Details for: CCR3

Gene ID: 1232

Symbol: CCR3

Ensembl ID: ENSG00000183625

Description: C-C motif chemokine receptor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.28
    Marker Score: 9577
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.12
    Marker Score: 8959
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.34
    Marker Score: 2358
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.89
    Marker Score: 3838
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.59
    Marker Score: 3282
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.44
    Marker Score: 863
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2349
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7577
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.02
    Marker Score: 2582
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.01
    Marker Score: 325
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48054
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14162
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.89
    Marker Score: 7518
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.7
    Marker Score: 390
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 125
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.44
    Marker Score: 211
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.38
    Marker Score: 367.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.35
    Marker Score: 156
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.32
    Marker Score: 209
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 134
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 282
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 146
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.22
    Marker Score: 182
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 402
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.16
    Marker Score: 108.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 93
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.12
    Marker Score: 123
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.12
    Marker Score: 214
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.11
    Marker Score: 83
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 133
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 160
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 55
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.09
    Marker Score: 593
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.09
    Marker Score: 148
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.09
    Marker Score: 56
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 84
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.08
    Marker Score: 38
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.08
    Marker Score: 143
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.08
    Marker Score: 73
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 46
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.08
    Marker Score: 174
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.08
    Marker Score: 270
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.07
    Marker Score: 64
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.07
    Marker Score: 72
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.07
    Marker Score: 73
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.06
    Marker Score: 29
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: group 2 innate lymphoid cell (CL0001069)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.06
    Marker Score: 74
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.06
    Marker Score: 65
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 55
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.05
    Marker Score: 54

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Other Information

**Key characteristics:** * CCR3 is a transmembrane protein with a molecular weight of approximately 180 kDa. * It is a member of the chemokine receptor superfamily. * CCR3 is expressed in high levels in endothelial cells, where it is involved in the regulation of vascular permeability and inflammation. * It is also expressed in immune cells, where it plays a role in the regulation of immune responses. * CCR3 is a key regulator of inflammation and cancer development. **Pathways and functions:** * CCR3 is a key regulator of the adenylate cyclase-modulating g protein-coupled receptor (ACMGPR) signaling pathway. * It is also a receptor for C-c chemokines, which are a family of proteins that are expressed in inflammation and cancer. * CCR3 signaling through the ACMGPR pathway leads to the activation of the G alpha (i) signaling cascade, which is a major pathway of inflammation. * This activation of the G alpha (i) pathway leads to the production of inflammatory cytokines and chemokines, which can promote inflammation and cancer growth. **Clinical significance:** * Mutations in the CCR3 gene have been linked to a number of human diseases, including rheumatoid arthritis, asthma, and cancer. * CCR3 inhibitors are being developed as novel therapies for these diseases. * CCR3 is a promising target for the treatment of inflammation and cancer. **Additional information:** * CCR3 is a highly conserved protein. It is expressed in mammals and birds, but it is not found in reptiles or amphibians. * CCR3 is a heterodimeric protein. It consists of two transmembrane subunits that are held together by a disulfide bond. * CCR3 is a constitutively active protein. This means that it is always active, regardless of the concentration of its ligand.

Genular Protein ID: 351032383

Symbol: CCR3_HUMAN

Name: C-C chemokine receptor type 3

UniProtKB Accession Codes:

P51677 B3KVQ1 F5GWL6 Q15748 Q2YDB9 Q86WD2 Q8TDP6 Q9ULY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 EMDB 1 Ensembl 4 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7622448

Title: Cloning and functional expression of a human eosinophil CC chemokine receptor.

PubMed ID: 7622448

DOI: 10.1074/jbc.270.28.16491

PubMed ID: 8642344

Title: Cloning, expression, and characterization of the human eosinophil eotaxin receptor.

PubMed ID: 8642344

DOI: 10.1084/jem.183.5.2349

PubMed ID: 8676064

Title: Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils.

PubMed ID: 8676064

DOI: 10.1084/jem.183.6.2437

PubMed ID: 11196669

Title: New variations of human CC-chemokine receptors CCR3 and CCR4.

PubMed ID: 11196669

DOI: 10.1038/sj.gene.6363638

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9789057

Title: HIV-1 Tat protein mimicry of chemokines.

PubMed ID: 9789057

DOI: 10.1073/pnas.95.22.13153

PubMed ID: 21077277

Title: Increased expression of chemokine receptor CCR3 and its ligands in ulcerative colitis: the role of colonic epithelial cells in in vitro studies.

PubMed ID: 21077277

DOI: 10.1111/j.1365-2249.2010.04248.x

PubMed ID: 30171954

Title: Unique N-terminal extension domain of human asparaginyl-tRNA synthetase elicits CCR3-mediated chemokine activity.

PubMed ID: 30171954

DOI: 10.1016/j.ijbiomac.2018.08.171

Sequence Information:

  • Length: 355
  • Mass: 41044
  • Checksum: E95DCD7A6C643874
  • Sequence:
    • MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 
KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE 
IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE 
TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL 
IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI 
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

Genular Protein ID: 4005947359

Symbol: Q8TDP4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TDP4

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PharmGKB 1 Proteomes 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 21
  • Mass: 2303
  • Checksum: 92F22DCE5269BBF1
  • Sequence:
    • MTTSLDTVET FGTTSYYDDV G

Genular Protein ID: 3128773599

Symbol: Q8TDP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TDP5

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 2 PharmGKB 1 Proteomes 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12079287

Title: Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between Drosophila and humans.

PubMed ID: 12079287

DOI: 10.1006/geno.2002.6801

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 80
  • Mass: 8983
  • Checksum: 1C9D63F3BF54135B
  • Sequence:
    • MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI 
KYRRLRIMTN IYLLNLAISD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.