
    Cell Significance Index: -8.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0760
    Cell Significance Index: -1.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0897
    Cell Significance Index: -2.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1006
    Cell Significance Index: -6.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1042
    Cell Significance Index: -0.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1079
    Cell Significance Index: -4.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1089
    Cell Significance Index: -8.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1110
    Cell Significance Index: -8.7900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1206
    Cell Significance Index: -0.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1224
    Cell Significance Index: -8.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1247
    Cell Significance Index: -3.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1360
    Cell Significance Index: -2.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1406
    Cell Significance Index: -6.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1476
    Cell Significance Index: -9.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1590
    Cell Significance Index: -8.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1741
    Cell Significance Index: -9.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1823
    Cell Significance Index: -9.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1826
    Cell Significance Index: -3.5700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.1874
    Cell Significance Index: -0.7800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1887
    Cell Significance Index: -1.6500
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1920
    Cell Significance Index: -1.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1962
    Cell Significance Index: -9.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2019
    Cell Significance Index: -8.9300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2134
    Cell Significance Index: -5.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2204
    Cell Significance Index: -7.7200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2224
    Cell Significance Index: -1.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2261
    Cell Significance Index: -8.5600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2383
    Cell Significance Index: -2.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2517
    Cell Significance Index: -8.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2581
    Cell Significance Index: -8.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2652
    Cell Significance Index: -7.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2670
    Cell Significance Index: -9.8000
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2683
    Cell Significance Index: -2.4600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2757
    Cell Significance Index: -3.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2880
    Cell Significance Index: -8.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2986
    Cell Significance Index: -8.8000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3093
    Cell Significance Index: -2.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3137
    Cell Significance Index: -8.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3159
    Cell Significance Index: -8.1200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3178
    Cell Significance Index: -8.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Chemokine receptor**: CCR1 is a C-C chemokine receptor that binds to specific chemokines, such as CCL3, CCL4, and CCL5, to regulate immune cell migration, adhesion, and activation. 2. **Immune cell expression**: CCR1 is significantly expressed on various immune cells, including monocytes, macrophages, dendritic cells, and immature innate lymphoid cells, which are essential for immune responses. 3. **Receptor activity**: CCR1 is a G-protein coupled receptor that activates signaling pathways, including calcium-mediated signaling, phospholipase C activity, and protein kinase C activation. 4. **Regulation of immune responses**: CCR1 plays a crucial role in regulating immune responses, including chemotaxis, cell adhesion, and signaling pathways, to prevent excessive inflammation and maintain tissue homeostasis. **Pathways and Functions** 1. **Chemotaxis**: CCR1 regulates the migration of immune cells towards chemokines, facilitating the recruitment of immune cells to sites of inflammation. 2. **Cell adhesion**: CCR1 promotes the adhesion of immune cells to endothelial cells, enabling their migration into tissues. 3. **Calcium-mediated signaling**: CCR1 activates calcium-mediated signaling pathways, which regulate various cellular processes, including cell migration, proliferation, and differentiation. 4. **Phospholipase C activity**: CCR1 activates phospholipase C, leading to the production of inositol trisphosphate and diacylglycerol, which regulate cellular signaling pathways. 5. **Signaling by GPCRs**: CCR1 is a member of the G-protein coupled receptor family, which regulates various cellular processes, including cell migration, proliferation, and differentiation. **Clinical Significance** 1. **Inflammatory diseases**: CCR1 has been implicated in the pathogenesis of various inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Cancer**: CCR1 has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in cancer progression and metastasis. 3. **Immunodeficiency disorders**: CCR1 has been linked to immunodeficiency disorders, such as chronic granulomatous disease, which highlights its importance in immune cell function and development. 4. **Infectious diseases**: CCR1 has been implicated in the pathogenesis of infectious diseases, including tuberculosis and malaria, suggesting its potential role in immune responses to infection. In conclusion, CCR1 is a critical component of the immune system, regulating immune responses, chemotaxis, cell adhesion, and signaling pathways. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of CCR1 in immune function and disease.

Genular Protein ID: 843499110

Symbol: CCR1_HUMAN

Name: C-C chemokine receptor type 1

UniProtKB Accession Codes:

P32246 Q86VA9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 5 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 34 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7679328

Title: Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.

PubMed ID: 7679328

DOI: 10.1016/0092-8674(93)90118-a

PubMed ID: 7683036

Title: Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor.

PubMed ID: 7683036

DOI: 10.1084/jem.177.5.1421

PubMed ID: 7505609

Title: Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors.

PubMed ID: 7505609

DOI: 10.1093/intimm/5.10.1239

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15001559

Title: Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines.

PubMed ID: 15001559

DOI: 10.1096/fj.03-0867fje

PubMed ID: 14991608

Title: Differential chemokine activation of CC chemokine receptor 1-regulated pathways: ligand selective activation of Galpha 14-coupled pathways.

PubMed ID: 14991608

DOI: 10.1002/eji.200324166

PubMed ID: 15905581

Title: Proteolytic activation of alternative CCR1 ligands in inflammation.

PubMed ID: 15905581

DOI: 10.4049/jimmunol.174.11.7341

PubMed ID: 18587271

Title: Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration.

PubMed ID: 18587271

DOI: 10.3858/emm.2008.40.3.332

PubMed ID: 29930254

Title: CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.

PubMed ID: 29930254

DOI: 10.1038/s41598-018-27710-9

PubMed ID: 34949837

Title: Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.

PubMed ID: 34949837

DOI: 10.1038/s41589-021-00918-z

Sequence Information:

  • Length: 355
  • Mass: 41173
  • Checksum: B2C100FFED275985
  • Sequence:
    • METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV 
QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH 
HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL 
IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI 
YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.