Genular: Defining Cellular Identity and Function

Details for: Anxa2

Gene ID: 12306

Symbol: Anxa2

Ensembl ID: ENSMUSG00000032231

Description: annexin A2

Associated with

Dissolution of fibrin clot
(R-MMU-75205)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Angiogenesis
(GO:0001525)
Anxa2-p11 complex
(GO:1990665)
Basement membrane
(GO:0005604)
Basolateral plasma membrane
(GO:0016323)
Body fluid secretion
(GO:0007589)
Bone sialoprotein binding
(GO:0044730)
Calcium-dependent phospholipid binding
(GO:0005544)
Calcium-dependent protein binding
(GO:0048306)
Calcium ion binding
(GO:0005509)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell cortex
(GO:0005938)
Cell junction
(GO:0030054)
Cell surface
(GO:0009986)
Cellular response to acid chemical
(GO:0071229)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen fibril organization
(GO:0030199)
Cornified envelope
(GO:0001533)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Epithelial cell apoptotic process
(GO:1904019)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibrinolysis
(GO:0042730)
Identical protein binding
(GO:0042802)
Late endosome membrane
(GO:0031902)
Lipid droplet
(GO:0005811)
Lung development
(GO:0030324)
Lysosomal membrane
(GO:0005765)
Macropinosome
(GO:0044354)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Midbody
(GO:0030496)
Mrna transcription by rna polymerase ii
(GO:0042789)
Myelin sheath adaxonal region
(GO:0035749)
Negative regulation of low-density lipoprotein particle receptor catabolic process
(GO:0032804)
Nuclear matrix
(GO:0016363)
Pcsk9-anxa2 complex
(GO:1990667)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Phosphatidylserine binding
(GO:0001786)
Phospholipase a2 inhibitor activity
(GO:0019834)
Phospholipase inhibitor activity
(GO:0004859)
Plasma membrane
(GO:0005886)
Plasma membrane protein complex
(GO:0098797)
Positive regulation of binding
(GO:0051099)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of low-density lipoprotein particle clearance
(GO:1905581)
Positive regulation of low-density lipoprotein particle receptor binding
(GO:1905597)
Positive regulation of low-density lipoprotein receptor activity
(GO:1905599)
Positive regulation of plasma membrane repair
(GO:1905686)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor-mediated endocytosis involved in cholesterol transport
(GO:1905602)
Positive regulation of receptor recycling
(GO:0001921)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
Regulation of neurogenesis
(GO:0050767)
Response to activity
(GO:0014823)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Ruffle
(GO:0001726)
S100 protein binding
(GO:0044548)
Sarcolemma
(GO:0042383)
Schmidt-lanterman incisure
(GO:0043220)
Serine-type endopeptidase inhibitor activity
(GO:0004867)
Small gtpase binding
(GO:0031267)
Stress fiber
(GO:0001725)
Vesicle
(GO:0031982)

Other Information

Proteins

Annexin A2

Genular Protein ID: 361270183

Symbol: ANXA2_MOUSE

Name: Annexin A2

UniProtKB Accession Codes:

P07356

Database IDs:

Citations:

PubMed ID: 3013423

Title: The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats.

PubMed ID: 3013423

DOI: 10.1016/0092-8674(86)90737-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2138915

Title: Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene.

PubMed ID: 2138915

DOI: 10.1021/bi00457a019

PubMed ID: 8634333

Title: Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons.

PubMed ID: 8634333

DOI: 10.1016/0167-4781(95)00238-3

PubMed ID: 14506282

Title: Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.

PubMed ID: 14506282

DOI: 10.1074/jbc.m307247200

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21645192

Title: Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.

PubMed ID: 21645192

DOI: 10.1111/j.1600-0854.2011.01226.x

PubMed ID: 22848640

Title: Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation.

PubMed ID: 22848640

DOI: 10.1371/journal.pone.0041865

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 339
Mass: 38676
Checksum: 4407E572097FB2C0
Sequence:

MSTVHEILCK LSLEGDHSTP PSAYGSVKPY TNFDAERDAL NIETAVKTKG VDEVTIVNIL 
TNRSNVQRQD IAFAYQRRTK KELPSALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG 
LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDII SDTSGDFRKL MVALAKGRRA 
EDGSVIDYEL IDQDARELYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM 
LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM 
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Anxa2

Associated with

Other Information

The cDNA sequence for the protein-tyrosine kinase substrate p36 (calpactin I heavy chain) reveals a multidomain protein with internal repeats. PubMed ID: 3013423

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure and chromosome assignment of the murine p36 (calpactin I heavy chain) gene. PubMed ID: 2138915

Complete structure of the murine p36 (annexin II) gene. Identification of mRNAs for both the murine and the human gene with alternatively spliced 5' noncoding exons. PubMed ID: 8634333

Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. PubMed ID: 14506282

Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. PubMed ID: 16139798

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment. PubMed ID: 21645192

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. PubMed ID: 22848640

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337