Details for: CCR5

Gene ID: 1234

Symbol: CCR5

Ensembl ID: ENSG00000160791

Description: C-C motif chemokine receptor 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 33.1736
    Cell Significance Index: -5.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.1851
    Cell Significance Index: -5.1600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.9079
    Cell Significance Index: -5.8600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5276
    Cell Significance Index: 5.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3599
    Cell Significance Index: 10.5700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0429
    Cell Significance Index: 0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0030
    Cell Significance Index: -5.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0062
    Cell Significance Index: -4.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0085
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0091
    Cell Significance Index: -5.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0095
    Cell Significance Index: -0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0097
    Cell Significance Index: -4.4200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0130
    Cell Significance Index: -0.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0143
    Cell Significance Index: -5.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0156
    Cell Significance Index: -4.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0223
    Cell Significance Index: -4.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0224
    Cell Significance Index: -4.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0240
    Cell Significance Index: -2.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0266
    Cell Significance Index: -5.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0268
    Cell Significance Index: -1.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0279
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0287
    Cell Significance Index: -4.9000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0289
    Cell Significance Index: -0.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0356
    Cell Significance Index: -4.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0359
    Cell Significance Index: -4.4100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0377
    Cell Significance Index: -4.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0382
    Cell Significance Index: -5.2500
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0393
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0453
    Cell Significance Index: -5.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0477
    Cell Significance Index: -6.1200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.0505
    Cell Significance Index: -0.2100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0510
    Cell Significance Index: -5.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0549
    Cell Significance Index: -2.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0613
    Cell Significance Index: -4.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0641
    Cell Significance Index: -0.9000
  • Cell Name: mature T cell (CL0002419)
    Fold Change: -0.0653
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0688
    Cell Significance Index: -1.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0692
    Cell Significance Index: -4.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0752
    Cell Significance Index: -5.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0797
    Cell Significance Index: -5.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0847
    Cell Significance Index: -5.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0937
    Cell Significance Index: -4.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0952
    Cell Significance Index: -1.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1049
    Cell Significance Index: -4.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1053
    Cell Significance Index: -5.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1360
    Cell Significance Index: -6.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1404
    Cell Significance Index: -1.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1414
    Cell Significance Index: -4.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1447
    Cell Significance Index: -5.3100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1523
    Cell Significance Index: -3.8800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.1529
    Cell Significance Index: -1.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1535
    Cell Significance Index: -4.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1576
    Cell Significance Index: -5.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1592
    Cell Significance Index: -6.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1605
    Cell Significance Index: -4.6000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1622
    Cell Significance Index: -2.1600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1648
    Cell Significance Index: -2.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1674
    Cell Significance Index: -5.3300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1678
    Cell Significance Index: -2.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1684
    Cell Significance Index: -4.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1691
    Cell Significance Index: -4.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1730
    Cell Significance Index: -4.6200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1749
    Cell Significance Index: -3.4200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1770
    Cell Significance Index: -1.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1780
    Cell Significance Index: -5.6300
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1829
    Cell Significance Index: -2.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1840
    Cell Significance Index: -2.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1874
    Cell Significance Index: -5.1000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1880
    Cell Significance Index: -5.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1895
    Cell Significance Index: -4.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1918
    Cell Significance Index: -4.6000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1949
    Cell Significance Index: -1.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1974
    Cell Significance Index: -4.9300
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1977
    Cell Significance Index: -2.0500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1996
    Cell Significance Index: -4.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2045
    Cell Significance Index: -5.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.2056
    Cell Significance Index: -2.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2101
    Cell Significance Index: -5.2400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2142
    Cell Significance Index: -1.7400
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2161
    Cell Significance Index: -2.9400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2182
    Cell Significance Index: -3.1800
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2189
    Cell Significance Index: -1.8500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2201
    Cell Significance Index: -4.3900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2217
    Cell Significance Index: -3.7900
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.2272
    Cell Significance Index: -2.3100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2283
    Cell Significance Index: -5.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2346
    Cell Significance Index: -5.4200
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2459
    Cell Significance Index: -2.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2467
    Cell Significance Index: -4.1500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2474
    Cell Significance Index: -3.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2481
    Cell Significance Index: -3.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2483
    Cell Significance Index: -5.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2494
    Cell Significance Index: -4.3000
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.2507
    Cell Significance Index: -1.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2507
    Cell Significance Index: -5.3200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2559
    Cell Significance Index: -5.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCR5 is a G-protein coupled receptor (GPCR) that belongs to the class A/1 (rhodopsin-like receptors). It is a heterodimeric receptor composed of a G protein-coupled receptor (GPCR) subunit and a chemokine receptor subunit. CCR5 is characterized by its ability to bind to chemokines, such as CCL3, CCL4, and CCL5, which are key players in the recruitment of immune cells to sites of inflammation and infection. **Pathways and Functions** CCR5 is involved in several signaling pathways, including: 1. **Chemotaxis**: CCR5 plays a crucial role in the recruitment of immune cells to sites of inflammation and infection by binding to chemokines and activating downstream signaling pathways. 2. **Cell surface receptor signaling pathway**: CCR5 is a key player in the cell surface receptor signaling pathway, which involves the activation of G-proteins and the subsequent regulation of various cellular processes, including cell migration, proliferation, and differentiation. 3. **Calcium-mediated signaling**: CCR5 is involved in the regulation of calcium ion concentration in the cytosol, which is essential for various cellular processes, including muscle contraction, neurotransmission, and cell signaling. 4. **G protein-coupled receptor signaling pathway**: CCR5 is a GPCR that activates G-proteins, which in turn regulate various downstream signaling pathways, including the MAPK cascade and the PI3K/AKT pathway. **Clinical Significance** CCR5 has been implicated in several diseases, including: 1. **HIV/AIDS**: CCR5 has been identified as a key player in the pathogenesis of HIV/AIDS. The CCR5 delta32 mutation, which is a deletion of 32 base pairs in the CCR5 gene, is associated with resistance to HIV infection. 2. **Atherosclerosis**: CCR5 has been implicated in the development of atherosclerosis, a condition characterized by the buildup of fatty plaques in the arteries. 3. **Multiple sclerosis**: CCR5 has been implicated in the pathogenesis of multiple sclerosis, a condition characterized by the demyelination of the central nervous system. 4. **Cancer**: CCR5 has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. In conclusion, CCR5 is a crucial chemokine receptor that plays a key role in the immune system, particularly in the recruitment of immune cells to sites of inflammation and infection. Its dysregulation has been implicated in several diseases, including HIV/AIDS, atherosclerosis, multiple sclerosis, and cancer. Further research is needed to fully understand the role of CCR5 in these diseases and to develop effective therapeutic strategies to target this receptor. **Significantly expressed cells** * Goblet cell * Immature innate lymphoid cell * Cerebral cortex GABAergic interneuron * Forebrain radial glial cell * Absorptive cell * Intestinal crypt stem cell of colon * Transit amplifying cell * Abnormal cell * Neoplastic cell * Mature T cell **Proteins** * CCR5_HUMAN (CHEMR13)

Genular Protein ID: 2174658008

Symbol: CCR5_HUMAN

Name: CHEMR13

UniProtKB Accession Codes:

P51681 O14692 O14693 O14695 O14696 O14697 O14698 O14699 O14700 O14701 O14702 O14703 O14704 O14705 O14706 O14707 O14708 O15538 Q9UPA4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EMBL 46 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8639485

Title: Molecular cloning and functional expression of a new human CC-chemokine receptor gene.

PubMed ID: 8639485

DOI: 10.1021/bi952950g

PubMed ID: 8663314

Title: Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.

PubMed ID: 8663314

DOI: 10.1074/jbc.271.29.17161

PubMed ID: 8699119

Title: Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES.

PubMed ID: 8699119

DOI: 10.1002/jlb.60.1.147

PubMed ID: 9343222

Title: Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.

PubMed ID: 9343222

DOI: 10.1128/jvi.71.11.8642-8656.1997

PubMed ID: 9359654

Title: HIV type 1 subtypes, coreceptor usage, and CCR5 polymorphism.

PubMed ID: 9359654

DOI: 10.1089/aid.1997.13.1357

PubMed ID: 9388201

Title: The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons.

PubMed ID: 9388201

DOI: 10.1074/jbc.272.49.30662

PubMed ID: 10917742

Title: Novel variant of the CCR5 gene in a Vietnamese population.

PubMed ID: 10917742

DOI: 10.1016/s1286-4579(99)80002-1

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8756719

Title: Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.

PubMed ID: 8756719

DOI: 10.1016/s0092-8674(00)80110-5

PubMed ID: 8649511

Title: Identification of a major co-receptor for primary isolates of HIV-1.

PubMed ID: 8649511

DOI: 10.1038/381661a0

PubMed ID: 8649512

Title: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.

PubMed ID: 8649512

DOI: 10.1038/381667a0

PubMed ID: 8751444

Title: Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.

PubMed ID: 8751444

DOI: 10.1038/382722a0

PubMed ID: 9632396

Title: A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding.

PubMed ID: 9632396

DOI: 10.1126/science.280.5371.1949

PubMed ID: 10089882

Title: Tyrosine sulfation of the amino terminus of CCR5 facilitates HIV-1 entry.

PubMed ID: 10089882

DOI: 10.1016/s0092-8674(00)80577-2

PubMed ID: 10085131

Title: Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.

PubMed ID: 10085131

DOI: 10.1074/jbc.274.13.8875

PubMed ID: 10383387

Title: Extracellular cysteines of CCR5 are required for chemokine binding, but dispensable for HIV-1 coreceptor activity.

PubMed ID: 10383387

DOI: 10.1074/jbc.274.27.18902

PubMed ID: 11323418

Title: Palmitoylation of CCR5 is critical for receptor trafficking and efficient activation of intracellular signaling pathways.

PubMed ID: 11323418

DOI: 10.1074/jbc.m100583200

PubMed ID: 11448957

Title: Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.

PubMed ID: 11448957

DOI: 10.1074/jbc.m102782200

PubMed ID: 11733580

Title: Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines.

PubMed ID: 11733580

DOI: 10.1084/jem.194.11.1661

PubMed ID: 15757671

Title: JM4 is a four-transmembrane protein binding to the CCR5 receptor.

PubMed ID: 15757671

DOI: 10.1016/j.febslet.2005.02.037

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 16418398

Title: CCR5 deficiency increases risk of symptomatic West Nile virus infection.

PubMed ID: 16418398

DOI: 10.1084/jem.20051970

PubMed ID: 22496149

Title: Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity.

PubMed ID: 22496149

DOI: 10.1182/blood-2011-08-372516

PubMed ID: 24405750

Title: CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.

PubMed ID: 24405750

DOI: 10.1111/tra.12148

PubMed ID: 30713770

Title: Tag7-Mts1 Complex Induces Lymphocytes Migration via CCR5 and CXCR3 Receptors.

PubMed ID: 30713770

PubMed ID: 12496074

Title: Structure modeling of the chemokine receptor CCR5: implications for ligand binding and selectivity.

PubMed ID: 12496074

DOI: 10.1016/s0006-3495(02)75307-1

PubMed ID: 14517611

Title: Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies.

PubMed ID: 14517611

DOI: 10.1007/s00894-003-0154-9

PubMed ID: 21763489

Title: The conformation and orientation of a 27-residue CCR5 peptide in a ternary complex with HIV-1 gp120 and a CD4-mimic peptide.

PubMed ID: 21763489

DOI: 10.1016/j.jmb.2011.04.023

PubMed ID: 24030490

Title: Structure of the CCR5 chemokine receptor-HIV entry inhibitor maraviroc complex.

PubMed ID: 24030490

DOI: 10.1126/science.1241475

PubMed ID: 9207783

Title: The extent of genetic variation in the CCR5 gene.

PubMed ID: 9207783

DOI: 10.1038/ng0797-221

PubMed ID: 9399903

Title: Novel alleles of the chemokine-receptor gene CCR5.

PubMed ID: 9399903

DOI: 10.1086/301645

PubMed ID: 11369664

Title: A homologous naturally occurring mutation in Duffy and CCR5 leading to reduced receptor expression.

PubMed ID: 11369664

DOI: 10.1182/blood.v97.11.3651

PubMed ID: 17092330

Title: Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks.

PubMed ID: 17092330

DOI: 10.1186/1742-4690-3-81

PubMed ID: 19073967

Title: Shared and distinct genetic variants in type 1 diabetes and celiac disease.

PubMed ID: 19073967

DOI: 10.1056/nejmoa0807917

Sequence Information:

  • Length: 352
  • Mass: 40524
  • Checksum: 88ECE1F38E6D45A7
  • Sequence:
    • MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR 
LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII 
LLTIDRYLAV VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS 
HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI 
MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV 
GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.