Genular: Defining Cellular Identity and Function

Details for: Capn2

Gene ID: 12334

Symbol: Capn2

Ensembl ID: ENSMUSG00000026509

Description: calpain 2

Associated with

Degradation of the extracellular matrix
(R-MMU-1474228)
Extracellular matrix organization
(R-MMU-1474244)
Behavioral response to pain
(GO:0048266)
Blastocyst development
(GO:0001824)
Calcium-dependent cysteine-type endopeptidase activity
(GO:0004198)
Calcium ion binding
(GO:0005509)
Calpain complex
(GO:0110158)
Cell projection
(GO:0042995)
Cellular response to amino acid stimulus
(GO:0071230)
Chromatin
(GO:0000785)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Focal adhesion
(GO:0005925)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Myoblast fusion
(GO:0007520)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Perinuclear endoplasmic reticulum
(GO:0097038)
Plasma membrane
(GO:0005886)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of phosphatidylcholine biosynthetic process
(GO:2001247)
Protein-containing complex binding
(GO:0044877)
Protein autoprocessing
(GO:0016540)
Protein catabolic process
(GO:0030163)
Proteolysis
(GO:0006508)
Proteolysis involved in protein catabolic process
(GO:0051603)
Pseudopodium
(GO:0031143)
Regulation of interleukin-6 production
(GO:0032675)

Other Information

Proteins

Calpain-2 catalytic subunit

Genular Protein ID: 4231526793

Symbol: CAN2_MOUSE

Name: Calpain-2 catalytic subunit

UniProtKB Accession Codes:

O08529 O35518 O54843

Database IDs:

Citations:

PubMed ID: 9339374

Title: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.

PubMed ID: 9339374

DOI: 10.1006/geno.1997.4870

PubMed ID: 9669314

Title: Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.

PubMed ID: 9669314

DOI: 10.1002/(sici)1097-4547(19980615)52:6<653::aid-jnr4>3.0.co;2-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22711986

Title: Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.

PubMed ID: 22711986

DOI: 10.1128/mcb.00296-12

Sequence Information:

Length: 700
Mass: 79872
Checksum: 682146B290968316
Sequence:

MAGIAIKLAK DREAAEGLGS HERAIKYLNQ DYETLRNECL EAGALFQDPS FPALPSSLGY 
KELGPYSSKT RGIEWKRPTE ICADPQFIIG GATRTDICQG ALGDCWLLAA IASLTLNEEI 
LARVVPPDQS FQENYAGIFH FQFWQYGEWV EVVVDDRLPT KDGELLFVHS AEGSEFWSAL 
LEKAYAKING CYEALSGGAT TEGFEDFTGG IAEWYELRKP PPNLFKIIQK ALEKGSLLGC 
SIDITSAADS EAVTYQKLVK GHAYSVTGAE EVESSGSLQK LIRIRNPWGQ VEWTGKWNDN 
CPSWNTVDPE VRANLTERQE DGEFWMSFSD FLRHYSRLEI CNLTPDTLTC DSYKKWKLTK 
MDGNWRRGST AGGCRNYPNT FWMNPQYLIK LEEEDEDEED GERGCTFLVG LIQKHRRRQR 
KMGEDMHTIG FGIYEVPEEL TGQTNIHLGK NFFLTTRARE RSDTFINLRE VLNRFKLPPG 
EYVLVPSTFE PHKDGDFCIR VFSEKKADYQ AVDDEIEANI EEIDANEEDI DDGFRRLFVQ 
LAGEDAEISA FELQTILRRV LAKRQDIKSD GFSIETCKIM VDMLDEDGSG KLGLKEFYIL 
WTKIQKYQKI YREIDVDRSG TMNSYEMRKA LEEAGFKLPC QLHQVIVARF ADDELIIDFD 
NFVRCLVRLE TLFKIFKQLD PENTGTIQLN LASWLSFSVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Capn2

Associated with

Other Information

A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. PubMed ID: 9339374

Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant. PubMed ID: 9669314

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334