Details for: CCR3

Gene ID: 1232

Symbol: CCR3

Ensembl ID: ENSG00000183625

Description: C-C motif chemokine receptor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 2.7200
    Cell Significance Index: -1.1100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.4907
    Cell Significance Index: 7.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.4425
    Cell Significance Index: 6.4300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2721
    Cell Significance Index: 6.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0820
    Cell Significance Index: 2.4100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0809
    Cell Significance Index: 2.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0677
    Cell Significance Index: 1.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0670
    Cell Significance Index: 1.7900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0379
    Cell Significance Index: 0.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0358
    Cell Significance Index: 0.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0334
    Cell Significance Index: 6.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0287
    Cell Significance Index: 5.6900
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.0237
    Cell Significance Index: 0.2100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0171
    Cell Significance Index: 0.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0137
    Cell Significance Index: 0.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0093
    Cell Significance Index: 0.4700
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.0092
    Cell Significance Index: 0.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0091
    Cell Significance Index: 0.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0081
    Cell Significance Index: 0.9900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.0064
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0057
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0021
    Cell Significance Index: 0.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0019
    Cell Significance Index: 2.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0003
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0010
    Cell Significance Index: -0.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0011
    Cell Significance Index: -0.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0015
    Cell Significance Index: -1.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0032
    Cell Significance Index: -0.1400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0047
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0063
    Cell Significance Index: -1.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0078
    Cell Significance Index: -0.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0078
    Cell Significance Index: -1.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0085
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0100
    Cell Significance Index: -1.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0117
    Cell Significance Index: -0.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0136
    Cell Significance Index: -1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0150
    Cell Significance Index: -0.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0151
    Cell Significance Index: -0.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0163
    Cell Significance Index: -1.0000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0164
    Cell Significance Index: -0.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0174
    Cell Significance Index: -0.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0192
    Cell Significance Index: -0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0202
    Cell Significance Index: -0.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0203
    Cell Significance Index: -0.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0212
    Cell Significance Index: -1.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0213
    Cell Significance Index: -1.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0214
    Cell Significance Index: -0.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0226
    Cell Significance Index: -1.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0229
    Cell Significance Index: -0.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0235
    Cell Significance Index: -1.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0246
    Cell Significance Index: -0.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0254
    Cell Significance Index: -0.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0258
    Cell Significance Index: -0.2100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0280
    Cell Significance Index: -0.3300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0289
    Cell Significance Index: -0.8500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0294
    Cell Significance Index: -0.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0301
    Cell Significance Index: -0.7500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0316
    Cell Significance Index: -1.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0316
    Cell Significance Index: -0.9100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0333
    Cell Significance Index: -0.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0334
    Cell Significance Index: -0.6600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0345
    Cell Significance Index: -0.4600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0352
    Cell Significance Index: -0.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0368
    Cell Significance Index: -1.0500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0385
    Cell Significance Index: -0.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0386
    Cell Significance Index: -0.3600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0419
    Cell Significance Index: -0.4500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0433
    Cell Significance Index: -0.6000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0436
    Cell Significance Index: -0.9100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0442
    Cell Significance Index: -0.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0458
    Cell Significance Index: -0.7900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0462
    Cell Significance Index: -0.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0471
    Cell Significance Index: -1.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0478
    Cell Significance Index: -1.2200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0481
    Cell Significance Index: -1.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0489
    Cell Significance Index: -0.5700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0503
    Cell Significance Index: -0.8700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0506
    Cell Significance Index: -0.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0507
    Cell Significance Index: -1.3800
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0509
    Cell Significance Index: -0.6400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0510
    Cell Significance Index: -0.6600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0512
    Cell Significance Index: -1.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0515
    Cell Significance Index: -0.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0520
    Cell Significance Index: -0.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0528
    Cell Significance Index: -0.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** CCR3 is a seven-transmembrane GPCR that binds to its specific ligands, leading to the activation of Gαi signaling pathways. This activation results in the modulation of adenylate cyclase activity, influencing cellular responses such as chemotaxis, cell adhesion, and immune response. 2. **Ligand Binding:** CCR3 binds to eotaxin-1, a chemokine produced by various cells, including epithelial cells and immune cells. This binding event triggers the activation of Gαi signaling pathways, leading to the regulation of immune responses. 3. **Cellular Expression:** CCR3 is highly expressed in various cell types, including immature innate lymphoid cells, blood vessel endothelial cells, and goblet cells. This widespread expression highlights the importance of CCR3 in regulating immune responses and inflammation in different tissues. 4. **Signaling Pathways:** CCR3 activation leads to the activation of several signaling pathways, including calcium-mediated signaling, cell adhesion, and chemotaxis. These pathways are crucial for the regulation of immune responses and inflammation. **Pathways and Functions:** 1. **Adenylate Cyclase-Modulating G Protein-Coupled Receptor Signaling Pathway:** CCR3 activation leads to the modulation of adenylate cyclase activity, influencing cellular responses such as chemotaxis and cell adhesion. 2. **Chemokine-Mediated Signaling Pathway:** CCR3 binds to its specific ligands, leading to the activation of Gαi signaling pathways, which regulate immune responses and inflammation. 3. **Cell Chemotaxis:** CCR3 activation leads to the regulation of chemotaxis, allowing cells to migrate towards or away from specific ligands. 4. **Immune Response:** CCR3 plays a crucial role in regulating immune responses, including the recruitment of immune cells to sites of inflammation. 5. **Inflammatory Response:** CCR3 is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of inflammation. **Clinical Significance:** The CCR3 gene has been implicated in various diseases, including: 1. **Asthma:** CCR3 is involved in the regulation of airway inflammation and the recruitment of eosinophils to the airways. 2. **Allergic Rhinitis:** CCR3 is involved in the regulation of nasal inflammation and the recruitment of eosinophils to the nasal mucosa. 3. **Cancer:** CCR3 has been implicated in the regulation of angiogenesis and the recruitment of immune cells to tumor sites. 4. **Infectious Diseases:** CCR3 is involved in the regulation of immune responses to infections, including the recruitment of immune cells to sites of infection. In conclusion, the CCR3 gene plays a crucial role in regulating immune responses and inflammation. Its involvement in various diseases highlights the importance of CCR3 in maintaining immune homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which CCR3 regulates immune responses and inflammation.

Genular Protein ID: 351032383

Symbol: CCR3_HUMAN

Name: C-C chemokine receptor type 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7622448

Title: Cloning and functional expression of a human eosinophil CC chemokine receptor.

PubMed ID: 7622448

DOI: 10.1074/jbc.270.28.16491

PubMed ID: 8642344

Title: Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

PubMed ID: 8642344

DOI: 10.1084/jem.183.5.2349

PubMed ID: 8676064

Title: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

PubMed ID: 8676064

DOI: 10.1084/jem.183.6.2437

PubMed ID: 11196669

Title: New variations of human CC-chemokine receptors CCR3 and CCR4.

PubMed ID: 11196669

DOI: 10.1038/sj.gene.6363638

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9789057

Title: HIV-1 Tat protein mimicry of chemokines.

PubMed ID: 9789057

DOI: 10.1073/pnas.95.22.13153

PubMed ID: 21077277

Title: Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies.

PubMed ID: 21077277

DOI: 10.1111/j.1365-2249.2010.04248.x

PubMed ID: 30171954

Title: Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.

PubMed ID: 30171954

DOI: 10.1016/j.ijbiomac.2018.08.171

Sequence Information:

  • Length: 355
  • Mass: 41044
  • Checksum: E95DCD7A6C643874
  • Sequence:
  • MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 
    KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 
    IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 
    TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 
    IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 
    YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

Genular Protein ID: 3128773599

Symbol: Q8TDP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 80
  • Mass: 8983
  • Checksum: 1C9D63F3BF54135B
  • Sequence:
  • MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 
    KYRRLRIMTN IYLLNLAISD

Genular Protein ID: 4005947359

Symbol: Q8TDP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 21
  • Mass: 2303
  • Checksum: 92F22DCE5269BBF1
  • Sequence:
  • MTTSLDTVET FGTTSYYDDV G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.