Details for: CCR5

Gene ID: 1234

Symbol: CCR5

Ensembl ID: ENSG00000160791

Description: C-C motif chemokine receptor 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7663
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.04
    Marker Score: 2108
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2416
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.81
    Marker Score: 8044
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 548
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.64
    Marker Score: 266
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 370
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.53
    Marker Score: 996
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.48
    Marker Score: 278
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 128
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.43
    Marker Score: 1216
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.4
    Marker Score: 292
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.4
    Marker Score: 167.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.39
    Marker Score: 429
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 361
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.37
    Marker Score: 2218
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5655
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.35
    Marker Score: 2222
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 189
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.33
    Marker Score: 102
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.32
    Marker Score: 186
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.31
    Marker Score: 279
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.3
    Marker Score: 775
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.29
    Marker Score: 329
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.28
    Marker Score: 187
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.28
    Marker Score: 144
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.26
    Marker Score: 191
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.26
    Marker Score: 470
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.25
    Marker Score: 81
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.25
    Marker Score: 208
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.24
    Marker Score: 248
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.23
    Marker Score: 261
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.23
    Marker Score: 79
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.21
    Marker Score: 181
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.21
    Marker Score: 90
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.21
    Marker Score: 334
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.18
    Marker Score: 574
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.18
    Marker Score: 217
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 218
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 83
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.16
    Marker Score: 110
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.16
    Marker Score: 352
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.16
    Marker Score: 151
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.15
    Marker Score: 168
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.15
    Marker Score: 119
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.15
    Marker Score: 243
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.15
    Marker Score: 40
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.15
    Marker Score: 287
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 137
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 166.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 28
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 128
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1387
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.11
    Marker Score: 205
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.11
    Marker Score: 41
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 51
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 168
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.09
    Marker Score: 5299
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.09
    Marker Score: 236
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.09
    Marker Score: 23

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Other Information

**Key characteristics:** * CCR5 is a chemokine receptor that belongs to the Class a/1 (rhodopsin-like receptors) of chemotactic receptors. * It is expressed in high levels in the immune system, particularly in mucosal and lymphoid tissues. * CCR5 is a key regulator of HIV entry into host cells. * It binds to HIV-1 and HIV-2 virions, facilitating their entry into target cells. * It also binds to other chemokines, including CXCR3 and CXCR4, which are expressed on immune cells. * Binding to these chemokines enhances the migration and activation of immune cells, promoting the immune response against HIV. **Pathways and functions:** * CCR5 binds to HIV-1 and HIV-2 virions, facilitating their entry into host cells. * Once inside the host cell, CCR5 helps to recruit and activate immune cells, promoting the inflammatory response against HIV. * It also modulates the activity of other immune cells, including dendritic cells and macrophages, which are critical for the control of HIV infection. * By binding to chemokines, CCR5 also plays a role in regulating inflammation and tissue remodeling in various inflammatory diseases, including HIV infection. **Clinical significance:** * Targeting CCR5 with small molecule inhibitors has emerged as a promising therapeutic strategy for HIV infection. * By blocking CCR5-HIV interactions, these inhibitors can inhibit viral entry into host cells and reduce the viral load, leading to improved clinical outcomes in HIV-1 and HIV-2 infected patients. * However, further research is needed to develop effective and safe CCR5 inhibitors for clinical use.

Genular Protein ID: 2174658008

Symbol: CCR5_HUMAN

Name: CHEMR13

UniProtKB Accession Codes:

P51681 O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703 O14704 O14705 O14706 O14707 O14708 O15538 Q9UPA4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 46 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 19 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8639485

Title: Molecular cloning and functional expression of a new human CC-chemokine receptor gene.

PubMed ID: 8639485

DOI: 10.1021/bi952950g

PubMed ID: 8663314

Title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.

PubMed ID: 8663314

DOI: 10.1074/jbc.271.29.17161

PubMed ID: 8699119

Title: Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES.

PubMed ID: 8699119

DOI: 10.1002/jlb.60.1.147

PubMed ID: 9343222

Title: Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.

PubMed ID: 9343222

DOI: 10.1128/jvi.71.11.8642-8656.1997

PubMed ID: 9359654

Title: HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.

PubMed ID: 9359654

DOI: 10.1089/aid.1997.13.1357

PubMed ID: 9388201

Title: The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons.

PubMed ID: 9388201

DOI: 10.1074/jbc.272.49.30662

PubMed ID: 10917742

Title: Novel variant of the CCR5 gene in a Vietnamese population.

PubMed ID: 10917742

DOI: 10.1016/s1286-4579(99)80002-1

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8756719

Title: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.

PubMed ID: 8756719

DOI: 10.1016/s0092-8674(00)80110-5

PubMed ID: 8649511

Title: Identification of a major co-receptor for primary isolates of HIV-1.

PubMed ID: 8649511

DOI: 10.1038/381661a0

PubMed ID: 8649512

Title: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

PubMed ID: 8649512

DOI: 10.1038/381667a0

PubMed ID: 8751444

Title: Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

PubMed ID: 8751444

DOI: 10.1038/382722a0

PubMed ID: 9632396

Title: A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

PubMed ID: 9632396

DOI: 10.1126/science.280.5371.1949

PubMed ID: 10089882

Title: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

PubMed ID: 10089882

DOI: 10.1016/s0092-8674(00)80577-2

PubMed ID: 10085131

Title: Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

PubMed ID: 10085131

DOI: 10.1074/jbc.274.13.8875

PubMed ID: 10383387

Title: Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity.

PubMed ID: 10383387

DOI: 10.1074/jbc.274.27.18902

PubMed ID: 11323418

Title: Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.

PubMed ID: 11323418

DOI: 10.1074/jbc.m100583200

PubMed ID: 11448957

Title: Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.

PubMed ID: 11448957

DOI: 10.1074/jbc.m102782200

PubMed ID: 11733580

Title: Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.

PubMed ID: 11733580

DOI: 10.1084/jem.194.11.1661

PubMed ID: 15757671

Title: JM4 is a four-transmembrane protein binding to the CCR5 receptor.

PubMed ID: 15757671

DOI: 10.1016/j.febslet.2005.02.037

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 16418398

Title: CCR5 deficiency increases risk of symptomatic West Nile virus infection.

PubMed ID: 16418398

DOI: 10.1084/jem.20051970

PubMed ID: 22496149

Title: Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity.

PubMed ID: 22496149

DOI: 10.1182/blood-2011-08-372516

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

PubMed ID: 30713770

Title: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

PubMed ID: 30713770

PubMed ID: 12496074

Title: Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.

PubMed ID: 12496074

DOI: 10.1016/s0006-3495(02)75307-1

PubMed ID: 14517611

Title: Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies.

PubMed ID: 14517611

DOI: 10.1007/s00894-003-0154-9

PubMed ID: 21763489

Title: The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide.

PubMed ID: 21763489

DOI: 10.1016/j.jmb.2011.04.023

PubMed ID: 24030490

Title: Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

PubMed ID: 24030490

DOI: 10.1126/science.1241475

PubMed ID: 9207783

Title: The extent of genetic variation in the CCR5 gene.

PubMed ID: 9207783

DOI: 10.1038/ng0797-221

PubMed ID: 9399903

Title: Novel alleles of the chemokine-receptor gene CCR5.

PubMed ID: 9399903

DOI: 10.1086/301645

PubMed ID: 11369664

Title: A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.

PubMed ID: 11369664

DOI: 10.1182/blood.v97.11.3651

PubMed ID: 17092330

Title: Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks.

PubMed ID: 17092330

DOI: 10.1186/1742-4690-3-81

PubMed ID: 19073967

Title: Shared and distinct genetic variants in type 1 diabetes and celiac disease.

PubMed ID: 19073967

DOI: 10.1056/nejmoa0807917

Sequence Information:

  • Length: 352
  • Mass: 40524
  • Checksum: 88ECE1F38E6D45A7
  • Sequence:
    • MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR 
LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII 
LLTIDRYLAV VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS 
HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI 
MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV 
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.