Calr | ENSMUSG00000003814 | NCBI 12317

Details for: Calr

Gene ID: 12317

Symbol: Calr

Ensembl ID: ENSMUSG00000003814

Description: calreticulin

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-MMU-983170)
Antigen processing-cross presentation
(R-MMU-1236975)
Asparagine n-linked glycosylation
(R-MMU-446203)
Binding and uptake of ligands by scavenger receptors
(R-MMU-2173782)
Calnexin/calreticulin cycle
(R-MMU-901042)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Er-phagosome pathway
(R-MMU-1236974)
Immune system
(R-MMU-168256)
Metabolism of proteins
(R-MMU-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-MMU-532668)
Post-translational protein modification
(R-MMU-597592)
Scavenging by class a receptors
(R-MMU-3000480)
Vesicle-mediated transport
(R-MMU-5653656)
Acrosomal vesicle
(GO:0001669)
Calcium ion binding
(GO:0005509)
Carbohydrate binding
(GO:0030246)
Cell surface
(GO:0009986)
Cellular senescence
(GO:0090398)
Collagen-containing extracellular matrix
(GO:0062023)
Complement component c1q complex binding
(GO:0001849)
Cortical actin cytoskeleton organization
(GO:0030866)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum quality control compartment
(GO:0044322)
Erad pathway
(GO:0036503)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hormone binding
(GO:0042562)
Integrin binding
(GO:0005178)
Iron ion binding
(GO:0005506)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mhc class i peptide loading complex
(GO:0042824)
Molecular sequestering activity
(GO:0140313)
Mrna binding
(GO:0003729)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of intracellular steroid hormone receptor signaling pathway
(GO:0033144)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of retinoic acid receptor signaling pathway
(GO:0048387)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of translation
(GO:0017148)
Negative regulation of trophoblast cell migration
(GO:1901164)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear envelope
(GO:0005635)
Nuclear export signal receptor activity
(GO:0005049)
Nucleus
(GO:0005634)
Peptide antigen assembly with mhc class i protein complex
(GO:0002502)
Peptide binding
(GO:0042277)
Perinuclear region of cytoplasm
(GO:0048471)
Phagocytic vesicle
(GO:0045335)
Positive regulation of cell cycle
(GO:0045787)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of non-canonical nf-kappab signal transduction
(GO:1901224)
Positive regulation of phagocytosis
(GO:0050766)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein export from nucleus
(GO:0006611)
Protein folding
(GO:0006457)
Protein localization to nucleus
(GO:0034504)
Protein stabilization
(GO:0050821)
Regulation of meiotic nuclear division
(GO:0040020)
Ribosome
(GO:0005840)
Sarcoplasmic reticulum
(GO:0016529)
Smooth endoplasmic reticulum
(GO:0005790)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Calreticulin

Genular Protein ID: 2402769006

Symbol: CALR_MOUSE

Name: Calreticulin

UniProtKB Accession Codes:

P14211 Q3TVD2

Database IDs:

Citations:

PubMed ID: 2583110

Title: Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein.

PubMed ID: 2583110

DOI: 10.1002/j.1460-2075.1989.tb08530.x

PubMed ID: 1398135

Title: Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method.

PubMed ID: 1398135

DOI: 10.1016/0378-1119(92)90096-8

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7523108

Title: Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.

PubMed ID: 7523108

DOI: 10.1002/elps.11501501101

PubMed ID: 8418194

Title: The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes.

PubMed ID: 8418194

DOI: 10.1084/jem.177.1.1

PubMed ID: 16931514

Title: Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

PubMed ID: 16931514

DOI: 10.1074/jbc.m605701200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20801878

Title: Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain.

PubMed ID: 20801878

DOI: 10.1074/jbc.m110.160101

PubMed ID: 24256100

Title: A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome.

PubMed ID: 24256100

DOI: 10.1186/1471-2121-14-50

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 20880849

Title: Structural basis of carbohydrate recognition by calreticulin.

PubMed ID: 20880849

DOI: 10.1074/jbc.m110.168294

PubMed ID: 21652723

Title: Structural and functional relationships between the lectin and arm domains of calreticulin.

PubMed ID: 21652723

DOI: 10.1074/jbc.m111.258467

Sequence Information:

Length: 416
Mass: 47995
Checksum: 24C03B00913408D8
Sequence:

MLLSVPLLLG LLGLAAADPA IYFKEQFLDG DAWTNRWVES KHKSDFGKFV LSSGKFYGDL 
EKDKGLQTSQ DARFYALSAK FEPFSNKGQT LVVQFTVKHE QNIDCGGGYV KLFPSGLDQK 
DMHGDSEYNI MFGPDICGPG TKKVHVIFNY KGKNVLINKD IRCKDDEFTH LYTLIVRPDN 
TYEVKIDNSQ VESGSLEDDW DFLPPKKIKD PDAAKPEDWD ERAKIDDPTD SKPEDWDKPE 
HIPDPDAKKP EDWDEEMDGE WEPPVIQNPE YKGEWKPRQI DNPDYKGTWI HPEIDNPEYS 
PDANIYAYDS FAVLGLDLWQ VKSGTIFDNF LITNDEAYAE EFGNETWGVT KAAEKQMKDK 
QDEEQRLKEE EEDKKRKEEE EAEDKEDDDD RDEDEDEEDE KEEDEEESPG QAKDEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Calr

Associated with

Other Information

Multiple zones in the sequence of calreticulin (CRP55, calregulin, HACBP), a major calcium binding ER/SR protein. PubMed ID: 2583110

Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method. PubMed ID: 1398135

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis. PubMed ID: 7523108

The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. PubMed ID: 8418194

Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. PubMed ID: 16931514

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain. PubMed ID: 20801878

A mouse protein that localizes to acrosome and sperm tail is regulated by Y-chromosome. PubMed ID: 24256100

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Structural basis of carbohydrate recognition by calreticulin. PubMed ID: 20880849

Structural and functional relationships between the lectin and arm domains of calreticulin. PubMed ID: 21652723